Binding effect of albumin on uptake of bilirubin by brain.

A mathematical model is presented to describe quantitatively the uptake of bilirubin into the brain from blood, under conditions of extensive binding to plasma proteins. The model relates bilirubin uptake to the rate constants for dissociation and association of the albumin/bilirubin complex and to the transit time of blood through brain capillaries. A rational basis is given for deciding between the total or the free bilirubin concentration as an appropriate indicator of brain exposure to the toxic effects of bilirubin. The effect of competition for binding sites by drugs such as sulfonamides on the brain uptake of bilirubin is also described quantitatively.

• Publication year

  1987

• Venue

  Pediatrics

• Publication date

  1987-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1542/peds.79.4.553PMID 3822673
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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