Endoplasmic Reticulum Stress Plays Critical Role in Brain Damage After Cerebral Ischemia/Reperfusion in Rats

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Neurotoxicity research

• Publication date

  2010-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s12640-009-9110-5PMID 19763736
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular Analysis of Endoplasmic Reticulum Stress Response After Global Forebrain Ischemia/Reperfusion in Rats: Effect of Neuroprotectant Simvastatin

  2009cited by this paper
• Molecular Mechanisms Leading to Neuroprotection/Ischemic Tolerance: Effect of Preconditioning on the Stress Reaction of Endoplasmic Reticulum

  2009cited by this paper
• Molecular Mechanisms of Apoptosis in Cerebral Ischemia: Multiple Neuroprotective Opportunities

  2008cited by this paper
• ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo

  2008cited by this paper
• Endoplasmic Reticulum Stress Inhibition Protects against Excitotoxic Neuronal Injury in the Rat Brain

  2007influential reference
• Molecular targets in cerebral ischemia for developing novel therapeutics.

  2007cited by this paper
• Preventing stroke: saving lives around the world.

  2007cited by this paper
• Apoptosis: Future Targets for Neuroprotective Strategies

  2006cited by this paper
• Cellular response to endoplasmic reticulum stress: a matter of life or death

  2006cited by this paper
• A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.

  2005cited by this paper
• Damage to the Endoplasmic Reticulum and Activation of Apoptotic Machinery by Oxidative Stress in Ischemic Neurons

  2005cited by this paper
• A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

  2005influential reference
• Cellular abnormalities linked to endoplasmic reticulum dysfunction in cerebrovascular disease--therapeutic potential.

  2005cited by this paper
• Stroke epidemiology in the developing world.

  2005cited by this paper
• Roles of CHOP/GADD153 in endoplasmic reticulum stress

  2004cited by this paper
• Cytoprotection by pre‐emptive conditional phosphorylation of translation initiation factor 2

  2004cited by this paper
• Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

  2004cited by this paper
• Molecular Identification of the Ischemic Penumbra

  2004cited by this paper
• Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP

  2004cited by this paper
• Cerebral ischemia and the unfolded protein response

  2004influential reference
• Coupling endoplasmic reticulum stress to the cell death program

  2004cited by this paper
• Loss of NeuN immunoreactivity after cerebral ischemia does not indicate neuronal cell loss: a cautionary note.

  2004cited by this paper
• Activation of caspase-12, an endoplasmic reticulum resident caspase, after permanent focal ischemia in rat

  2003cited by this paper
• Dysfunction of the Unfolded Protein Response during Global Brain Ischemia and Reperfusion

  2003cited by this paper
• Ischemic tolerance and endogenous neuroprotection.

  2003cited by this paper
• Induction of Grp78/BiP by Translational Block

  2003cited by this paper
• XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

  2003cited by this paper
• Inhibition of a constitutive translation initiation factor 2α phosphatase, CReP, promotes survival of stressed cells

  2003cited by this paper
• Induction of GRP78 by Ischemic Preconditioning Reduces Endoplasmic Reticulum Stress and Prevents Delayed Neuronal Cell Death

  2003cited by this paper
• Activation of caspase-12 by endoplasmic reticulum stress induced by transient middle cerebral artery occlusion in mice.

  2003cited by this paper
• An Endoplasmic Reticulum Stress-specific Caspase Cascade in Apoptosis

  2002cited by this paper
• IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

  2002influential reference
• Molecular Pathways of Protein Synthesis Inhibition during Brain Reperfusion: Implications for Neuronal Survival or Death

  2002influential reference
• Translational control in the endoplasmic reticulum stress response.

  2002cited by this paper
• The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas

  2002cited by this paper
• Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival.

  2001cited by this paper
• Coupling Endoplasmic Reticulum Stress to the Cell Death Program

  2001cited by this paper
• Translational control is required for the unfolded protein response and in vivo glucose homeostasis.

  2001cited by this paper
• Brain ischemia and reperfusion activates the eukaryotic initiation factor 2α kinase, PERK

  2001cited by this paper
• The unfolding tale of the unfolded protein response.

