Revisiting an old acquaintance: CD26 and its molecular mechanisms in T cell function.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Trends in immunology

• Publication date

  2008-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.it.2008.02.010PMID 18456553
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Caveolin-1 Triggers T-cell Activation via CD26 in Association with CARMA1*

  2007cited by this paper
• Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis.

  2007cited by this paper
• TGF-β1-Mediated Control of Central Nervous System Inflammation and Autoimmunity through the Inhibitory Receptor CD261

  2007cited by this paper
• Increased Expression of Plasma and CD4+ T Lymphocyte Costimulatory Molecule CD26 in Adult Patients with Allergic Asthma

  2007cited by this paper
• T-cell activation via CD26 and caveolin-1 in rheumatoid synovium

  2006cited by this paper
• The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.

  2006cited by this paper
• Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.

  2005cited by this paper
• CD26 Mediates Dissociation of Tollip and IRAK-1 from Caveolin-1 and Induces Upregulation of CD86 on Antigen-Presenting Cells

  2005cited by this paper
• CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse.

  2005cited by this paper
• Circulating CD26 is negatively associated with inflammation in human and experimental arthritis.

  2005cited by this paper
• Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity.

  2004cited by this paper
• A new dipeptide naphthylamidase hydrolyzing glycyl-prolyl-β-naphthylamide

  2004cited by this paper
• CD26 up-regulates expression of CD86 on antigen-presenting cells by means of caveolin-1.

  2004cited by this paper
• One Site Mutation Disrupts Dimer Formation in Human DPP-IV Proteins*

  2004cited by this paper
• N‐linked glycosylation of dipeptidyl peptidase IV (CD26): Effects on enzyme activity, homodimer formation, and adenosine deaminase binding

  2004cited by this paper
• Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic.

  2004cited by this paper
• The multifunctional or moonlighting protein CD26/DPPIV.

  2003cited by this paper
• Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog

  2003cited by this paper
• A Novel Consensus Motif in Fibronectin Mediates Dipeptidyl Peptidase IV Adhesion and Metastasis*

  2003cited by this paper
• Endocytosis Via Caveolae

  2002cited by this paper
• The interaction properties of costimulatory molecules revisited.

  2002cited by this paper
• CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO

  2001cited by this paper
• Soluble CD26/Dipeptidyl Peptidase IV Induces T Cell Proliferation Through CD86 Up-Regulation on APCs1

  2001cited by this paper
• Targeting Dipeptidyl Peptidase IV (CD26) Suppresses Autoimmune Encephalomyelitis and Up-Regulates TGF-β1 Secretion In Vivo1

  2001cited by this paper
• The expanding world of co-stimulation: the two-signal model revisited.

  2001cited by this paper
• Dipeptidyl peptidase IV-like molecules: homologous proteins or homologous activities?

  2001cited by this paper
• ICOS is critical for CD40-mediated antibody class switching

  2001cited by this paper
• The Binding Site of Human Adenosine Deaminase for Cd26/Dipeptidyl Peptidase IV

  2000cited by this paper
• Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8.

  2000cited by this paper
• Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26.

  2000cited by this paper
• Dipeptidyl peptidase IV (DP IV/CD26) mRNA expression in PWM-stimulated T-cells is suppressed by specific DP IV inhibition, an effect mediated by TGF-beta(1).

  2000cited by this paper
• Dipeptidyl Peptidase IV (DP IV/CD26) mRNA Expression in PWM-Stimulated T-Cells Is Suppressed by Specific DP IV Inhibition, an Effect Mediated by TGF-β1

  2000cited by this paper
• Fibroblast Activation Protein, a Dual Specificity Serine Protease Expressed in Reactive Human Tumor Stromal Fibroblasts*

  1999cited by this paper
• Caveolins, Liquid-Ordered Domains, and Signal Transduction

  1999cited by this paper
• Truncation of Macrophage-derived Chemokine by CD26/ Dipeptidyl-Peptidase IV beyond Its Predicted Cleavage Site Affects Chemotactic Activity and CC Chemokine Receptor 4 Interaction*

  1999cited by this paper
• Sequence, Purification, and Cloning of an Intracellular Serine Protease, Quiescent Cell Proline Dipeptidase*

  1999cited by this paper
• Dipeptidyl-peptidase IV-beta--further characterization and comparison to dipeptidyl-peptidase IV activity of CD26.

  1998cited by this paper
• Enzymatic and extraenzymatic role of ecto‐adenosine deaminase in lymphocytes

  1998cited by this paper
• The structure and function of CD26 in the T‐cell immune response

  1998cited by this paper
• Dipeptidyl‐peptidase IV‐β

  1998cited by this paper
• Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions.

  1998cited by this paper
• Inhibitors of dipeptidyl peptidase IV/CD26 suppress activation of human MBP-specific CD4+ T cell clones.

  1998cited by this paper
• The effect of anti-CD26 antibodies on DNA synthesis and cytokine production (IL-2, IL-10 and IFN-gamma) depends on enzymatic activity of DP IV/CD26.

  1997cited by this paper
• Cell surface characterization of T lymphocytes and allergen-specific T cell clones: correlation of CD26 expression with T(H1) subsets.

  1997cited by this paper
• Inhibition of CD26/dipeptidyl peptidase IV activity in vivo prolongs cardiac allograft survival in rat recipients.

  1997cited by this paper
• Regulation of the Receptor Specificity and Function of the Chemokine RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) by Dipeptidyl Peptidase IV (CD26)-mediated Cleavage

  1997cited by this paper
• Determination of adenosine deaminase binding domain on CD26 and its immunoregulatory effect on T cell activation.

  1997cited by this paper
• Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) induces secretion of transforming growth factor-beta 1 (TGF-beta 1) in stimulated mouse splenocytes and thymocytes.

  1997cited by this paper
• Inhibitors of dipeptidyl peptidase IV induce secretion of transforming growth factor‐β1 in PWM‐stimulated PBMC and T cells

  1997cited by this paper
• Suppression of arthritis by the inhibitors of dipeptidyl peptidase IV.

  1997cited by this paper
• Identification of Peptide and Protein Ligands for the Caveolin-scaffolding Domain

  1997cited by this paper
• Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) induces secretion of transforming growth factor-β1 (TGF-β1) in stimulated mouse splenocytes and thymocytes

  1997cited by this paper
• Suppression of arthritis by the inhibitors of dipeptidyl peptidase IV

  1997cited by this paper
• Increased population of high fluorescence 1F7 (CD26) antigen on T cells in synovial fluid of patients with rheumatoid arthritis.

  1996cited by this paper
• Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex. Possible role of adenosine deaminase as costimulatory molecule.

  1995cited by this paper
• Phenotypic characterization of CD4+ T cells that exhibit a transendothelial migratory capacity.

  1995cited by this paper
• Differential CD26-mediated activation of the CD3 and CD2 pathways after CD6-depleted allogeneic bone marrow transplantation.

  1995cited by this paper
• CD26: a surface protease involved in T-cell activation.

  1994cited by this paper
• Enhancement of antigen-induced T-cell proliferation by soluble CD26/dipeptidyl peptidase IV.

  1994cited by this paper
• Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). A member of a novel family of nonclassical serine hydrolases.

  1993cited by this paper
• The costimulatory activity of the CD26 antigen requires dipeptidyl peptidase IV enzymatic activity.

  1993cited by this paper
• Cloning and functional expression of the T cell activation antigen CD26.

  1993cited by this paper
• Direct association of adenosine deaminase with a T cell activation antigen, CD26.

  1993cited by this paper
• Cloning and functional expression of the T cell activation antigen CD26.

  1992cited by this paper
• Fibronectin promotes proliferation of naive and memory T cells by signaling through both the VLA-4 and VLA-5 integrin molecules.

  1990cited by this paper
• VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin

  1990cited by this paper
• Comitogenic effect of solid-phase immobilized anti-1F7 on human CD4 T cell activation via CD3 and CD2 pathways.

  1990cited by this paper
• FcR-mediated crosslinking of Ta1 (CDw26) induces human T lymphocyte activation.

  1990cited by this paper
• 1F7, a novel cell surface molecule, involved in helper function of CD4 cells.

  1989cited by this paper
• A novel pathway of human T cell activation via a 103 kD T cell activation antigen.

  1987cited by this paper
• In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

  1985cited by this paper
• The dipeptidyl peptidase IV, a membrane enzyme involved in the proliferation of T lymphocytes.

  1985cited by this paper
• Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody.

  1984cited by this paper
• Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxins

  1982cited by this paper
• A new dipeptide naphthylamidase hydrolyzing glycyl-prolyl-beta-naphthylamide.

