PRDM5 Identified as a Target of Epigenetic Silencing in Colorectal and Gastric Cancer

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Clinical Cancer Research

• Publication date

  2007-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1078-0432.CCR-07-0305PMID 17699856
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dominant-negative histone H3 lysine 27 mutant derepresses silenced tumor suppressor genes and reverses the drug-resistant phenotype in cancer cells.

  2006cited by this paper
• Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma

  2006cited by this paper
• The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer

  2006cited by this paper
• Enhancer of Zeste 2 as a marker of preneoplastic progression in the breast.

  2006cited by this paper
• Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer

  2006cited by this paper
• Inactivation of the PRDM 1 / BLIMP 1 gene in diff use large B cell lymphoma

  2006cited by this paper
• Epigenetic changes in solid and hematopoietic tumors.

  2005cited by this paper
• Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.

  2005cited by this paper
• The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer.

  2005cited by this paper
• Akt-Mediated Phosphorylation of EZH2 Suppresses Methylation of Lysine 27 in Histone H3

  2005cited by this paper
• Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-γ-induced HLA-DR expression in colorectal and gastric cancer cells

  2004cited by this paper
• Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

  2004cited by this paper
• Molecular mechanisms of leukemogenesis by AML1/EVI-1

  2004cited by this paper
• PRDM5 is silenced in human cancers and has growth suppressive activities

  2004cited by this paper
• Critical Role of Histone Methylation in Tumor Suppressor Gene Silencing in Colorectal Cancer

  2003cited by this paper
• Inactivation of a histone methyltransferase by mutations in human cancers.

  2003cited by this paper
• EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

  2003cited by this paper
• Epigenetic inactivation of CHFR in human tumors

  2003cited by this paper
• Biallelic inactivation of the RIZ1 gene in human gastric cancer

  2003cited by this paper
• Causal relationship between the loss of RUNX3 expression and gastric cancer.

  2002cited by this paper
• The fundamental role of epigenetic events in cancer

  2002cited by this paper
• Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine.

  2002cited by this paper
• The polycomb group protein EZH2 is involved in progression of prostate cancer

  2002cited by this paper
• Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

  2002influential reference
• DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers

  2002cited by this paper
• Dependence of histone modifications and gene expression on DNA hypermethylation in cancer.

  2002cited by this paper
• Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily.

  2001cited by this paper
• Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia

  2001cited by this paper
• A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells.

  2000cited by this paper
• Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.

  2000cited by this paper
• Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

  1999cited by this paper
• Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.

  1998cited by this paper
• COBRA: a sensitive and quantitative DNA methylation assay.

  1997cited by this paper
• 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

  1995cited by this paper
• Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

  1995cited by this paper
• High sensitivity mapping of methylated cytosines.

  1994cited by this paper
• Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells.

  1994cited by this paper
• Blimp-1 is the murine homolog of the human transcriptional repressor PRDI-BF1.

  1994cited by this paper

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  2023cites this paper
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  2022cites this paper
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  2022cites this paper
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• Recent Advance of Histone Modification in Gastric Cancer : A Review

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• Downregulation of promoter methylation gene PRDM5 contributes to the development of tumor proliferation and predicts poor prognosis in gastric cancer

  2021cites this paper
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  2020cites this paper
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  2019cites this paper
• Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials

  2019cites this paper
• Brittle cornea syndrome

  2019cites this paper
• Histone methylases as novel drug targets. Focus on EZH2 inhibition

  2019cites this paper
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  2018cites this paper
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  2018cites this paper
• PRDM8 exhibits antitumor activities toward hepatocellular carcinoma by targeting NAP1L1

  2018cites this paper
• The Ehlers–Danlos syndromes, rare types

  2017cites this paper
• Analysis of methylation profiling data of hyperplasia and primary and metastatic endometrial cancers.

  2017cites this paper
• Methylation modification in gastric cancer and approaches to targeted epigenetic therapy (Review).

  2017cites this paper
• Lack of Aberrant Methylation in an Adjacent Area of Left-Sided Colorectal Cancer

  2017cites this paper
• PRDM5 promotes the apoptosis of epithelial cells induced by IFN-γ during Crohn's disease.

  2017cites this paper
• Mutational analysis of driver genes with tumor suppressive and oncogenic roles in gastric cancer

  2017cites this paper
• Revealing potential long non-coding RNA biomarkers in lung adenocarcinoma using long non-coding RNA-mediated competitive endogenous RNA network

  2017cites this paper
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  2016cites this paper
• PRDM5 Expression and Essential Role After Acute Spinal Cord Injury in Adult Rat

  2016cites this paper
• Analysis of Helicobacter pylori genotypes in clinical gastric wash samples

  2016cites this paper
• DNA methylation patterns as noninvasive biomarkers and targets of epigenetic therapies in colorectal cancer.

