RECK—a newly discovered inhibitor of metastasis with prognostic significance in multiple forms of cancer

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Cancer Metastasis Review

• Publication date

  2007-09-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s10555-007-9093-8PMID 17828469
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chitosan microparticles encapsulating PEDF plasmid demonstrate efficacy in an orthotopic metastatic model of osteosarcoma.

  2007cited by this paper
• RECK expression in osteosarcoma: correlation with matrix metalloproteinases activation and tumor invasiveness

  2007cited by this paper
• HER-2/neu Represses the Metastasis Suppressor RECK via ERK and Sp Transcription Factors to Promote Cell Invasion*

  2006cited by this paper
• Pigment epithelium-derived factor: a multimodal tumor inhibitor

  2006cited by this paper
• Biophysical delivery of peptides: applicability for cancer therapy.

  2006cited by this paper
• Loss of Krüppel-Like Factor 4 Expression Contributes to Sp1 Overexpression and Human Gastric Cancer Development and Progression

  2006cited by this paper
• Correlation of reversion-inducing cysteine-rich protein with kazal motifs (RECK) and extracellular matrix metalloproteinase inducer (EMMPRIN), with MMP-2, MMP-9, and survival in colorectal cancer.

  2006cited by this paper
• Recent advances in MMP inhibitor design

  2006cited by this paper
• Expression of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) as a prognostic indicator in gastric cancer.

  2006influential reference
• Carrier-mediated delivery of peptidic drugs for cancer therapy.

  2006cited by this paper
• Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues

  2005cited by this paper
• RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines.

  2005cited by this paper
• Prognostic Significance of Reversion-Inducing Cysteine-Rich Protein With Kazal Motifs Expression in Resected Pathologic Stage IIIA N2 Non–Small-Cell Lung Cancer

  2005cited by this paper
• Effect of vasopressin on blood flow and RI of the uterine artery during laparoscopic myomectomy.

  2005cited by this paper
• Down-regulation of overexpressed sp1 protein in human fibrosarcoma cell lines inhibits tumor formation.

  2005cited by this paper
• Cyclodextrins and Oligonucleotide Delivery to Solid Tumours

  2004cited by this paper
• Expression of a novel matrix metalloproteinase regulator, RECK, and its clinical significance in resected non-small cell lung cancer.

  2004cited by this paper
• Involvement of histone deacetylation in ras-induced down-regulation of the metastasis suppressor RECK.

  2004cited by this paper
• The Membrane-Anchored Matrix Metalloproteinase (MMP) Regulator RECK in Combination with MMP-9 Serves as an Informative Prognostic Indicator for Colorectal Cancer

  2004influential reference
• Expression and localisation of the new metalloproteinase inhibitor RECK (reversion inducing cysteine-rich protein with Kazal motifs) in inflamed synovial membranes of patients with rheumatoid arthritis

  2004cited by this paper
• Membrane associated proteases and their inhibitors in tumour angiogenesis

  2004cited by this paper
• Evolutionary families of peptidase inhibitors.

  2004cited by this paper
• Medicine. Gene therapy--new challenges ahead.

  2003cited by this paper
• Gene Therapy--New Challenges Ahead

  2003cited by this paper
• Expression of matrix metalloproteinases (MMP-2 and -9) and their inhibitors (TIMP-1 and -2) in prostate cancer tissue

  2003cited by this paper
• Modified microplex vector enhances transfection of cells in culture while maintaining tumour‐selective gene delivery in‐vivo

  2003cited by this paper
• RECK expression in pancreatic cancer: its correlation with lower invasiveness and better prognosis.

  2003cited by this paper
• An evidence-based approach to the surgical management of resectable pancreatic adenocarcinoma.

  2003cited by this paper
• Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion.

  2003cited by this paper
• Hepatocellular carcinoma

  2003cited by this paper
• RECK is a target of Epstein–Barr virus latent membrane protein 1

  2003cited by this paper
• Matrix metalloproteinase inhibitor reversion‐inducing cysteine‐rich protein with Kazal motifs

  2003cited by this paper
• Transcriptional control of the RECK metastasis/angiogenesis suppressor gene.

  2002cited by this paper
• Interaction of phosphatidylinositolglycan(-peptides) with plasma membrane lipid rafts triggers insulin-mimetic signaling in rat adipocytes.

