Quality control of MHC class II associated peptides by HLA-DM/H2-M.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Seminars in Immunology

• Publication date

  1999-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/SMIM.1999.0197PMID 10625593
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Limited polymorphism in HLA-DM does not involve the peptide binding groove

  2004cited by this paper
• MHC ligands and peptide motifs: first listing

  2004cited by this paper
• HLA-DM - an endosomal and lysosomal chaperone for the immune system.

  1999cited by this paper
• Identification of destabilizing residues in HLA class II‐selected bacteriophage display libraries edited by HLA‐DM

  1999cited by this paper
• The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation.

  1998cited by this paper
• Invariant Chain–independent Function of H-2M in the Formation of Endogenous Peptide–Major Histocompatibility Complex Class II Complexes In Vivo

  1998cited by this paper
• The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules.

  1998cited by this paper
• Highly Restricted T Cell Repertoire Shaped by a Single Major Histocompatibility Complex–Peptide Ligand in the Presence of a Single Rearranged T Cell Receptor β Chain

  1998cited by this paper
• A role for HLA‐DO as a co‐chaperone of HLA‐DM in peptide loading of MHC class II molecules

  1998cited by this paper
• The phenotype of H‐2M‐deficient mice is dependent on the MHC class II molecules expressed

  1998cited by this paper
• Crystal structure of mouse H2-M.

  1998cited by this paper
• Altered antigen presentation in mice lacking H2-O.

  1998cited by this paper
• A critical, invariant chain-independent role for H2-M in antigen presentation.

  1998cited by this paper
• The antigen presentation pathway in medullary thymic epithelial cells, but not that in cortical thymic epithelial cells, conforms to the endocytic pathway

  1998cited by this paper
• Antigen presentation: coming out gracefully.

  1998cited by this paper
• How HLA-DM affects the peptide repertoire bound to HLA-DR molecules.

  1997cited by this paper
• Receptor-mediated endocytosis of antigens overcomes the requirement for HLA-DM in class II-restricted antigen presentation.

  1997cited by this paper
• HLA-DO is an intracellular class II molecule with distinctive thymic expression.

  1997cited by this paper
• Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes.

  1997cited by this paper
• Negative regulation by HLA-DO of MHC class II-restricted antigen processing.

  1997cited by this paper
• HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH.

  1997cited by this paper
• How HLA-DM edits the MHC class II peptide repertoire: survival of the fittest?

  1997cited by this paper
• Short precursor shortens memory

  1997cited by this paper
• HLA‐DR‐restricted presentation of purified myelin basic protein is independent of intracellular processing

  1997cited by this paper
• HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading.

  1997cited by this paper
• Interaction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH.

  1997cited by this paper
• Editing of the HLA‐DR‐peptide repertoire by HLA‐DM.

  1996cited by this paper
• Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs

  1996cited by this paper
• HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR Molecules

  1996cited by this paper
• Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules

  1996cited by this paper
• Kinetic analysis of peptide loading onto HLA-DR molecules mediated by HLA-DM.

  1996cited by this paper
• Enhanced Dissociation of HLA-DR-Bound Peptides in the Presence of HLA-DM

  1996cited by this paper
• A structural transition in class II major histocompatibility complex proteins at mildly acidic pH

  1996cited by this paper
• Evidence for a conformational change in a class II major histocompatibility complex molecule occurring in the same pH range where antigen binding is enhanced

  1996cited by this paper
• Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression.

  1996cited by this paper
• Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway.

  1996cited by this paper
• H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection.

  1996cited by this paper
• Antigen Presentation and T Cell Development in H2-M-Deficient Mice

  1996cited by this paper
• Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells

  1996cited by this paper
• Developing and shedding inhibitions: how MHC class II molecules reach maturity.

  1996cited by this paper
• Association between HLA-DM and HLA-DR in vivo.

  1996cited by this paper
• HLA‐DO is a lysosomal resident which requires association with HLA‐DM for efficient intracellular transport.

