The biochemical role of SRY in sex determination

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Molecular Reproduction and Development

• Publication date

  1994-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/mrd.1080390211PMID 7826621
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Definition of a consensus DNA binding site for SRY.

  1994cited by this paper
• Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation

  1993cited by this paper
• Identification of the transcriptional unit, structural organization, and promoter sequence of the human sex-determining region Y (SRY) gene, using a reverse genetic approach.

  1993cited by this paper
• Circular transcripts of the testis-determining gene Sry in adult mouse testis.

  1993cited by this paper
• SRY recognizes conserved DNA sites in sex-specific promoters.

  1993cited by this paper
• Seven new members of the Sox gene family expressed during mouse development.

  1993cited by this paper
• Transcription of the sex-determining region genes Sry and Zfy in the mouse preimplantation embryo.

  1993cited by this paper
• Sequence‐specific interaction of the HMG box proteins TCF‐1 and SRY occurs within the minor groove of a Watson‐Crick double helix.

  1992cited by this paper
• The role of the sex-determining region of the Y chromosome (SRY) in the etiology of 46,XX true hermaphroditism

  1992cited by this paper
• XY sex reversal associated with a nonsense mutation in SRY.

  1992cited by this paper
• The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures.

  1992cited by this paper
• An SRY‐related gene expressed during spermatogenesis in the mouse encodes a sequence‐specific DNA‐binding protein.

  1992cited by this paper
• HMG has DNA wrapped up

  1992cited by this paper
• SRY, like HMG1, recognizes sharp angles in DNA.

  1992cited by this paper
• DNA binding activity of recombinant SRY from normal males and XY females.

  1992influential reference
• A conserved family of genes related to the testis determining gene, SRY.

  1992cited by this paper
• A familial mutation in the testis-determining gene SRY shared by both sexes

  1992cited by this paper
• Mutational analysis of SRY: nonsense and missense mutations in XY sex reversal

  1992cited by this paper
• DNA--protein interactions. HMG has DNA wrapped up.

  1992cited by this paper
• Evidence for increased prevalence of SRY mutations in XY females with complete rather than partial gonadal dysgenesis.

  1992cited by this paper
• Myoblast diversity in skeletal myogenesis: how much and to what end?

  1992cited by this paper
• XY sex reversal associated with a deletion 5' to the SRY "HMG box" in the testis-determining region.

  1992cited by this paper
• Inverted repeat structure of the Sry locus in mice.

  1992cited by this paper
• Characterization and sequence of the 5' flanking region of the human testis-determining factor SRY

  1992cited by this paper
• Evolution of sex determination and the Y chromosome: SRY-related sequences in marsupials

  1992cited by this paper
• Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development.

  1991cited by this paper
• Male development of chromosomally female mice transgenic for Sry

  1991cited by this paper
• The isolation of conserved DNA sequences related to the human sex-determining region Y gene from the lesser black-backed gull (Larus fuscus)

  1991cited by this paper
• A deletion map of the human immunoglobulin heavy chain variable region

  1991cited by this paper
• Identification and cloning of TCF‐1, a T lymphocyte‐specific transcription factor containing a sequence‐specific HMG box.

  1991cited by this paper
• DNA-binding properties of the product of the testis-determining gene and a related protein

  1991cited by this paper
• DNA-binding properties of the HMG domain of the lymphoid-specific transcriptional regulator LEF-1.

  1991cited by this paper
• A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer.

  1991cited by this paper
• A deletion map of the human Yq11 region: implications for the evolution of the Y chromosome and tentative mapping of a locus involved in spermatogenesis.

  1991cited by this paper
• LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected].

  1991cited by this paper
• In situ analysis of fetal, prepuberal and adult XX----XY chimaeric mouse testes: Sertoli cells are predominantly, but not exclusively, XY.

  1991cited by this paper
• Similarity of human mitochondrial transcription factor 1 to high mobility group proteins.

