The Effect of Oxidation on Sorbitol Pathway Kinetics

No abstract is available for this paper.

• Publication year

  1986

• Venue

  Diabetes

• Publication date

  1986-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.2337/diab.35.4.426PMID 3956880
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sorbitol/fructose metabolism in the lens.

  1985cited by this paper
• Direct Measurement of Polyol Pathway Activity in the Ocular Lens

  1984cited by this paper
• Nonenzymatic glycosylation and the pathogenesis of diabetic complications.

  1984cited by this paper
• The Effect of an Aldose Reductase Inhibitor (Sorbinil) on the Level of Metabolites in Lenses of Diabetic Rats

  1983cited by this paper
• Response of the lens to oxidative-osmotic stress.

  1983cited by this paper
• Aldose reductase activity in retinal and cerebral microvessels and cultured vascular cells.

  1983cited by this paper
• The role of glutathione metabolism in the detoxification of H2O2 in rabbit lens.

  1982cited by this paper
• The sorbitol pathway in the human lens: aldose reductase and polyol dehydrogenase.

  1981cited by this paper
• Pyridine nucleotides in ocular tissues as determined by the cycling assay.

  1980cited by this paper
• Human diabetic endoneurial sorbitol, fructose, and myo‐inositol related to sural nerve morphometry

  1980cited by this paper
• Role of sorbitol pathway in neuropathy.

  1973cited by this paper
• The sorbitol pathway and the complications of diabetes.

  1973cited by this paper
• Activators and inhibitors of lens aldose reductase.

  1971cited by this paper
• Glucose utilization by the polyol pathway in human erythrocytes.

  1970cited by this paper
• A biochemical evaluation of a cataract induced in a high-glucose medium.

  1969cited by this paper
• EPIDEMIOLOGICAL AND BIOCHEMICAL STUDIES OF CATARACT AND DIABETES.

  1965cited by this paper
• Formation of Polyols by the Lens of the Rat with ‘Sugar’ Cataract

  1959cited by this paper

• Müller cells trophism and pathology as the next therapeutic targets for retinal diseases.

  2025cites this paper
• Elevated fasting serum xylitol levels are associated with a lower risk of incident type 2 diabetes among individuals with prediabetes in the Chinese population

  2025cites this paper
• Repositioning of rhodanine-thiazole hybrids as aldose reductase inhibitors

  2025cites this paper
• The Effect of Oxidative Stress and Antioxidants Treatment on Gestational Diabetes Mellitus Outcome: A Scoping Review

  2024cites this paper
• Interconnections between diabetic corneal neuropathy and diabetic retinopathy: diagnostic and therapeutic implications

  2024cites this paper
• The Impact of Aging on Ocular Diseases: Unveiling Complex Interactions

  2024cites this paper
• The Role of Müller Cells in Diabetic Macular Edema

  2023cites this paper
• Reductions in liver enzymes are associated with anti‐hyperglycaemic and anti‐obesity effects of tofogliflozin in people with type 2 diabetes: Post‐hoc analyses

  2023cites this paper
• Recent advances in the study of circadian rhythm disorders that induce diabetic retinopathy.

  2023cites this paper
• Role of oxidative stress in diabetes-induced complications and their management with antioxidants

  2023cites this paper
• The Mechanism of Hyperglycemia-Induced Renal Cell Injury in Diabetic Nephropathy Disease: An Update

  2023cites this paper
• Systematic Investigations on the Metabolic and Transcriptomic Regulation of Lactate in the Human Colon Epithelial Cells

  2022cites this paper
• Algal metabolites: Paving the way towards new generation antidiabetic therapeutics

  2022cites this paper
• Rationale and Design of the Aldose Reductase Inhibition for Stabilization of Exercise Capacity in Heart Failure Trial (ARISE-HF) in Patients with High-Risk Diabetic Cardiomyopathy.

  2022cites this paper
• The role of inflammation and neurodegeneration in diabetic macular edema

  2021cites this paper
• Retinal Physiology and Circulation: Effect of Diabetes.

  2020cites this paper
• Aldosereductase: structure, mechanism of action, biological role and functioning according to normo and hyperglycemia

  2020cites this paper
• Metabolic Dysregulation and Neurovascular Dysfunction in Diabetic Retinopathy

  2020cites this paper
• Endothelium as a Therapeutic Target in Diabetes Mellitus: From Basic Mechanisms to Clinical Practice.

  2020cites this paper
• Oxidative stress and diabetic retinopathy

  2020cites this paper
• A non-invasive, multi-target approach to treat diabetic retinopathy.

