Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Diabetes

• Publication date

  2001-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2337/DIABETES.50.12.2641PMID 11723044
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor

  2001influential reference
• Release of the angiogenesis inhibitor angiostatin in patients with proliferative diabetic retinopathy: association with retinal photocoagulation

  2000cited by this paper
• Pigment-epithelium-derived factor--a key coordinator of retinal neuronal and vascular functions.

  2000influential reference
• Binding of Pigment Epithelium-derived Factor (PEDF) to Retinoblastoma Cells and Cerebellar Granule Neurons

  1999cited by this paper
• Pigment epithelium-derived factor: a potent inhibitor of angiogenesis.

  1999influential reference
• Immunolocalisation of the VEGF receptors FLT-1, KDR, and FLT-4 in diabetic retinopathy

  1999cited by this paper
• Pigment Epithelium‐Derived Factor Protects Cultured Cerebellar Granule Cells Against Glutamate‐Induced Neurotoxicity

  1997cited by this paper
• Identification of proteins differentially expressed in quiescent and proliferatively senescent fibroblast cultures.

  1995cited by this paper
• Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders.

  1994influential reference
• Vitreous levels of the insulin-like growth factors I and II, and the insulin-like growth factor binding proteins 2 and 3, increase in neovascular eye disease. Studies in nondiabetic and diabetic subjects.

  1993cited by this paper
• Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state.

  1993cited by this paper
• Early photocoagulation for diabetic retinopathy. ETDRS report number 9. Early Treatment Diabetic Retinopathy Study Research Group.

  1991cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper

• Relationship of OCT-Based Diabetic Retinal Neurodegeneration to the Development and Progression of Diabetic Retinopathy: A Cohort Study

  2025cites this paper
• [A modern perspective on the pathogenesis of proliferative diabetic retinopathy].

  2025cites this paper
• Suppressive Role of Pigment Epithelium-derived Factor in a Rat Model of Corneal Allograft Rejection

  2024cites this paper
• Probing the familial ties between serpin members Kallistatin and PEDF: A comparative analysis review.

  2024cites this paper
• The progress of assessment methods and treatments of neovascular glaucoma secondary to central retinal vein occlusion

  2024cites this paper
• Tissue-targeted and localized AAV5-DCN and AAV5-PEDF combination gene therapy abrogates corneal fibrosis and concurrent neovascularization in rabbit eyes in vivo.

  2024cites this paper
• Loss of Pigment Epithelium Derived Factor Sensitizes C57BL/6J Mice to Light-Induced Retinal Damage

  2024cites this paper
• Functional Roles of Pigment Epithelium-Derived Factor in Retinal Degenerative and Vascular Disorders: A Scoping Review

  2024cites this paper
• Diabetic Retinopathy: Soluble and Imaging Ocular Biomarkers

  2023cites this paper
• Enhanced therapeutic effect of PEDF-loaded mesenchymal stem cell-derived small extracellular vesicles against oxygen-induced retinopathy through increased stability and penetrability of PEDF

  2023cites this paper
• Receptors that bind to PEDF and their therapeutic roles in retinal diseases

  2023cites this paper
• Changes in aqueous and vitreous inflammatory cytokine levels in proliferative diabetic retinopathy: a systematic review and meta-analysis

  2022cites this paper
• Aryl hydrocarbon receptor deficiency augments dysregulated microangiogenesis and diabetic retinopathy.

  2022cites this paper
• PEDF-Mediated Mitophagy Triggers the Visual Cycle by Enhancing Mitochondrial Functions in a H2O2-Injured Rat Model

  2021cites this paper
• Tofacitinib Ameliorates Retinal Vascular Leakage in a Murine Model of Diabetic Retinopathy with Type 2 Diabetes

  2021cites this paper
• The biological relevance of pigment epithelium-derived factor on the path from aging to age-related disease.

  2021cites this paper
• Antiangiogenic therapy in diabetic nephropathy: A double-edged sword

  2021cites this paper
• Polyphenol Metabolite Pyrogallol-O-Sulfate Decreases Microglial Activation and VEGF in Retinal Pigment Epithelium Cells and Diabetic Mouse Retina

  2021cites this paper
• Therapeutic Potential of Tpl2 (Tumor Progression Locus 2) Inhibition on Diabetic Vasculopathy Through the Blockage of the Inflammasome Complex

  2020cites this paper
• Pigment epithelium-derived factor (PEDF) ameliorates arsenic-induced vascular endothelial dysfunction in rats and toxicity in endothelial EA.hy926 cells.