  1966cited by this paper
• THE FINE STRUCTURE OF THE GALL BLADDER EPITHELIUM OF THE MOUSE

  1955cited by this paper

• Electroacupuncture in Combination with Bevacizumab Hydrogel Provides a Therapeutic Strategy for Bladder Cancer.

  2026cites this paper
• Preclinical pharmacological profiles of cofrogliptin, a novel and bi-weekly DPP-4 inhibitor

  2026cites this paper
• Combined Use of Vitamin D and DPP-4 Inhibitors as a Potential Adjuvant Treatment Strategy to Enhance the Efficacy of Novel Beta-Cell Replacement Therapies for Type 1 Diabetes

  2025cites this paper
• Gliptin-Induced Bullous Pemphigoid: Are Statins and Angiotensin Receptor Blockers the Cause?

  2025cites this paper
• Dipeptidyl Peptidase 4 Inhibitors: Novel Therapeutic Agents in the Management of Type II Diabetes Mellitus

  2025cites this paper
• Type 2 diabetes mellitus – conventional therapies and future perspectives in innovative treatment

  2025cites this paper
• Dipeptidyl Peptidase-4 Inhibitors Associated with Lower Psoriatic Disease Risk in Type 2 Diabetes: A 13-Year Nationwide Cohort Study with Mechanistic Validation

  2025cites this paper
• Children With Celiac Disease Have a Higher Degree of Activated or Exhausted CD4 + and CD8 + T Cells Compared to Healthy References

  2025cites this paper
• DPPPRED-IV: An Ensembled QSAR-Based Web Server for the Prediction of Dipeptidyl Peptidase 4 Inhibitors

  2025cites this paper
• CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signalling Pathway to Reduce Ferroptosis and Macrophage Polarisation

  2025cites this paper
• Anti-CD26 Antibody Suppresses Epithelial-Mesenchymal Transition in Colorectal Cancer Stem Cells

  2025cites this paper
• An abnormal increase in CD26(-)CD28(-) cytotoxic effector CD4 and CD8 T cell populations in patients with systemic lupus erythematosus.

  2024cites this paper
• Beyond FOXP3: a 20-year journey unravelling human regulatory T-cell heterogeneity

  2024cites this paper
• Exploring the conformational dynamics and key amino acids in the CD26-caveolin-1 interaction and potential therapeutic interventions

  2024cites this paper
• Functional roles of CD26/DPP4 in lipopolysaccharide-induced lung injury.

  2024cites this paper
• Drug associated bullous pemphigoid: what's new?

  2024cites this paper
• Transcriptome Analysis of Fibroblasts in Hypoxia-Induced Vascular Remodeling: Functional Roles of CD26/DPP4

  2024cites this paper
• Ocular cicatricial pemphigoid following Dipeptidyl Peptidase-4 inhibitor use: A case report

  2023cites this paper
• Bullous Pemphigoid Associated With Dipeptidyl Peptidase-4 Inhibitors: A Case Report and Review of Current Evidence

  2023cites this paper
• Potential clinical implications of CD4+CD26high T cells for nivolumab treated melanoma patients

  2023cites this paper
• Virtual screening strategy for anti-DPP-IV natural flavonoid derivatives based on machine learning

  2023cites this paper
• Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis.

  2023cites this paper
• Functional roles of CD26/DPP4 in bleomycin‐induced pulmonary fibrosis

  2023cites this paper
• Dipeptidylpeptidase-4 inhibitor-associated bullous pemphigoid is characterized by an altered expression of cytokines in the skin.

  2022cites this paper
• Gliptin-induced bullous pemphigoid: withdrawal of gliptin allows for faster control of the disease

  2022cites this paper
• Extracellular Vesicles as Biomarkers of Acute Graft-vs.-Host Disease After Haploidentical Stem Cell Transplantation and Post-Transplant Cyclophosphamide

  2022cites this paper
• The role of insulin and incretin-based drugs in biliary tract cancer: epidemiological and experimental evidence

  2022cites this paper
• In-Depth Immunophenotyping With Mass Cytometry During TB Treatment Reveals New T-Cell Subsets Associated With Culture Conversion

  2022cites this paper
• Drug allergy and non-HIV immune reconstitution inflammatory syndrome.

