Vaccines for mucosal immunity to combat emerging infectious diseases.

The mucosal immune system consists of molecules, cells, and organized lymphoid structures intended to provide immunity to pathogens that impinge upon mucosal surfaces. Mucosal infection by intracellular pathogens results in the induction of cell- mediated immunity, as manifested by CD4-positive (CD4 + ) T helper-type 1 cells, as well as CD8 + cytotoxic T-lymphocytes. These responses are normally accompanied by the synthesis of secretory immunoglobulin A (S-IgA) antibodies, which provide an important first line of defense against invasion of deeper tissues by these pathogens. New-generation live, attenuated viral vaccines, such as the cold-adapted, recombinant nasal influenza and oral rotavirus vaccines, optimize this form of mucosal immune protection. Despite these advances, new and reemerging infectious diseases are tipping the balance in favor of the parasite; continued mucosal vaccine development will be needed to effectively combat these new threats.

• Publication year

  2000

• Venue

  Emerging Infectious Diseases

• Publication date

  2000-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3201/EID0602.000204PMID 10756145PMCID 2640846
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Emerging Infectious Diseases

  2014cited by this paper
• Genetic vaccines.

  1999cited by this paper
• Adhesins as targets for vaccine development.

  1999cited by this paper
• Natural killer cells from HIV-1+ patients produce C-C chemokines and inhibit HIV-1 infection.

  1998cited by this paper
• Detection of HIV-1-specific CTLs in the semen of HIV-infected individuals.

  1998cited by this paper
• Virus-specific CD8+ T cells in primary and secondary influenza pneumonia.

  1998cited by this paper
• Macaques infected with live attenuated SIVmac are protected against superinfection via the rectal mucosa.

  1997cited by this paper
• Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria.

  1997cited by this paper
• Cytotoxic T cells and viral hepatitis.

  1997influential reference
• Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms

  1997cited by this paper
• HIV-1 Induces Cytotoxic T Lymphocytes in the Cervix of Infected Women

  1997cited by this paper
• Epithelial M cells: gateways for mucosal infection and immunization.

  1996cited by this paper
• Long-lived cytotoxic T lymphocyte memory in mucosal tissues after mucosal but not systemic immunization

  1996cited by this paper
• Minireview Gateways for Mucosal Infection and Immunization

  1996cited by this paper
• Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella.

  1996cited by this paper
• Protective Effect of Rotavirus VP6-Specific IgA Monoclonal Antibodies That Lack Neutralizing Activity

  1996cited by this paper
• Evaluation of live attenuated influenza vaccines in children 6-18 months of age: safety, immunogenicity, and efficacy. National Institute of Allergy and Infectious Diseases, Vaccine and Treatment Evaluation Program and the Wyeth-Ayerst ca Influenza Vaccine Investigators Group.

  1996cited by this paper
• Regulation of the interaction between Th1 and Th2 T cell clones to provide help for antibody production in vivo

  1995cited by this paper
• Novel in vitro model for high-rate IgA class switching.

  1995cited by this paper
• Ig-secreting and interferon-gamma-producing cells in mice mucosally immunized with influenza virus.

  1995cited by this paper
• Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches

  1994influential reference
• Interleukin 10 induces B lymphocytes from IgA-deficient patients to secrete IgA.

  1994cited by this paper
• Transepithelial transport of immunoglobulins.

  1994cited by this paper
• Epithelial transcytosis of monomeric IgA and IgG cross-linked through antigen to polymeric IgA. A role for monomeric antibodies in the mucosal immune system.

  1994cited by this paper
• Handbook of mucosal immunology

  1994cited by this paper
• 56 – Endocrine Regulation of Mucosal Immunity: Effect of Sex Hormones and Cytokines on the Afferent and Efferent Arms of the Immune System in the Female Reproductive Tract

  1994cited by this paper
• Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues

  1993cited by this paper
• Rat intestinal M cells contain acidic endosomal-lysosomal compartments and express class II major histocompatibility complex determinants.

  1993cited by this paper
• Partitioning of responder CD8+ T cells in lymph node and lung of mice with Sendai virus pneumonia by LECAM-1 and CD45RB phenotype.

  1993cited by this paper
• Induction of immunoglobulin synthesis by CD4+ T cell clones.

  1993cited by this paper
• Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia

  1993cited by this paper
• Intracellular neutralization of virus by immunoglobulin A antibodies.

