Caveolae are an essential component of the pathway for endothelial cell signaling associated with abrupt reduction of shear stress.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Biochimica et Biophysica Acta

• Publication date

  2008-10-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.bbamcr.2008.05.010PMID 18573285PMCID PMC2615406
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Participation of caveolae in beta‐1 integrin‐mediated mechanotransduction

  2007cited by this paper
• Lipid Raft Redox Signaling Platforms in Endothelial Dysfunction

  2007cited by this paper
• Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels.

  2006cited by this paper
• Lung endothelial cell proliferation with decreased shear stress is mediated by reactive oxygen species.

  2006cited by this paper
• KATP Channels Are an Important Component of the Shear‐Sensing Mechanism in the Pulmonary Microvasculature

  2006cited by this paper
• Endothelin‐1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ETB receptor, NADPH oxidase and caveolin‐1

  2005cited by this paper
• cAbl Tyrosine Kinase Mediates Reactive Oxygen Species– and Caveolin-Dependent AT1 Receptor Signaling in Vascular Smooth Muscle: Role in Vascular Hypertrophy

  2005cited by this paper
• Novel Role of ARF6 in Vascular Endothelial Growth Factor–Induced Signaling and Angiogenesis

  2005cited by this paper
• Membrane depolarization and NADPH oxidase activation in aortic endothelium during ischemia reflect altered mechanotransduction.

  2005cited by this paper
• The expression of the NADPH oxidase subunit p22phox is regulated by a redox-sensitive pathway in endothelial cells.

  2005cited by this paper
• Activation of endothelial NADPH oxidase during normoxic lung ischemia is KATP channel dependent.

  2005cited by this paper
• Integrin mechanotransduction stimulates caveolin-1 phosphorylation and recruitment of Csk to mediate actin reorganization.

  2005cited by this paper
• Caveolin-1 Facilitates Mechanosensitive Protein Kinase B (Akt) Signaling In Vitro and In Vivo

  2005cited by this paper
• Caveolin-1 Is Essential for Activation of Rac1 and NAD(P)H Oxidase After Angiotensin II Type 1 Receptor Stimulation in Vascular Smooth Muscle Cells: Role in Redox Signaling and Vascular Hypertrophy

  2005cited by this paper
• Reactive oxygen species as mediators of angiogenesis signaling. Role of NAD(P)H oxidase

  2004cited by this paper
• Endothelial Cell Proliferation Associated with Abrupt Reduction in Shear Stress Is Dependent on Reactive Oxygen Species

  2004cited by this paper
• Ca2+ Flux Through Voltage‐Gated Channels with Flow Cessation in Pulmonary Microvascular Endothelial Cells

  2004cited by this paper
• Recruitment of endothelial caveolae into mechanotransduction pathways by flow conditioning in vitro.

  2003cited by this paper
• Shear stress increases expression of a KATP channel in rat and bovine pulmonary vascular endothelial cells.

  2003cited by this paper
• Caveolin-1 Regulates Transforming Growth Factor (TGF)-β/SMAD Signaling through an Interaction with the TGF-β Type I Receptor*

  2001cited by this paper
• Signaling pathway for nitric oxide generation with simulated ischemia in flow-adapted endothelial cells.

  2001cited by this paper
• An immediate endothelial cell signaling response to lung ischemia.

  2001cited by this paper
• Oxidative burst and NO generation as initial response to ischemia in flow-adapted endothelial cells.

  2001cited by this paper
• Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor.

  2001cited by this paper
• Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities.

  2001cited by this paper
• Laminar shear stress inhibits vascular endothelial cell proliferation by inducing cyclin-dependent kinase inhibitor p21(Sdi1/Cip1/Waf1)

  2000cited by this paper
• Shear-induced tyrosine phosphorylation in endothelial cells requires Rac1-dependent production of ROS.

  1999cited by this paper
• Simulated ischemia in flow-adapted endothelial cells leads to generation of reactive oxygen species and cell signaling.

  1999cited by this paper
• Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product.

  1999cited by this paper
• Endothelial NADPH oxidase as the source of oxidants in lungs exposed to ischemia or high K+.

  1998cited by this paper
• ATP-independent membrane depolarization with ischemia in the oxygen-ventilated isolated rat lung.

  1998cited by this paper
• A general strategy for isolation of endothelial cells from murine tissues. Characterization of two endothelial cell lines from the murine lung and subcutaneous sponge implants.

  1997cited by this paper
• Intracellular generation of reactive oxygen species during nonhypoxic lung ischemia.

  1997cited by this paper
• Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats.

