Insulator dynamics and the setting of chromatin domains

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Bioessays

• Publication date

  2004-05-01

• Fields of study

  Biology, Medicine, Physics

• Identifiers
  DOI 10.1002/BIES.20028PMID 15112232
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species.

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• Barrier Proteins Remodel and Modify Chromatin To Restrict Silenced Domains

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• Insulator and silencer sequences in the imprinted region of human chromosome 11p15.5.

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• Sequential recruitment of HAT and SWI/SNF components to condensed chromatin by VP16.

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• Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: A potential mechanism for position-effect variegation

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• Histone and chromatin cross-talk.

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• chromatin and CD4, CD8a and CD8b gene expression during thymic differentiation

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• Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin.

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• The histone minority report: the variant shall not be silenced.

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• Stable inheritance of telomere chromatin structure and function in the absence of telomeric repeats.

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• Transcription factor YY1 functions as a PcG protein in vivo

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  2003cited by this paper
• Gene autonomy: Positions, please...

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• Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1.

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• Condensed chromatin domains in the mammalian nucleus are accessible to large macromolecules

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• Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin boundaries.

  2003influential reference
• An uncertainty principle in chromosome positioning.

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• Rationally designed insulator‐like elements can block enhancer action in vitro

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• Structural and dynamic functions establish chromatin domains.

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• The beta -globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation.

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• A targeted histone acetyltransferase can create a sizable region of hyperacetylated chromatin and counteract the propagation of transcriptionally silent chromatin.

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• Conserved histone variant H2A.Z protects euchromatin from the ectopic spread of silent heterochromatin.

  2003cited by this paper
• A hypothesis for chromatin domain opening.

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• Chromatin insulation by a transcriptional activator

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• A conserved RING finger protein required for histone H2B monoubiquitination and cell size control.

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• Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation.

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• Rap1p and other transcriptional regulators can function in defining distinct domains of gene expression.

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• Dot1p modulates silencing in yeast by methylation of the nucleosome core.

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• Unravelling heterochromatin: competition between positive and negative factors regulates accessibility.

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• Inappropriate gene activation in FSHD: a repressor complex binds a chromosomal repeat deleted in dystrophic muscle.

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• Long-range chromatin regulatory interactions in vivo

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• Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine16 and spreading of heterochromatin

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• Looping and interaction between hypersensitive sites in the active beta-globin locus.

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• Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencing

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• Position-effect protection and enhancer blocking by the chicken β-globin insulator are separable activities

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• Decision making in the immune system: Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation

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• Chromatin boundaries in budding yeast: the nuclear pore connection.

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• Establishment and Maintenance of a Heterochromatin Domain

  2002cited by this paper
• Protosilencers as building blocks for heterochromatin.

  2002influential reference
• Activators antagonize heterochromatic silencing: reply to Eissenberg.

  2002cited by this paper
• Single-Cell Gene Expression Profiling

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• Activators antagonize heterochromatic silencing: Reply to Eissenberg/Reply to Martin

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• CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease.

  2001cited by this paper
• An activation‐independent role of transcription factors in insulator function

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• Effects of cis arrangement of chromatin insulators on enhancer-blocking activity.

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• CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease.

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• RNA polymerase III and RNA polymerase II promoter complexes are heterochromatin barriers in Saccharomyces cerevisiae

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• Large-scale chromatin decondensation and recondensation regulated by transcription from a natural promoter

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• Silenced chromatin is permissive to activator binding and PIC recruitment.

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• Topological challenges to DNA replication: Conformations at the fork

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• Transcriptional enhancers--on/off gene regulation as an adaptation to silencing in higher eukaryotic nuclei.

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• Genomic context modulates insulator activity through promoter competition.

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• Loss of insulator activity by paired Su(Hw) chromatin insulators.

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• A chromatin insulator determines the nuclear localization of DNA.

  2000cited by this paper
• Yeast heterochromatin is a dynamic structure that requires silencers continuously.

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• Subnuclear dynamics and transcription factor function

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• Functional gene expression domains: defining the functional unit of eukaryotic gene regulation.

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• Global histone acetylation and deacetylation in yeast

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• A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR.

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• SIR proteins and the assembly of silent chromatin in budding yeast.

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