  2019cites this paper
• Aldose Reductase Inhibitors of Plant Origin in the Prevention and Treatment of Alcoholic Liver Disease: A Minireview

  2019cites this paper
• Diabetes, a Contemporary Risk for Parkinson’s Disease: Epidemiological and Cellular Evidences

  2019cites this paper
• Diabetic retinopathy: a complex pathophysiology requiring novel therapeutic strategies

  2018cites this paper
• Diabetic Retinopathy– An Overview

  2018cites this paper
• Diabetic macular oedema: under‐represented in the genetic analysis of diabetic retinopathy

  2018cites this paper
• Molecular pathobiology of Diabetic Retinopathy

  2018cites this paper
• NEUROPROTECTIVE EFFECT OF EPALRESTAT ON MEMORY IMPAIRMENT IN STREPTOZOTOCIN-INDUCED TYPE-2 DIABETIC RATS USING DIFFERENT BEHAVIORAL MODELS.

  2018cites this paper
• A Review on Pathophysiology, Diagnosis and Management of Diabetic Retinopathy

  2018cites this paper
• Discovery of Leptin and its Catabolic and Glucose-Lowering Action In 1994

  2017cites this paper
• Aldose Reductase Inhibitiory Effect of Gymnemic Acid, Trigonelline and Ferulic Acid- An In Silico Approach

  2017cites this paper
• Diabetic retinopathy: Breaking the barrier.

  2017cites this paper
• Mechanisms of Vascular Defects in Diabetes Mellitus

  2017influential citation
• Central Regulation of Glucose Homeostasis.

  2017cites this paper
• Pathogenetic Mechanisms in Diabetic Retinopathy: From Molecules to Cells to Tissues

  2017cites this paper
• Propolis, a Constituent of Honey, Inhibits the Development of Sugar Cataracts and High-Glucose-Induced Reactive Oxygen Species in Rat Lenses

  2016cites this paper
• Inhibition of Aldose Reductase and Sorbitol Accumulation by Hydroalcoholic Extract of Propolis

  2016cites this paper
• BIOCHEMICAL BASIS AND EMERGING MOLECULAR TARGETS TO TREAT DIABETIC RETINOPATHY

  2016cites this paper
• Retinal Thickness Irregularities in Preclinical Diabetic Retinopathy

  2016cites this paper
• Aldose reductase, ocular diabetic complications and the development of topical Kinostat(®).

  2016cites this paper
• A basic scientific understanding of diabetic retinopathy

  2015cites this paper
• The inhibitory effect of Isoflavones isolated from Caesalpinia pulcherrima on aldose reductase in STZ induced diabetic rats.

  2015cites this paper
• Evaluacion de factores de riesgo exógenos y endógenos para la retinopatía diabética en pacientes con diabetes mellitus tipo 2 de larga evolución en un seguimiento a 18 meses

  2015cites this paper
• Hyperglycaemia-induced oxidative stress in gestational diabetes mellitus ( GDM )

  2015cites this paper
• Polyol pathway: A possible mechanism of diabetes complications in the eye

  2015cites this paper
• Metabolome and proteome changes with aging in Caenorhabditis elegans.

  2015cites this paper
• Diabetic Retinopathy – An Update on Pathophysiology, Classification, Investigation and Treatment

  2014cites this paper
• Effect of oral N-acetyl cysteine supplementation in type 2 diabetic patients on intracellular glutathione content and innate immune responses to Burkholderia pseudomallei.

  2014cites this paper
• Glycemic Variability in Type 1 DiabetesDoes It Matter

  2014cites this paper
• Oxidative Stress: Implications for the Development of Diabetic Retinopathy and Antioxidant Therapeutic Perspectives

  2014cites this paper
• Rôle des acides gras polyinsaturés alimentaires dans l'homéostasie lipidique de la rétine en conditions physiologiques et pathologiques liées au vieillissement

  2014cites this paper
• Antioxidant Potential of Fungal Metabolite Nigerloxin during Eye Lens Abnormalities in Galactose-Fed Rats

  2013cites this paper
• Pathophysiology of Diabetic Retinopathy

  2013cites this paper
• Pharmacologically tested aldose reductase inhibitors isolated from plant sources-A concise report

  2012cites this paper
• Modulation of the Antidiabetic Effect of Glimepiride by Diazepam in Diabetic Rats

  2012cites this paper
• Oxidant stress and skeletal muscle microvasculopathy in the metabolic syndrome.

