Thymocytes in Thy-1−/− mice show augmented TCR signaling and impaired differentiation

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Current Biology

• Publication date

  1997-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0960-9822(06)00300-9
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Influence on CD8 of TCR/CD3-generated signals in CTL clones and CTL precursor cells.

  1997cited by this paper
• Making the T cell receptor go the distance: a topological view of T cell activation.

  1997cited by this paper
• Role of thymic selection in the development of thymic lymphomas in TCR transgenic mice.

  1997cited by this paper
• TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck.

  1996influential reference
• Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1

  1996cited by this paper
• Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation.

  1996cited by this paper
• A role for CD5 in TCR-mediated signal transduction and thymocyte selection.

  1995cited by this paper
• The influence of positive selection on RAG expression in thymocytes

  1995cited by this paper
• Turnover of naive- and memory-phenotype T cells

  1994cited by this paper
• ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells.

  1994cited by this paper
• Thy-1 triggers mouse thymocyte apoptosis through a bcl-2-resistant mechanism

  1994cited by this paper
• Normal sequence of phenotypic transitions in one cohort of 5-bromo-2'-deoxyuridine-pulse-labeled thymocytes. Correlation with T cell receptor expression.

  1993cited by this paper
• Transmembrane signalling through the T-cell-receptor-CD3 complex.

  1993cited by this paper
• Thy-1, the enigmatic extrovert on the neuronal surface.

  1992cited by this paper
• GPI-anchored cell-surface molecules complexed to protein tyrosine kinases.

  1991cited by this paper
• Thy-1 supports adhesion of mouse thymocytes to thymic epithelial cells through a Ca2(+)-independent mechanism

  1991cited by this paper
• Developmental biology of T cells in T cell-receptor transgenic mice.

  1990cited by this paper
• T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages

  1990cited by this paper
• The structure of Thy-1 antigen.

  1989cited by this paper
• Thy-1 functions as a signal transduction molecule in T lymphocytes and transfected B lymphocytes

  1986cited by this paper
• Specificity of Isoantisera against Leukæmic and Thymic Lymphocytes

  1963cited by this paper

• Ageing Affects Thymopoiesis and Experimental Autoimmune Encephalomyelitis Development in a Strain-Dependent Manner

  2023cites this paper
• Thymic changes as a contributing factor in the increased susceptibility of old Albino Oxford rats to EAE development.

  2022cites this paper
• Naïve Primary Mouse CD8+ T Cells Retain In Vivo Immune Responsiveness After Electroporation-Based CRISPR/Cas9 Genetic Engineering

  2022cites this paper
• Naïve and in vitro-activated primary mouse CD8+ T cells retain in vivo immune responsiveness after electroporation-based CRISPR/Cas9 genetic engineering

  2021cites this paper
• The multiple roles of Thy-1 in cell differentiation and regeneration.

  2020cites this paper
• Sexual dimorphism in rat thymic involution: a correlation with thymic oxidative status and inflammation

  2019cites this paper
• Thy‐1: more than a marker for mesenchymal stromal cells

  2019cites this paper
• Strain differences in thymic atrophy in rats immunized for EAE correlate with the clinical outcome of immunization

  2018cites this paper
• Thy-1, a Pathfinder Protein for the Post-genomic Era

  2018influential citation
• Intrinsic and Extrinsic Thymic Adrenergic Networks: Sex Steroid-Dependent Plasticity

  2018cites this paper
• Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway.

  2017cites this paper
• A Role for Glycosylphosphatidylinositol Anchored Proteins in T Lymphocyte Homeostasis

  2017cites this paper
• Thy-1 stimulation of mouse T cells induces a delayed T cell receptor-like signal that results in Ca2+‑independent cytotoxicity.

  2017cites this paper
• This information is current as Transcriptome and Proteome Analysis Proteins in Mouse B Cells by Comparative Identification of Novel STAT 6-Regulated Warscheid and

  2017cites this paper
• Identification of Novel STAT6-Regulated Proteins in Mouse B Cells by Comparative Transcriptome and Proteome Analysis

  2017cites this paper
• A reduction in CD90 (THY-1) expression results in increased differentiation of mesenchymal stromal cells

  2016cites this paper
• Thy1 (CD90) controls adipogenesis by regulating activity of the Src family kinase, Fyn

  2015cites this paper
• Autonomic Neuroscience: Basic and Clinical

  2014cites this paper
• Autonomic regulation of cellular immune function.

  2014cites this paper
• Ovarian hormone withdrawal in prepubertal developmental stage does not prevent thymic involution in rats

  2013cites this paper
• Melanoma cells use Thy-1 (CD90) on endothelial cells for metastasis formation.

  2013cites this paper
• Gonadal hormone dependent developmental plasticity of catecholamine:β2-adrenoceptor signaling complex in male rat thymus: putative implications for thymopoiesis.

  2013influential citation
• End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology

  2012cites this paper
• Enhanced response of T lymphocytes from Pgap3 knockout mouse: Insight into roles of fatty acid remodeling of GPI anchored proteins.

  2012cites this paper
• Role of gonadal hormones in programming developmental changes in thymopoietic efficiency and sexual diergism in thymopoiesis

  2012cites this paper
• Thy-1 Signaling in T cells is Weaker and Has Delayed Signaling Kinetics, Promotes Delayed Acquisition and Triggering of Cytotoxic Effector Function, and Preferentially Promotes IL-17A and IL-4 Production in Comparison to TcR Signaling

  2012cites this paper
• Induction of CD4+CD25+Foxp3− regulatory T cells by Thy‐1 stimulation of CD4+ T cells

  2012cites this paper
• Glucocorticoid–catecholamine interplay within the composite thymopoietic regulatory network

  2012cites this paper
• Epitope Determination of Anti Rat Thy-1 Monoclonal Antibody That Regulates Neurite Outgrowth

  2012cites this paper
• End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology

  2012cites this paper
• The Roles of THY1 and Integrin Beta3 in Cell Adhesion During Theca Cell Layer Formation and the Effect of Follicle-Stimulating Hormone on THY1 and Integrin Beta3 Localization in Mouse Ovarian Follicles

  2011cites this paper
• Modulation of immune cell function by α(1)-adrenergic receptor activation.

  2011cites this paper
• Isolation of nano–meso scale detergent resistant membrane that has properties expected of lipid ‘rafts’

  2011cites this paper
• Age-Associated Remodeling of Neural and Nonneural Thymic Catecholaminergic Network Affects Thymopoietic Productivity

  2011cites this paper
• Inhibition of T cell activation through down-regulation of TCR-CD3 expression mediated by an anti-CD90 Ab.

  2011cites this paper
• Cellular and nerve fibre catecholaminergic thymic network: steroid hormone dependent activity.

  2011cites this paper
• Thy‐1 (CD90) regulates the extravasation of leukocytes during inflammation

  2011cites this paper
• RBM4 down-regulates PTB and antagonizes its activity in muscle cell–specific alternative splicing

  2011cites this paper
• Neonatal androgenization affects the efficiency of β-adrenoceptor-mediated modulation of thymopoiesis.

  2011cites this paper
• Glucocorticoids, master modulators of the thymic catecholaminergic system?

  2010influential citation
• Hemoglobinuria Cells as Revealed by a Mouse Model of Paroxysmal Nocturnal Different Roles of Glycosylphosphatidylinositol in Various Hematopoietic

  2010cites this paper
• Thy-1 Attenuates TNF-α-Activated Gene Expression in Mouse Embryonic Fibroblasts via Src Family Kinase

  2010cites this paper
• Age-associated plasticity of α1-adrenoceptor-mediated tuning of T-cell development.

  2010cites this paper
• Atlas of Genetics and Cytogenetics in Oncology and Haematology

  2010cites this paper
• Thy-1 mRNA destabilization by norepinephrine a 3' UTR cAMP responsive decay element and involves RNA binding proteins.

  2010cites this paper
• Role of ovarian hormones in age-associated thymic involution revisited.

  2010cites this paper
• Polypyrimidine tract‐binding protein stimulates the poliovirus IRES by modulating eIF4G binding

  2010cites this paper
• Isolation at physiological temperature of detergent-resistant membranes with properties expected of lipid rafts: the influence of buffer composition.

  2009cites this paper
• Role of mitogen-activated protein kinases in Thy-1-induced T-lymphocyte activation.

  2009cites this paper
• Expression of alpha1-adrenoceptors on thymic cells and their role in fine tuning of thymopoiesis.

  2009cites this paper
• Neonatal testosterone imprinting affects thymus development and leads to phenotypic rejuvenation and masculinization of the peripheral blood T-cell compartment in adult female rats.

  2009cites this paper
• Catecholamines as immunomodulators: a role for adrenoceptor-mediated mechanisms in fine tuning of T-cell development.

  2008cites this paper
• Age-Associated Remodeling of Thymopoiesis: Role for Gonadal Hormones and Catecholamines

  2008cites this paper
• Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein.

  2008cites this paper
• Polypyrimidine Tract Binding Protein 2 Stabilizes Phosphoglycerate Kinase 2 mRNA in Murine Male Germ Cells by Binding to Its 3′UTR1

  2007cites this paper
• Long-term beta-adrenergic receptor blockade increases levels of the most mature thymocyte subsets in aged rats.

  2007cites this paper
• Concise Review: Stem Cell Antigen‐1: Expression, Function, and Enigma

  2007cites this paper
• Neonatal castration affects intrathymic kinetics of T-cell differentiation and the spleen T-cell level.

  2007cites this paper
• Early postnatal castration affects thymic and thymocyte noradrenaline levels and beta-adrenoceptor-mediated influence on the thymopoiesis in adult rats.

  2007cites this paper
• Age-associated changes in CD90 expression on thymocytes and in TCR-dependent stages of thymocyte maturation in male rats.

