A molecular framework for the actions of glucocorticoid hormones in the nervous system.

No abstract is available for this paper.

• Publication year

  1989

• Venue

  Neuron

• Publication date

  1989-02-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/0896-6273(89)90177-3PMID 2696502
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Zinc fingers: gilt by association.

  1988cited by this paper
• The steroid and thyroid hormone receptor superfamily.

  1988cited by this paper
• Signal transduction and transcriptional regulation by glucocorticoid receptor-LexA fusion proteins.

  1988cited by this paper
• Nuclear receptors enhance our understanding of transcription regulation.

  1988cited by this paper
• The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function.

  1988cited by this paper
• Zinc fingers: gilt by association.

  1988cited by this paper
• Alternative splicing generates messages encoding rat c-erbA proteins that do not bind thyroid hormone.

  1988cited by this paper
• The N-terminal region of the chicken progesterone receptor specifies target gene activation

  1988cited by this paper
• A region in the steroid binding domain determines formation of the non-DNA-binding, 9 S glucocorticoid receptor complex.

  1988cited by this paper
• Cloning of human androgen receptor complementary DNA and localization to the X chromosome.

  1988cited by this paper
• Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor

  1988cited by this paper
• Synergistic action of the glucocorticoid receptor with transcription factors.

  1988cited by this paper
• Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formation.

  1988cited by this paper
• Identification of a new class of steroid hormone receptors

  1988cited by this paper
• How eukaryotic transcriptional activators work

  1988cited by this paper
• Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene.

  1988cited by this paper
• Identification of a second human retinoic acid receptor

  1988cited by this paper
• The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response.

  1988cited by this paper
• Cloning and expression of full-length cDNA encoding human vitamin D receptor.

  1988cited by this paper
• Metal binding ‘finger’ structures in the glucocorticoid receptor defined by site‐directed mutagenesis.

  1988cited by this paper
• The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain

  1988cited by this paper
• Molecular cloning of human and rat complementary DNA encoding androgen receptors.

  1988cited by this paper
• Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated.

  1988cited by this paper
• Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors.

  1988cited by this paper
• Multiple and cooperative trans-activation domains of the human glucocorticoid receptor.

  1988cited by this paper
• Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement

  1987cited by this paper
• Molecular cloning and characterization of rat estrogen receptor cDNA.

  1987cited by this paper
• Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement

  1987cited by this paper
• Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor

  1987cited by this paper
• A human retinoic acid receptor which belongs to the family of nuclear receptors

  1987cited by this paper
• Identification of a receptor for the morphogen retinoic acid

  1987cited by this paper
• Identification and spatial distribution of retinoids in the developing chick limb bud

  1987cited by this paper
• Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system.

  1987cited by this paper
• Domains of the glucocorticoid receptor involved in specific and nonspecific deoxyribonucleic acid binding, hormone activation, and transcriptional enhancement.

  1987cited by this paper
• Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor.

  1987cited by this paper
• Adrenocortical steroids and the brain.

  1987cited by this paper
• Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor.

  1987cited by this paper
• Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA.

  1987cited by this paper
• Regulation of ACTH secretion: variations on a theme of B.

  1987cited by this paper
• The hormone response element of the mouse mammary tumour virus DNA mediates the progestin and androgen induction of transcription in the proviral long terminal repeat region.

  1987cited by this paper
• Functional domains of the human estrogen receptor.

  1987cited by this paper
• Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo.

  1987cited by this paper
• Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age.

  1987cited by this paper
• Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor.

  1987cited by this paper
• Two signals mediate hormone‐dependent nuclear localization of the glucocorticoid receptor.

  1987cited by this paper
• ‘Zinc fingers’: a novel protein motif for nucleic acid recognition

  1987cited by this paper
• Thyroid hormones and brain development.

  1987cited by this paper
• The c-erb-A gene encodes a thyroid hormone receptor

  1986cited by this paper
• Functional domains of the human glucocorticoid receptor.

  1986cited by this paper
• Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA.

  1986cited by this paper
• Adrenal steroid receptors and actions in the nervous system.

  1986cited by this paper
• Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

  1986cited by this paper
• Sequence and expression of human estrogen receptor complementary DNA.

  1986cited by this paper
• The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction.

  1986cited by this paper
• The c-erb-A protein is a high-affinity receptor for thyroid hormone

  1986cited by this paper
• Aldosterone effects on salt appetite in adrenalectomized rats.

  1986cited by this paper
• Cell surface changes accompanying the neural differentiation of an embryonal carcinoma cell line

  1986cited by this paper
• Cloning and sequence analysis of rabbit progesterone-receptor complementary DNA.

  1986cited by this paper
• The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild‐type and mutant receptor proteins.

