Janus-faced Enzymes Yeast Tgl3p and Tgl5p Catalyze Lipase and Acyltransferase Reactions

Sona Rajakumari,G. Daum

Published 2010 in Molecular Biology of the Cell

ABSTRACT

The yeast triacylglycerol (TAG) lipases Tgl3p and Tgl5p not only contain a TAG lipase, but also an acyltransferase motif. We show that purified Tgl3p and Tgl5p indeed exhibit lysophospholipid acyltransferase activity. Both Tgl3p and Tgl5p affect the level of glycerophospholipids, and Tgl3p is also important for efficient sporulation of yeast.

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