Therapeutic Role of Rifaximin in Inflammatory Bowel Disease: Clinical Implication of Human Pregnane X Receptor Activation

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  2010-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1124/jpet.110.170225PMID 20627999PMCID PMC2957776
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inflammatory bowel disease.

  2011cited by this paper
• Adjunctive Antibiotic Therapy with Rifaximin May Help Reduce Crohn’s Disease Activity

  2010cited by this paper
• Inflammatory bowel disease.

  2010cited by this paper
• Rifaximin and Crohn’s Disease: A New Solution to an Old Problem?

  2010cited by this paper
• Rifaximin: a unique gastrointestinal-selective antibiotic for enteric diseases

  2010cited by this paper
• The signaling function of the IL-13Ralpha2 receptor in the development of gastrointestinal fibrosis and cancer surveillance.

  2009cited by this paper
• Rifampicin-Activated Human Pregnane X Receptor and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity

  2009cited by this paper
• Use and Safety of Rifaximin in Children With Inflammatory Bowel Disease

  2009cited by this paper
• A Randomized, Double-Blind, Placebo-Controlled Trial of Rifaximin, a Nonabsorbable Antibiotic, in the Treatment of Tropical Enteropathy

  2009cited by this paper
• Rifampin-associated pseudomembranous colitis.

  2009cited by this paper
• The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism

  2009cited by this paper
• Acute brucellosis as a cause of infective colitis.

  2008cited by this paper
• Roles of NF-κB Activation and Peroxisome Proliferator-Activated Receptor Gamma Inhibition in the Effect of Rifampin on Inducible Nitric Oxide Synthase Transcription in Human Lung Epithelial Cells

  2008cited by this paper
• The pregnane X receptor: from bench to bedside

  2008cited by this paper
• Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis.

  2008cited by this paper
• Antituberculosis drug‐induced hepatotoxicity: Concise up‐to‐date review

  2008cited by this paper
• Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression.

  2007cited by this paper
• Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-κB target gene expression

  2007influential reference
• Rifaximin versus Other Antibiotics in the Primary Treatment and Retreatment of Bacterial Overgrowth in IBS

  2007cited by this paper
• The Pregnane X Receptor Gene-Humanized Mouse: A Model for Investigating Drug-Drug Interactions Mediated by Cytochromes P450 3A

  2007cited by this paper
• Rifaximin Is a Gut-Specific Human Pregnane X Receptor Activator

  2007cited by this paper
• Xenobiotic receptor meets NF-κB, a collision in the small bowel

  2006cited by this paper
• Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation.

  2006cited by this paper
• Antimicrobials in the Management of Inflammatory Bowel Disease

  2006cited by this paper
• The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease.

  2006cited by this paper
• A Novel Pregnane X Receptor-mediated and Sterol Regulatory Element-binding Protein-independent Lipogenic Pathway*

  2006cited by this paper
• Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents.

  2006cited by this paper
• Xenobiotic receptor meets NF-kappaB, a collision in the small bowel.

  2006cited by this paper
• 2004 drug approval highlights: FDA update.

  2005cited by this paper
• Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes.

  2004cited by this paper
• Animal Models of Inflammatory Bowel Disease: An Overview

  2003cited by this paper
• A case of rifampicin induced pseudomembraneous colitis.

  2003cited by this paper
• The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.

  2000cited by this paper
• Humanized xenobiotic response in mice expressing nuclear receptor SXR

  2000cited by this paper
• Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction.

  1998cited by this paper
• Clinicopathologic study of dextran sulfate sodium experimental murine colitis.

  1993cited by this paper
• 4-Deoxypyrido[1',2':1,2]imidazo[5,4-c]rifamycin SV derivatives. A new series of semisynthetic rifamycins with high antibacterial activity and low gastroenteric absorption.

  1985cited by this paper
• Animal models of inflammatory bowel disease—An overview

  1985cited by this paper

• A comprehensive review of small molecules, targets, and pathways in ulcerative colitis treatment.