  1991cited by this paper
• A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

  1990cited by this paper
• Neurospora crassa a mating-type region.

  1990cited by this paper
• Consensus sequence for HMG1-like DNA binding domains.

  1990cited by this paper
• Genetic evidence equating SRY and the testis-determining factor

  1990cited by this paper
• A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

  1990cited by this paper
• High mobility group proteins 1 and 2 function as general class II transcription factors.

  1990cited by this paper
• A sensitive method for the determination of protein-DNA binding specificities.

  1990cited by this paper
• A human XY female with a frame shift mutation in the candidate testis-determining gene SRY

  1990cited by this paper
• Expression of a candidate sex-determining gene during mouse testis differentiation

  1990influential reference
• Additional deletion in sex-determining region of human Y chromosome resolves paradox of X,t(Y;22) female

  1990cited by this paper
• Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins

  1990cited by this paper
• Duplication, deletion, and polymorphism in the sex-determining region of the mouse Y chromosome.

  1989cited by this paper
• Zfy gene expression patterns are not compatible with a primary role in mouse sex determination

  1989cited by this paper
• Eukaryotic transcriptional regulatory proteins.

  1989cited by this paper
• Chromosome mapping and expression of a putative testis-determining gene in mouse.

  1989cited by this paper
• Genetic evidence that ZFY is not the testis-determining factor

  1989cited by this paper
• Duplication of an Xp segment that includes the ZFX locus causes sex inversion in man

  1989cited by this paper
• A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1.

  1989cited by this paper
• Cell-autonomous action of the testis-determining gene: Sertoli cells are exclusively XY in XX----XY chimaeric mouse testes.

  1988cited by this paper
• Sequences homologous to ZFY, a candidate human sex-determining gene, are autosomal in marsupials

  1988cited by this paper
• High mobility group proteins 1 and 2 stimulate binding of a specific transcription factor to the adenovirus major late promoter.

  1988cited by this paper
• The developmental history of female germ cells in mammals.

  1988cited by this paper
• Molecular and cytogenetic evidence for the location of Tdy and Hya on the mouse Y chromosome short arm.

  1988cited by this paper
• Four mating‐type genes control sexual differentiation in the fission yeast.

  1988cited by this paper
• An unbalanced autosomal translocation (7;9) associated with feminization

  1988cited by this paper
• Exchange of terminal portions of X- and Y-chromosomal short arms in human XX males

  1987cited by this paper
• Variable transfer of Y-specific sequences in XX males

  1986cited by this paper
• Double autosomal chromosomal aberration (3p trisomy/9p monosomy) and sex-reversal.

  1986cited by this paper
• Human rRNA transcription is modulated by the coordinate binding of two factors to an upstream control element.

  1986cited by this paper
• A deletion map of the human Y chromosome based on DNA hybridization.

  1986cited by this paper
• Genetic control of primary sex determination in mice.

  1986cited by this paper
• Deletion mapping of the testis determining locus with DNA probes in 46,XX males and in 46,XY and 46,X,dic(Y) females.

  1986cited by this paper
• Nonhistone chromosomal protein HMG 1 interactions with DNA. Fluorescence and thermal denaturation studies.

  1985cited by this paper
• The human Y chromosome.

  1985cited by this paper
• Human XX males with Y single-copy DNA fragments

  1984cited by this paper
• [The human Y chromosome].

  1983cited by this paper
• Inherited partial X chromosome duplication in a mentally retarded male.

  1982cited by this paper
• Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversal.

  1982cited by this paper
• Abnormality of the X chromosome in human 46,XY female siblings with dysgenetic ovaries.

  1980cited by this paper
• Probable inverted tandem duplication of Xp in a 46,Xp+Y boy

  1979cited by this paper
• A new case of trisomy for the distal part of 13q due to maternal translocation, t(9;13)(p21;q21)

  1976cited by this paper
• Rat gonadal and ovarioan organogenesis with and without germ cells. An ultrastructural study.