  2001cited by this paper
• Changes in the phosphorylation of initiation factor eIF‐2α, elongation factor eEF‐2 and p70 S6 kinase after transient focal cerebral ischaemia in mice

  2001cited by this paper
• Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

  2000cited by this paper
• Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction

  2000cited by this paper
• Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

  2000cited by this paper
• Perk is essential for translational regulation and cell survival during the unfolded protein response.

  2000influential reference
• Protein Aggregation after Transient Cerebral Ischemia

  2000cited by this paper
• Regulated translation initiation controls stress-induced gene expression in mammalian cells.

  2000influential reference
• The neuroprotective potential of heat shock protein 70 (HSP70).

  1999cited by this paper
• Middle cerebral artery occlusion in the mouse by intraluminal suture coated with poly-L-lysine: neurological and histological validation.

  1999cited by this paper
• Disturbances of the Functioning of Endoplasmic Reticulum: A Key Mechanism Underlying Neuronal Cell Injury?

  1999influential reference
• Activation of gadd153 expression through transient cerebral ischemia: evidence that ischemia causes endoplasmic reticulum dysfunction.

  1998cited by this paper
• Characterization of seven murine caspase family members

  1997cited by this paper
• Temporal profile of ischemic tissue damage, neutrophil response, and vascular plugging following permanent and transient (2H) middle cerebral artery occlusion in the rat.

  1994cited by this paper
• Viability thresholds and the penumbra of focal ischemia

  1994cited by this paper
• Reversible phosphorylation of eukaryotic initiation factor 2α in response to endoplasmic reticular signaling

  1993cited by this paper
• Role of the major heat shock proteins as molecular chaperones.

  1993cited by this paper
• Induction of heat shock hsp70 mRNA and HSP70 kDa protein in neurons in the 'penumbra' following focal cerebral ischemia in the rat.

  1993cited by this paper
• HSP70 heat shock gene regulation during ischemia.

  1993cited by this paper
• Reversible middle cerebral artery occlusion without craniectomy in rats.

  1989cited by this paper
• Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

  1986cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Repositioning of Alogliptin to Mitigate Secondary Injury Induced by Repetitive TBI: Potential Role of its Antioxidant and Anti- Inflammatory Effects

  2026cites this paper
• Dynamic Oxidative States: Interplay of Aging, Metabolic Stress, and Circadian Rhythms in Modulating Stroke Severity

  2025cites this paper
• SERP1 Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting ER Stress‐Mediated Apoptosis

  2025cites this paper
• Indole-3-carbinol exerts neuroprotective effect in cerebral ischaemia/reperfusion through the modulation of Nrf2-mediated antioxidant responses and the restoration of chaperone activity.

  2025cites this paper
• CHPG's role in regulating apoptosis in heat-stressed microglia through endoplasmic reticulum stress: A new perspective☆

  2025cites this paper
• Cardiopulmonary Bypass-Induced IL-17A Aggravates Caspase-12-Dependent Neuronal Apoptosis Through the Act1-IRE1-JNK1 Pathway

  2025cites this paper
• Imatinib attenuates neurobehavioral deficits and hippocampal neuronal damage after global cerebral ischemia in gerbils

  2025cites this paper
• Lipid droplet accumulation in microglia and their potential roles

  2025cites this paper
• Heat shock proteins in cerebral ischemia-reperfusion injury: Mechanisms and therapeutic implications.

  2025cites this paper
• Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke

  2025cites this paper
• Mitochondrial dysfunction and NLRP3 inflammasome: key players in kidney stone formation

  2024cites this paper
• Linarin ameliorates ischemia-reperfusion injury by the inhibition of endoplasmic reticulum stress targeting AKR1B1.

  2024cites this paper
• Therapeutic Potential of Targeting the PERK Signaling Pathway in Ischemic Stroke

  2024cites this paper
• A mechanistic exploration of the metabolome of African mango seeds and its potential to alleviate cognitive impairment induced by high-fat/high-carbohydrate diets: Involvement of PI3K/AKT/GSK-3β/CREB, PERK/CHOP/Bcl-2, and AMPK/SIRT-1/mTOR Axes.

