Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Nature Medicine

• Publication date

  2005-07-24

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/nm1275PMID 16041383
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• AT1 and AT2 receptor in the kidney: role in health and disease.

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• EGF receptor ligands.

  2003cited by this paper
• International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

  2003cited by this paper
• JunD protects against chronic kidney disease by regulating paracrine mitogens.

  2003cited by this paper
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  2003cited by this paper
• Between-patient differences in the renal response to renin-angiotensin system intervention: clue to optimising renoprotective therapy?

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  2002cited by this paper
• Renoprotective effects of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes

  2002cited by this paper
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  2002cited by this paper
• Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability.

  2002cited by this paper
• Tumor necrosis factor-a converting enzyme

  2002cited by this paper
• A novel inhibitor of tumor necrosis factor-alpha converting enzyme ameliorates polycystic kidney disease.

  2001cited by this paper
• Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes.

  2001cited by this paper
• Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission

  2001cited by this paper
• Overexpression of Epidermal Growth Factor Induced Hypospermatogenesis in Transgenic Mice*

  2000cited by this paper
• Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury.

  2000cited by this paper
• International union of pharmacology. XXIII. The angiotensin II receptors.

  2000cited by this paper
• Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE).

  2000cited by this paper
• Angiotensin II-induced growth of vascular smooth muscle cells requires an Src-dependent activation of the epidermal growth factor receptor.

  2000cited by this paper
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  2000cited by this paper
• Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase.

  2000cited by this paper
• Stimulation-induced down-regulation of tumor necrosis factor-alpha converting enzyme.

  2000cited by this paper
• Angiotensin II-induced growth of vascular smooth muscle cells requires an Src-dependent activation of the epidermal growth factor receptor1

  2000cited by this paper
• Stimulation-induced Down-regulation of Tumor Necrosis Factor-α Converting Enzyme*

  2000cited by this paper
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  1999cited by this paper
• Angiotensin receptor blockers in chronic renal disease: the promise of a bright clinical future.

  1999cited by this paper
• Angiotensin II receptors.

  1999cited by this paper
• Calcium-dependent Epidermal Growth Factor Receptor Transactivation Mediates the Angiotensin II-induced Mitogen-activated Protein Kinase Activation in Vascular Smooth Muscle Cells*

  1998cited by this paper
• Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease.

  1998cited by this paper
• Early molecular mechanisms in the progression of renal failure: role of growth factors and protooncogenes.

  1998cited by this paper
• Volume expansion-sensing outward-rectifier Cl- channel: fresh start to the molecular identity and volume sensor.

  1997cited by this paper
• Reduction of renal mass is lethal in mice lacking vimentin. Role of endothelin-nitric oxide imbalance.

  1997cited by this paper
• Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients.

  1997cited by this paper
• Early role of Fsp1 in epithelial-mesenchymal transformation.

  1997cited by this paper
• Early role of Fsp1 in epithelial-mesenchymal transformation.

  1997cited by this paper
• Mechanisms of injury in progressive renal disease.

  1996cited by this paper
• ACE Inhibitors and the Kidney

  1996cited by this paper
• Angiotensin II Activates at Least Two Tyrosine Kinases in Rat Liver Epithelial Cells

  1995cited by this paper
• Progression of renal disease and renal hypertrophy.

  1995cited by this paper
• EGF and TGF-α in the human kidney: Identification of octopal cells in the collecting duct

  1994cited by this paper
• EGF and TGF-alpha in the human kidney: identification of octopal cells in the collecting duct.

  1994cited by this paper
• Renal cysts in transgenic mice expressing transforming growth factor-alpha.

  1994cited by this paper
• TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice.

  1993cited by this paper
• TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice

  1993cited by this paper
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  1993cited by this paper
• Angiotensin II receptor blockade limits glomerular injury in rats with reduced renal mass.

  1992cited by this paper
• Immunohistochemical identification of tubular segments in percutaneous renal biopsies

  1991cited by this paper
• Segmental distribution of epidermal growth factor binding sites in rabbit nephron.

  1990cited by this paper
• High molecular weight type-alpha transforming growth factor in the urine of patients with surgical bone wound involved in mandibular osteotomy.

  1990cited by this paper
• Effects of epidermal growth factor on collagen synthesis by an epithelioid cell line derived from normal rat kidney.

  1990cited by this paper
• Characterization of high molecular weight transforming growth factor alpha produced by rat hepatocellular carcinoma cells.

  1988cited by this paper
• EGF-induced mitogenesis in proximal tubular cells: potentiation by angiotensin II.

  1987cited by this paper
• Effects of Kidney Disease

  1971cited by this paper

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  2024cites this paper
• Mitochondrial fission inhibition protects against hypertension induced by angiotensin II

  2024cites this paper
• [Towards understanding chronic kidney disease].

  2023cites this paper
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  2023cites this paper
• Comparison of Urinary Ace 2 Levels in Individuals with Hypertension and Type 2 Diabetes with Individuals who have Hypertension but not Diabetes

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  2023cites this paper
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  2022cites this paper
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  2022cites this paper
• Angiotensin Receptors in the Kidney and Vasculature in Hypertension and Kidney Disease.

  2021cites this paper
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  2021cites this paper
• Effects of calcitriol and paricalcitol on renal fibrosis in CKD.

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Increased urinary angiotensin converting enzyme 2 and neprilysin in patients with type 2 diabetes.

  2018cites this paper
• Circulating ADAMs are associated with renal and cardiovascular outcomes in chronic kidney disease patients.

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells

  2017cites this paper
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  2017cites this paper
• ADAM17: A Molecular Switch to Control TNFR2 During Atherogenesis In Vivo.

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016influential citation
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  2016cites this paper
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  2016cites this paper
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  2016influential citation
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper