Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Cancer Research

• Publication date

  2002-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 12067980
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

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  2000influential reference
• The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages

  2000cited by this paper
• Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia.

  2000cited by this paper
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• Regulation of Multidrug Resistance 1 (MDR1)/P-glycoprotein Gene Expression and Activity by Heat-Shock Transcription Factor 1 (HSF1)*

  2000cited by this paper
• Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies.

  2000influential reference
• Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)

  2000cited by this paper
• Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1.

  2000cited by this paper
• Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3

  2000cited by this paper
• Sp1 Increases Expression of Cyclooxygenase-2 in Hypoxic Vascular Endothelium

  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Multidrug resistance-associated protein subfamily transporters and drug resistance.

  1999cited by this paper
• Critical Role of cAMP Response Element Binding Protein Expression in Hypoxia-elicited Induction of Epithelial Tumor Necrosis Factor-α*

  1999cited by this paper
• Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross-coupled NF-kappa B/p65 and c-Fos transcription factors and their interaction with the CAAT region.

  1999cited by this paper
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  1999cited by this paper
• Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway.

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• Transcriptional Regulation of the MDR1 Gene by Histone Acetyltransferase and Deacetylase Is Mediated by NF-Y

  1998cited by this paper
• Transcription Factors Sp1 and Sp3 Alter Vascular Endothelial Growth Factor Receptor Expression through a Novel Recognition Sequence*

  1998cited by this paper
• Regulation of the MDR1 promoter by cyclic AMP-dependent protein kinase and transcription factor Sp1.

  1998cited by this paper
• HIF‐1α is required for solid tumor formation and embryonic vascularization

  1998cited by this paper
• Direct Involvement of the Y-box Binding Protein YB-1 in Genotoxic Stress-induced Activation of the Human Multidrug Resistance 1 Gene*

  1998cited by this paper
• Cell culture as spheroids: an approach to multicellular resistance.

  1998cited by this paper
• Multidrug resistance: clinical relevance in solid tumours and strategies for circumvention.

  1998cited by this paper
• HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

  1998cited by this paper
• Autocrine regulation of epithelial permeability by hypoxia: role for polarized release of tumor necrosis factor alpha.

  1998cited by this paper
• Hypoxia-inducible factor 1: master regulator of O2 homeostasis.

  1998influential reference
• Targeting gene expression to hypoxic tumor cells

  1997cited by this paper
• Wild-type p53 gene increases MDR1 gene expression but decreases drug resistance in an MDR cell line KBV200.

  1997cited by this paper
• Involvement of the transcription factor NF-IL6 in phorbol ester induction of P-glycoprotein in U937 cells.

  1997cited by this paper
• Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

  1997cited by this paper
• The plasma membrane polarity of human biliary epithelial cells: in situ immunohistochemical analysis and functional implications.

  1997cited by this paper
• The physiological function of drug-transporting P-glycoproteins.

  1997cited by this paper
• Monoclonal antibodies specific for P-glycoprotein

  1997cited by this paper
• Deglycosylated Products of Endogenous Digoxin-like Immunoreactive Factor in Mammalian Tissue (*)

  1996cited by this paper
• Epithelial exposure to hypoxia modulates neutrophil transepithelial migration

  1996cited by this paper
• Expression monitoring by hybridization to high-density oligonucleotide arrays

  1996cited by this paper
• The P-glycoprotein multidrug transporter.

  1996cited by this paper
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  1996cited by this paper
• Effects of hypoxia on drug resistance phenotype and genotype in human glioma cell lines

  1996cited by this paper
• MDR1 gene expression in solid tumours.

  1996influential reference
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  1996cited by this paper
• Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells.

  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1993cited by this paper
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  1993cited by this paper
• Hypoxia-induced drug resistance: comparison to P-glycoprotein-associated drug resistance.

  1991cited by this paper
• Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.

  1990cited by this paper
• Comparison of fluorochrome-labeled and 51Cr-labeled targets for natural killer cytotoxicity assay.

  1989cited by this paper
• Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.

  1987cited by this paper
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  1978cited by this paper

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