AMPK at the crossroads of circadian clocks and metabolism.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Molecular and Cellular Endocrinology

• Publication date

  2013-02-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.mce.2012.06.017PMID 22750052PMCID PMC3502724
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011influential reference
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  2011cited by this paper
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  2008cited by this paper
• AMPK phosphorylation of raptor mediates a metabolic checkpoint.

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• Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle.

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  2007influential reference
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• Insect cryptochromes: gene duplication and loss define diverse ways to construct insect circadian clocks.

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  2006cited by this paper
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  2006cited by this paper
• F-box proteins: the key to protein degradation.

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  2005cited by this paper
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  2004cited by this paper
• Regulation of the Mammalian Circadian Clock by Cryptochrome*

  2004cited by this paper
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• Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.

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• Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus.

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• Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions.

  1999influential reference
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