  2025cites this paper
• Rifaximin reduces gut-derived inflammation in severe acute pancreatitis: an experimental animal model and randomized controlled trial

  2025cites this paper
• SARS-CoV-2 infection and gut-lung axis: the potential role of rifaximin

  2025influential citation
• Gut microbiota dysbiosis in inflammatory bowel disease: interaction with intestinal barriers and microbiota-targeted treatment options

  2025cites this paper
• Tanshinone IIA Improves Intestinal Barrier Integrity in Septic Rats

  2025cites this paper
• Pregnane X Receptor Signaling Pathway and Vitamin K: Molecular Mechanisms and Clinical Relevance in Human Health

  2024cites this paper
• Role of peripheral inflammation in minimal hepatic encephalopathy

  2024cites this paper
• Therapeutic potential of rifaximin in liver diseases.

  2024cites this paper
• Reverse metabolomics as a novel strategy to annotate the human metabolome.

  2024cites this paper
• Delineating the role of nuclear receptors in colorectal cancer, a focused review

  2024cites this paper
• Regulation of PXR in drug metabolism: chemical and structural perspectives

  2024cites this paper
• Identification of PXR Activators from Uncaria Rhynchophylla (Gou Teng) and Uncaria Tomentosa (Cat’s Claw)

  2023cites this paper
• Reverse metabolomics for the discovery of chemical structures from humans

  2023cites this paper
• The potential for development of clinically relevant microbial resistance to rifaximin-α: a narrative review

  2023cites this paper
• Toll-like receptors in inflammatory bowel disease: A review of the role of phytochemicals.

  2023cites this paper
• Rifaximin Alfa and Liver Diseases: More Than a Treatment for Encephalopathy, a Disease Modifier

  2023cites this paper
• Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand.

  2023cites this paper
• Reduction in Gastrointestinal Cancers in Cirrhotic Patients Receiving Rifaximin vs Lactulose Only Therapy for Hepatic Encephalopathy

  2023cites this paper
• Theonella: A Treasure Trove of Structurally Unique and Biologically Active Sterols

  2023influential citation
• New Lactobacillus plantarum membrane proteins (LpMPs) towards oral anti-inflammatory agents against dextran sulfate sodium-induced colitis.

  2022cites this paper
• Pregnane X Receptor Mediates Atherosclerosis Induced by Dicyclohexyl Phthalate in LDL Receptor-Deficient Mice

  2022cites this paper
• Rifaximin in gut microbiota modification in acute pancreatitis: 15 years of retrospective clinical study.

  2022influential citation
• Buspirone Ameliorates Colon Inflammation in TNBS-Induced Rat Acute Colitis: The Involvement of TLR4/NF-kB Pathway.

  2022cites this paper
• Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond

  2022cites this paper
• Effects of Rifaximin on Luminal and Wall-Adhered Gut Commensal Microbiota in Mice

  2021cites this paper
• Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis

  2021cites this paper
• The Interface between Cell Signaling Pathways and Pregnane X Receptor

  2021cites this paper
• Pregnane X Receptor: Understanding Its Function and Activity at the Molecular Level

  2021cites this paper
• St. John’s Wort alleviates dextran sodium sulfate‐induced colitis through pregnane X receptor‐dependent NFκB antagonism

  2021cites this paper
• Therapeutic efficacy of rifaximin loaded tamarind gum polysaccharide nanoparticles in TNBS induced IBD model Wistar rats

  2021cites this paper
• Effect of different bile acids on the intestine through enterohepatic circulation based on FXR

  2021cites this paper
• Natural History of Ulcerative Colitis with Coexistent Colonic Diverticulosis

  2021cites this paper
• Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis

  2021cites this paper
• The Use of Rifaximin in Patients With Cirrhosis

  2021cites this paper
• Clinical Management of the Microbiome in Irritable Bowel Syndrome

  2020cites this paper
• Bupropion Ameliorates Acetic Acid–Induced Colitis in Rat: the Involvement of the TLR4/NF-kB Signaling Pathway

  2020cites this paper
• Rifaximin-Alpha and Other Crystalline Forms of Rifaximin: Are There Any Differences?

