A comparison of the acute effects of radiation therapy, including or excluding the thymus, on the lymphocyte subpopulations of cancer patients.

No abstract is available for this paper.

• Publication year

  1975

• Venue

  Journal of Clinical Investigation

• Publication date

  1975-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1172/JCI108084PMID 1095613PMCID PMC436559
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• LYMPHOCYTE RESPONSE AFTER RADIOTHERAPY

  1974cited by this paper
• Thoracic irradiation--induced lymphopenia in mice.

  1974cited by this paper
• Letter: Lymphocyte response after radiotherapy.

  1974cited by this paper
• Purification of human T and B lymphocytes.

  1974cited by this paper
• Antibodies specific for human T lymphocytes in cold agglutinin and lymphocytotoxic sera

  1973cited by this paper
• In vitro methods of assessing lymphocyte transformation in patients undergoing radiotherapy for bronchogenic cancer.

  1973cited by this paper
• Cellular immune competence of breast cancer patients receiving radiotherapy.

  1973cited by this paper
• Lymphocyte response after radiotherapy.

  1973cited by this paper
• SURFACE MARKERS ON HUMAN T AND B LYMPHOCYTES

  1972cited by this paper
• Receptors for complement and immunoglobulin on human leukemic cells and human lymphoblastoid cell lines.

  1972cited by this paper
• The human rosette-forming cell as a marker of a population of thymus-derived cells.

  1972cited by this paper
• Lymphopenia and change in distribution of human B and T lymphocytes in peripheral blood induced by irradiation for mammary carcinoma.

  1972cited by this paper
• BRAIN-ASSOCIATED STEM CELL ANTIGEN: AN ANTIGEN SHARED BY BRAIN AND HEMOPOIETIC STEM CELLS

  1972cited by this paper
• Turnover rate of normal blood lymphocytes and exchangeable pool size in man, calculated from analysis of chromosomal aberrations sustained during extracorporeal irradiation of the blood.

  1972cited by this paper
• Effect of postoperative radiotherapy on peripheral blood lymphocytes in patients with carcinoma of the breast

  1972cited by this paper
• Tissue localization of two populations of human lymphocytes distinguished by membrane receptors.

  1972cited by this paper
• Effect of irradiation on the release of lymphocytes from the thymus.

  1972cited by this paper
• Cytotoxic Lymphocytes as Effector Cells of Cell-Mediated Immunity*

  1971cited by this paper
• Blood lymphocyte replicating ability as a measurement of radiation dosage.

  1971cited by this paper
• Rosette formation, a test for cellular immunity.

  1971cited by this paper
• Further developments of the rosette inhibition test for the testing of antihuman lymphocyte serum.

  1971cited by this paper
• Effect of therapeutic irradiation on lymphocyte transformation in lung cancer

  1971cited by this paper
• Theta-Bearing and Complement-Receptor Lymphocytes Are Distinct Populations of Cells

  1971cited by this paper
• IMMUNOGLOBULINS ON THE SURFACE OF LYMPHOCYTES

  1971cited by this paper
• A MICROASSAY FOR CELL-MEDIATED IMMUNITY

  1970cited by this paper
• Cooperation of Immune Lymphoid Cells with Macrophages in Tumour Immunity

  1970cited by this paper
• Immunoglobulin Determinants on the Surface of Mouse Lymphoid Cells

  1970cited by this paper
• Receptor sites for complement on certain human peripheral blood lymphocytes.

  1970cited by this paper
• The interaction of monocytes and macrophages with immunoglobulins and complement.

  1970cited by this paper
• Rosette-formation between human lymphocytes and sheep red cells not involving immunoglobulin receptors.

  1970cited by this paper
• Cytotoxic effects of lymphoid cells in vitro.

  1969cited by this paper
• The thymus humoral factor under scrutiny

  1969cited by this paper
• Purification of lymphocytes and platelets by gradient centrifugation.

  1968cited by this paper
• Effects of heavy mediastinal x-irradiation on sex-specific histocompatibility.

  1967cited by this paper
• Effect of previous irradiation on the transformation of blood lymphocytes

  1965cited by this paper
• Irradiation of the Blood: Method for Reducing Lymphocytes in Blood and Spleen

  1964cited by this paper
• Effect of x-irradiation on the pituitary-adrenal axis of the rat.

  1963cited by this paper
• Reduction of gamma-globulins.

  1962cited by this paper
• Reduction of gamma-globulins.