  1975cited by this paper
• Impact of cool temperatures on transformation of human and armadillo lymphocytes (Dasypus novemcinctus, Linn.) as related to leprosy

  1974cited by this paper
• Juvenile nephrono phthisis

  1973cited by this paper
• Gene Mapping

  1973cited by this paper
• Studies on sex differentiation in mammals.

  1973cited by this paper
• Definitive Evidence for the Short Arm of the Y Chromosome associating with the X Chromosome during Meiosis in the Human Male

  1970cited by this paper
• X-Y chromosomal interchange in the aetiology of true hermaphroditism and of XX Klinefelter's syndrome.

  1966cited by this paper

• Validation of male-specific markers confirmed an XY/XX-type sex determination system in Chinese dark sleeper (Odontobutis sinensis).

  2025cites this paper
• Sex determination using forensic DNA and focused research in forensic odontology: A systematic review.

  2025cites this paper
• scCompass: An Integrated Multi‐Species scRNA‐seq Database for AI‐Ready

  2025cites this paper
• Sex chromosomes and sex hormones differently shape microglial properties during normal physiological conditions in the adult mouse hippocampus

  2025cites this paper
• The Role of de novo and Ultra-Rare Variants in Hirschsprung Disease (HSCR): Extended Gene Discovery for Risk Profiling of Patients

  2025cites this paper
• Genome wide analysis of the sox32 gene in germline maintenance and differentiation in leopard coral grouper (Plectropomus leopardus).

  2024cites this paper
• Genetic control of typical and atypical sex development

  2023cites this paper
• Transcriptional Regulation of the Y-Linked Mammalian Testis-Determining Gene SRY

  2021cites this paper
• Leydig Cell and Spermatogenesis.

  2021cites this paper
• Knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigs

  2020cites this paper
• Production of monoclonal antibody against recombinant bovine sex determining region Y (SRY) and their preferential binding to Y-chromosome bearing sperm.

  2020cites this paper
• Nonneoplastic Diseases of the Testis

  2020cites this paper
• Molecular analysis for sex determination in forensic dentistry: a systematic review

  2020cites this paper
• Cytogenetic evolution of genus Salmo

  2019cites this paper
• Prenatal exposures to bisphenol A and di (2-ethylhexyl) phthalate disrupted seminiferous tubular development in growing male rats.

  2019cites this paper
• The knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigs

  2019cites this paper
• The structure-activity relationship (SAR) for phthalate-mediated developmental and reproductive toxicity in males.

  2019cites this paper
• An Update on Genetics of Disorders of Sexual Development Along with Signal Transduction Pathways-Clinical Implications: A Review

  2018cites this paper
• FUNCTION OFSEXUAL GLANDS AND MECHANISM OF DIFFERENTIATION SEX

  2017cites this paper
• Bovine Sex Determining Region Y: Cloning, Optimized Expression, and Purification

  2017cites this paper
• Sry and SoxE genes: How they participate in mammalian sex determination and gonadal development?

  2017cites this paper
• INVESTIGATING THE REPRODUCTIVE ROLE OF ANTI-MULLERIAN HORMONE VIA ANTI-MULLERIAN HORMONE RECEPTOR, TYPE II IN THE HEN

  2017cites this paper
• CONSIDERACIONES GENERALES EN EL ESTABLECIMIENTO DEL SEXO EN MAMÍFEROS

  2017cites this paper
• Epigenetics of sex determination in mammals

  2016cites this paper
• Comparative In silico Study of Sex-Determining Region Y (SRY) Protein Sequences Involved in Sex-Determining.

  2016cites this paper
• How Australian mammals contributed to our understanding of sex determination and sex chromosomes

  2016cites this paper
• SHORT ARTICLE: COMPARATIVE IN SILICO STUDY OF SEX-DETERMINING REGION Y (SRY) PROTEIN SEQUENCES INVOLVED IN SEX-DETERMINING

  2016cites this paper
• Strategies and Approaches for Studying Sex Differences in Physiology

  2016cites this paper
• DNA methyltransferases exhibit dynamic expression during spermatogenesis.