  1992cited by this paper
• Effect of transforming growth factor (TGF)-beta 1 on IgA isotype expression. TGF-beta 1 induces a small increase in sIgA+ B cells regardless of the method of B cell activation.

  1992cited by this paper
• Memory and distribution of virus-specific cytotoxic T lymphocytes (CTLs) and CTL precursors after rotavirus infection

  1991cited by this paper
• Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesis.

  1991cited by this paper
• Rotavirus-specific cytotoxic T lymphocytes passively protect against gastroenteritis in suckling mice

  1990cited by this paper
• Molecular characterization of germ-line immunoglobulin A transcripts produced during transforming growth factor type beta-induced isotype switching.

  1990cited by this paper
• Failure of infiltrating precursor cytotoxic T cells to acquire direct cytotoxic function in immunologically privileged sites.

  1990cited by this paper
• Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes

  1989cited by this paper
• Rotavirus-specific cytotoxic T lymphocytes appear at the intestinal mucosal surface after rotavirus infection

  1989cited by this paper
• Mechanism of neutralization of influenza virus by secretory IgA is different from that of monomeric IgA or IgG

  1985cited by this paper
• Preferential induction of polyclonal IgA secretion by murine Peyer's patch dendritic cell-T cell mixtures

  1984cited by this paper
• Intestinal M cells: a pathway for entry of reovirus into the host.

  1981cited by this paper
• Distribution of R Plasmids Among the O-Antigen Types of Escherichia coli Isolated from Various Clinical Sources

  1976cited by this paper
• CONTROL OF INFECTIOUS DISEASES

  1955cited by this paper
• Control of Infectious Diseases

  1943cited by this paper

• Recombinant influenza A/H1N1pdm09 vaccine expressing streptococcal surface epitope for dual protection

  2025cites this paper
• A review of sebum in mammals in relation to skin diseases, skin function, and the skin microbiome

  2023cites this paper
• A CTB-SARS-CoV-2-ACE-2 RBD Mucosal Vaccine Protects Against Coronavirus Infection

  2023cites this paper
• Bacteria-enabled oral delivery of a replicon-based mRNA vaccine candidate protects against ancestral and delta variant SARS-CoV-2

  2022cites this paper
• Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge

  2021cites this paper
• Challenges and Prospects of Plant-Derived Oral Vaccines against Hepatitis B and C Viruses

  2021cites this paper
• Secretory immunoglobulin A of the respiratory system and COVID-19

  2021cites this paper
• Nasal vaccination against SARS-CoV-2: Synergistic or alternative to intramuscular vaccines?

  2021cites this paper
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  2021cites this paper
• Intranasal Vaccination Strategy to Control the COVID-19 Pandemic from a Veterinary Medicine Perspective

  2021cites this paper
• Emerging Role of Mucosal Vaccine in Preventing Infection with Avian Influenza A Viruses

  2020cites this paper
• New Horizons in Food Science via Agricultural Immunity

  2020cites this paper
• Assessment of the Immunogenicity of a Novel Live Recombinant Rift Valley Fever arMP-12andDelta;NSm21/384 Vaccine Candidate Following Intranasal Vaccination of Goats, Sheepand Calves in Tanzania

  2020cites this paper
• Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 in mice

  2020cites this paper
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  2019cites this paper
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  2019cites this paper
• The Role of Antibiotics in Mucosal Colonization and Invasion with Regards to Gut Microbes

  2019cites this paper
• Live respiratory syncytial virus attenuated by M2-2 deletion and stabilized temperature sensitivity mutation 1030s is a promising vaccine candidate in children.

  2019cites this paper
• Intragastric delivery of recombinant Lactococcus lactis displaying ectodomain of influenza matrix protein 2 (M2e) and neuraminidase (NA) induced focused mucosal and systemic immune responses in chickens.

  2019cites this paper
• Drug Carrier Systems for Anticancer Agents

  2019cites this paper
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  2018cites this paper
• Nanomaterial-Enabled Immunotherapeutic Applications

  2017cites this paper
• Dendritic Cell-Mediated Mechanisms Triggered by LT-IIa-B5, a Mucosal Adjuvant Derived from a Type II Heat-Labile Enterotoxin of Escherichia coli.

