The anthocyanin metabolites gallic acid, 3‐O‐methylgallic acid, and 2,4,6‐trihydroxybenzaldehyde decrease human colon cancer cell viability by regulating pro‐oncogenic signals

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Molecular Carcinogenesis

• Publication date

  2014-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/mc.21974PMID 23124926
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of gallic acid on xenobiotic metabolizing enzymes in 1,2-dimethyl hydrazine induced colon carcinogenesis in Wistar rats--a chemopreventive approach.

  2011cited by this paper
• Gut metabolites of anthocyanins, gallic acid, 3-O-methylgallic acid, and 2,4,6-trihydroxybenzaldehyde, inhibit cell proliferation of Caco-2 cells.

  2010cited by this paper
• Peonidin 3-Glucoside Inhibits Lung Cancer Metastasis by Downregulation of Proteinases Activities and MAPK Pathway

  2010cited by this paper
• Activation of Stat1, IRF-1, and NF-κB is Required for the Induction of Uridine Phosphorylase by Tumor Necrosis Factor-α and Interferon-γ

  2010cited by this paper
• Profiling of phenols in human fecal water after raspberry supplementation.

  2010cited by this paper
• Pilot Study of Oral Anthocyanins for Colorectal Cancer Chemoprevention

  2009cited by this paper
• Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1.

  2009cited by this paper
• Anti-Invasive Activity of Anthocyanins Isolated from Vitis coignetiae in Human Hepatocarcinoma Cells

  2009cited by this paper
• Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1.

  2009cited by this paper
• Curcumin Suppresses the Induction of Indoleamine 2,3-Dioxygenase by Blocking the Janus-activated Kinase-Protein Kinase Cδ-STAT1 Signaling Pathway in Interferon-γ-stimulated Murine Dendritic Cells*

  2009cited by this paper
• Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

  2009cited by this paper
• Carob fibre compounds modulate parameters of cell growth differently in human HT29 colon adenocarcinoma cells than in LT97 colon adenoma cells.

  2008cited by this paper
• Identification of Cabernet Sauvignon anthocyanin gut microflora metabolites.

  2008cited by this paper
• Structure-function relationships of anthocyanins from various anthocyanin-rich extracts on the inhibition of colon cancer cell growth.

  2008cited by this paper
• Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis

  2008cited by this paper
• Ups and downs: the STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling.

  2008cited by this paper
• Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines.

  2007cited by this paper
• Limited stability in cell culture medium and hydrogen peroxide formation affect the growth inhibitory properties of delphinidin and its degradation product gallic acid.

  2007cited by this paper
• Protocatechuic acid is the major human metabolite of cyanidin-glucosides.

  2007cited by this paper
• Transcription factors control invasion: AP-1 the first among equals

  2007cited by this paper
• Ethanol beverages containing polyphenols decrease nuclear factor kappa-B activation in mononuclear cells and circulating MCP-1 concentrations in healthy volunteers during a fat-enriched diet.

  2007cited by this paper
• AP-1 a target for cancer prevention.

  2007cited by this paper
• Stability and biotransformation of various dietary anthocyanins in vitro

  2006cited by this paper
• The redox regulation of thiol dependent signaling pathways in cancer.

  2006cited by this paper
• Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation.

  2006cited by this paper
• Effect of cyanidin‐3‐glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis—Relationship with tissue anthocyanin levels

  2006cited by this paper
• Analysis of anthocyanins in rat intestinal contents--impact of anthocyanin chemical structure on fecal excretion.

  2005cited by this paper
• In vitro metabolism of anthocyanins by human gut microflora

  2005cited by this paper
• Human fecal water content of phenolics: the extent of colonic exposure to aromatic compounds.

  2005cited by this paper
• OCT‐1 is over‐expressed in intestinal metaplasia and intestinal gastric carcinomas and binds to, but does not transactivate, CDX2 in gastric cells

  2005cited by this paper
• Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis.

