Transthyretin: a review from a structural perspective

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Cellular and Molecular Life Sciences (CMLS)

• Publication date

  2001-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/PL00000791PMID 11693529PMCID PMC11337270
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sites of prealbumin production in the human fetus using the indirect immunoperoxidase technique

  2004cited by this paper
• The preaggregated state of an amyloidogenic protein: hydrostatic pressure converts native transthyretin into the amyloidogenic state.

  2000cited by this paper
• The transthyretin-retinol-binding protein complex.

  2000cited by this paper
• Review: history of the amyloid fibril.

  2000cited by this paper
• Deuterium-proton exchange on the native wild-type transthyretin tetramer identifies the stable core of the individual subunits and indicates mobility at the subunit interface.

  2000cited by this paper
• A comparative analysis of 23 structures of the amyloidogenic protein transthyretin.

  2000cited by this paper
• Review: TTR amyloidosis-structural features leading to protein aggregation and their implications on therapeutic strategies.

  2000cited by this paper
• The Protein Data Bank

  2000cited by this paper
• Comparative calorimetric study of non-amyloidogenic and amyloidogenic variants of the homotetrameric protein transthyretin.

  2000cited by this paper
• The beta-slip: a novel concept in transthyretin amyloidosis.

  2000cited by this paper
• Exposure of cryptic epitopes on transthyretin only in amyloid and in amyloidogenic mutants.

  1999cited by this paper
• The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP.

  1999cited by this paper
• Impact of age and amyloidosis on thiol conjugation of transthyretin in hereditary transthyretin amyloidosis.

  1999cited by this paper
• Enhanced amyloidogenicity of sulfonated transthyretin in vitro, a hypothetical etiology of senile amyloidosis.

  1999cited by this paper
• The Tetrameric Protein Transthyretin Dissociates to a Non-native Monomer in Solution

  1999cited by this paper
• The Crystal Structure of Amyloidogenic Leu55→ Pro Transthyretin Variant Reveals a Possible Pathway for Transthyretin Polymerization into Amyloid Fibrils*

  1998cited by this paper
• From the globular to the fibrous state: protein structure and structural conversion in amyloid formation

  1998cited by this paper
• Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation.

  1998cited by this paper
• Tertiary structures of amyloidogenic and non-amyloidogenic transthyretin variants: new model for amyloid fibril formation.

  1998cited by this paper
• Protein subunit interactions and structural integrity of amyloidogenic transthyretins: evidence from electrospray mass spectrometry.

  1998cited by this paper
• Analysis of x-ray diffraction patterns from amyloid of biopsied vitreous humor and kidney of transthyretin (TTR) Met30 familial amyloidotic polyneuropathy (FAP) patients: axially arrayed TTR monomers constitute the protofilament.

  1998cited by this paper
• Characterization of two highly amyloidogenic mutants of transthyretin.

  1997cited by this paper
• Analysis of amyloid deposition in a transgenic mouse model of homozygous familial amyloidotic polyneuropathy.

  1997cited by this paper
• The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution

  1997cited by this paper
• Role of the C-termini of human and chicken plasma retinol-binding proteins.

  1997cited by this paper
• Ultrastructural organization of hemodialysis-associated beta 2-microglobulin amyloid fibrils.

  1997cited by this paper
• A high resolution ultrastructural study of experimental murine AA amyloid.

  1996cited by this paper
• Retinoid binding to retinol-binding protein and the interference with the interaction with transthyretin.

  1996cited by this paper
• The crystal structure of transthyretin from chicken.

  1996cited by this paper
• Structural changes in transthyretin produced by the Ile 84 Ser mutation which result in decreased affinity for retinol-binding protein

  1996cited by this paper
• Improvement in the polyneuropathy associated with familial amyloid polyneuropathy after liver transplantation

  1996cited by this paper
• Synchrotron X-ray studies suggest that the core of the transthyretin amyloid fibril is a continuous beta-sheet helix.

  1996cited by this paper
• Synchrotron X-ray studies suggest that the core of the transthyretin amyloid fibril is a continuous β-sheet helix

  1996cited by this paper
• Retinol binding protein and transthyretin are secreted as a complex formed in the endoplasmic reticulum in HepG2 human hepatocarcinoma cells.