  1962cited by this paper
• Pituitary-adrenal cortical control of lymphocyte structure and function as revealed by experimental X-radiation.

  1946cited by this paper

• Prospective assessment of MR-guided single-fraction stereotactic ablative radiotherapy for peripheral lung metastases: dosimetric and clinical outcomes.

  2025cites this paper
• Mitochondrial function changes in T cell subsets during radiotherapy for patients with nasopharyngeal carcinoma

  2025cites this paper
• Dosimetric Effect of Thymus on Radiation-Induced Lymphopenia in Breast Cancer Patients Who Received Adjuvant Radiotherapy

  2025cites this paper
• Defining the Optimal Radiation-induced Lymphopenia Metric to Discern Its Survival Impact in Esophageal Cancer

  2025cites this paper
• Can lymphocytes serve as a predictor of response to preoperative chemoradiation therapy for locally advanced rectal cancer?

  2023cites this paper
• Effect of Lymphopenia on Tumor Response and Clinical Outcomes Following Chemoradiotherapy in Stage III Non-Small Cell Lung Cancer

  2023cites this paper
• Lymphocytopenia repercussions on stage III Non-small cell lung cancer (NSCLC) patients\' tumour progression and their clinical results after chemoradiation

  2023cites this paper
• Neoadjuvant chemoradiotherapy induced lymphopenia in gastric cancer and associations with spleen dosimetry and survival outcomes.

  2023cites this paper
• Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation

  2022cites this paper
• The Volume of Low-Dose Thoracic Irradiation Influences Systemic Inflammation-Immunity Status After Chemoradiation in Esophageal Cancer.

  2021cites this paper
• Dosimetric Modeling of Lymphopenia in Patients With Metastatic Cancer Receiving Palliative Radiation and PD-1 Immune Checkpoint Inhibitors

  2021cites this paper
• Risk and impact of radiation related lymphopenia in lung cancer: A systematic review and meta-analysis.

  2021cites this paper
• Association of severe lymphopenia and disease progression in unresectable locally advanced non-small cell lung cancer treated with definitive chemoradiation and immunotherapy.

  2021cites this paper
• The influence of severe radiation-induced lymphopenia on overall survival in solid tumors: a systematic review and meta-analysis.

  2021cites this paper
• Radiotherapy for unresectable locally advanced non-small cell lung cancer: a narrative review of the current landscape and future prospects in the era of immunotherapy

  2020cites this paper
• Radiation-induced lymphopenia correlates with survival in nasopharyngeal carcinoma: impact of treatment modality and the baseline lymphocyte count

  2020cites this paper
• Prediction of severe lymphopenia during chemoradiotherapy for esophageal cancer: development and validation of a pretreatment nomogram.

  2020cites this paper
• Lymphopenia during radiotherapy in patients with oropharyngeal cancer.

  2020cites this paper
• A nomogram to predict short-term outcome of radiotherapy or chemoradiotherapy based on pre/post-treatment inflammatory biomarkers and their dynamic changes in esophageal squamous cell carcinoma.

  2020cites this paper
• A Phase I trial assessing the safety and tolerability of a therapeutic DNA vaccination against HPV16 and HPV18 E6/E7 oncogenes after chemoradiation for cervical cancer.

  2020cites this paper
• Using the Systemic Immune-Inflammation Index (SII) as a Mid-Treatment Marker for Survival among Patients with Stage-III Locally Advanced Non-Small Cell Lung Cancer (NSCLC)

  2020cites this paper
• Is clinical target volume necessary?—a failure pattern analysis in patients with locally advanced non-small cell lung cancer treated with concurrent chemoradiotherapy using intensity-modulated radiotherapy technique

  2020cites this paper
• Chemoradiotherapy-Induced CD4+ and CD8+ T-Cell Alterations to Predict Patient Outcomes in Esophageal Squamous Cell Carcinoma

  2019cites this paper
• A novel deep learning model using dosimetric and clinical information for grade 4 radiotherapy-induced lymphopenia prediction

  2019cites this paper
• Dosimetry of the brain and hypothalamus predicting acute lymphopenia and the survival of glioma patients with postoperative radiotherapy

  2019cites this paper
• Lymphocyte-Sparing Effect of Proton Therapy in Patients with Esophageal Cancer Treated with Definitive Chemoradiation.

