Molecular determinants for the subtype specificity of μ-conotoxin SIIIA targeting neuronal voltage-gated sodium channels.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Neuropharmacology

• Publication date

  2011-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.neuropharm.2011.03.008PMID 21419143
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pain channelopathies

  2010cited by this paper
• Sodium channelopathies and pain

  2010cited by this paper
• Mechanosensitivity of Nav1.5, a voltage‐sensitive sodium channel

  2010cited by this paper
• μ-conotoxin KIIIA derivatives with divergent affinities versus efficacies in blocking voltage-gated sodium channels.

  2010cited by this paper
• A Subtle Alternative Splicing Event of the NaV1.8 Voltage-Gated Sodium Channel is Conserved in Human, Rat, and Mouse

  2010cited by this paper
• A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides

  2009cited by this paper
• Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA.

  2008cited by this paper
• Neuronally Selective μ-Conotoxins from Conus striatus Utilize an α-Helical Motif to Target Mammalian Sodium Channels*

  2008cited by this paper
• Structure/Function Characterization of μ-Conotoxin KIIIA, an Analgesic, Nearly Irreversible Blocker of Mammalian Neuronal Sodium Channels*

  2007cited by this paper
• Conotoxins containing nonnatural backbone spacers: cladistic-based design, chemical synthesis, and improved analgesic activity.

  2007cited by this paper
• Docking of μ-Conotoxin GIIIA in the Sodium Channel Outer Vestibule

  2007cited by this paper
• µO-Conotoxins Inhibit NaV Channels by Interfering with their Voltage Sensors in Domain-2

  2007cited by this paper
• Conotoxins of the O-superfamily affecting voltage-gated sodium channels

  2007cited by this paper
• An SCN9A channelopathy causes congenital inability to experience pain

  2006cited by this paper
• A novel conotoxin from Conus striatus, mu-SIIIA, selectively blocking rat tetrodotoxin-resistant sodium channels.

  2006cited by this paper
• The μO‐conotoxin MrVIA inhibits voltage‐gated sodium channels by associating with domain‐3

  2006cited by this paper
• Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels.

  2005cited by this paper
• Molecular interaction of δ‐conotoxins with voltage‐gated sodium channels

  2005cited by this paper
• Molecular interaction of delta-conotoxins with voltage-gated sodium channels.

  2005cited by this paper
• Conus venoms: a rich source of novel ion channel-targeted peptides.

  2004cited by this paper
• A δ-Conotoxin from Conus ermineus Venom Inhibits Inactivation in Vertebrate Neuronal Na+ Channels but Not in Skeletal and Cardiac Muscles*

  2004cited by this paper
• Interactions of the C-11 hydroxyl of tetrodotoxin with the sodium channel outer vestibule.

  2003cited by this paper
• Mechanisms of the inhibition of Shaker potassium channels by protons

  2003cited by this paper
• Critical molecular determinants of voltage-gated sodium channel sensitivity to mu-conotoxins GIIIA/B.

  2002cited by this paper
• Evolution of voltage-gated Na(+) channels.

  2002cited by this paper
• Mu-conotoxin SmIIIA, a potent inhibitor of tetrodotoxin-resistant sodium channels in amphibian sympathetic and sensory neurons.

  2002cited by this paper
• Clockwise Domain Arrangement of the Sodium Channel Revealed by μ-Conotoxin (GIIIA) Docking Orientation*

  2001cited by this paper
• μ-Conotoxin Giiia Interactions with the Voltage-Gated Na+ Channel Predict a Clockwise Arrangement of the Domains

  2000cited by this paper
• Modulation of cloned skeletal muscle sodium channels by the scorpion toxins Lqh II, Lqh III, and LqhαIT

  2000cited by this paper
• NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy.

  1998cited by this paper
• Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site.

  1998cited by this paper
• Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons

  1998cited by this paper
• A single serine residue confers tetrodotoxin insensitivity on the rat sensory‐neuron‐specific sodium channel SNS

  1997cited by this paper
• A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons

  1996cited by this paper
• Structure and Function of a Novel Voltage-gated, Tetrodotoxin-resistant Sodium Channel Specific to Sensory Neurons (*)

  1996cited by this paper
• A Missense Mutation in the Sodium Channel Scn8a Is Responsible for Cerebellar Ataxia in the Mouse Mutant jolting

  1996cited by this paper
• A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule.

