A SCARECROW-RETINOBLASTOMA Protein Network Controls Protective Quiescence in the Arabidopsis Root Stem Cell Organizer

Ben Scheres and colleagues report that in the growing tip of plant roots, a gene regulatory network that includes the plant homologue of Retinoblastoma regulates the divisions of long-term stem cells to replenish tissue and to protect the root stem cell niche.

• Publication year

  2013

• Venue

  PLoS Biology

• Publication date

  2013-11-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1371/journal.pbio.1001724PMID 24302889PMCID 3841101
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• Faculty Opinions recommendation of Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.

  2009cited by this paper
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  2009cited by this paper
• The Arabidopsis ATRIP ortholog is required for a programmed response to replication inhibitors.

  2009cited by this paper
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  2009influential reference
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  2009cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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  1976cited by this paper
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  1972cited by this paper
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