  1986cited by this paper
• Actions of Progesterone on the Brain

  1985cited by this paper
• Primary structure and expression of a functional human glucocorticoid receptor cDNA

  1985cited by this paper
• Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product

  1985cited by this paper
• Glucocorticoid and progesterone receptors bind to the same sites in two hormonally regulated promoters

  1985cited by this paper
• Biochemical effects of corticosteroids on neural tissues.

  1985cited by this paper
• Characterization of aldosterone binding sites in circulating human mononuclear leukocytes.

  1985cited by this paper
• Gonadal steroid induction of structural sex differences in the central nervous system.

  1984cited by this paper
• Aldosterone blocks the response to corticosterone in the raphe-hippocampal serotonin system.

  1983cited by this paper
• Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity.

  1983cited by this paper
• Characterization of rat brain aldosterone receptors reveals high affinity for corticosterone.

  1983cited by this paper
• Decreased serotonin turnover in the dorsal hippocampus of rat brain shortly after adrenalectomy: selective normalization after corticosterone substitution.

  1982cited by this paper
• Steroid hormones: humoral signals which alter brain cell properties and functions.

  1982cited by this paper
• Corticosterone increases the amount of protein 1, a neuron-specific phosphoprotein, in rat hippocampus.

  1981cited by this paper
• Glucocorticoid receptors.

  1979cited by this paper
• [Regulation of ACTH secretion].

  1978cited by this paper
• Thyroid hormones and brain development

  1977cited by this paper
• Differences in corticosterone and dexamethasone binding to rat brain and pituitary.

  1975cited by this paper

• Glucocorticoid feedback paradox: a homage to Mary Dallman

  2023cites this paper
• The cortisol switch between vulnerability and resilience

  2023cites this paper
• Mineralocorticoid receptor and glucocorticoid receptor work alone and together in cell-type-specific manner: Implications for resilience prediction and targeted therapy

  2022cites this paper
• Journal Pre-proof receptor and glucocorticoid receptor work alone and together in cell-type-specific manner: Implications for resilience prediction and targeted therapy

  2022cites this paper
• Non-genomic steroid signaling through the mineralocorticoid receptor: Involvement of a membrane-associated receptor?

  2021cites this paper
• A proposed role for glucocorticoids in mediating dopamine-dependent cue-reward learning

  2020cites this paper
• Top‐down and bottom‐up control of stress‐coping

  2019cites this paper
• Mechanisms of Mineralocorticoid Receptor Signaling.

  2019cites this paper
• Regulation of epithelial sodium channels in vasopressin neurons in the hypothalamus

  2018cites this paper
• Chapter 2 Regulation of Excitatory Synapses by Stress Hormones

  2018cites this paper
• Aldosterone Mediated Regulation of Epithelial Sodium Channel (ENaC) Subunits in the Rat Hypothalamus.

  2018cites this paper
• Tinnitus and Stress

  2017cites this paper
• University of Groningen ANXIOLYTIC-LIKE EFFECTS OF SELECTIVE MINERALOCORTICOID AND GLUCOCORTICOID ANTAGONISTS ON FEAR-ENHANCED BEHAVIOR IN THE ELEVATED PLUS-MAZE KORTE

  2017cites this paper
• A Refill for the Brain Mineralocorticoid Receptor: The Benefit of Cortisol Add-On to Dexamethasone Therapy

  2017cites this paper
• Glucocorticoid hormones are both a major circadian signal and major stress signal: How this shared signal contributes to a dynamic relationship between the circadian and stress systems.

  2017cites this paper
• 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Coregulators as mediators of mineralocorticoid receptor signalling diversity.

  2017cites this paper
• Stress and Glucocorticoid Action in the Brain and Ear: Implications for Tinnitus

  2017cites this paper
• Corticosteroid Receptor Balance Hypothesis

  2016cites this paper
• Steroid Hormone Signaling Pathways and Sex Differences in Neuroendocrine and Behavioral Responses to Stress

  2016cites this paper
• Construction of sensitive reporter assay yeasts for comprehensive detection of ligand activities of human corticosteroid receptors through inactivation of CWP and PDR genes.

  2015cites this paper
• Regulation of Excitatory Synapses by Stress Hormones

  2014cites this paper
• The multifaceted mineralocorticoid receptor.

  2014cites this paper
• Stress hormone receptors change as range expansion progresses in house sparrows

  2013cites this paper
• The interplay between rapid and slow corticosteroid actions in brain.

  2013cites this paper
• Physiological and Behavioral Mechanisms of Range Expansion in the House Sparrow (Passer domesticus)

  2013cites this paper
• Perinatal stress : Characteristics and effects on adult eating behavior

  2013cites this paper
• Contribution of glucocorticoids and glucocorticoid receptors to the regulation of neurodegenerative processes.