  2020cites this paper
• Anti‐inflammatory effect of amitriptyline in a rat model of acetic acid‐induced colitis: the involvement of the TLR4/NF‐kB signaling pathway

  2020cites this paper
• Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice[S]

  2020cites this paper
• Effects of Vitamin D3 on Intestinal Flora in a Mouse Model of Inflammatory Bowel Disease Treated with Rifaximin

  2020cites this paper
• Nuclear receptor phosphorylation in xenobiotic signal transduction

  2020cites this paper
• Risperidone attenuates acetic acid-induced colitis in rats through inhibition of TLR4/NF-kB signaling pathway

  2020cites this paper
• Patchouli alcohol activates PXR and suppresses the NF-κB-mediated intestinal inflammatory.

  2020cites this paper
• Effective Combination Therapy of Angiotensin-II Receptor Blocker and Rifaximin for Hepatic Fibrosis in Rat Model of Nonalcoholic Steatohepatitis

  2020cites this paper
• Bupropion Ameliorates Acetic Acid–Induced Colitis in Rat: the Involvement of the TLR4/NF-kB Signaling Pathway

  2020cites this paper
• Lipopolysaccharide Promotes Inflammatory Response via Enhancing IFIT1 Expression in Human Umbilical Vein Endothelial Cells

  2020cites this paper
• Arthrocen, an avocado-soy unsaponifiable agent, improves acetic acid-induced colitis in rat by inhibition of NF-kB signaling pathway.

  2020cites this paper
• The p38 MAPK Signaling Activation in Colorectal Cancer upon Therapeutic Treatments

  2020cites this paper
• Activation of PXR by Alpinetin Contributes to Abrogate Chemically Induced Inflammatory Bowel Disease

  2020influential citation
• Phosphorylation Modulates the Coregulatory Protein Exchange of the Nuclear Receptor Pregnane X Receptor

  2020cites this paper
• Antibiotics and probiotics in inflammatory bowel disease: when to use them?

  2019cites this paper
• Emerging roles of bile acids in mucosal immunity and inflammation

  2019cites this paper
• Rifamycin SV exhibits strong anti-inflammatory in vitro activity through pregnane X receptor stimulation and NFκB inhibition.

  2019cites this paper
• Thymol reduces acetic acid-induced inflammatory response through inhibition of NF-kB signaling pathway in rat colon tissue

  2019cites this paper
• Constitutive androstane receptor and pregnane X receptor cooperatively ameliorate DSS-induced colitis.

  2019cites this paper
• Anti-Diarrheal Drug Repositioning in Tumour Cell Cytotoxicity.

  2019cites this paper
• Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer

  2019cites this paper
• Activation of PXR by alantolactone ameliorates DSS-induced experimental colitis via suppressing NF-κB signaling pathway

  2019cites this paper
• The association of pregnane X receptor activation with outcomes after liver transplantation—A retrospective study

  2019cites this paper
• Possible involvement of the competition for the transcriptional coactivator glucocorticoid receptor-interacting protein 1 in the inflammatory signal-dependent suppression of PXR-mediated CYP3A induction in vitro.

  2019cites this paper
• Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium‐induced colitis in mice

  2018cites this paper
• Update on Bile Acid Malabsorption: Finally Ready for Prime Time?

  2018cites this paper
• Beneficial effects of Rifaximin in post‐infectious irritable bowel syndrome mouse model beyond gut microbiota

  2018cites this paper
• The intriguing role of Rifaximin in gut barrier chronic inflammation and in the treatment of Crohn’s disease

  2018cites this paper
• Berberine Upregulates P-Glycoprotein in Human Caco-2 Cells and in an Experimental Model of Colitis in the Rat via Activation of Nrf2-Dependent Mechanisms

  2018cites this paper
• Pharmacokinetic drug evaluation of rifaximin for treatment of diarrhea-predominant irritable bowel syndrome

  2018cites this paper
• Melatonin ameliorates TNBS-induced colitis in rats through the melatonin receptors: involvement of TLR4/MyD88/NF-κB signalling pathway

  2018cites this paper
• Looking beyond gut inflammation in inflammatory bowel disease.