  2020cites this paper
• Inflammatory and angiogenic biomarkers in diabetic retinopathy

  2020cites this paper
• Comparison of Topical Pigment Epithelium-Derived Factor (PEDF) with Topical Bevacizumab for Accelerating the Regression of Corneal Neovascularization in an Experimental Model of Rabbit Corneal Angiogenesis

  2020cites this paper
• Angiogenesis-Inflammation Cross Talk in Diabetic Retinopathy: Novel Insights From the Chick Embryo Chorioallantoic Membrane/Human Vitreous Platform

  2020cites this paper
• EFFECT OF LASER PHOTOCOAGULATION ON MACULAR EDEMA ASSOCIATED WITH MACULAR HOLES

  2019cites this paper
• Therapeutic Potential of Pigment Epithelium-derived Factor in Cancer.

  2019cites this paper
• The role of pigment epithelium-derived factor in protecting against cellular stress

  2019cites this paper
• Human vitreous in proliferative diabetic retinopathy: Characterization and translational implications.

  2019cites this paper
• Genetic Regulation of Pigment Epithelium-Derived Factor (PEDF): An Exome-Chip Association Analysis in Chinese Subjects With Type 2 Diabetes

  2018cites this paper
• Pigment epithelium‐derived factor: a key mediator in bone homeostasis and potential for bone regenerative therapy

  2018cites this paper
• Susceptibility genes for diabetic retinopathy

  2017cites this paper
• Ischemic optic neuropathy as a model of neurodegenerative disorder: A review of pathogenic mechanism of axonal degeneration and the role of neuroprotection.

  2017cites this paper
• Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway.

  2017cites this paper
• CD4-CD8 and CD28 Expression in T Cells Infiltrating the Vitreous Fluid in Patients With Proliferative Diabetic Retinopathy

  2017cites this paper
• Angiogenesis-Based Therapies for Eye Diseases

  2017cites this paper
• Evaluation of mRNA/ Gene Expression of Pro-Angiogenic Factors – Ang 1, Ang 2 and HGF in Periodontal Health and Disease

  2017cites this paper
• Perspectives in New Advances in Retinal Neovascularization Pathogenesis and Therapeutic Approaches

  2017cites this paper
• Biochemical Basis and Therapeutic Implications of Angiogenesis

  2017cites this paper
• serine protease inhibitor , is renoprotective by Pigment epithelium-derived factor , a noninhibitory inhibiting the Wnt pathway

  2016cites this paper
• Biomarkers of Diabetic Retinopathy

  2016cites this paper
• The Suppression of Kallistatin on High-Glucose-Induced Proliferation of Retinal Endothelial Cells in Diabetic Retinopathy

  2016cites this paper
• Quantitative proteomic analysis of mice corneal tissues reveals angiogenesis-related proteins involved in corneal neovascularization.

  2016cites this paper
• Is Angiostatin Involved in Physiological Foveal Avascularity?

  2016cites this paper
• Low plasma levels of brain derived neurotrophic factor are potential risk factors for diabetic retinopathy in Chinese type 2 diabetic patients.

  2016cites this paper
• Kallistatin as a marker of microvascular complications in children and adolescents with type 1 diabetes mellitus: Relation to carotid intima media thickness

  2015cites this paper
• PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases

  2015cites this paper
• PEDF in the Retina

  2015cites this paper
• Pigment Epitel Kaynaklı Faktör (PEDF): Çok Yönlü ve Fonksiyonlu Yeni Bir Terapötik Ajan

  2015cites this paper
• Antioxidant Function of Pigment Epithelium Derived Factor in Adipose Tissue, the Prostate, and Prostate Cancer

  2015cites this paper
• Pigment Epitel Kaynakli Faktör (PEDF): Çok Yönlü ve Fonksiyonlu Yeni Bir Terapötik Ajan Pigment Epithelium-Derived Factor (PEDF): A Multifaceted and Functional New Therapeutic Agent

  2015cites this paper
• Vitreous humor in the pathologic scope: Insights from proteomic approaches

  2015cites this paper
• Recombinant pigment epithelium-derived factor PEDF binds vascular endothelial growth factor receptors 1 and 2

  2015cites this paper
• Current Treatment Limitations in Age-Related Macular Degeneration and Future Approaches Based on Cell Therapy and Tissue Engineering

  2014cites this paper
• Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF

  2014cites this paper
• Pigment epithelium-derived factor (PEDF) and cardiometabolic disorders.

  2014cites this paper
• Development of gene therapy for treatment of age‐related macular degeneration

  2014influential citation
• Diabetic Macular Oedema and the Importance of Vascular Endothelial Growth Factor Therapies in its Treatment

  2014cites this paper
• Enhanced survival of retinal ganglion cells is mediated by Müller glial cell-derived PEDF.