  1996cited by this paper
• HLA-DM is present in one-fifth the amount of HLA-DR in the class II peptide-loading compartment where it associates with leupeptin-induced peptide (LIP)-HLA-DR complexes.

  1996cited by this paper
• Mediation by HLA-DM of dissociation of peptides from HLA-DR

  1995cited by this paper
• HLA-DM: an in vivo facilitator of MHC class II peptide loading.

  1995cited by this paper
• The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

  1995cited by this paper
• Invariant chain peptides enhancing or inhibiting the presentation of antigenic peptides by major histocompatibility complex class II molecules.

  1995cited by this paper
• Differential stability of HLA-DR alleles independent of endogenous peptides.

  1995cited by this paper
• How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway.

  1995cited by this paper
• The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif.

  1995cited by this paper
• Structural features of the invariant chain fragment CLIP controlling rapid release from HLA-DR molecules and inhibition of peptide binding.

  1995cited by this paper
• DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide.

  1995cited by this paper
• HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading.

  1995cited by this paper
• Interference of distinct invariant chain regions with superantigen contact area and antigenic peptide binding groove of HLA-DR.

  1995cited by this paper
• Self-Release of CLIP in Peptide Loading of HLA-DR Molecules

  1995cited by this paper
• A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments

  1995cited by this paper
• Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II

  1995cited by this paper
• Invriant chain peptides enhancing or inhibiting the presentation of antigenic peptides by major histocompatibility complex class II molecules

  1995cited by this paper
• The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent

  1995cited by this paper
• Antigen presentation and assembly by mouse I-Ak class II molecules in human APC containing deleted or mutated HLA DM genes.

  1994cited by this paper
• The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy

  1994cited by this paper
• In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides.

  1994cited by this paper
• Selective release of some invariant chain-derived peptides from HLA-DR1 molecules at endosomal pH

  1994cited by this paper
• Invariant-cognate peptide exchange restores class II dimer stability in HLA-DM mutants.

  1994cited by this paper
• Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells.

  1994cited by this paper
• High-affinity binding of short peptides to major histocompatibility complex class II molecules by anchor combinations.

  1994cited by this paper
• An essential role for HLA–DM in antigen presentation by class II major histocompatibility molecules

  1994cited by this paper
• MHC class II function preserved by low-affinity peptide interactions preceding stable binding

  1994cited by this paper
• Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

  1994cited by this paper
• HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells

  1994cited by this paper
• Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments.

  1994cited by this paper
• Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells.

  1994cited by this paper
• Evidence for a differential avidity model of T cell selection in the thymus.

  1994cited by this paper
• Ligand motifs of HLA-DRB5*0101 and DRB1*1501 molecules delineated from self-peptides.

  1994cited by this paper
• Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain.

  1994cited by this paper
• Mice lacking the MHC class II-associated invariant chain.

  1993cited by this paper
• Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression

  1993cited by this paper
• Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules

  1993cited by this paper
• Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles

  1993cited by this paper
• MHC class II deletion mutant expresses normal levels of transgene encoded class II molecules that have abnormal conformation and impaired antigen presentation ability.

  1992cited by this paper
• The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide

  1992cited by this paper
• The human class II MHC protein HLA-DR1 assembles as empty alpha beta heterodimers in the absence of antigenic peptide.

  1992cited by this paper
• Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant.

  1992cited by this paper
• Immunological aspects of demyelinating diseases.

  1992cited by this paper
• Irreversible association of peptides with class II MHC molecules in living cells

  1992cited by this paper
• Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

  1992cited by this paper
• HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

  1992cited by this paper
• A role for peptide in determining MHC class II structure

  1991cited by this paper
• Catalysis of the oxidative folding of ribonuclease A by protein disulfide isomerase: dependence of the rate on the composition of the redox buffer.

  1991cited by this paper
• A new human HLA class II-related locus, DM

  1991cited by this paper
• MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

  1991cited by this paper
• Molecular chaperones.