  2022cites this paper
• Dipeptidyl Peptidase-4 (DPP4) Inhibitors

  2022cites this paper
• Therapeutic Perspectives of CD26 Inhibitors in Imune-Mediated Diseases

  2022cites this paper
• Application of Antimicrobial Peptide LL-37 as an Adjuvant for Middle East Respiratory Syndrome-Coronavirus Antigen Induces an Efficient Protective Immune Response Against Viral Infection After Intranasal Immunization

  2022cites this paper
• Distinct T cell subsets in adipose tissue are associated with obesity

  2022cites this paper
• New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors

  2022cites this paper
• Physiological and pharmacological actions of glucagon like peptide-1 (GLP-1) in domestic animals

  2022cites this paper
• Sitagliptin to Prevent Acute Graft-versus-Host Disease.

  2021cites this paper
• Effect of identified non-synonymous mutations in DPP4 receptor binding residues among highly exposed human population in Morocco to MERS-CoV through computational approach

  2021cites this paper
• DMSO_A_294742 565..573

  2021cites this paper
• DPP4 inhibition mitigates Ang II-mediated kidney immune activation and injury in male mice.

  2021cites this paper
• Pleiotropic Benefits of DPP-4 Inhibitors Beyond Glycemic Control

  2021influential citation
• Functional Dissection of CD26 and Its Pharmacological Inhibition by Sitagliptin During Skin Wound Healing

  2021cites this paper
• Peripheral endomorphins drive mechanical alloknesis under the enzymatic control of CD26/DPPIV.

  2021cites this paper
• Analysis of the Clinical Characteristics of Dipeptidyl Peptidase-4 Inhibitor–Induced Bullous Pemphigoid

  2021cites this paper
• In-depth immunophenotyping with mass cytometry during TB treatment reveals non-canonical T-cell subsets associated with sputum culture conversion

  2021cites this paper
• Lung development and immune status under chronic LPS exposure in rat pups with and without CD26/DPP4 deficiency

  2021cites this paper
• Anti-Diabetic Drugs GLP-1 Agonists and DPP-4 Inhibitors may Represent Potential Therapeutic Approaches for COVID-19.

  2021cites this paper
• The Impact of Deranged Glucose Metabolism and Diabetes in The Pathogenesis and Prognosis of The Novel Sars-Cov-2: A Systematic Review of Literature.

  2021cites this paper
• Incretins in the Therapy of Diabetic Kidney Disease

  2021cites this paper
• Comparative cellular immune responses in calves after infection with Mycobacterium avium subsp. paratuberculosis, M. avium subsp. avium, M. kansasii and M. bovis.

  2021cites this paper
• Fecal Dipeptidyl Peptidase-4: An Emergent Biomarker in Inflammatory Bowel Disease

  2021cites this paper
• Dipeptidyl peptidase 4 inhibitors: Applications in innate immunity?

  2021cites this paper
• Emerging Roles of Dipeptidyl Peptidase-4 Inhibitors in Delaying the Progression of Type 1 Diabetes Mellitus

  2021cites this paper
• Association between plasma dipeptidyl peptidase-4 levels and cognitive function in perinatal pregnant women with gestational diabetes mellitus

  2021cites this paper
• Dipeptidyl Peptidase (DPP)-4 Inhibitor Impairs the Outcomes of Patients with Type 2 Diabetes Mellitus After Curative Resection for Colorectal Cancer

  2021cites this paper
• The Serine Protease CD26/DPP4 in Non-Transformed and Malignant T Cells

  2021cites this paper
• Targeting Chronic Myeloid Leukemia Stem/Progenitor Cells Using Venetoclax-Loaded Immunoliposome

  2021cites this paper
• Systemic DPP4/CD26 is associated with natural HIV-1 control: Implications for COVID-19 susceptibility

  2021cites this paper
• Bullous pemphigoid in diabetic patients treated by gliptins: the other side of the coin

  2021cites this paper
• MERS Coronavirus: Methods and Protocols

  2020cites this paper
• Design, synthesis, molecular simulation, and biological activities of novel quinazolinone-pyrimidine hybrid derivatives as dipeptidyl peptidase-4 inhibitors and anticancer agents

  2020cites this paper
• Role of Caveolin-1 in Diabetes and Its Complications

  2020cites this paper
• Incretin drugs in diabetic kidney disease: biological mechanisms and clinical evidence

  2020cites this paper
• Molecular and Cellular Mechanisms of Itch in Psoriasis

  2020cites this paper
• Effects of the Antidiabetic Drugs Evogliptin and Sitagliptin on the Immune Function of CD26/DPP4 in Th1 Cells

  2020cites this paper
• CD26 upregulates proliferation and invasion in keloid fibroblasts through an IGF-1-induced PI3K/AKT/mTOR pathway

  2020cites this paper
• Deciphering the Neuroprotective Role of Glucagon-like peptide-1 Agonists in Diabetic Neuropathy: Current Perspective and Future Directions.