  2017cites this paper
• The Prognostic Value of Treatment-Related Lymphopenia in Nasopharyngeal Carcinoma Patients

  2017cites this paper
• Anesthesia, Surgery, Immuno Suppression, and Tumor Growth

  2017cites this paper
• Prognostic potential of neutrophil-to-lymphocyte ratio and lymphocyte nadir in stage III non-small-cell lung cancer.

  2017cites this paper
• Minimum absolute lymphocyte counts during radiation are associated with a worse prognosis in patients with unresectable hepatocellular carcinoma

  2016cites this paper
• Interpretation of a heterogeneous radiological response as tumor heterogeneity or a non-tumor diagnosis: A case report.

  2015cites this paper
• Lymphopenia association with gross tumor volume and lung V5 and its effects on non-small cell lung cancer patient outcomes.

  2014cites this paper
• Association between severe treatment‐related lymphopenia and progression‐free survival in patients with newly diagnosed squamous cell head and neck cancer

  2014cites this paper
• Prolonged severe immunodeficiency following thymectomy and radiation: a case report

  2014cites this paper
• Head and Neck Oncology

  2011influential citation
• Circulating lymphocyte is an important determinant of the effectiveness of preoperative radiotherapy in advanced rectal cancer

  2011cites this paper
• Opportunistic Infections in Patients after Complex Therapy of Cancer

  2011cites this paper
• Circulating lymphocyte number has a positive association with tumor response in neoadjuvant chemoradiotherapy for advanced rectal cancer

  2010cites this paper
• Therapeutic approaches to cancer-associated immune suppression

  2009cites this paper
• Brain irradiation-induced lymphocytosis predicts response in cancer patients with brain metastases.

  2008cites this paper
• Brain Irradiation-Induced Lymphocytosis Predicts Response in Cancer Patients with Brain Metastases

  2008cites this paper
• The use of pharmacokinetic and pharmacodynamic end points to determine the dose of AQ4N, a novel hypoxic cell cytotoxin, given with fractionated radiotherapy in a phase I study.

  2007cites this paper
• EFFECT O F THYMOSIN IN VITRO ON T CELL LEVELS DURING RADIATION THERAPY

  2006cites this paper
• Abrogation of the tumor promoting effect of allogeneic blood transfusion by polyadenylic-polyuridylic acid (poly A-poly U)

  2004cites this paper
• Irradiation accidentelle et reconstitution lymphocytaire T : données récentes et perspectives

  1999cites this paper
• Einfluß der primären Radiochemotherapie auf zelluläre und subzelluläre immunologische Parameter

  1999cites this paper
• [Effect of primary radiochemotherapy on cellular and subcellular immunologic parameters].

  1999cites this paper
• Cellular immune defect caused by postsurgical radiation therapy in patients with head and neck cancer

  1998cites this paper
• Effects of glutamine supplements and radiochemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer.

  1998cites this paper
• Phenotypic and immunohistological analyses of the human adult thymus: evidence for an active thymus during adult life.

  1997cites this paper
• The effect of radiation therapy on immune function in patients with squamous cell lung carcinoma.

  1994cites this paper
• Effects of Space Radiation on Humoral and Cellular Immunity in Rhesus Monkeys.

  1992cites this paper
• The Effect of Radiation Therapy on Cellular Immune Response in Patients with Squamous Cell Lung Carcinoma

  1991cites this paper
• Late Immunobiological Effects of Space Radiation

  1990cites this paper
• Immunologic late effects in children and adults.

  1989cites this paper
• Effects of long-term low dose radiation--Epstein-Barr virus-specific antibodies in radiological technologists.

  1988cites this paper
• Histological analysis of lymphocyte subsets infiltrated into mouse tumor tissue exposed to local irradiation.

  1987cites this paper
• Selection of optimal therapy for neuroblastoma: A Study of the Immunomodulatory Effects of Surgery and Irradiation in the Murine C1300 Neuroblastoma Model

  1987cites this paper
• Relative Radiosensitivities of the Thymus, Spleen, and Lymphohemopoietic Systems

  1987cites this paper
• Prognostic value of assays of immune competency

  1987cites this paper
• Incomplete rejoining of DNA double-strand breaks in unstimulated normal human lymphocytes.

  1986cites this paper
• Exclusion of an interactive effect of combined x-irradiation and activated cyclophosphamide in tissue culture.

  1986cites this paper
• Effect of oral contraceptives on leukocyte phagocytic activity and plasma levels of prostaglandin E2 and thromboxane B2 in normal menstruating women.