  1997cited by this paper
• Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

  1997cited by this paper

• A549 and CI-hAELVi cell lines coculture as a new human alveolar epithelium model for air-liquid interface exposure.

  2026cites this paper
• Post-myocardial Infarction Cardiac Remodeling: Multidimensional Mechanisms and Clinical Prospects of Stem Cell Therapy

  2025cites this paper
• Contribution of inwardly rectifying potassium channel 4.1 in orofacial neuropathic pain: Regulation of pannexin 3 via the reactive oxygen species‐activated P38 MAPK signal pathway

  2024cites this paper
• Shear stress-induced restoration of pulmonary microvascular endothelial barrier function following ischaemia reperfusion injury requires VEGFR2 signalling.

  2024cites this paper
• Mechanotransduction Regulates the Interplays Between Alveolar Epithelial and Vascular Endothelial Cells in Lung

  2022cites this paper
• The Role of Glycocalyx and Caveolae in Vascular Homeostasis and Diseases

  2021cites this paper
• Mechanosensing and Mechanotransduction in Pulmonary Hypertension

  2021cites this paper
• The effect of shear stress reduction on endothelial cells: A microfluidic study of the actin cytoskeleton.

  2020cites this paper
• Caveolae and lipid sorting: Shaping the cellular response to stress

  2020cites this paper
• The Evolution of Cholesterol-Rich Membrane in Oxygen Adaption: The Respiratory System as a Model

  2019cites this paper
• NADPH oxidase in the vasculature: Expression, regulation and signalling pathways; role in normal cardiovascular physiology and its dysregulation in hypertension.

  2019cites this paper
• Understanding mechanobiology in cultured endothelium: A review of the orbital shaker method

  2019cites this paper
• Redox-Dependent Circuits Regulating B Lymphocyte Physiology

  2018cites this paper
• Peroxiredoxin 6 in the repair of peroxidized cell membranes and cell signaling.

  2017cites this paper
• Effects of shear stress on endothelial cells: go with the flow

  2017cites this paper
• The inner blood‐retinal barrier: Cellular basis and development

  2017cites this paper
• Onset of Inflammation With Ischemia: Implications for Donor Lung Preservation and Transplant Survival

  2016cites this paper
• Caveolae: A Role in Endothelial Inflammation and Mechanotransduction?

  2016influential citation
• Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction

  2016cites this paper
• From embryonic development to human diseases: The functional role of caveolae/caveolin.

  2016cites this paper
• The blood–brain barrier after stroke: Structural studies and the role of transcytotic vesicles

  2016cites this paper
• Peroxiredoxin 6 homodimerization and heterodimerization with glutathione S-transferase pi are required for its peroxidase but not phospholipase A2 activity.

  2016cites this paper
• How Do We Prevent the Vulnerable Atherosclerotic Plaque From Rupturing? Insights From In Vivo Assessments of Plaque, Vascular Remodeling, and Local Endothelial Shear Stress

  2015cites this paper
• Shear-Dependent Attenuation of Cellular ROS Levels can Suppress Proinflammatory Cytokine Injury to Human Brain Microvascular Endothelial Barrier Properties

  2015cites this paper
• Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses.

  2015cites this paper
• Keratinocyte Growth Factor and Glucocorticoid Induction of Human Peroxiredoxin 6 Gene Expression Occur by Independent Mechanisms That Are Synergistic

  2014cites this paper
• Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury.

  2014cites this paper
• Mechanotransduction: Forces, Sensors, and Redox Signaling

  2014cites this paper
• Shear stress-related mechanosignaling with lung ischemia: lessons from basic research can inform lung transplantation.

  2014cites this paper
• Protection against LPS-induced acute lung injury by a mechanism-based inhibitor of NADPH oxidase (type 2).

  2014cites this paper
• Remote ischemic preconditioning differentially affects NADPH oxidase isoforms during hepatic ischemia-reperfusion.

  2014cites this paper
• The serpentine path to a novel mechanism-based inhibitor of acute inflammatory lung injury.

  2014cites this paper
• S-Glutathionylation of Ion Channels: Insights into the Regulation of Channel Functions, Thiol Modification Crosstalk, and Mechanosensing

  2014cites this paper
• Mechanotransduction in the Endothelium: Role of Membrane Proteins and Reactive Oxygen Species in Sensing, Transduction, and Transmission of the Signal with Altered Blood Flow

  2014influential citation
• Mechanotransduction Drives Post Ischemic Revascularization Through KATP Channel Closure and Production of Reactive Oxygen Species

  2014cites this paper
• ENDOTHELIAL MECHANOTRANSDUCTION MECHANISMS FOR VASCULAR PHYSIOLOGY AND ATHEROSCLEROSIS

  2014cites this paper
• Hypertension-induced inflammation: from cellular mechanisms to disease

  2014cites this paper
• Rôle de la sérotonine et de la connexine 43 dans la paroi artérielle pulmonaire : implications dans l'hypertension pulmonaire

  2014cites this paper
• Impaired expression of caveolin-1 contributes to hepatic ischemia and reperfusion injury.