  2016cites this paper
• Unreported intrinsic disorder in proteins: Disorder emergency room

  2015cites this paper
• In retrospect: Twenty-five years of the sex-determining gene

  2015cites this paper
• A Review on Effect of Estrogen on Neural Growth and Sexual Dimorphism in the Brain

  2015cites this paper
• Perspectives in Pediatric Pathology, Chapter 5. Gonadal Dysgenesis

  2015cites this paper
• Prenatal Exposures of Male Rats to the Environmental Chemicals Bisphenol A and Di(2-Ethylhexyl) Phthalate Impact the Sexual Differentiation Process.

  2015cites this paper
• Effects of Androgen Receptor Overexpression on Select Sexually Dimorphic Neural Structures

  2014cites this paper
• Regulation of male sex determination: genital ridge formation and Sry activation in mice

  2014cites this paper
• HMGB1 in health and disease.

  2014cites this paper
• Mechanism of SOX9 action as a route to diagnostic strategies in liver fibrosis

  2013cites this paper
• Sex determination in the Caenorhabditis elegans germline.

  2013cites this paper
• Production of Sry knockout mouse using TALEN via oocyte injection

  2013cites this paper
• A Review of the Management of Intersex

  2012cites this paper
• Involvement of the AHR in Development and Functioning of the Female and Male Reproductive Systems

  2011cites this paper
• Molecular Mechanisms of Sexual Development

  2011cites this paper
• SRY protein function in sex determination: thinking outside the box

  2011cites this paper
• Exclusion of Sall 4 as the sex-determining gene in the Mandarin vole Microtus mandarinus mandarinus.

  2011cites this paper
• Sry: the master switch in mammalian sex determination

  2010cites this paper
• Physiology of women's sexual function: basic knowledge and new findings.

  2010cites this paper
• Sexual Differentiation of Brain Structure and Function

  2010cites this paper
• Sexual Differentiation of the Brain: Genetic, Hormonal and Trophic Factors

  2009cites this paper
• New tricks by an old dogma: mechanisms of the Organizational/Activational Hypothesis of steroid-mediated sexual differentiation of brain and behavior.

  2009influential citation
• Sox9 Inhibits Wnt Signaling by Promoting β-Catenin Phosphorylation in the Nucleus*

  2009cites this paper
• Physiology of Women's Sexual Function: Basic Knowledge and New Findings: Psychophysiology of Women's Sexual Arousal and Orgasm

  2009cites this paper
• CHAPTER 31 – Cytogenetics in Reproduction

  2009cites this paper
• Mammalian brain development

  2009cites this paper
• Cellular mechanisms of estradiol-mediated masculinization of the brain.

  2008cites this paper
• Differential activities of multiple Sry proteins encoded on the rat Y chromosome.

  2008cites this paper
• Sex determination of Microtus mandarinus mandarinus is independent of Sry gene

  2008cites this paper
• Gender-based differences in endocrine and reproductive toxicity.

  2007cites this paper
• Ovarian-specific expression of a new gene regulated by the goat PIS region and transcribed by a FOXL2 bidirectional promoter.

  2005cites this paper
• G-CSF-primed hematopoietic stem cells or G-CSF per se accelerate recovery and improve survival after liver injury, predominantly by promoting endogenous repair programs.

  2005cites this paper
• Molecular mechanisms in male determination and germ cell differentiation

  2004cites this paper
• A slug, a fox, a pair of sox: transcriptional responses to neural crest inducing signals.

  2004cites this paper
• The Journal of Toxicological Sciences

  2004cites this paper
• Localization and Characterization of Nucleotide Sequences From the Canine Y Chromosome

  2004cites this paper
• Molecular determinants of sexual differentiation

  2004cites this paper
• Function of sexual glands and mechanism of sex differentiation.