  2024cites this paper
• Overexpression of Growth Differentiation Factor 15 Reduces Neuronal Cell Damage Induced by Oxygen‐Glucose Deprivation/Reoxygenation via Inhibiting Endoplasmic Reticulum Stress‐Mediated Ferroptosis

  2024cites this paper
• Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress

  2024cites this paper
• Advancements in Genetic and Biochemical Insights: Unraveling the Etiopathogenesis of Neurodegeneration in Parkinson’s Disease

  2024cites this paper
• Hypoxia and its effect on the cellular system

  2024cites this paper
• Hesperetin Inhibits Bladder Cancer Cell Proliferation and Promotes Apoptosis and Cycle Arrest by PI3K/AKT/FoxO3a and ER Stress-mitochondria Pathways.

  2024cites this paper
• A Comprehensive Systematic Review Coupled with an Interacting Network Analysis Identified Candidate Genes and Biological Pathways Related to Bovine Temperament

  2024cites this paper
• Modulation of the endoplasmic reticulum stress and unfolded protein response mitigates the behavioral effects of early-life stress

  2023cites this paper
• Hydroxysafflor Yellow A Exerts Neuroprotective Effect by Reducing Aβ Toxicity Through Inhibiting Endoplasmic Reticulum Stress in Oxygen–Glucose Deprivation/Reperfusion Cell Model

  2023cites this paper
• Punicalagin’s Protective Effects on Parkinson’s Progression in Socially Isolated and Socialized Rats: Insights into Multifaceted Pathway

  2023cites this paper
• Multi-Drug Cocktail Therapy Improves Survival and Neurological Function after Asphyxial Cardiac Arrest in Rodents

  2023cites this paper
• Inhibition of the Activating Transcription Factor 6 Branch of Endoplasmic Reticulum Stress Ameliorates Brain Injury after Deep Hypothermic Circulatory Arrest

  2023cites this paper
• Endoplasmic reticulum stress in Alzheimer's disease: Molecular mechanisms and therapeutic prospects.

  2023cites this paper
• Impacts of acute cold-stress in Pacific white shrimp Litopenaeus vannamei: investigating the tissue-specific stress resistance response

  2023cites this paper
• ADP‐ribose transferase PARP16 mediated‐unfolded protein response contributes to neuronal cell damage in cerebral ischemia/reperfusion

  2023cites this paper
• Ketogenic Diet and Ketone Bodies against Ischemic Injury: Targets, Mechanisms, and Therapeutic Potential

  2023cites this paper
• Proteostasis plays an important role in demyelinating Charcot Marie Tooth disease.

  2023cites this paper
• Role of PERK‐mediated pathway in the effect of mild hypothermia after cerebral ischaemia/reperfusion

  2023cites this paper
• ALKBH5 protects against stroke by reducing endoplasmic reticulum stress-dependent inflammation injury via the STAT5/PERK/EIF2α/CHOP signaling pathway in an m6A-YTHDF1-dependent manner.

  2023cites this paper
• RGC-specific ATF4 and/or CHOP deletion rescues glaucomatous neurodegeneration and visual function

  2023cites this paper
• Exploring the molecular mechanism of Yinao Fujian formula on ischemic stroke based on network pharmacology and experimental verification

  2023cites this paper
• PERK inhibitor, GSK2606414, ameliorates neuropathological damage, memory and motor functional impairments in cerebral ischemia via PERK/p-eIF2ɑ/ATF4/CHOP signaling

  2023cites this paper
• Modulation of the autophagy‐lysosomal pathway and endoplasmic reticulum stress by ketone bodies in experimental models of stroke

  2023cites this paper
• Post-treatment with apocynin at a lower dose regulates the UPR branch of eIF2α and XBP-1 pathways after stroke.

  2022cites this paper
• Early Aerobic Exercise Promotes Neurological Function Recovery of Rats after Cerebral Ischemia/Reperfusion by Upregulating the Expression of Heat Shock Protein A5

  2022cites this paper
• The functions of IRE1α in neurodegenerative diseases: Beyond ER stress.