  2014cites this paper
• Mechanosensory Pathways in Angiocrine Mediated Tissue Regeneration

  2013cites this paper
• Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions.

  2013cites this paper
• Sterol-Dependent Induction of Plant Defense Responses by a Microbe-Associated Molecular Pattern from Trichoderma viride1[W][OPEN]

  2013cites this paper
• p67phox terminates the phospholipase A2‐derived signal for activation of NADPH oxidase (NOX2)

  2013cites this paper
• MICU1 motifs define mitochondrial calcium uniporter binding and activity.

  2013cites this paper
• The FASEB JournalResearch Communication p67 phox terminates the phospholipase A 2 -derived signal for activation of NADPH oxidase (NOX2)

  2013cites this paper
• The less-often-traveled surface of stem cells: caveolin-1 and caveolae in stem cells, tissue repair and regeneration

  2013cites this paper
• Functional interaction of glutathione S-transferase pi and peroxiredoxin 6 in intact cells.

  2013cites this paper
• PECAM-1 and caveolae form the mechanosensing complex necessary for NOX2 activation and angiogenic signaling with stopped flow in pulmonary endothelium.

  2013influential citation
• Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae

  2012cites this paper
• Chinese medicine, flowing blood, biomechanopharmacology and future preventive medicine

  2012cites this paper
• Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS.

  2012influential citation
• Pulmonary endothelial cell NOX.

  2012cites this paper
• Physical activity opposes coronary vascular dysfunction induced during high fat feeding in mice

  2012cites this paper
• Regulation of Cell Signaling and Function by Endothelial Caveolins: Implications in Disease

  2012influential citation
• Stop the flow: a paradigm for cell signaling mediated by reactive oxygen species in the pulmonary endothelium.

  2012influential citation
• Caveolae, Caveolins, Cavins, and Endothelial Cell Function: New Insights

  2012influential citation
• Flow-dependent endothelial function and kidney dysfunction.

  2012cites this paper
• Red in Translation Pulmonary Endothelial Cell NOX

  2012cites this paper
• Caveolin-1 regulation of endothelial nitric oxide synthase function and oxidative stress in the endothelium

  2012cites this paper
• Role of endothelial shear stress in the destabilization of coronary plaque: Acute coronary syndromes and rapid plaque progression

  2012cites this paper
• Rab38 targets to lamellar bodies and normalizes their sizes in lung alveolar type II epithelial cells.

  2011cites this paper
• Shear Stress, Cell Signaling, and Pulmonary Vascular Remodeling

  2011cites this paper
• Peroxiredoxin 6 Phosphorylation and Subsequent Phospholipase A2 Activity Are Required for Agonist-mediated Activation of NADPH Oxidase in Mouse Pulmonary Microvascular Endothelium and Alveolar Macrophages*

  2011cites this paper
• Mechanisms for Vascular Cell Adhesion Molecule-1 Activation of ERK1/2 during Leukocyte Transendothelial Migration

  2011cites this paper
• Endothelial caveolae and caveolin-1 as key regulators of atherosclerosis.

  2010cites this paper
• Mechanical Strain-Induced RhoA Activation Requires NADPH Oxidase-Mediated ROS Generation in Caveolae

  2010cites this paper
• Caveolin-1 Induces Formation of Membrane Tubules That Sense Actomyosin Tension and Are Inhibited by Polymerase I and Transcript Release Factor/Cavin-1

  2010cites this paper
• Involvement of Caveolin-1 in Repair of DNA Damage through Both Homologous Recombination and Non-Homologous End Joining

  2010cites this paper
• Dietary Curcumin Increases Antioxidant Defenses in Lung, Ameliorates Radiation-Induced Pulmonary Fibrosis, and Improves Survival in Mice

  2010cites this paper
• Membrane rafts and caveolae in cardiovascular signaling

  2009cites this paper
• Ras and Nox: Linked signaling networks?

  2009cites this paper
• Microfluidic Systems for Pathogen Sensing: A Review

  2009cites this paper
• Redox Signaling Across Cell Membranes

  2009cites this paper
• Lipid Rafts and Caveolae and Their Role in Compartmentation of Redox Signaling

  2009cites this paper
• Lung Ischemia: A Model for Endothelial Mechanotransduction

  2008cites this paper