  1996cited by this paper
• The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid.

  1996cited by this paper
• Tertiary structure of an amyloid immunoglobulin light chain protein: a proposed model for amyloid fibril formation.

  1995cited by this paper
• Ultrastructural and immunohistochemical studies of microfibril-associated components in the posterior chamber of the eye

  1995cited by this paper
• A 6-kb upstream region of the human transthyretin gene can direct developmental, tissue-specific, and quantitatively normal expression in transgenic mouse.

  1995cited by this paper
• Liver transplantation halts the progress of familial amyloidotic polyneuropathy.

  1995cited by this paper
• Studies on the Metabolism of Retinol and Retinol-binding Protein in Transthyretin-deficient Mice Produced by Homologous Recombination (*)

  1995cited by this paper
• Change in variant transthyretin levels in patients with familial amyloidotic polyneuropathy type I following liver transplantation.

  1995cited by this paper
• Studies on the metabolism of retinol and retinol-binding protein in transthyretin-deficient mice produced by homologous recombination.

  1995cited by this paper
• Ultrastructural organization of connective tissue microfibrils in the posterior chamber of the eye in vivo and in vitro

  1995cited by this paper
• Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein.

  1995cited by this paper
• Amyloid fibril composition and transthyretin gene structure in senile systemic amyloidosis.

  1995cited by this paper
• Purification and characterization of amyloid-related transthyretin associated with familial amyloidotic cardiomyopathy.

  1995cited by this paper
• Low plasma concentrations of retinol-binding protein in individuals with mutations affecting position 84 of the transthyretin molecule.

  1995cited by this paper
• Crystal structure of the transthyretin--retinoic-acid complex.

  1995cited by this paper
• Transthyretin (prealbumin) in health and disease: nutritional implications.

  1994cited by this paper
• Lipoprotein lipase hydrolysis of retinyl ester. Possible implications for retinoid uptake by cells.

  1994cited by this paper
• The Ile-84-->Ser amino acid substitution in transthyretin interferes with the interaction with plasma retinol-binding protein.

  1994cited by this paper
• Crystal structure of the trigonal form of human plasma retinol-binding protein at 2.5 A resolution.

  1994cited by this paper
• Mechanism of molecular recognition. Structural aspects of 3,3'-diiodo-L-thyronine binding to human serum transthyretin.

  1994cited by this paper
• Thyroxine binding by human transthyretin variants: mutations at position 119, but not position 54, increase thyroxine binding affinity.

  1994cited by this paper
• Systemic amyloidosis in transgenic mice carrying the human mutant transthyretin (Met 30) gene

  1994cited by this paper
• Crystal structure of liganded and unliganded forms of bovine plasma retinol-binding protein.

  1994cited by this paper
• Classification of acid denaturation of proteins: intermediates and unfolded states.

  1994cited by this paper
• Structural analysis of peptide fragment 71-93 of transthyretin by NMR spectroscopy and electron microscopy: insight into amyloid fibril formation.

  1994cited by this paper
• Thyroid hormone metabolism in a transthyretin-null mouse strain.

  1994cited by this paper
• Mechanisms of transthyretin amyloidogenesis. Antigenic mapping of transthyretin purified from plasma and amyloid fibrils and within in situ tissue localizations.

  1994cited by this paper
• A chemical approach to elucidate tin mechanism of transthyretin and β-protein amyloid fibril formation

  1994cited by this paper
• Thyroxine binding in a TTR Met 119 kindred.

  1993cited by this paper
• Modifications of transthyretin in amyloid fibrils: analysis of amyloid from homozygous and heterozygous individuals with the Met30 mutation.

  1993cited by this paper
• Intermolecular disulfide linkages are not required for transthyretin amyloid fibril formation in vitro.

  1993cited by this paper
• The x-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30-->Met variant to 1.7-A resolution.

  1993cited by this paper
• The X-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30→Met variant to 1.7-Å resolution

  1993cited by this paper
• Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis.

  1993cited by this paper
• Structure of Met30 variant of transthyretin and its amyloidogenic implications.