  2005cited by this paper
• Antiproliferative effects of dietary phenolic substances and hydrogen peroxide.

  2005cited by this paper
• Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora.

  2005cited by this paper
• Epicatechin, catechin, and dimeric procyanidins inhibit PMA‐induced NF‐κB activation at multiple steps in Jurkat T cells

  2004cited by this paper
• Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells.

  2003cited by this paper
• Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2)

  2002cited by this paper
• AP-1 in cell proliferation and survival

  2001cited by this paper
• Catalase contents in cells determine sensitivity to the apoptosis inducer gallic acid.

  2001cited by this paper
• Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine.

  2001cited by this paper
• Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells.

  2000cited by this paper
• DNA fragmentation in apoptosis

  2000cited by this paper
• Induction of apoptosis by gallic acid in human stomach cancer KATO III and colon adenocarcinoma COLO 205 cell lines.

  2000cited by this paper
• Hyperoxia induces S-phase cell-cycle arrest and p21(Cip1/Waf1)-independent Cdk2 inhibition in human carcinoma T47D-H3 cells.

  2000cited by this paper
• a Loop-Powered 4 – 20 mASensor Transmitter

  1995cited by this paper
• Chemoprevention of colon carcinogenesis by the natural product of a simple phenolic compound protocatechuic acid: suppressing effects on tumor development and biomarkers expression of colon tumorigenesis.

  1993cited by this paper

• Polyphenol-rich Chinese olive extracts attenuate lipid accumulation in HepG2 cells, accompanied by AMPK phosphorylation and miRNA alterations.

  2026cites this paper
• Microbiota Metabolism and Immune Regulation: From Mechanisms to Immunotherapeutic Applications in Cancer.

  2025cites this paper
• Polyphenol Intake in Elderly Patients: A Novel Approach to Counteract Colorectal Cancer Risk?

  2025influential citation
• Bioavailability of Tea Polyphenols: A Key Factor in Understanding Their Mechanisms of Action In Vivo and Health Effects

  2025cites this paper
• The GmMYB1-GmbHLHA-GmCPC-like module regulates light-induced anthocyanin production in soybean sprouts.

  2025cites this paper
• Nopal Mucilage-Encapsulated Poly (Butylene Adipate-co-Terephthalate) Nanoparticles for Efficient Gallic Acid Delivery in Glioblastoma Cells

  2025cites this paper
• Bioavailability and Bioaccessibility of Grain Polyphenols: A Comprehensive Review

  2025cites this paper
• Caffeic Acid's Influence on the Viability and Apoptosis of a Diverse Array of Cancer Cell Lines

  2025cites this paper
• For a Colorful Life: Recent Advances in Anthocyanin Biosynthesis during Leaf Senescence

  2024cites this paper
• Relevance of Anthocyanin Metabolites Generated During Digestion on Bioactivity Attributed to Intact Anthocyanins

  2024cites this paper
• Green hydrothermal synthesis of gallic acid carbon dots: characterization and cytotoxic effects on colorectal cancer cell line

  2024cites this paper
• A Comprehensive Review of Free Radicals, Oxidative Stress, and Antioxidants: Overview, Clinical Applications, Global Perspectives, Future Directions, and Mechanisms of Antioxidant Activity of Flavonoid Compounds

  2024cites this paper
• Electrochemical Detection of Dopamine at a Novel poly(2,4,6‐trihydroxybenzaldehyde) Film Modified Electrode

  2024cites this paper
• Stabilization of Anthocyanins from Coffee (Coffea arabica L.) Husks and In Vivo Evaluation of Their Antioxidant Activity

  2023cites this paper
• Nutritional and functional profile of carob bean (Ceratonia siliqua): a comprehensive review

  2023cites this paper
• Gallic acid mediates tumor-suppressive effects on osteosarcoma through the H19-Wnt/β-catenin regulatory axis

  2023cites this paper
• Combination of metformin and gallic acid induces autophagy and apoptosis in human breast cancer cells

  2023cites this paper
• Effects of anthocyanin supplementation in diet on glycemic and related cardiovascular biomarkers in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

  2023cites this paper
• Anthocyanin Effects on Vascular and Endothelial Health: Evidence from Clinical Trials and Role of Gut Microbiota Metabolites

  2023influential citation
• Synthesis, Docking Study, and Cytotoxicity Evaluation of New Hydroxy benzoic Acid Derivatives

  2023cites this paper
• Mucoadhesive Hydrogel with Anti-gastric Acid and Sustained-Release Functions for Amelioration of DSS-Induced Ulcerative Colitis.