  2017cites this paper
• Current prospects and future challenges for nasal vaccine delivery

  2017cites this paper
• Update on Chlamydia trachomatis Vaccinology

  2017cites this paper
• Chapter 13 – Vaccine Development

  2017cites this paper
• Mucosal Vaccine Development Based on Liposome Technology

  2016cites this paper
• An Overview of Challenges Limiting the Design of Protective Mucosal Vaccines for Finfish

  2015cites this paper
• Anticancer Agents: Drug Carrier Systems

  2015cites this paper
• A simple and inexpensive enteric-coated capsule for delivery of acid-labile macromolecules to the small intestine

  2015cites this paper
• Mast cell recruitment and activation as measures of cyathostomin burden

  2015cites this paper
• Methylglycol chitosan and a synthetic TLR4 agonist enhance immune responses to influenza vaccine administered sublingually.

  2015cites this paper
• Combinatorial Approach of Antigen Delivery Using M Cell-Homing Peptide and Mucoadhesive Vehicle to Enhance the Efficacy of Oral Vaccine.

  2015cites this paper
• Nanotechnology, Drug Delivery Systems and their Potential Applications in Hepatitis B Vaccine

  2015cites this paper
• Nasal Vaccines Against Hepatitis B: An Update.

  2015cites this paper
• Chitosan-based systems for intranasal immunization against foot-and-mouth disease

  2014cites this paper
• DNA Vaccines Approach: From Concepts to Applications

  2014cites this paper
• Oral delivery of probiotic expressing M cell homing peptide conjugated BmpB vaccine encapsulated into alginate/chitosan/alginate microcapsules.

  2014cites this paper
• Sublingual immunization with a subunit influenza vaccine elicits comparable systemic immune response as intramuscular immunization, but also induces local IgA and TH17 responses.

  2014cites this paper
• Liposomes as nanovaccine delivery systems.

  2014cites this paper
• Approaches to tuberculosis mucosal vaccine development using nanoparticles and microparticles: a review.

  2014cites this paper
• Induction of mucosal immunity by intranasal immunization with recombinant adenovirus expressing major epitopes of Porcine circovirus-2 capsid protein.

  2013cites this paper
• MUCOSAL IMMUNITY AND VACCINES

  2013cites this paper
• Passive administration of purified secretory IgA from human colostrum induces protection against Mycobacterium tuberculosis in a murine model of progressive pulmonary infection

  2013cites this paper
• Harnessing What Lies Within: Programming Immunity With Biocompatible Devices to Treat Human Disease

  2013cites this paper
• COMPARISON OF RETINOIC ACID (ORAL AND SUBCUTANEOUS) AND VITAMIN A (ORAL) EFFECTS ON IMMUNE RESPONSE IN VITAMIN A DEFICIENT MICE

  2012cites this paper
• Construction of recombinant lactobacilli expressing the core neutralizing epitope (COE) of porcine epidemic diarrhea virus and a fusion protein consisting of COE and Escherichia coli heat-labile enterotoxin B, and comparison of the immune responses by orogastric immunization.

  2012cites this paper
• Structure-activity relationship for the development of a self-adjuvanting mucosally active lipopeptide vaccine against Streptococcus pyogenes.

  2012cites this paper
• Engineering Nano‐ and Microparticles to Tune Immunity

  2012cites this paper
• Design of solid dosage forms for mucosal vaccination - Investigations on the influence of excipients on product performance

  2012cites this paper
• Adjuvant effect of liposome in chicken result from induction of nitric oxide

  2011cites this paper
• Mucosal immunization of rhesus macaques with Rift Valley Fever MP-12 vaccine.

  2011cites this paper
• The impact of vaccines and vaccinations: Challenges and opportunities for modelers.

  2011cites this paper
• Mucosal immunization with liposome-nucleic acid adjuvants generates effective humoral and cellular immunity.

  2011cites this paper
• Intranasal delivery of Norwalk virus-like particles formulated in an in situ gelling, dry powder vaccine.

  2011cites this paper
• Topical and mucosal liposomes for vaccine delivery.