  1991cited by this paper
• A novel class II MHC molecule with unusual tissue distribution

  1991cited by this paper
• A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis

  1991cited by this paper
• Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

  1991cited by this paper
• New class ll-like genes in the murine MHC

  1991cited by this paper
• MHC class II-associated invariant chain contains a sorting signal for endosomal compartments.

  1990cited by this paper
• Intracellular transport of class II MHC molecules directed by invariant chain

  1990cited by this paper
• Degenerate binding of immunogenic peptides to HLA-DR proteins on B cell surfaces.

  1990cited by this paper
• Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes

  1990cited by this paper

• A prognostic model of lung adenocarcinoma constructed based on circadian rhythm genes and its potential clinical significance

  2025cites this paper
• Identification of novel prognostic targets in glioblastoma using bioinformatics analysis

  2022cites this paper
• Processing of CD74 by the intramembrane protease SPPL2a in B cells : Impact on endosomal trafficking and signaling

  2015cites this paper
• Immunodeficiency and Autoimmunity in H2-O–Deficient Mice

  2013cites this paper
• The Control of the Specificity of CD4 T Cell Responses: Thresholds, Breakpoints, and Ceilings

  2013cites this paper
• Generation of MHC class II–peptide ligands for CD4 T-cell allorecognition of MHC class II molecules

  2010cites this paper
• Novel fusion protein-expressing lentiviral vectors ameliorate collagen induced arthritis

  2010cites this paper
• The relative energetic contributions of dominant P1 pocket versus hydrogen bonding interactions to peptide:class II stability: implications for the mechanism of DM function.

  2008cites this paper
• Direct Ex Vivo Analyses of HLA-DR1 Transgenic Mice Reveal an Exceptionally Broad Pattern of Immunodominance in the Primary HLA-DR1-Restricted CD4 T-Cell Response to Influenza Virus Hemagglutinin

  2007cites this paper
• CD4 T cell immunodominance: Studies on the impact of major histocompatibility class II isotypes and DM

  2007cites this paper
• Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine design

  2007cites this paper
• Peptide-binding motifs for the I-Ad MHC class II molecule: alternate pH-dependent binding behavior.

  2006cites this paper
• Presence and regulation of messenger ribonucleic acids encoding components of the class II major histocompatibility complex-associated antigen processing pathway in the bovine corpus luteum.

  2006cites this paper
• The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes

  2005cites this paper
• The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance.

  2005cites this paper
• West Nile premembrane-envelope genetic vaccine encoded as a chimera containing the transmembrane and cytoplasmic domains of a lysosome-associated membrane protein: increased cellular concentration of the transgene product, targeting to the MHC II compartment, and enhanced neutralizing antibody respo

  2005cites this paper
• Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape.

  2005cites this paper
• The role of tapasin in MHC class 1 antigen presentation.

  2004cites this paper
• Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer.

  2004cites this paper
• Antigen presentation by MHC class II molecules : Role of the accessory MHC molecules HLA-DM and HLA-DO ( G 0400-2 )

  2003cites this paper
• Bacterial Evasion of Host Immune Responses: CD1 and nonpeptide antigen recognition systems in microbial immunity

  2003cites this paper
• On cross‐priming of MHC class I‐specific CTL: rule or exception?

  2002cites this paper
• Recruitment of MHC Class I Molecules by Tapasin into the Transporter Associated with Antigen Processing-Associated Complex Is Essential for Optimal Peptide Loading

  2002cites this paper
• Diversity in MHC class II antigen presentation

  2002cites this paper
• Immunological aspects of maternal-foetal interactions in mice

  2001cites this paper
• Is tapasin a modified Mhc class I molecule?

  2001cites this paper
• MHC Class II Allosteric Site Drugs: New Immunotherapeutics for Malignant, Infectious and Autoimmune Diseases *

  2001cites this paper
• Altered major histocompatibility complex class II peptide loading in H2‐O‐deficient mice

  2000cites this paper
• Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 608 Immunological Aspects of Maternal-foetal Interactions in Mice Table of Contents

  year unknowncites this paper