  2023cites this paper
• Bioaccessibility and Bioavailability of Diet Polyphenols and Their Modulation of Gut Microbiota

  2023cites this paper
• Enhancing health benefits of bakery products using phytochemicals.

  2022cites this paper
• Anthocyanins: Plant-based flavonoid pigments with diverse biological activities

  2022cites this paper
• Influence of zinc and gallic acid on haematological alterations, hepatic and intestinal toxicity induced by sub-acute exposure to Dibutyl-n-phthalate (DBP) in Wistar rats

  2022cites this paper
• Comparative Metabolomic Profiling Reveals Key Secondary Metabolites Associated with High Quality and Nutritional Value in Broad Bean (Vicia faba L.)

  2022cites this paper
• Plasma anthocyanins and their metabolites reduce in vitro migration of pancreatic cancer cells, PANC-1, in a FAK- and NF-kB dependent manner: Results from the ATTACH-study a randomized, controlled, crossover trial in healthy subjects.

  2022cites this paper
• Distribution, Antioxidant Capacity, Bioavailability and Biological Properties of Anthocyanin Pigments in Blood Oranges and Other Citrus Species

  2022cites this paper
• Antioxidative and Immunomodulating Properties of Aronia melanocarpa Extract Rich in Anthocyanins

  2022cites this paper
• VrMYB90 Synergistically Functions in Regulating Anthocyanin Biosynthesis with VrbHLHA and VrMYB3 in Mung Bean.

  2022cites this paper
• Study comparative of the characteristics agronomic and chemical of three cultivars of purple corn in Peru

  2022cites this paper
• Anticancer, Cardio-Protective and Anti-Inflammatory Potential of Natural-Sources-Derived Phenolic Acids

  2022cites this paper
• Estudio comparativo de las características agronómicas y químicas de tres cultivares de maíz morado en Perú

  2022cites this paper
• The Effective Analysis for Blue Honeysuckle Extract in the Treatment of Hepatocellular Carcinoma

  2022cites this paper
• Co-assembling of natural drug-food homologous molecule into composite hydrogel for accelerating diabetic wound healing.

  2022cites this paper
• Yiqi Jianpi Huayu Jiedu Decoction Inhibits Metastasis of Colon Adenocarcinoma by Reversing Hsa-miR-374a-3p/Wnt3/β-Catenin-Mediated Epithelial–Mesenchymal Transition and Cellular Plasticity

  2022cites this paper
• Gallic Acid: A Natural Phenolic Compound Exerting Antitumoral Activities in Colorectal Cancer via Interaction with G-Quadruplexes

  2022cites this paper
• Influence of zinc and gallic acid on haematological alterations, hepatic and intestinal toxicity induced by sub-acute exposure to Dibutyl-n-phthalate (DBP) in Wistar rats

  2022cites this paper
• An Insight into the Therapeutic Potential of Phytochemicals for Colorectal Cancer: Latest Perspective

  2021cites this paper
• Antioxidant Effects of Elderberry Anthocyanins in Human Colon Carcinoma Cells: A Study on Structure–Activity Relationships

  2021cites this paper
• Effects of Gallic Acid on Endometrial Cancer Cells in Two and Three Dimensional Cell Culture Models

  2021cites this paper
• Anticancer Effects and Molecular Target of Theaflavins from Black Tea Fermentation in Vitro and in Vivo.