  2004cites this paper
• Fast sex identification in wild mammals using PCR amplification of the Sry gene

  2003cites this paper
• SRY gene structure and phylogeny in the cetacean species

  2003cites this paper
• The relationship between müllerian inhibiting substance and androgens in boys with hypospadias.

  2002cites this paper
• Sexual Differentiation of the Brain: Genes, Estrogen, and Neurotrophic Factors

  2002cites this paper
• Molecular Genetics of Sex Determination

  2002cites this paper
• Equilibrium Binding Assays Reveal the Elevated Stoichiometry and Salt Dependence of the Interaction between Full-length Human Sex-determining Region on the Y Chromosome (SRY) and DNA*

  2002cites this paper
• Steroid Modulation of Astrocytes in the Neonatal Brain: Implications for Adult Reproductive Function

  2002cites this paper
• PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version

  2001cites this paper
• 46, XY pure gonadal dysgenesis: a case with Graves' disease and exceptionally tall stature.

  2001cites this paper
• Developmental profile of Sry transcripts in mouse brain

  2000cites this paper
• Identification of a new missense mutation (Gly95Glu) in a highly conserved codon within the high-mobility group box of the sex-determining region Y gene: report on a 46,XY female with gonadal dysgenesis and yolk-sac tumor.

  2000cites this paper
• Mammalian sex reversal and intersexuality: deciphering the sex-determination cascade.

  2000cites this paper
• The cell biology and molecular genetics of testis determination.

  2000cites this paper
• Differential effect of oestradiol and astroglia‐conditioned media on the growth of hypothalamic neurons from male and female rat brains

  2000cites this paper
• Characterization of novel promoter and enhancer elements of the mouse homologue of the Dent disease gene, CLCN5, implicated in X-linked hereditary nephrolithiasis.

  1999cites this paper
• Ascertainment and mutational studies of SRY in nine XY females.

  1999cites this paper
• Sexing of carcass remains of the Sika deer (Cervus nippon) using PCR amplification of the Sry gene.

  1998cites this paper
• The basic helix-loop-helix, leucine zipper transcription factor, USF (upstream stimulatory factor), is a key regulator of SF-1 (steroidogenic factor-1) gene expression in pituitary gonadotrope and steroidogenic cells.

  1998cites this paper
• Regulation of sexual dimorphism in mammals.

  1998cites this paper
• Direct Interaction of SRY-Related Protein SOX9 and Steroidogenic Factor 1 Regulates Transcription of the Human Anti-Müllerian Hormone Gene

  1998cites this paper
• A novel missense mutation (S18N) in the 5′ non-HMG box region of the SRY gene in a patient with partial gonadal dysgenesis and his normal male relatives

  1998cites this paper
• The Y-chromosomal genes SRY and ZFY are transcribed in adult human brain

  1998cites this paper
• Two DNA sequences specific for the canine Y chromosome.

  1998cites this paper
• AND-1, a natural chimeric DNA-binding protein, combines an HMG-box with regulatory WD-repeats.

  1997cites this paper
• Mutations in SRY and SOX9: Testis‐determining genes

  1997cites this paper
• Mammalian cell DNA replication.

  1997cites this paper
• Testis‐Determining Factor and Gonadal Dysgenesis

  1997cites this paper
• Multiple, polymorphic copies of SRY in both males and females of the vole Microtus cabrerae.

  1997cites this paper
• Sexual differentiation of the zebra finch song system: positive evidence, negative evidence, null hypotheses, and a paradigm shift.

  1997cites this paper
• Transcription of Y‐ and X‐linked genes in preimplantation ovine embryos

  1996cites this paper
• [Sex determination and transgenesis].

  1996cites this paper
• Porcine SRY gene locus and genital ridge expression.

  1996cites this paper
• Campomelic Dysplasia with XY Sex Reversal: Diverse Phenotypes Resulting from Mutations in a Single Gene a

  1996cites this paper
• Sex Differentiation of Rat Hippocampal GABAergic Neurons

  1996cites this paper