  2002cited by this paper
• Establishment of the genomic structure and identification of thirteen single-nucleotide polymorphisms in the human RECK gene

  2002cited by this paper
• Induction of RECK by nonsteroidal anti-inflammatory drugs in lung cancer cells

  2002cited by this paper
• Liposomes Containing Cationic Dimethyl Dioctadecyl Ammonium Bromide: Formulation, Quality Control, and Lipofection Efficiency

  2002cited by this paper
• RECK gene expression in hepatocellular carcinoma: Correlation with invasion‐related clinicopathological factors and its clinical significance

  2001cited by this paper
• The Membrane-Anchored MMP Inhibitor RECK Is a Key Regulator of Extracellular Matrix Integrity and Angiogenesis

  2001influential reference
• A Microsphere-Liposome (Microplex) Vector for Targeted Gene Therapy of Cancer. II. In Vivo Biodistribution Study in a Solid Tumor Model

  2000cited by this paper
• Involvement of the Sp1 site in ras-mediated downregulation of the RECK metastasis suppressor gene.

  1999cited by this paper
• Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK.

  1998influential reference
• Identification of three distinct tumor suppressor loci on the short arm of chromosome 9 in small cell lung cancer.

  1997cited by this paper
• Epidermal growth factor.

  1990cited by this paper
• Hepatocellular carcinoma.

  1986cited by this paper
• Epidermal growth factor

  1972cited by this paper

• The Roles of the Membrane-Anchored Glycoprotein RECK in Animal Development, Tumor Suppression, and Beyond

  2026cites this paper
• RECK as a Potential Crucial Molecule for the Targeted Treatment of Sepsis

  2025cites this paper
• Harmine inhibits ovarian cancer migration and invasion and epithelial-mesenchymal transition (EMT) by inhibiting HDAC7 to restore RECK expression.

  2025cites this paper
• Anti-Angiogenic Effects of Ocimum basilicum Ethanolic Extract: In Vitro and Ex Vivo Evidence of Endothelial Inhibition

  2025cites this paper
• A primer on metabolic contributions in tumor angiogenic microenvironment.

  2025cites this paper
• How to rejuvenate the prostate damaged by cancer

  2025cites this paper
• Expression of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) Gene and Its Regulation by miR200b in Ovarian Endometriosis

  2024cites this paper
• Matrix Metalloproteinases in the Periodontium—Vital in Tissue Turnover and Unfortunate in Periodontitis

  2024cites this paper
• Bioinformatics and meta-analysis of the clinical significance of RECK expression and its genetic polymorphisms in cancer

  2024cites this paper
• SIAH1 facilitates the migration and invasion of gastric cancer cells through promoting the ubiquitination and degradation of RECK

  2024cites this paper
• miR-200b-3p accelerates progression of pituitary adenomas by negatively regulating expression of RECK.

  2024cites this paper
• Modulating pancreatic cancer microenvironment: The efficacy of Huachansu in mouse models via TGF-β/Smad pathway.

  2024cites this paper
• Association between the Reduced Expression of RECK and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease

  2024cites this paper
• Non‐cell‐autonomous suppression of tumor growth by RECK in immunocompetent mice

  2024cites this paper
• RECK/GPR124‐driven WNT signaling in pancreatic and gastric cancer cells

  2024cites this paper
• Chronic Intermittent Hypoxia Facilitates the Development of Angiotensin II-Induced Abdominal Aortic Aneurysm in Male Mice.

  2024cites this paper
• Extracellular Matrix of Echinoderms

  2023influential citation
• Recent Updates on the Therapeutic Prospects of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) in Liver Injuries

  2023cites this paper
• Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis

  2023cites this paper
• Identification of RECK as a protective prognostic indicator and a tumor suppressor through regulation of the ERK/MAPK signaling pathway in gastric cancer

  2023cites this paper
• Genomic and proteomic profiling of osteosarcoma

  2022cites this paper
• RECK Variants are Associated with Clinicopathological Features and Decreased Susceptibility in Mexican Patients with Colorectal Cancer.