  2021cites this paper
• Silvopasture for Food Security in a Changing Climate

  2021cites this paper
• Gallic Acid: A Potential Anti-Cancer Agent

  2021cites this paper
• Anthocyanins in Colorectal Cancer Prevention Review

  2021cites this paper
• Gallic Acid: A Versatile Molecule with Promising Pharmacological Effect

  2021cites this paper
• Gallic Acid Suppressed Tumorigenesis by an LncRNA MALAT1-Wnt/β-Catenin Axis in Hepatocellular Carcinoma

  2021cites this paper
• Inhibitory effect of polyphenols (phenolic acids, lignans, and stilbenes) on cancer by regulating signal transduction pathways: a review

  2021cites this paper
• Absorption, metabolism and bioavailability of flavonoids: a review

  2021cites this paper
• Use of Gallic acid for cancer treatment: Molecular mechanisms and improvement of efficacy by nanoformulations.

  2021cites this paper
• In vitro and in vivo anticancer effects of syringic acid on colorectal cancer: Possible mechanistic view.

  2021cites this paper
• Antiproliferative Activity on Human Colon Adenocarcinoma Cells and In Vitro Antioxidant Effect of Anthocyanin-Rich Extracts from Peels of Species of the Myrtaceae Family

  2021cites this paper
• Biological evaluation of gallic acid and quercetin derived from Ceriops tagal: insights from extensive in vitro and in silico studies

  2020cites this paper
• Anthocyanins As Modulators of Cell Redox-Dependent Pathways in Non-Communicable Diseases.

  2020cites this paper
• Can Agro-Industrial By-Products Rich in Polyphenols be Advantageously Used in the Feeding and Nutrition of Dairy Small Ruminants?

  2020cites this paper
• Partitioned Extracts of Bauhinia championii Induce G0/G1 Phase Arrest and Apoptosis in Human Colon Cancer Cells.

  2020cites this paper
• Do Aspirin and Flavonoids Prevent Cancer through a Common Mechanism Involving Hydroxybenzoic Acids?—The Metabolite Hypothesis

  2020cites this paper
• The ameliorating effects of anthocyanins on the cross-linked signaling pathways of cancer dysregulated metabolism.

  2020cites this paper
• State of the Art of Anthocyanins: Antioxidant Activity, Sources, Bioavailability, and Therapeutic Effect in Human Health

  2020cites this paper
• Protocatechuic acid attenuates adipogenesis-induced inflammation and mitochondrial dysfunction in 3T3-L1 adipocytes by regulation of AMPK pathway

  2020cites this paper
• Chemopreventive Effect of Dietary Anthocyanins against Gastrointestinal Cancers: A Review of Recent Advances and Perspectives

  2020influential citation
• Impact of Gallic Acid on Gut Health: Focus on the Gut Microbiome, Immune Response, and Mechanisms of Action

  2020cites this paper
• A comprehensive overview of colon cancer- a grim reaper of the 21st century.

  2020cites this paper
• Antioxidant and anticancer activities of gallic acid loaded sodium alginate microspheres on colon cancer

  2020cites this paper
• The Flavonoid Metabolite 2,4,6-Trihydroxybenzoic Acid Is a CDK Inhibitor and an Anti-Proliferative Agent: A Potential Role in Cancer Prevention

  2019cites this paper
• Therapeutic Effects of Gallic Acid: Current Scenario

  2019cites this paper
• The Polyphenols as Potential Agents in Prevention and Therapy of Prostate Diseases

  2019cites this paper
• In vivo formed metabolites of polyphenols and their biological efficacy.

  2019cites this paper
• Effect of Juice and Extracts from Saposhnikovia divaricata Root on the Colon Cancer Cells Caco-2

  2019cites this paper
• Anthocyanins/anthocyanidins and colorectal cancer: What is behind the scenes?