  2006cites this paper
• Thy‐1 as a regulator of cell‐cell and cell‐matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis

  2006cites this paper
• Characterization of thymocyte phenotypic alterations induced by long-lasting β-adrenoceptor blockade in vivo and its effects on thymocyte proliferation and apoptosis

  2006cites this paper
• Thy-1, a versatile modulator of signaling affecting cellular adhesion, proliferation, survival, and cytokine/growth factor responses.

  2006cites this paper
• Viral and Cellular Proteins Involved in Coronavirus Replication

  2005cites this paper
• Putting RNAs in the right place at the right time: RNA localization in the frog oocyte

  2005cites this paper
• Accelerated transition from the double-positive to single-positive thymocytes in G alpha i2-deficient mice.

  2005cites this paper
• Polymerase μ is up‐regulated during the T cell‐dependent immune response and its deficiency alters developmental dynamics of spleen centroblasts

  2005cites this paper
• Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity.

  2004cites this paper
• MarkerThy-1: More than a Mouse Pan-T Cell

  2004cites this paper
• Conserved and clustered RNA recognition sequences are a critical feature of signals directing RNA localization in Xenopus oocytes.

  2004cites this paper
• The Membrane Domains Occupied by Glycosylphosphatidylinositol-anchored Prion Protein and Thy-1 Differ in Lipid Composition*

  2004cites this paper
• Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal.

  2004cites this paper
• Thy-1: More than a Mouse Pan-T Cell Marker1

  2004cites this paper
• Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors

  2004cites this paper
• Rafts, little caves and large potholes: how lipid structure interacts with membrane proteins to create functionally diverse membrane environments.

  2004cites this paper
• T Lymphocytes Glycosylphosphatidylinositol Anchor-Deficient Enhanced Responses of Nishimura

  2004cites this paper
• Enhanced Responses of Glycosylphosphatidylinositol Anchor-Deficient T Lymphocytes1

  2004cites this paper
• From the nucleus toward the cell periphery: a guided tour for mRNAs.

  2003cites this paper
• EFFECTS OF BETA-ADRENOCEPTOR BLOCKADE ON THE PHENOTYPIC CHARACTERISTICS OF THYMOCYTES AND PERIPHERAL BLOOD LYMPHOCYTES

  2003cites this paper
• Thy-1 Signaling in the Context of Costimulation Provided by Dendritic Cells Provides Signal 1 for T Cell Proliferation and Cytotoxic Effector Molecule Expression, but Fails to Trigger Delivery of the Lethal Hit1

  2003cites this paper
• Binding of a candidate splice regulator to a calcitonin-specific splice enhancer regulates calcitonin/CGRP pre-mRNA splicing.

  2003cites this paper
• Anti-membrane-bound transferrin-like protein antibodies induce cell-shape change and chondrocyte differentiation in the presence or absence of concanavalin A

  2003cites this paper
• Thymopoiesis Following Chronic Blockade of β‐Adrenoceptors

  2003cites this paper
• Marginal Zone B Cells in Neonatal Rats Express Intermediate Levels of CD90 (Thy-1)

  2002cites this paper
• Lipid microdomains are involved in neurospecific binding and internalisation of clostridial neurotoxins.

  2002cites this paper
• Function of quaking in myelination: Regulation of alternative splicing

  2002cites this paper
• Control of Insulin mRNA Stability in Rat Pancreatic Islets

  2002cites this paper
• mRNA Splicing: Regulated and Differential

  2002cites this paper
• Testing the role of the cell-surface molecule Thy-1 in regeneration and plasticity of connectivity in the CNS.

  2002cites this paper
• Neuronal plasticity and cellular immunity: shared molecular mechanisms.

  2001cites this paper
• Alternative RNA splicing in the nervous system.

  2001cites this paper
• Selective pharmacological inhibitors reveal differences between Thy-1- and T cell receptor-mediated signal transduction in mouse T lymphocytes.

  2001cites this paper
• Lipid rafts act as specialized domains for tetanus toxin binding and internalization into neurons.

  2001cites this paper
• Investigation into an engraftment defect induced by culturing primitive hematopoietic cells with cytokines.

  2001cites this paper
• THY‐1 ASSOCIATED PP85–90 IS A POTENTIAL DOCKING SITE FOR SH2 DOMAIN‐CONTAINING SIGNAL TRANSDUCTION MOLECULES

  2001cites this paper
• The Heterogeneous Nuclear Ribonucleoproteins I and K Interact with a Subset of the Ro Ribonucleoprotein-associated Y RNAs in Vitro and in Vivo *

  2001cites this paper
• Glucocorticoids and thymocyte development.

  2000cites this paper
• CD59 cross‐linking induces secretion of APO2 ligand in overactivated human T cells

  2000cites this paper
• The splicing determinants of a regulated exon in the axonal MAP tau reside within the exon and in its upstream intron.

  2000cites this paper
• Mice lacking the cell adhesion molecule Thy-1 fail to use socially transmitted cues to direct their choice of food.

  2000cites this paper