MyoD induces apoptosis in the absence of RB function through a p21WAF1-dependent re-localization of cyclin/cdk complexes to the nucleus

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Oncogene

• Publication date

  2002-11-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1206010PMID 12444547
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of MyoD function in the dividing myoblast

  2001cited by this paper
• Regulation of the G2/M transition by p53

  2001cited by this paper
• MyoD Can Induce Cell Cycle Arrest but Not Muscle Differentiation in the Presence of Dominant Negative SWI/SNF Chromatin Remodeling Enzymes*

  2001cited by this paper
• Myc down-regulation induces apoptosis in M14 melanoma cells by increasing p27kip1 levels

  2001cited by this paper
• Binding of p300/CBP Co-activators by Polyoma Large T Antigen*

  2001cited by this paper
• MyoD activity upregulates E2F1 and enhances transcription from the cyclin E promoter in differentiating myoblasts lacking a functional retinoblastoma protein.

  2001cited by this paper
• Insulin-Like Growth Factor-Mediated Muscle Cell Survival: Central Roles for Akt and Cyclin-Dependent Kinase Inhibitor p21

  2000cited by this paper
• p21(WAF1/Cip1): more than a break to the cell cycle?

  2000cited by this paper
• Regulation of muscle regulatory factors by DNA‐binding, interacting proteins, and post‐transcriptional modifications

  2000cited by this paper
• Hematopoietic stem cell quiescence maintained by p21cip1/waf1.

  2000cited by this paper
• E2F1 and p53 are dispensable, whereas p21(Waf1/Cip1) cooperates with Rb to restrict endoreduplication and apoptosis during skeletal myogenesis.

  2000cited by this paper
• MEF2: a transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation.

  1999cited by this paper
• Critical Role Played by Cyclin D3 in the MyoD-Mediated Arrest of Cell Cycle during Myoblast Differentiation

  1999influential reference
• Direct inhibition of G1 cdk kinase activity by MyoD promotes myoblast cell cycle withdrawal and terminal differentiation

  1999cited by this paper
• E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways.

  1999cited by this paper
• CDK inhibitors: positive and negative regulators of G1-phase progression.

  1999influential reference
• pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation.

  1999cited by this paper
• Human Cyclin a Is Required for Mitosis until Mid Prophase

  1999cited by this paper
• Cell proliferation and apoptosis.

  1999cited by this paper
• Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists.

  1999cited by this paper
• p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step.

  1999cited by this paper
• Adenovirus-Mediated p21(WAF1/SDII/CIP1)Gene Transfer Induces Apoptosis of Human Cervical Cancer Cell Lines

  1999cited by this paper
• Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21WAF1/CIP1 and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity

  1999cited by this paper
• p53-independent apoptosis induced by muscle differentiation stimuli in polyomavirus large T-expressing myoblasts.

  1999cited by this paper
• All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners.

  1999cited by this paper
• Effects of p21Cip1/Waf1 at Both the G1/S and the G2/M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication

  1998cited by this paper
• Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression

  1998cited by this paper
• Requirement for p53 and p21 to sustain G2 arrest after DNA damage.

  1998cited by this paper
• Nuclear Accumulation of p21Cip1 at the Onset of Mitosis: a Role at the G2/M-Phase Transition

  1998cited by this paper
• The activity of differentiation factors induces apoptosis in polyomavirus large T-expressing myoblasts.

  1998influential reference
• Effects of poly(ADP‐ribose) polymerase inhibition on cell death and chromosome damage induced by VP16 and bleomycin

  1998cited by this paper
• p21Waf1/Cip1 protects against p53-mediated apoptosis of human melanoma cells

  1997cited by this paper
• Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

  1997cited by this paper
• New functional activities for the p21 family of CDK inhibitors.

  1997cited by this paper
• p21(Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells.

  1997cited by this paper
• Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome

  1997cited by this paper
• p300 is required for MyoD‐dependent cell cycle arrest and muscle‐specific gene transcription

  1997cited by this paper
• Interdependence between muscle differentiation and cell-cycle control.

  1997cited by this paper
• Inhibition of Myogenesis by Multiple Cyclin-Cdk Complexes

  1997cited by this paper
• pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis.

  1996influential reference
• Resistance to Apoptosis Conferred by Cdk Inhibitors During Myocyte Differentiation

  1996cited by this paper
• Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity.

  1996cited by this paper
• The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells

  1996cited by this paper
• The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.

  1996cited by this paper
• Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle

  1996influential reference
• Suppression of Apoptosis by Dominant Negative Mutants of Cyclin-dependent Protein Kinases (*)

  1996cited by this paper
• Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint.