  2019cites this paper
• Cytotoxic activity of caffeic acid and gallic acid against MCF-7 human breast cancer cells: An in silico and in vitro study

  2019cites this paper
• Anthocyanins, delphinidin-3-O-glucoside and cyanidin-3-O-glucoside, inhibit immune checkpoints in human colorectal cancer cells in vitro and in silico

  2019cites this paper
• The Epigenetic Targets of Berry Anthocyanins in Cancer Prevention

  2019cites this paper
• Insights into the intestinal bacterial metabolism of flavonoids and the bioactivities of their microbe-derived ring cleavage metabolites

  2018cites this paper
• The Impact of the Roast Levels of Coffee Extracts on their Potential Anticancer Activities.

  2018cites this paper
• Fruits: A Source of Polyphenols and Health Benefits

  2018cites this paper
• Chemopreventive effects of some popular phytochemicals on human colon cancer: a review.

  2018cites this paper
• Dietary phytochemicals in colorectal cancer prevention and treatment: A focus on the molecular mechanisms involved.

  2018cites this paper
• Flavonoids and Colorectal Cancer Prevention

  2018cites this paper
• Improvement of the functionality of pancreatic Langerhans islets via reduction of bacterial contamination and apoptosis using phenolic compounds

  2018cites this paper
• Alterations in phenolic compound levels and antioxidant activity in response to cooking technique effects: A meta-analytic investigation

  2018cites this paper
• Enhancing the Cancer Cell Growth Inhibitory Effects of Table Grape Anthocyanins.

  2018cites this paper
• Amalgamation of polyphenols and probiotics induce health promotion

  2018cites this paper
• Impact of Thermal Degradation of Cyanidin-3-O-Glucoside of Haskap Berry on Cytotoxicity of Hepatocellular Carcinoma HepG2 and Breast Cancer MDA-MB-231 Cells

  2018cites this paper
• Metabolic engineering of anthocyanins in dark tobacco varieties.

  2017cites this paper
• CS-PEG decorated PLGA nano-prototype for delivery of bioactive compounds: A novel approach for induction of apoptosis in HepG2 cell line.

  2017cites this paper
• Health benefits of anthocyanins and molecular mechanisms: Update from recent decade

  2017cites this paper
• Evaluation of the therapeutic potential of red clover extract and red grape seed extract on human adult malignant brain tumours in vitro

  2017cites this paper
• Greens and Other Vegetable Foods

  2017cites this paper
• Bioavailability of Black Tea Theaflavins: Absorption, Metabolism, and Colonic Catabolism.

  2017cites this paper
• Anti-inflammatory effects of Dioscorea alata L. anthocyanins in a TNBS-induced colitis model.

  2017cites this paper
• Exploring the Colonic Metabolism of Grape and Strawberry Anthocyanins and Their in Vitro Apoptotic Effects in HT-29 Colon Cancer Cells.

  2017cites this paper
• Anthocyanins from roselle extract arrest cell cycle G2/M phase transition via ATM/Chk pathway in p53‐deficient leukemia HL‐60 cells

  2017cites this paper
• Inhibition of pancreatic cancer cell migration by plasma anthocyanins isolated from healthy volunteers receiving an anthocyanin-rich berry juice

  2017cites this paper
• Regulation of Anthocyanin Biosynthesis in Purple Leaves of Zijuan Tea (Camellia sinensis var. kitamura)

  2017cites this paper
• The role of JAK/STAT signaling pathway and TNF-α crosstalk in human colorectal cancer

  2016cites this paper
• Anti-cancer activity of quercetin, gallic acid, and ellagic acid against hepg2 and hct 116 cell lines: in vitro

  2016cites this paper
• Anticancer Properties of Phenolic Acids in Colon Cancer A Review

  2016cites this paper
• Vanillin Analogues o-Vanillin and 2,4,6-Trihydroxybenzaldehyde Inhibit NFĸB Activation and Suppress Growth of A375 Human Melanoma.

  2016cites this paper
• Antioxidant and phenolic characterization, bioavailability and protective effects under oxidative stress and endothelial dysfunction of a red wine pomace seasoning (RWPS)

  2016cites this paper