  2013cites this paper
• Charakterisierung pflanzlicher Glucocorticoidrezeptor- Modulatoren und ihrer Wirkungen auf den epithelialen Natriumkanal (ENaC)

  2013cites this paper
• Estresse peri-natal: suas características e repercussões sobre o comportamento alimentar na vida adulta

  2013cites this paper
• Immunohistochemical analysis of the colocalization of corticotropin-releasing hormone receptor and glucocorticoid receptor in kisspeptin neurons in the hypothalamus of female rats.

  2012cites this paper
• Combination of chewing and stress up-regulates hippocampal glucocorticoid receptor in contrast to the increase of mineralocorticoid receptor under stress only.

  2012cites this paper
• Mechanisms of ligand specificity of the mineralocorticoid receptor.

  2012cites this paper
• Stress, emotional learning and AMPA receptors: from behavior to molecule

  2011cites this paper
• Glutamatergic System and Mood Disorders

  2011cites this paper
• CALL FOR PAPERS Integrative Aspects of Renal Endocrinology Regulation of epithelial Na channels by adrenal steroids: mineralocorticoid and glucocorticoid effects

  2011cites this paper
• INFLUÊNCIA DAS VARIAÇÕES DE CUIDADO MATERNO NA REATIVIDADE AO ESTRESSE DE RATOS NO PERÍODO NEONATAL

  2009cites this paper
• Injury-induced mineralocorticoid receptor expression involves differential promoter usage: a novel role for the rat MRbeta variant.

  2009cites this paper
• Mineralocorticoid receptor mRNA expression is increased in human hippocampus following brief cerebral ischaemia

  2009cites this paper
• Central corticosteroid actions: Search for gene targets.

  2008cites this paper
• Chronic Stress-induced Hippocampal Vulnerability: The Glucocorticoid Vulnerability Hypothesis

  2008cites this paper
• Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis.

  2007cites this paper
• Hippocampale Mineralocorticoidrezeptoren und ihre inhibitorische Wirkung auf die Limbisch-Hypothalamisch-Hypophysär-Adrenale-Achse bei Patienten mit Posttraumatischer Belastungsstörung (PTSD)

  2006cites this paper
• Abnormalities of the HPA axis in affective disorders: clinical subtypes and potential treatments

  2006cites this paper
• Brain Corticosteroid Receptor Dynamics and Trafficking: Implications from Live Cell Imaging

  2006cites this paper
• Differential Promotion of Glutamate Transporter Expression and Function by Glucocorticoids in Astrocytes from Various Brain Regions*

  2005cites this paper
• Neurotensinergic Systems

  2005cites this paper
• Tolloid-like 1 is negatively regulated by stress and glucocorticoids.

  2005cites this paper
• Hormetic Influence of Glucocorticoids on Human Memory

  2005cites this paper
• Hippocampale Mineralocorticoidrezeptoren inhibieren die Limbisch- Hypothalamisch-Hypophysär-Adrenale-Achse beim Menschen: Vergleich der Mineralocorticoidrezeptoragonisten Fludrocortison und Aldosteron

  2005cites this paper
• Visualization of Glucocorticoid Receptor and Mineralocorticoid Receptor Interactions in Living Cells with GFP-Based Fluorescence Resonance Energy Transfer

  2004cites this paper
• Hormones and the stressed brain.

  2004cites this paper
• Short ReviewGlucocorticoid Receptor Antagonists: New Tools to Investigate Disorders Characterized by Cortisol Hypersecretion

  2004cites this paper
• CHAPTER 14 – Anatomical Substrates of Hypothalamic Integration

  2004cites this paper
• Hormones and the Stressed Brain

  2004cites this paper
• Programming of the Hypothalamo–Pituitary–Adrenal Axis: Serotonergic Involvement

  2004cites this paper
• Acute Glucocorticoid Pretreatment Suppresses Stress‐Induced Hypothalamic‐Pituitary‐Adrenal Axis Hormone Secretion and Expression of Corticotropin‐Releasing Hormone hnRNA but Does Not Affect c‐fos mRNA or Fos Protein Expression in the Paraventricular Nucleus of the Hypothalamus

  2003cites this paper
• Neuroendocrine pharmacology of stress.

  2003cites this paper
• Dexamethasone Inhibits TNF-α Synthesis More Effectively in Alzheimer’s Disease Patients than in Healthy Individuals

  2003cites this paper
• Larger amygdala volumes in first depressive episode as compared to recurrent major depression and healthy control subjects.