  2011cites this paper
• Inducción de IgA e IgG anti-omp48 en conejos inmunizados intragástricamente con una fracción extracelular de Aeromonas veronii

  2011cites this paper
• VACINAS:: PROGRESSOS E NOVOS DESAFIOS PARA O CONTROLE DE DOENÇAS IMUNOPREVENÍVEIS

  2011cites this paper
• Development of adenoviral vector-based mucosal vaccine against influenza

  2011cites this paper
• Comparison of the immune responses induced by oral immunization of mice with Lactobacillus casei-expressing porcine parvovirus VP2 and VP2 fused to Escherichia coli heat-labile enterotoxin B subunit protein

  2010cites this paper
• Influence of Salmonella enterica Serovar Typhimurium Infection on Intestinal Goblet Cells and Villous Morphology in Broiler Chicks

  2010cites this paper
• Chloroplast-based Overexpression Of Pharmaceuticals To Develop Cost-effective Therapeutics

  2010cites this paper
• Chloroplast-based overexpression of Pharmaceuticals to develop Cost-effective Therapeutics

  2010cites this paper
• Nanotechnology solutions for mucosal immunization.

  2010cites this paper
• Entwicklung eines Lebend- und eines Totimpfstoffes gegen intrazelluläre Erreger auf Basis von Yersinia enterocolitica

  2010cites this paper
• The development of recombinant Adenoviral vaccines to target pneumovirus infection

  2010cites this paper
• Factors affecting secretion and surface display of heterologous proteins in Lactococcus lactis

  2010cites this paper
• IN INFANCY AND EARLY CHILDHOOD : IMPLICATIONS IN SUCCESSFUL ORAL IMMUNIZATION

  2010cites this paper
• Identification of the outer membrane immunoproteome of the uropathogen Proteus mirabilis: Insights into virulence and potential vaccine candidates

  2010cites this paper
• Vaccination against Chlamydia Genital Infection Utilizing the Murine C. muridarum Model

  2010influential citation
• Chitosan based delivery systems for mucosal immunization against bovine herpesvirus 1 (BHV-1).

  2010cites this paper
• Role and Importance of NS1 Protein of Avian Influenza Virus to Grow in the Presence of Interferon and Evaluation of the NS1 Mutant Viruses as Potential DIVA Vaccines

  2010cites this paper
• Delivery strategies to enhance mucosal vaccination

  2009cites this paper
• Immunization via the anal mucosa and adjacent skin to protect against respiratory virus infections and allergic rhinitis: A hypothesis

  2009cites this paper
• Delivery strategies to enhance mucosal vaccination.

  2009cites this paper
• Characterization of proteins Msp22 and Msp75 as vaccine antigens of Moraxella catarrhalis.

  2009cites this paper
• Mucosal Immune System

  2009cites this paper
• Adaptive immune response-modifying and antimicrobial properties of Andrographis paniculata and andrographolide

  2009cites this paper
• Adjuvant strategies required for targeting mucosal tissues.

  2009cites this paper
• Replicating adenovirus vector prime/protein boost strategies for HIV vaccine development

  2008cites this paper
• Cinétique de la réponse cytokinaire lors d'infections aux Escherichia coli entéropathogènes dans un modèle de culture d'iléon (IVOC) d'origine porcine

  2008cites this paper
• Mouse models for the study of mucosal vaccination against otitis media.

  2008cites this paper
• Intestinal cytokine response of commercial source broiler chicks to Salmonella typhimurium infection.

  2008cites this paper
• Immunité et vaccinations antivirales : exemple de la muqueuse respiratoire

  2007cites this paper
• Pulmonary vaccine delivery

  2007cites this paper
• Effects of aerosolized rabies virus exposure on bats and mice.

  2007cites this paper
• Contagious bovine pleuropneumonia: A rationale for the development of a mucosal sub-unit vaccine

  2007influential citation
• Mucosal vaccine vectors: replication-competent versus replication-deficient poxviruses.

  2007cites this paper
• Modulation of immune responses on mucosal surfaces through vaccination and dietary intervention

  2007cites this paper
• Nutrition support in severe acute pancreatitis.

  2007cites this paper
• Charakterisierung antigenspezifischer CD8+ T-Zellsubpopulationen nach oraler Immunisierung mit rekombinanten Salmonella typhimurium-Impfstämmen

  2007cites this paper
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  2006cites this paper
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  2006cites this paper
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  2006cites this paper
• Delivery systems and adjuvants for oral vaccines

  2006cites this paper
• Cytokine Responses in Gnotobiotic Pigs after Infection with Virulent or Attenuated Human Rotavirus

  2006cites this paper
• Anatomical and hormonal influences on women's dermatologic health.

  2006cites this paper
• Modified Bacterial Toxins

  2006cites this paper
• CAN PROBIOTICS HAVE A BENEFICIAL IMPACT ON THE HEALTH STATUS OF FARMED ANIMALS

  2006cites this paper
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  2006cites this paper