  2022cites this paper
• RETRACTED: Long-Lasting Exendin-4-Loaded PLGA Nanoparticles Ameliorate Cerebral Ischemia/Reperfusion Damage in Diabetic Rats

  2022cites this paper
• Silencing ATF4 inhibits JMJD3‐dependent JUNB/ETS1 axis and mitigates cerebral ischemic injury

  2022cites this paper
• Investigating a Genetic Link Between Alzheimer’s Disease and CADASIL-Related Cerebral Small Vessel Disease

  2022cites this paper
• Increased serum concentrations of Mesencephalic astrocyte-derived neurotrophic factor in patients and rats with ischemic stroke.

  2022cites this paper
• Comprehensive Assessment of the STIMs and Orais Expression in Polycystic Ovary Syndrome

  2022cites this paper
• UPR Responsive Genes Manf and Xbp1 in Stroke

  2022cites this paper
• Downregulated XBP-1 Rescues Cerebral Ischemia/Reperfusion Injury-Induced Pyroptosis via the NLRP3/Caspase-1/GSDMD Axis

  2022cites this paper
• Eleutheroside E alleviates cerebral ischemia-reperfusion injury in a 5-hydroxytryptamine receptor 2C (Htr2c)-dependent manner in rats

  2022cites this paper
• Omarigliptin attenuates rotenone-induced Parkinson's disease in rats: Possible role of oxidative stress, endoplasmic reticulum stress and immune modulation.

  2022cites this paper
• Proteotoxicity and endoplasmic reticulum stress-mediated cell death

  2022cites this paper
• NOX activation in reactive astrocytes regulates astrocytic LCN2 expression and neurodegeneration

  2022cites this paper
• Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cerebral Ischemia/Reperfusion Injury

  2022cites this paper
• Zinc Accumulation Aggravates Cerebral Ischemia/Reperfusion Injury Through Inducing Endoplasmic Reticulum Stress

  2022cites this paper
• RETRACTED ARTICLE: Isoginkgetin attenuates endoplasmic reticulum stress-induced autophagy of brain after ischemic reperfusion injury

  2021cites this paper
• Exacerbated VEGF up-regulation accompanies diabetes-aggravated hemorrhage in mice after experimental cerebral ischemia and delayed reperfusion

  2021cites this paper
• N-Methyl-D-Aspartate Receptor Signaling-Protein Kinases Crosstalk in Cerebral Ischemia.

  2021cites this paper
• Evaluation of cerebroprotective effect of Ricinus communis leaves against ischemia reperfusion injury in rats

  2021cites this paper
• Orexin-A alleviates cerebral ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress-mediated apoptosis

  2021cites this paper
• Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats

  2021cites this paper
• Long-Lasting Exendin-4-Loaded PLGA Nanoparticles Ameliorate Cerebral Ischemia/Reperfusion Evoked Brain Injury and Voiding Dysfunction in Diabetic Rats

  2021cites this paper
• The integrated stress response in ischemic diseases

  2021cites this paper
• Brown seaweeds added in the diet improved the response to thermal shock and reduced Vibrio spp. in pacific white shrimp post‐larvae reared in a biofloc system

  2021cites this paper
• Celeboxib-mediated neuroprotection in focal cerebral ischemia: an interplay between unfolded protein response and inflammation

  2021influential citation
• Electroacupuncture Regulates Endoplasmic Reticulum Stress and Ameliorates Neuronal Injury in Rats with Acute Ischemic Stroke

  2021influential citation
• Mechanism of Endoplasmic Reticulum Stress in Cerebral Ischemia

  2021cites this paper
• Rosuvastatin protects PC12 cells from hypoxia/reoxygenation-induced injury by inhibiting endoplasmic reticulum stress-induced apoptosis

  2021cites this paper
• CTRP1 Attenuates Cerebral Ischemia/Reperfusion Injury via the PERK Signaling Pathway

  2021cites this paper
• Biochanin A Alleviates Cerebral Ischemia/Reperfusion Injury by Suppressing Endoplasmic Reticulum Stress-Induced Apoptosis and p38MAPK Signaling Pathway In Vivo and In Vitro

  2021cites this paper
• How cytosolic compartments play safeguard functions against neuroinflammation and cell death in cerebral ischemia

  2021cites this paper
• The Protective Effect of Liquiritin in Hypoxia/Reoxygenation-Induced Disruption on Blood Brain Barrier

  2021cites this paper
• Research Paper: Comparative Protective Effects of Viola Spathulata, Urtica Dioica, and Lamium Album on Endoplasmic Reticulum (ER) Stress in Rat Stroke Model

  2021cites this paper
• Chronic treatment of 4-phenylbutyric acid ameliorates cognitive impairment after focal cerebral ischemia/ reperfusion injury in rats

  2021cites this paper
• Protective Effect of Hydrogen Gas on Mice Hind Limb Ischemia-Reperfusion Injury.