  1986cites this paper
• Experimental radiosensitizer therapy for malignant tumor transplanted to nude mice

  1986cites this paper
• Analysis of peripheral blood lymphocytes of atomic bomb survivors using monoclonal antibodies.

  1986cites this paper
• A randomized trial to evaluate the immunorestorative properties of synthetic thymosin-alpha 1 in patients with lung cancer.

  1985cites this paper
• T‐cell abnormalities after mediastinal irradiation for lung cancer. The in vitro influence of synthetic thymosin alpha‐1

  1985cites this paper
• Effects of Radiation Therapy on T-Lymphocyte Subpopulations in Patients with Head and Neck Cancer

  1985cites this paper
• T-cell phenotypic profile and colony formation during recovery from cytotoxic therapy-induced marrow aplasia.

  1985cites this paper
• The intrinsic radiosensitivity of lymphocytes in chronic lymphocytic leukaemia, quantitatively determined independently of cell death rate factors.

  1985cites this paper
• A prospective study of the changes in immune status following radiotherapy for Hodgkin's disease

  1984cites this paper
• Hematologie parameters in the adjustment of chemotherapy doses in combined modality treatments involving radiation

  1984cites this paper
• Lymphocyte subpopulations in Hodgkin's disease and non-Hodgkin's lymphoma and the effects of radiotherapy.

  1984cites this paper
• Immunopharmacologic effects of radiation therapy in head and neck cancers

  1984cites this paper
• Depressed mononuclear cell phagocytic activity associated with menstruation.

  1984cites this paper
• Peripheral lymphocyte response to PHA and T cell population among atomic bomb survivors.

  1983cites this paper
• Antibody-dependent cellular cytotoxicity-mediated serotherapy against murine neuroblastoma

  1983cites this paper
• Multimodal therapy in the treatment of breast cancer

  1983cites this paper
• Phase I-II study of 120-hour infused 5-FU and split-course radiation therapy in localized non-small cell lung cancer.

  1983cites this paper
• Effect of Immunomodulating Factors Present in Ascitic Fluids and Sera From Cancer Patients on the Responses of Cultured Mononuclear Cells From Normal Subjects

  1982cites this paper
• Depressed Mononuclear Cell Function in Advanced Neoplastic Disease

  1982cites this paper
• The short effect of pelvic radiotherapy of gynecological cancers on humoral and cell mediated immunity.

  1982cites this paper
• Recovery of lymphocyte function after radiation therapy for cancer in relationship to prognosis.

  1982cites this paper
• Immunobiology of primary intracranial tumors. Part 5: Correlation of a lymphocyte index and clinical status.

  1981cites this paper
• The calculation of the dose to lymphocytes in external beam radiation therapy.

  1981cites this paper
• Stress and cancer.

  1981cites this paper
• The immunoinhibitory activities of the lung lavage materials and sera from patients with pulmonary alveolar proteinosis (PAP).

  1981cites this paper
• Lymphocyte migration and radiation lymphopenia.

  1981cites this paper
• Demonstration by polyacrylamide gel electrophoresis or cancer-associated globulin in sera of newly diagnosed patients.

  1980cites this paper
• Lymphocyte replication in lung cancer patients undergoing radiotherapy.

  1980cites this paper
• A comparison of cell‐mediated immunity and suppressor T‐cell function in asthmatic and normal children

  1980cites this paper
• The effect of radiotherapy on blood mononuclear cell numbers and phagocyte migration.

  1980cites this paper
• Recovery of lymphocyte status after radiotherapy.

  1980cites this paper
• Cellular and humoral immunity in the pathogenesis of recurrent herpes viral infections in patients with lymphoma.

  1980cites this paper
• Impact of Hodgkin's disease upon the immune system.

  1980cites this paper
• [A study on non-specific immunity of breast cancer patients with postoperative irradiation (author's transl)].

  1979cites this paper
• Computer analysis of defined populations of lymphocytes irradiated in vitro. III. Evaluation of human T and B cells of peripheral blood origin.

  1979cites this paper
• Macrophage precursors in ovarian carcinoma.

  1979cites this paper
• Clinical status and rate of recovery of blood lymphocyte levels after radiotherapy for bladder cancer.

  1979cites this paper
• Immune impairment and metastatic tumor growth. The need for an immunorestorative drug as an adjunct to surgery

  1979cites this paper