  2018cites this paper
• Drug Response And Metabolism In Crohn's Disease

  2018cites this paper
• Insights into the development of peri-biliary fibrosis following hepatic ischaemia-reperfusion injury and the ameliorating effect of PXR activation

  2018cites this paper
• Constitutive androstane receptor regulates the intestinal mucosal response to injury

  2017influential citation
• Susceptibility to rifaximin and other antimicrobials of bacteria isolated in patients with acute gastrointestinal infections in Southeast Mexico.

  2017cites this paper
• Ototoxic effect of topical rifamycin SV applied in the middle ear of rats

  2017cites this paper
• Differential activation of pregnane X receptor by carnosic acid, carnosol, ursolic acid, and rosmarinic acid

  2017cites this paper
• Rifaximin induces and maintains clinical remission in a dachshund with chronic enteropathy: antibiotic-responsive diarrhoea or inflammatory bowel disease?

  2017cites this paper
• Assessment of the Efficacy of Rifaximin in the Management of Irritable Bowel Syndrome (IBS)

  2017cites this paper
• Immunomodulatory tetracyclines: Facing the complexity of intestinal inflammation

  2017cites this paper
• Epigenetic impact of endocrine disrupting chemicals on lipid homeostasis and atherosclerosis: a pregnane X receptor-centric view

  2017cites this paper
• Rifaximin exerts beneficial effects in PI-IBS mouse model beyond gut microbiota

  2017cites this paper
• Targeting nuclear receptors for the treatment of fatty liver disease

  2017cites this paper
• The Intricate Link among Gut “Immunological Niche,” Microbiota, and Xenobiotics in Intestinal Pathology

  2017cites this paper
• Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseases

  2017cites this paper
• Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice

  2017cites this paper
• Eubiotic properties of rifaximin: Disruption of the traditional concepts in gut microbiota modulation

  2017cites this paper
• Susceptibility to rifaximin and other antimicrobials of bacteria isolated in patients with acute gastrointestinal infections in Southeast Mexico

  2017cites this paper
• Rifaximin Improves Clostridium difficile Toxin A-Induced Toxicity in Caco-2 Cells by the PXR-Dependent TLR4/MyD88/NF-κB Pathway

  2016cites this paper
• Novel functions of PXR in cardiometabolic disease.

  2016cites this paper
• Rifaximin for the treatment of irritable bowel syndrome – a drug safety evaluation

  2016cites this paper
• PXR- and CAR-mediated herbal effect on human diseases.

  2016cites this paper
• Review article: the potential mechanisms of action of rifaximin in the management of inflammatory bowel diseases

  2016influential citation
• Decreased Pregnane X Receptor Expression in Children with Active Crohn’s Disease

  2016cites this paper
• Use of rifaximin in gastrointestinal and liver diseases.

  2016cites this paper
• Small-molecule modulators of PXR and CAR.

  2016influential citation
• Rifamycins, Alone and in Combination.

  2016cites this paper
• Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation

  2016cites this paper
• New and emerging therapies for the treatment of irritable bowel syndrome: an update for gastroenterologists

  2016cites this paper
• Rifaximin, a non-absorbable antibiotic, inhibits the release of pro-angiogenic mediators in colon cancer cells through a pregnane X receptor-dependent pathway.

  2016cites this paper
• THE ROLE OF PXR AND IKKβ SIGNALING IN CARDIOMETABOLIC DISEASE

  2016cites this paper
• Rifaximin is an effective alternative to metronidazole for the treatment of chronic enteropathy in dogs: a randomised trial

  2016cites this paper
• Rifaximin for the treatment of diarrhea-predominant irritable bowel syndrome

  2016cites this paper