Activation of kynurenine pathway in ex vivo fibroblasts from patients with bipolar disorder or schizophrenia: cytokine challenge increases production of 3-hydroxykynurenine.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Psychiatric Research

• Publication date

  2013-11-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/j.jpsychires.2013.08.008PMID 24012176
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014influential reference
• An expanding range of targets for kynurenine metabolites of tryptophan.

  2013cited by this paper
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  2012cited by this paper
• Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia.

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  2012cited by this paper
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  2012influential reference
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  2011cited by this paper
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  2011influential reference
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011influential reference
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  2011cited by this paper
• Elevation of cerebrospinal fluid interleukin-1ß in bipolar disorder.

  2011cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  1988cited by this paper
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  1988cited by this paper

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