  2014cites this paper
• Amniotic membrane properties and current practice of amniotic membrane use in ophthalmology in Slovenia

  2014cites this paper
• D M J B Pigment Epithelium-Derived Factor in Proliferative Diabetic Retinopathy

  2013cites this paper
• The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential

  2013cites this paper
• Targeting neovascularization in ischemic retinopathy: recent advances

  2013cites this paper
• PEDF Expression Is Inhibited by Insulin Treatment in Adipose Tissue via Suppressing 11β-HSD1

  2013cites this paper
• Antiangiogenic and Antineuroinflammatory Effects of Kallistatin Through Interactions With the Canonical Wnt Pathway

  2013cites this paper
• Retinal pigment epithelium, age-related macular degeneration and neurotrophic keratouveitis.

  2013cites this paper
• The many facets of PEDF in drug discovery and disease: a diamond in the rough or split personality disorder?

  2013cites this paper
• Adaptation of the central retina for high acuity vision: cones, the fovea and the avascular zone.

  2013influential citation
• Anti-angiogenic and anti-neuroinflammatory effects of kallistatin through interactions with the canonical Wnt pathway Running title: kallistatin and diabetic retinopathy

  2013cites this paper
• PEDF in Diabetic Retinopathy: A Protective Effect of Oxidative Stress

  2012cites this paper
• Inflammation and Angiogenesis in Diabetic Retinopathy 165 types in the retina in diabetes

  2012cites this paper
• Osteopontin and Other Regulators of Angiogenesis and Fibrogenesis in the Vitreous from Patients with Proliferative Vitreoretinal Disorders

  2012cites this paper
• Hypoxia‐induced upregulation of pigment epithelium‐derived factor by retinal glial (Müller) cells

  2012cites this paper
• Aplicació de tècniques proteòmiques de quantificació i validació en recerca biomèdica

  2012cites this paper
• Imbalanced levels of angiogenic and angiostatic factors in vitreous, plasma and postmortem retinal tissue of patients with proliferative diabetic retinopathy.

  2012cites this paper
• [Recombinant fragment of pigment epithelium-derived factor (44-77) prevents pathological corneal neovascularization].

  2012cites this paper
• Inflammation and Angiogenesis in Diabetic Retinopathy

  2012cites this paper
• Prospectives for Gene Therapy of Retinal Degenerations

  2012cites this paper
• Influence of Lactic Acid on Differential Expression of Vascular Endothelial Growth Factor and Pigment Epithelium-derived Factor in Explants of Rat Retina

  2012cites this paper
• PEDF-derived peptide inhibits corneal angiogenesis by suppressing VEGF expression.

  2012cites this paper
• Recombinant fragment 44–77 of the pigment epithelium-derived factor prevents the development of the pathological cornea neovascularization

  2012cites this paper
• Pigment Epithelium-Derived Factor: Chemistry, Structure, Biology, and Applications

  2012cites this paper
• Angiogenesis-related cytokines in serum of proliferative diabetic retinopathy patients before and after vitrectomy.

  2012cites this paper
• Decreased K5 receptor expression in the retina, a potential pathogenic mechanism for diabetic retinopathy

  2012cites this paper
• Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization.

  2011cites this paper
• Influence of vitreous factors after vitrectomy for macular edema in patients with central retinal vein occlusion

  2011cites this paper
• Serum level of pigment epithelium-derived factor is a marker of atherosclerosis in humans.

  2011cites this paper
• Vitreous Levels of Pigment Epithelium–Derived Factor and Vascular Endothelial Growth Factor in Macular Edema with Central Retinal Vein Occlusion

  2011cites this paper
• Human retinal pigment epithelium cells as functional models for the RPE in vivo.

  2011cites this paper
• Managing diabetic macular edema: The leading cause of diabetes blindness.

  2011cites this paper
• Cytokines in neovascular age-related macular degeneration: fundamentals of targeted combination therapy

  2011cites this paper
• Regulation of Pigment Epithelium-Derived Factor (PEDF), an Insulin Resistance-Inducing Adipocytokine, in 3T3-L1 Adipocytes

  2011cites this paper
• Diabetische Retinopathie und Makulopathie

  2011cites this paper
• Advanced glycation end products (AGEs), oxidative stress and diabetic retinopathy.

  2011cites this paper
• Nanosecond pulse lasers for retinal applications

  2011cites this paper
• PEDF Regulates Vascular Permeability by a γ-Secretase-Mediated Pathway

  2011cites this paper
• Anti-Angiogenic and Anti-Inflammatory Effects of SERPINA3K on Corneal Injury

  2011cites this paper
• Identification of a Novel Inhibitor of the Canonical Wnt Pathway

  2011cites this paper
• Pigment epithelium‐derived factor binds to cell‐surface F1‐ATP synthase

  2010cites this paper
• Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy

  2010cites this paper
• Plasma level of pigment epithelium-derived factor is independently associated with the development of the metabolic syndrome in Chinese men: a 10-year prospective study.

  2010cites this paper
• Antiangiogenic effects and transcriptional regulation of pigment epithelium-derived factor in diabetic retinopathy.

  2010cites this paper