  2022cites this paper
• Suppression of tumor metastasis by a RECK-activating small molecule

  2022cites this paper
• Helicobacter pylori regulated microRNA map of human gastric cells

  2022cites this paper
• Current Situation and Progress of Tumor-Suppressor Gene Related to Gastric Cancer in Liver Metastasis

  2022cites this paper
• RECK expression is associated with angiogenesis and immunogenic Tumor Microenvironment in Hepatocellular Carcinoma, and is a prognostic factor for better survival

  2021cites this paper
• Dysregulated MicroRNAs as Biomarkers or Therapeutic Targets in Cisplatin-Induced Nephrotoxicity: A Systematic Review

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• The Role of RECK in Hepatobiliary Neoplasia Reveals Its Therapeutic Potential in NASH

  2021cites this paper
• Expression and localization of the MMP inhibitor RECK in a rat model of COPD: its involvement in the development of COPD.

  2020cites this paper
• Sinomenine Inhibits Migration and Invasion of Human Lung Cancer Cell through Downregulating Expression of miR-21 and MMPs

  2020cites this paper
• LncRNA MAGI2-AS3 is downregulated in non-small cell lung cancer and may be a sponge of miR-25

  2020cites this paper
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  2020cites this paper
• Molecular Mechanisms of Heat Shock Factors in Cancer

  2020cites this paper
• Phyllanthus Species

  2020cites this paper
• Participation of MicroRNAs in the Treatment of Cancer with Phytochemicals

  2020cites this paper
• GAS5 Regulates RECK Expression and Inhibits Invasion Potential of HCC Cells by Sponging miR-135b

  2019cites this paper
• Epigenetic downregulation of TET3 reduces genome‐wide 5hmC levels and promotes glioblastoma tumorigenesis

  2019cites this paper
• The RNA Binding Protein HuR: A Promising Drug Target for Anticancer Therapy.

  2019cites this paper
• Exome-Wide Rare Variant Analysis From the DiscovEHR Study Identifies Novel Candidate Predisposition Genes for Endometrial Cancer

  2019cites this paper
• miR-21 reverses impaired decidualization through modulation of KLF12 and NR4A1 expression in human endometrial stromal cells†.

  2019cites this paper
• miR‐15b‐5p facilitates the tumorigenicity by targeting RECK and predicts tumour recurrence in prostate cancer

  2018cites this paper
• The Roles of miR-25 and Its Targeted Genes in Human Cancer

  2018cites this paper
• [Advances in the molecular mechanisms of perineural invasion in salivary adenoid cystic carcinoma].

  2018cites this paper
• The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis

  2018cites this paper
• Generation and characterization of a mouse line carrying Reck‐CreERT2 knock‐in allele

  2018cites this paper
• HDAC Inhibitors and RECK Modulate Endoplasmic Reticulum Stress in Tumor Cells

  2017cites this paper
• The clinicopathologic relevance of RECK gene polymorphisms in ameloblastoma.

  2017cites this paper
• Casticin inhibits the activity of transcription factor Sp1 and the methylation of RECK in MGC803 gastric cancer cells.

  2017cites this paper
• TGF-beta 1 modulates the homeostasis between MMPs and MMP inhibitors through p 38 MAPK and ERK 1 / 2 in highly invasive breast cancer cells

  2017cites this paper
• Osteosarcoma: From Molecular Biology to Mesenchymal Stem Cells

  2017cites this paper
• MiRNA-516b inhibits ameloblastoma cell proliferation and invasion by regulating MYCBP/c-myc/RECK/MMP pathway

  2017cites this paper
• Small role with big impact: miRNAs as communicators in the cross-talk between cancer-associated fibroblasts and cancer cells

  2017cites this paper
• Is dual inhibition of metalloenzymes HDAC‐8 and MMP‐2 a potential pharmacological target to combat hematological malignancies?

  2017cites this paper
• Tumor Microenvironment

  2017cites this paper
• Solasodine inhibits invasion of human lung cancer cell through downregulation of miR-21 and MMPs expression.

  2017cites this paper
• Unravelling the complexity of signalling networks in cancer: A review of the increasing role for computational modelling.

  2017cites this paper
• Promoter hypermethylation of the RECK gene is associated with its low expression and poor survival of esophageal squamous cell carcinoma.

  2017cites this paper
• Identification and Validation of DLG2 as a Novel Tumor Suppressor in Osteosarcoma

  2016cites this paper
• RECK Gene Promoter rs10814325 Polymorphism in Egyptian Patients with Hepatocellular Carcinoma on Top of Chronic Hepatitis C Viral Infection.