  2012cites this paper
• Possible modulation of the antidiabetic effect of rosiglitazone by buspirone

  2012cites this paper
• Effect of Different Solvent Extracts of Potentilla Fulgens L. on Aldose Reductase and Sorbitol Dehydrogenase in &ormoglycemic and Diabetic Mice

  2011cites this paper
• Inhibition of Aldose Activity by Essential Phytochemicals of Cymbopogon Citratus ( DC . ) Stapf

  2011cites this paper
• Alterations to the Blood–Retinal Barrier in Diabetes: Cytokines and Reactive Oxygen Species

  2011cites this paper
• Pharmacokinetics, Pharmacodynamics, Tolerability, and Safety of a Novel Sorbitol Dehydrogenase Inhibitor in Healthy Participants

  2010cites this paper
• Elevated Serum Sorbitol and not Fructose in Type 2 Diabetic Patients

  2010cites this paper
• Protective potential of fruits against diabetes and its complications

  2010cites this paper
• Biological Indicators of Lifestyle-related Diseases and Urinary 8-Hydroxydeoxyguanosine Level

  2009cites this paper
• Retinal insulin receptor signaling in hyperosmotic stress.

  2009cites this paper
• Aldose reductase inhibitor, epalrestat, reduces lipid hydroperoxides in type 2 diabetes.

  2009cites this paper
• Attenuation of aldose reductase gene suppresses high-glucose-induced apoptosis and oxidative stress in rat lens epithelial cells.

  2008cites this paper
• The Polyol Pathway and Diabetic Retinopathy

  2008cites this paper
• Diabetic neuropathy: mechanisms to management.

  2008cites this paper
• Gene Expression Profiling of Diabetic and Galactosemic Cataractous Rat Lens by Microarray Analysis 2 )

  2008cites this paper
• Aldose reductase, still a compelling target for diabetic neuropathy.

  2008cites this paper
• The Polyol Pathway as a Mechanism for Diabetic Retinopathy: Attractive, Elusive, and Resilient

  2007cites this paper
• Up-regulation of P-glycoprotein expression by osmotic stress in rat sugar cataract.

  2007cites this paper
• The role of polyol pathway in high glucose-induced endothelial cell damages.

  2006cites this paper
• [Oxidative stress in diabetes].

  2005cites this paper
• Gene expression profiling of diabetic and galactosaemic cataractous rat lens by microarray analysis

  2005cites this paper
• Polyol pathway-dependent osmotic and oxidative stresses in aldose reductase-mediated apoptosis in human lens epithelial cells: role of AOP2.

  2004cites this paper
• The role of endothelium in the pathogenesis of diabetic microangiopathy

  2004cites this paper
• Increasing of oxidative stress from mitochondria in type 2 diabetic patients

  2004cites this paper
• Tip II Diabetes Mellituslu Hastalarda Plazma Total Tiyol Ve Eritrosit Redükte Glutatyon Düzeyleri

  2002cites this paper
• Acute transient bilateral diabetic posterior subcapsular cataracts(1).

  2001cites this paper
• Evaluation of renal biopsy samples of patients with diabetic nephropathy.

  2001cites this paper
• Endothelin and diabetic nephropathy: a new pathogenetic factor?

  2001cites this paper
• Effect of zenarestat, an aldose reductase inhibitor, on endoneurial blood flow in experimental diabetic neuropathy of rat.

  2001cites this paper
• Acute transient bilateral diabetic posterior subcapsular cataracts

  2001cites this paper
• Diabetic Vascular Disease: Biochemical and Molecular Perspectives

  2000cites this paper
• Effect of vitamin E and allylamine on the proliferation of cultured aortic smooth muscle cells from streptozotocin-induced diabetic rats.

  1999cites this paper
• Effects of water extract of 1:1 mixture of Phellodendron cortex and Aralia cortex on polyol pathway and oxidative damage in lenses of diabetic rats

  1999cites this paper
• Susceptibility of low‐ and high‐density lipoproteins from diabetic subjects to in vitro oxidative modification

  1999cites this paper
• Carbonyl stress in the pathogenesis of diabetic nephropathy.

  1999cites this paper
• Metalloproteinases in the Pathogenesis of Diabetic Nephropathy

  1998cites this paper
• Alpha-lipoic acid in liver metabolism and disease.

  1998cites this paper
• Oxidative stress measurement by in vivo electron spin resonance spectroscopy in rats with streptozotocin-induced diabetes

  1998cites this paper
• Effect of the aldose reductase inhibitor tolrestat on nerve conduction velocity, Na/K ATPase activity, and polyols in red blood cells, sciatic nerve, kidney cortex, and kidney medulla of diabetic rats.

  1998cites this paper
• Polyol pathway activation and glutathione redox status in non-insulin-dependent diabetic patients.

  1997cites this paper
• The erythrocyte glutathione levels during oral glucose tolerance test

  1997cites this paper
• The effects of gliclazide and other sulfonylureas on low-density lipoprotein oxidation in vitro.

  1997cites this paper
• The diabetic cataract: an unusual presentation in a young subject: case report.

  1997cites this paper
• The pathobiology of diabetes mellitus: implications for surgeons.

  1996cites this paper
• Inhibition of development of peripheral neuropathy in streptozotocin-induced diabetic rats with N-acetylcysteine

  1996cites this paper