  1993cited by this paper
• X-ray crystal structure of the Ala-109-->Thr variant of human transthyretin which produces euthyroid hyperthyroxinemia.

  1993cited by this paper
• Thyroxine interactions with transthyretin: a comparison of 10 different naturally occurring human transthyretin variants.

  1993cited by this paper
• Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone.

  1993cited by this paper
• Transthyretin expression in the rat brain: effect of thyroid functional state and role in thyroxine transport.

  1993cited by this paper
• Comparison of the modelled thyroxine binding site in TBG with the experimentally determined site in transthyretin.

  1992cited by this paper
• Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro.

  1992cited by this paper
• Production and functional analysis of normal and variant recombinant human transthyretin proteins.

  1992cited by this paper
• Crystal structure determination at 2.3-A resolution of human transthyretin-3',5'-dibromo-2',4,4',6-tetrahydroxyaurone complex.

  1992cited by this paper
• Interactions of retinol with binding proteins: studies with retinol-binding protein and with transthyretin.

  1992cited by this paper
• A Novel Variant of Transthyretin (Prealbumin), Thr119 to Met, Associated with Increased Thyroxine Binding

  1992cited by this paper
• Alteration in molecular structure which results in disease: the Met-30 variant of human plasma transthyretin.

  1992cited by this paper
• Normal transthyretin and synthetic transthyretin fragments form amyloid-like fibrils in vitro.

  1991cited by this paper
• Biochemical and clinical characterization of prealbuminCHICAGO: an apparently benign variant of serum prealbumin (transthyretin) discovered with high-resolution two-dimensional electrophoresis.

  1991cited by this paper
• Biochemical effect of liver transplantation in two Swedish patients with familial amyloidotic polyneuropathy (FAP‐met30)

  1991cited by this paper
• The transthyretin cDNA sequence is normal in transthyretin‐derived senile systemic amyloidosis

  1991cited by this paper
• Familial amyloidotic polyneuropathy type 1 in Kumamoto, Japan: a clinicopathologic, histochemical, immunohistochemical, and ultrastructural study.

  1991cited by this paper
• Prenatal diagnosis of hereditary amyloidosis in a Portuguese family.

  1991cited by this paper
• An inherited non-amyloidogenic transthyretin variant, [Ser6]-TTR, with increased thyroxine-binding affinity, characterized by DNA sequencing.

  1991cited by this paper
• Transthyretin (prealbumin) gene expression in choroid plexus is strongly conserved during evolution of vertebrates.

  1991cited by this paper
• A program to produce both detailed and schematic plots of protein structures

  1991cited by this paper
• Role of serum amyloid P component for systemic amyloidosis in transgenic mice carrying human mutant transthyretin gene.

  1991cited by this paper
• Production of recombinant human transthyretin with biological activities toward the understanding of the molecular basis of familial amyloidotic polyneuropathy (FAP).

  1991cited by this paper
• Systemic amyloidosis in transgenic mice carrying the human mutant transthyretin (Met30) gene. Pathologic similarity to human familial amyloidotic polyneuropathy, type I.

  1991cited by this paper
• Transthyretin Acid Induced Denaturation is Required for Amyloid Fibril Formation in Vitro

  1991cited by this paper
• A transgenic mouse line developed to express human amyloidogenic transthyretin cDNA in the brain.

  1991cited by this paper
• Thyroxine transport from blood to brain via transthyretin synthesis in choroid plexus.

  1990cited by this paper
• Fibril in senile systemic amyloidosis is derived from normal transthyretin.

  1990cited by this paper
• Hereditary amyloidosis: detection of variant prealbumin genes by restriction enzyme analysis of amplified genomic DNA sequences

  1990cited by this paper
• Retinol metabolism in rats with low vitamin A status: a compartmental model.

  1990cited by this paper
• [Familial amyloidotic polyneuropathy].

  1990cited by this paper
• A point mutation in transthyretin increases affinity for thyroxine and produces euthyroid hyperthyroxinemia.

  1990cited by this paper
• Amyloid enhancing factor-loaded macrophages in amyloid fibril formation.

  1990cited by this paper

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