  1995cited by this paper
• Structure and functional expression of a new member of the tetrodotoxin‐sensitive voltage‐activated sodium channel family from human neuroendocrine cells.

  1995cited by this paper
• Visual identification of individual transfected cells for electrophysiology using antibody-coated beads.

  1994cited by this paper
• Primary structure of the adult human skeletal muscle voltage‐dependent sodium channel

  1992cited by this paper
• Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel.

  1992cited by this paper
• Molecular localization of an ion-binding site within the pore of mammalian sodium channels.

  1992cited by this paper
• Molecular basis for pharmacological differences between brain and cardiac sodium channels

  1992cited by this paper
• A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties

  1992cited by this paper
• Primary structure and functional expression of a mammalian skeletal muscle sodium channel.

  1989cited by this paper
• Expression of functional sodium channels from cloned cDNA

  1986cited by this paper
• Sodium channels in nerve apparently have two conductance states

  1977cited by this paper

• Marine-derived bioactive compounds for neuropathic pain: pharmacology and therapeutic potential

  2025influential citation
• Conotoxins Targeting Voltage-Gated Sodium Ion Channels

  2024cites this paper
• Voltage-Gated Sodium Channel Inhibition by µ-Conotoxins

  2024influential citation
• Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels

  2023cites this paper
• µ-Conotoxins Targeting the Human Voltage-Gated Sodium Channel Subtype NaV1.7

  2022cites this paper
• Voltage-Gated Sodium Channels: A Prominent Target of Marine Toxins

  2021cites this paper
• Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible NaV Channel Inhibitor

  2020cites this paper
• Neurobiological activity of conotoxins via sodium channel modulation.

  2020cites this paper
• Virtual insights on G protein inhibition and ion channel block – a computer-based study

  2019cites this paper
• In Silico Analysis of the Subtype Selective Blockage of KCNA Ion Channels through the µ-Conotoxins PIIIA, SIIIA, and GIIIA

  2019cites this paper
• Insights into the Folding of Disulfide-Rich μ-Conotoxins

  2018cites this paper
• Where cone snails and spiders meet: design of small cyclic sodium‐channel inhibitors

  2018cites this paper
• 6.12 – Ion Channels☆

  2018cites this paper
• A novel &mgr;‐conotoxin from worm‐hunting Conus tessulatus that selectively inhibit rat TTX‐resistant sodium currents

  2017cites this paper
• Subtype-specific block of voltage-gated K+ channels by μ-conopeptides.

  2017cites this paper
• The hitchhiker’s guide to the voltage-gated sodium channel galaxy

  2016cites this paper
• Beiträge zur nachhaltigen Synthese und Anwendung von BINBAM-Derivaten und aminosäurebasierten ionischen Flüssigkeiten

  2016cites this paper
• The Role of Individual Disulfide Bonds of μ-Conotoxin GIIIA in the Inhibition of NaV1.4

  2016cites this paper
• Heterologous expression of NaV1.9 chimeras in various cell systems

  2015cites this paper
• Α- and β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ.

  2015cites this paper
• Animal toxins influence voltage-gated sodium channel function.

  2014cites this paper
• Re-engineering the μ-conotoxin SIIIA scaffold.

  2014cites this paper
• Conotoxins and Other Conopeptides

  2014cites this paper
• Mechanism of μ-Conotoxin PIIIA Binding to the Voltage-Gated Na+ Channel NaV1.4

  2014cites this paper
• Pharmacological fractionation of tetrodotoxin‐sensitive sodium currents in rat dorsal root ganglion neurons by μ‐conotoxins

  2013cites this paper
• Advances in Targeting Voltage‐Gated Sodium Channels with Small Molecules

  2012cites this paper
• Design of Bioactive Peptides from Naturally Occurring μ-Conotoxin Structures*

  2012cites this paper
• Mechanism and molecular basis for the sodium channel subtype specificity of µ‐conopeptide CnIIIC

  2012cites this paper
• Design of Bioactive Peptides from Naturally Occurring

  2012cites this paper
• Conotoxins Targeting Neuronal Voltage-Gated Sodium Channel Subtypes: Potential Analgesics?

  2012cites this paper
• Conus Venom Peptide Pharmacology

  2012cites this paper
• Biophysical properties of Nav1.8/Nav1.2 chimeras and inhibition by µO‐conotoxin MrVIB

  2012cites this paper
• Engineering of conotoxins for the treatment of pain.

  2011cites this paper