  2021cites this paper
• Pharmacological Approach for Neuroprotection After Cardiac Arrest—A Narrative Review of Current Therapies and Future Neuroprotective Cocktail

  2021cites this paper
• Targeting TDP-43 Pathology Alleviates Cognitive and Motor Deficits Caused by Chronic Cerebral Hypoperfusion

  2021cites this paper
• An updated review of autophagy in ischemic stroke: From mechanisms to therapies.

  2021cites this paper
• Insight into the effects of melatonin on endoplasmic reticulum, mitochondrial function, and their cross-talk in the stroke.

  2021cites this paper
• Lipid droplets in the nervous system

  2021cites this paper
• Endoplasmic reticulum stress in human chronic wound healing: Rescue by 4‐phenylbutyrate

  2020cites this paper
• Targeting endoplasmic reticulum stress and autophagy as therapeutic approaches for neurological diseases.

  2020cites this paper
• Glutamine protects intestine against ischemia-reperfusion injury by alleviating endoplasmic reticulum stress induced apoptosis in rats

  2020cites this paper
• Harpagide from Scrophularia protects rat cortical neurons from oxygen-glucose deprivation and reoxygenation-induced injury by decreasing endoplasmic reticulum stress.

  2020cites this paper
• Celecoxib-Dependent Neuroprotection in a Rat Model of Transient Middle Cerebral Artery Occlusion (tMCAO) Involves Modifications in Unfolded Protein Response (UPR) and Proteasome

  2020cites this paper
• Curcumin attenuates cytoplasmic/endoplasmic reticulum stress, apoptosis and cholinergic dysfunction in diabetic rat hippocampus

  2020cites this paper
• The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target

  2020cites this paper
• Unbiased proteomic screening identifies a novel role for the E3 ubiquitin ligase Nedd4‐2 in translational suppression during ER stress

  2020cites this paper
• Neuroinflammation and fibrosis in stroke: The good, the bad and the ugly.

  2020cites this paper
• Nao-Fu-Cong ameliorates diabetic cognitive dysfunction by inhibition of JNK/CHOP/Bcl2-mediated apoptosis in vivo and in vitro.

  2020cites this paper
• Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke

  2020cites this paper
• Unfolded protein response in cardiovascular disease.

  2020cites this paper
• Involvement of endoplasmic reticulum stress in amyloid β (1-42)-induced Alzheimer's like neuropathological process in rat brain.

  2020cites this paper
• Nafamostat mesylate attenuates the pathophysiologic sequelae of neurovascular ischemia

  2020cites this paper
• The PERK Pathway Plays a Neuroprotective Role During the Early Phase of Secondary Brain Injury Induced by Experimental Intracerebral Hemorrhage.

  2020cites this paper
• Oxidative stress and endoplasmic stress in calcium oxalate stone disease: the chicken or the egg?

  2020cites this paper
• Inhibition of NADPH oxidase alleviates germ cell apoptosis and ER stress during testicular ischemia reperfusion injury

  2020cites this paper
• PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis

  2020cites this paper
• Neuroprotective Effect of the Inhibitor Salubrinal after Cardiac Arrest in a Rodent Model

  2020cites this paper
• A Critical Role for ISGylation, Ubiquitination and, SUMOylation in Brain Damage: Implications for Neuroprotection

  2020cites this paper
• Astragalin alleviates ischemia/reperfusion‑induced brain injury via suppression of endoplasmic reticulum stress.

  2020cites this paper
• Adipose-Derived Stem Cells Protect Ischemia-Reperfusion and Partial Hepatectomy by Attenuating Endoplasmic Reticulum Stress

  2020cites this paper
• Osteopontin mediates necroptosis in lung injury after transplantation of ischaemic renal allografts in rats.

  2019cites this paper