  1995cited by this paper
• MyoD-induced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation

  1995influential reference
• p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells

  1995cited by this paper
• Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD

  1995cited by this paper
• Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1

  1995cited by this paper
• Radiation-induced cell cycle arrest compromised by p21 deficiency

  1995cited by this paper
• Premature p34cdc2 activation required for apoptosis.

  1994cited by this paper
• MyoD induces retinoblastoma gene expression during myogenic differentiation.

  1994cited by this paper
• Production of high-titer helper-free retroviruses by transient transfection.

  1993cited by this paper
• Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation.

  1993cited by this paper
• Mammalian G1 cyclins.

  1993cited by this paper
• Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts

  1993cited by this paper
• The MyoD family and myogenesis: redundancy, networks, and thresholds.

  1993cited by this paper
• Effects of an Rb mutation in the mouse

  1992cited by this paper
• Cell proliferation inhibited by MyoD1 independently of myogenic differentiation

  1990cited by this paper
• MyoD induces growth arrest independent of differentiation in normal and transformed cells.

  1990cited by this paper
• Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.

  1989cited by this paper
• Expression of a single transfected cDNA converts fibroblasts to myoblasts.

  1987cited by this paper

• Mesenchymal stem cell differentiation and usage for biotechnology applications: tissue engineering and food manufacturing

  2022cites this paper
• Effect of constant compressive stress induced by imitating Tuina stimulation with various durations on the cell cycle, cellular secretion, apoptosis, and expression of myogenic differentiation and myogenic factor 5 of rat skeletal muscle cells in vitro.

  2020cites this paper
• Cellular localization of the cell cycle inhibitor Cdkn1c controls growth arrest of adult skeletal muscle stem cells

  2018cites this paper
• Separation and purification of the bovine milk fat globule membrane protein and its effect on improvement of C2C12 mouse skeletal muscle cell proliferation

  2017cites this paper
• CDK inhibitors for muscle stem cell differentiation and self-renewal.

  2017cites this paper
• The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways

  2016cites this paper
• Changes in granulosa cells gene expression associated with growth, plateau and atretic phases in medium bovine follicles

  2014cites this paper
• p63 regulates glutaminase 2 expression

  2013cites this paper
• Rb1 Gene Inactivation Expands Satellite Cell and Postnatal Myoblast Pools*

  2011cites this paper
• The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis

  2011cites this paper
• The role of TBX22 in craniofacial development

  2011influential citation
• MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3

  2010cites this paper
• Development and Functional Anatomy of the Spine

  2010cites this paper
• Regulation of Apoptosis by the Muscle Regulatory Transcription Factor MyoD

  2009cites this paper
• Insights into the transcriptional and chromatin regulation of mesenchymal stem cells in musculo-skeletal tissues.

  2009cites this paper
• Downregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1–cyclin‐dependent kinase 4–p21 pathway

  2009cites this paper
• Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates.

  2009cites this paper
• Increased expression of the pro-apoptotic Bcl2 family member PUMA and apoptosis by the muscle regulatory transcription factor MyoD in response to a variety of stimuli

  2009cites this paper
• Differential p53‐mediated responses to solar‐simulated radiation in human papillomavirus type 16‐infected keratinocytes

  2007cites this paper
• Opposite roles of MRF4 and MyoD in cell proliferation and myogenic differentiation.

  2007cites this paper
• Functional studies in Rb regulation of skeletal myogenic program

  2007cites this paper
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  2007cites this paper
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  2006cites this paper
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  2006cites this paper
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  2006cites this paper
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  2006cites this paper
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  2006cites this paper
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  2006cites this paper
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  2005cites this paper
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  2005cites this paper
• The Role and Regulation of p21 in Myelopoiesis

  2005cites this paper
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• NRAGE Regulates Life and Death of Neural Progenitors

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  2004cites this paper
• PTF1α/p48 and cell proliferation

  2004cites this paper
• Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation

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• p21Cip1 and p27Kip1 Act in Synergy to Alter the Sensitivity of Naive T Cells to TGF-β-Mediated G1 Arrest through Modulation of IL-2 Responsiveness

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• Expression of a Mutant Lamin A That Causes Emery-Dreifuss Muscular Dystrophy Inhibits In Vitro Differentiation of C2C12 Myoblasts

  2004cites this paper
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  2004cites this paper
• MyoD induces the expression of p57Kip2 in cells lacking p21Cip1/Waf1: Overlapping and distinct functions of the two cdk inhibitors

  2004cites this paper
• Differential effects of cell cycle regulatory protein p21(WAF1/Cip1) on apoptosis and sensitivity to cancer chemotherapy.

  2003cites this paper
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