  2020cites this paper
• Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus

  2020cites this paper
• Evaluation of Interleukin-23 and JAKs/STATs/SOCSs/ROR-γt Expression in Type 2 Diabetes Mellitus Patients Treated With or Without Sitagliptin

  2020cites this paper
• Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs

  2020cites this paper
• Dipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus

  2020cites this paper
• Improvement of pure sensory mononeuritis multiplex and IgG1 deficiency with sitagliptin plus Vitamin D3.

  2020cites this paper
• Coronavirus in human diseases: Mechanisms and advances in clinical treatment

  2020cites this paper
• Antiproteinuric effect of DPP-IV inhibitors in diabetic and non-diabetic kidney diseases.

  2020cites this paper
• Clinical Features and Outcomes of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid (DPP4i-Associated BP) in Thai Patients

  2020cites this paper
• Dipeptidyl peptidase 4 inhibitors and their potential immune modulatory functions

  2020influential citation
• Treatment of steroid resistant acute graft versus host disease with an anti-CD26 monoclonal antibody—Begelomab

  2020cites this paper
• Targeting cancer stem cell pathways for cancer therapy

  2020cites this paper
• Identification of human CD4+ T cell populations with distinct antitumor activity

  2020cites this paper
• The role of Dipeptidyl Peptidase‐4 in cutaneous disease

  2020cites this paper
• Serum soluble CD26/DPP4 titer variation is a potential prognostic biomarker in cancer therapy with a humanized anti-CD26 antibody

  2020cites this paper
• The emerging role of dipeptidyl-peptidase-4 as a therapeutic target in lung disease

  2020cites this paper
• Single-Cell Heterogeneity of Cutaneous T-Cell Lymphomas Revealed Using RNA-Seq Technologies

  2020cites this paper
• Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis

  2019cites this paper
• Search for biomarkers related to rhinitis and different asthma phenotypes by serum proteomics and immunoassays

  2019cites this paper
• Genetically Engineering a Susceptible Mouse Model for MERS-CoV-Induced Acute Respiratory Distress Syndrome

  2019cites this paper
• T cells expressing CD26-specific chimeric antigen receptors exhibit extensive self-antigen-driven fratricide

  2019cites this paper
• More than just an enzyme: Dipeptidyl peptidase-4 (DPP-4) and its association with diabetic kidney remodelling.

  2019cites this paper
• Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid

  2019cites this paper
• DPP8 is a novel therapeutic target for multiple myeloma

  2019cites this paper
• Dipeptidyl peptidase IV inhibitor-associated bullous pemphigoid: a recently recognized autoimmune blistering disease with unique clinical, immunological and genetic characteristics

  2019cites this paper
• Expansion of different subpopulations of CD26−/low T cells in allergic and non-allergic asthmatics

  2019cites this paper
• Dipeptidyl peptidase‐4 inhibitors lower the risk of autoimmune disease in patients with type 2 diabetes mellitus: A nationwide population‐based cohort study

  2019cites this paper
• CD26 expression is attenuated by TGF‐β and SDF‐1 autocrine signaling on stromal myofibroblasts in human breast cancers

  2019cites this paper
• Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2 Diabetes

  2019cites this paper
• The perceptions of natural compounds against dipeptidyl peptidase 4 in diabetes: from in silico to in vivo

  2019cites this paper
• Effect of narrowband ultraviolet B therapy on serum levels of CD26/dipeptidyl-peptidase IV and truncated forms of substance P in psoriasis patients with pruritus Clinical, Cosmetic and Investigational Dermatology

  2019cites this paper
• Universitet Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2

  2019cites this paper
• Comparison of chronic myeloid leukemia stem cells and hematopoietic stem cells by global proteomic analysis.

  2019cites this paper
• Development of novel monoclonal antibodies with specific binding affinity for denatured human CD26 in formalin-fixed paraffin-embedded and decalcified specimens

  2019cites this paper
• Effect of narrowband ultraviolet B therapy on serum levels of CD26/dipeptidyl-peptidase IV and truncated forms of substance P in psoriasis patients with pruritus

  2019cites this paper