  2016cites this paper
• Reversion‐Inducing‐Cysteine‐Rich Protein With Kazal Motifs (RECK) Gene Single Nucleotide Polymorphism With Hepatocellular Carcinoma: A Case–Control Study

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• Matrix metalloproteinase 14 modulates signal transduction and angiogenesis in the cornea.

  2016cites this paper
• Pattern of RECK CpG methylation as a potential marker for predicting breast cancer prognosis and drug-sensitivity

  2016cites this paper
• MicroRNA-15b regulates reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression in human uterine leiomyoma

  2016cites this paper
• Reversion-inducing cysteine-rich protein with Kazal motifs and its regulation by glycogen synthase kinase 3 signaling in oral cancer

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• MicroRNAs as diagnostic and prognostic biomarkers in colorectal cancer.

  2016cites this paper
• The Wnt7's Tale: A story of an orphan who finds her tie to a famous family

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• Bioinformatic Studies to Predict MicroRNAs with the Potential of Uncoupling RECK Expression from Epithelial–Mesenchymal Transition in Cancer Cells

  2016cites this paper
• miR-590-5p regulates gastric cancer cell growth and chemosensitivity through RECK and the AKT/ERK pathway

  2016cites this paper
• A Hypothesis for the Role of RECK in Angiogenesis.

  2015cites this paper
• Identification of biomarkers for metastatic osteosarcoma based on DNA microarray data.

  2015cites this paper
• β-Asarone inhibits gastric cancer cell proliferation.

  2015cites this paper
• RECK Gene Polymorphism is Associated with Susceptibility and Prognosis of Wilms’ Tumor in Chinese Children

  2015cites this paper
• RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice

  2015cites this paper
• miR-221 and miR-222 Simultaneously Target RECK and Regulate Growth and Invasion of Gastric Cancer Cells

  2015cites this paper
• RECK is not an independent prognostic marker for breast cancer

  2015cites this paper
• Ras induces experimental lung metastasis through up-regulation of RbAp46 to suppress RECK promoter activity

  2015cites this paper
• Expression of RECK and MMPs in Hepatoblastoma and Neuroblastoma and Comparative Analysis on the Tumor Metastasis.

  2015cites this paper
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  2015cites this paper
• Epigallocatechin‑3‑gallate inhibits the invasion of salivary adenoid cystic carcinoma cells by reversing the hypermethylation status of the RECK gene.

  2015cites this paper
• Gene and proteomic profiling of osteosarcoma

  2015cites this paper
• Activation of farnesoid X receptor induces RECK expression in mouse liver.

  2014cites this paper
• MicroRNA-135b, a HSF1 target, promotes tumor invasion and metastasis by regulating RECK and EVI5 in hepatocellular carcinoma

  2014cites this paper
• RECK overexpression reduces invasive ability in ameloblastoma cells.

  2014cites this paper
• The RECK gene and invasive cancer development

  2014cites this paper
• The RECK gene and invasive cancer

  2014cites this paper
• Proteomics of osteosarcoma

  2014cites this paper
• Downregulation of reversion-inducing cysteine-rich protein with Kazal motifs in malignant melanoma: inverse correlation with membrane-type 1-matrix metalloproteinase and tissue inhibitor of metalloproteinase 2

  2014cites this paper
• The RECK gene and biological malignancy--its significance in angiogenesis and inhibition of matrix metalloproteinases.

  2014cites this paper
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  2014influential citation
• Loss of CADM1 expression is associated with poor prognosis and brain metastasis in breast cancer patients

  2014cites this paper
• α-Solanine Inhibits Invasion of Human Prostate Cancer Cell by Suppressing Epithelial-Mesenchymal Transition and MMPs Expression

  2014cites this paper
• The RECK gene and invasive cancer development The significance of RECK in angiogenesis and inhibition of matrix metalloproteinases

  2014cites this paper
• A novel compound RY10-4 induces apoptosis and inhibits invasion via inhibiting STAT3 through ERK-, p38-dependent pathways in human lung adenocarcinoma A549 cells.

  2014cites this paper
• JWA suppresses tumor angiogenesis via Sp1-activated matrix metalloproteinase-2 and its prognostic significance in human gastric cancer.

  2014cites this paper
• Effects of 5-aza-2′deoxycytidine on RECK gene expression and tumor invasion in salivary adenoid cystic carcinoma

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