  2016cites this paper
• Molecular bases of aberrant miR‐182 expression in ovarian cancer

  2016cites this paper
• Identification of Mutations in the PRDM5 Gene in Brittle Cornea Syndrome

  2016cites this paper
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  2016cites this paper
• PRDM 5 expression correlates with malignant behaviors and indicates favorable prognosis in HCC

  2016cites this paper
• Nonhistone Lysine Methylation in the Regulation of Cancer Pathways.

  2016cites this paper
• A role for repressive complexes and H3K9 di-methylation in PRDM5-associated brittle cornea syndrome.

  2015cites this paper
• Hypermethylation in gastric cancer.

  2015cites this paper
• Genetics of the Ehlers–Danlos syndrome: more than collagen disorders

  2015cites this paper
• Loss of PRDM11 promotes MYC-driven lymphomagenesis.

  2015cites this paper
• Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups

  2015influential citation
• Epigenetic alterations in gastric cancer (Review)

  2015cites this paper
• PRDM14 Promotes the Migration of Human Non-small Cell Lung Cancer Through Extracellular Matrix Degradation in vitro

  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Epigenetics: an emerging player in gastric cancer.

  2014cites this paper
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  2013cites this paper
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  2013cites this paper
• DNA promoter and histone H3 methylation downregulate NGX6 in gastric cancer cells

  2013cites this paper
• DNA and histone methylation in gastric carcinogenesis.

  2013cites this paper
• insulator binding proteins in embryonic stem cells 2

  2013cites this paper
• Gene methylation in gastric cancer.

  2013cites this paper
• High expression of PRDM14 correlates with cell differentiation and is a novel prognostic marker in resected non-small cell lung cancer

  2013cites this paper
• Genome-scale DNA methylation analysis in GI cancers

  2012cites this paper
• Promoter methylation of tumor-related genes in gastric carcinogenesis.

  2012cites this paper
• The cellular level of histone H3 lysine 4 dimethylation correlates with response to adjuvant gemcitabine in Japanese pancreatic cancer patients treated with surgery.

  2012cites this paper
• PRDM proteins: important players in differentiation and disease.

  2012cites this paper
• Hypermethylation of Sox17 gene is useful as a molecular diagnostic application in early gastric cancer

  2012cites this paper
• Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing Bone

  2012cites this paper
• Characterization of DNA hypermethylation in two cases of peritoneal mesothelioma

  2012cites this paper
• KPC1 Expression and Essential Role After Acute Spinal Cord Injury in Adult Rat

  2011cites this paper
• Frequent Alteration of MLL3 Frameshift Mutations in Microsatellite Deficient Colorectal Cancer

  2011influential citation
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  2011cites this paper
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  2011cites this paper
• Clinical significance of the expression of DNA methyltransferase proteins in gastric cancer.

  2011cites this paper
• Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1

  2011cites this paper
• Stomach – Genetic and epigenetic alterations of preneoplastic and neoplastic lesions

  2011cites this paper
• Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer

  2010cites this paper
• Investigations of Potential Modifier Genes in Hereditary Haemochromatosis

  2010cites this paper
• Histone methyltransferases in cancer.

  2010cites this paper
• DNA methylation and carcinogenesis of PRDM5 in cervical cancer

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• DNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae

  2010cites this paper
• Array comparative genomic hybridization analysis revealed four genomic prognostic biomarkers for primary gastric cancers.

  2010cites this paper
• PRDM14在非小细胞肺癌中的表达及其与临床病理因素的关系

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• Loss of promoter methylation contributes to the expression of functionally impaired PRDM1β isoform in diffuse large B-cell lymphoma

  2010cites this paper
• Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM)

  2010cites this paper
• Sensitive and specific detection of early gastric cancer with DNA methylation analysis of gastric washes.

  2009cites this paper
• The epigenome of colorectal cancer

  2009cites this paper
• 8 Histone Methylation and the Initiation of Cancer

  2009cites this paper
• Blimp1: a conserved transcriptional repressor critical for differentiation of many tissues.

  2009cites this paper
• The Tumor Suppressor PRDM5 Regulates Wnt Signaling at Early Stages of Zebrafish Development

  2009cites this paper
• Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states

  2009cites this paper
• The Global Histone Modification Pattern Correlates with Cancer Recurrence and Overall Survival in Gastric Adenocarcinoma

  2008cites this paper
• Therapeutic Advances in Gastroenterology Targeting Histone Methylation for Colorectal Cancer

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