  2003cites this paper
• Hormones, brain and stress.

  2003cites this paper
• Hormones, brain and stress

  2003cites this paper
• Molecular Genetics of Adrenal Disease

  2002cites this paper
• Corticosteroid actions on electrical activity in the brain

  2002cites this paper
• Reversed effects of RU486 and anisomycin on memory retention of light exposure or corticosterone facilitation in the dark-incubated chicks

  2001cites this paper
• Psychological Stress Increases Hippocampal Mineralocorticoid Receptor Levels: Involvement of Corticotropin-Releasing Hormone

  2001cites this paper
• Alterations in Corticosterone Receptor mRNA Induced by Methamphetamine in Two Inbred Strains of Rats

  2001cites this paper
• Insights Into Glucocorticoid-Associated Hypertension.

  2001cites this paper
• Anabolic steroid misuse: How much should we know?

  2001cites this paper
• Insights Into Glueocorticoid-Associated Hypertension

  2001cites this paper
• Dynamic changes in subcellular localization of mineralocorticoid receptor in living cells: in comparison with glucocorticoid receptor using dual-color labeling with green fluorescent protein spectral variants.

  2001cites this paper
• Glucocorticoids and serotonin alter glucocorticoid receptor (GR) but not mineralocorticoid receptor (MR) mRNA levels in fetal mouse hippocampal neurons, in vitro.

  2001cites this paper
• Stress, memory, and the hippocampus: can't live with it, can't live without it.

  2001cites this paper
• Congenital adrenal hyperplasia owing to 21-hydroxylase deficiency.

  2001cites this paper
• Possible role of cortisol and dehydroepiandrosterone in human development and psychopathology

  2001cites this paper
• Contemporary Neuropsychiatry

  2001cites this paper
• Regulation of the Rat Serotonin-1A Receptor Gene by Corticosteroids*

  2000cites this paper
• Two Inbred Strains of Rats, Fischer 344 and Lewis, Showed Differential Behavior and Brain Expression of Corticosterone Receptor mRNA Induced by Methamphetamine

  2000cites this paper
• Glucocorticoid and mineralocorticoid receptor mRNA expression in squirrel monkey brain.

  2000cites this paper
• Congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

  2000cites this paper
• Mineralocorticoid action.

  2000cites this paper
• Neurobiology of Interpreting and Responding to Stressful Events: Paradigmatic Role of the Hippocampus

  2000cites this paper
• Mechanisms of Glucocorticoid Actions in Stress and Brain Aging

  2000cites this paper
• Brain Distribution and Regulation of Neuroendocrine Receptors and Processing Enzymes

  1999cites this paper
• Real‐time imaging of glucocorticoid receptor dynamics in living neurons and glial cells in comparison with non‐neural cells

  1999cites this paper
• Association of the glucocorticoid receptor alternatively‐spliced transcript 1A with the presence of the high molecular weight membrane glucocorticoid receptor in mouse lymphoma cells

  1999cites this paper
• Effect of Serotonin Inhibition on Glucocorticoid and Mineralocorticoid Expression in Various Brain Structures

  1999cites this paper
• Membrane-initiated steroid actions and the proteins that mediate them.

  1999cites this paper
• Membrane-Initiated Steroid Actions and the Proteins that Mediate Them

  1999cites this paper
• Molekularbiologie, Klinik und Therapie steroidbedingter Hypertonien

  1998cites this paper
• Brain corticosteroid receptor balance in health and disease.

  1998cites this paper
• Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism.

  1998cites this paper
• [Aldosterone receptors: new insights in hormonal signal transduction].

  1998cites this paper
• Distribution of glucocorticoid receptors in the brain of rainbow trout (Oncorhynchus mykiss): possible relationships with the neuroendocrine systems controlling reproduction

  1998cites this paper
• Regulation of the Human Na/K-ATPase β1 Gene Promoter by Mineralocorticoid and Glucocorticoid Receptors*

  1998cites this paper
• Corticosterone can facilitate as well as inhibit corticotropin-releasing hormone gene expression in the rat hypothalamic paraventricular nucleus.

  1998cites this paper
• Mineralocorticoid receptors regulate bcl‐2 and p53 mRNA expression in hippocampus

  1998cites this paper
• Dexamethasone modulates the expression of endothelin-1 and -A receptors in A7r5 vascular smooth muscle cells.

  1998cites this paper
• Steroid hormones and their receptors in the brain.

  1998cites this paper
• Effects of glucocorticoids on oxidative stress-induced hippocampal cell death: implications for the pathogenesis of Alzheimer's disease.

  1998cites this paper
• Decreased brain glucose utilization in patients with Cushing's disease.

  1998cites this paper