The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Molecular and Cellular Biology

• Publication date

  1996-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.16.4.1335PMID 8657106PMCID PMC231117
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• High-frequency developmental abnormalities in p53-deficient mice.

  1995cited by this paper
• Growth factor modulation of p53-mediated growth arrest versus apoptosis.

  1995cited by this paper
• p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells

  1995cited by this paper
• TrkA neurogenic receptor regulates differentiation of neuroblastoma cells.

  1995influential reference
• Cyclin E is expressed in neurons and forms complexes with cdk5

  1995cited by this paper
• NGF regulates the PC12 cell cycle machinery through specific inhibition of the Cdk kinases and induction of cyclin D1

  1995cited by this paper
• Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3.

  1995cited by this paper
• Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA.

  1995cited by this paper
• Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors.

  1995cited by this paper
• Radiation-induced cell cycle arrest compromised by p21 deficiency

  1995cited by this paper
• Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons.

  1995cited by this paper
• Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD

  1995cited by this paper
• Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase

  1995cited by this paper
• Differential expression of D type cyclins during neuronal maturation.

  1994cited by this paper
• Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen.

  1994cited by this paper
• Transforming growth factor β1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells

  1994cited by this paper
• Mechanisms of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathways.

  1994cited by this paper
• Induction of WAF1/CIP1 by a p53-independent pathway.

  1994cited by this paper
• Premature p34cdc2 activation required for apoptosis.

  1994cited by this paper
• Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death.

  1994cited by this paper
• Nerve growth factor regulates the expression and activity of p33cdk2 and p34cdc2 kinases in PC12 pheochromocytoma cells.

  1994cited by this paper
• p21-containing cyclin kinases exist in both active and inactive states.

  1994cited by this paper
• Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells.

  1994cited by this paper
• WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

  1994cited by this paper
• The Cell Cycle

  1994cited by this paper
• Activation of cyclin A-dependent protein kinases during apoptosis.

  1994cited by this paper
• Cisplatin induces apoptosis in a human ovarian carcinoma cell line without concomitant internucleosomal degradation of DNA.

  1994cited by this paper
• Induction of p21 (WAF-1/CIP1) during differentiation.

  1994cited by this paper
• Gene inhibition using antisense oligodeoxynucleotides

  1994cited by this paper
• p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

  1994cited by this paper
• Neurotrophins regulate sequential changes in neurotrophin receptor expression by sympathetic neuroblasts.

  1994cited by this paper
• Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53.

  1994cited by this paper
• Functions of the p53 protein in growth regulation and tumor suppression.

  1994cited by this paper
• Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

  1993cited by this paper
• Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.

  1993cited by this paper
• RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis

  1993cited by this paper
• The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

  1993cited by this paper
• Mutations of the p53 gene are involved in Ewing's sarcomas but not in neuroblastomas.

  1993cited by this paper
• Immunohistochemical localization of Trk receptor protein in pediatric small round blue cell tumors.

  1993cited by this paper
• Absence of p53 gene mutations in primary neuroblastomas.

  1993cited by this paper
• Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma.

  1993cited by this paper
• Lack of high-affinity nerve growth factor receptors in aggressive neuroblastomas.

  1993cited by this paper
• Coexpression of messenger RNA for TRK protooncogene and low affinity nerve growth factor receptor in neuroblastoma with favorable prognosis.

  1993cited by this paper
• Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells.

  1993cited by this paper
• Do all programmed cell deaths occur via apoptosis?

  1993cited by this paper
• WAF1, a potential mediator of p53 tumor suppression.

  1993influential reference
• The MyoD family and myogenesis: redundancy, networks, and thresholds.

  1993cited by this paper
• Neuronal differentiation triggered by blocking cell proliferation.

  1992cited by this paper
• Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

  1992cited by this paper
• The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation.

  1992cited by this paper
• p53 function and dysfunction.

  1992cited by this paper
• Expression of p53 in human neuroblastoma- and neuroepithelioma-derived cell lines.

  1992cited by this paper
• Downregulation of CDC2 upon terminal differentiation of neurons.

  1991cited by this paper
• Downregulation of CDC2 upon terminal differentiation of neurons.

  1991cited by this paper
• Activation of Epstein–Barr virus latent genes protects human B cells from death by apoptosis

  1991cited by this paper
• Nerve growth factor-induced differentiation of human neuroblastoma and neuroepithelioma cell lines.

  1990cited by this paper
• Analysis of nerve growth factor receptor expression in human neuroblastoma and neuroepithelioma cell lines.

  1989cited by this paper
• Cell cycle‐specific action of nerve growth factor in PC12 cells: differentiation without proliferation.

  1989cited by this paper
• Structure and developmental expression of the chicken CDC2 kinase.

  1989cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Phenotypic differentiation of aphidicolin-selected human neuroblastoma cultures after long-term exposure to nerve growth factor.

  1987cited by this paper
• Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene.

  1985cited by this paper
• Enhanced chemiluminescent method for the detection of DNA dot-hybridization assays.

  1985cited by this paper
• Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

  1984influential reference
• Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed

  1983cited by this paper
• Nerve growth factor effects and receptors in cultured human neuroblastoma cell lines

  1982cited by this paper
• Sounding board. Regression of neuroblastoma IV-S: a genetic hypothesis.

  1980cited by this paper
• Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones.

  1978cited by this paper

• Sublethal effects of dimethoate on energy metabolism and its link to cellular senescence due to impaired mitochondrial respiration and ATP production in SH-SY5Y cells.

  2025cites this paper
• A review of the botany, phytochemistry, pharmacology, synthetic biology and comprehensive utilization of Silybum marianum

  2024cites this paper
• A Prognostic Model for Predicting Liver Cancer Patients Based On Immune Checkpoint Gene-Related Basement Membrane Genes, And Analyzing Immunity and Potential Drug Candidates

  2022cites this paper
• BEND3 safeguards pluripotency by repressing differentiation-associated genes

  2022cites this paper
• E2F1 sumoylation as a protective cellular mechanism in oxidative stress response

  2020cites this paper
• The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy

  2019cites this paper
• Aspirin inhibits proliferation and promotes differentiation of neuroblastoma cells via p21Waf1 protein up‐regulation and Rb1 pathway modulation

  2019cites this paper
• Silencing of heart and neural crest derivatives expressed transcript 2 attenuates transforming growth factor-β1-enhanced apoptosis of human bronchial epithelial cells

  2018cites this paper
• The Role of CDKN3 in Neuroblastoma Differentiation

  2017cites this paper
• The Molecular Mechanisms of Protective Role of Se on the G2/M Phase Arrest of Jejunum Caused by AFB1

  2017cites this paper
• Reduced Expression of Foxp1 as a Contributing Factor in Huntington's Disease

  2017cites this paper
• Current Understanding on the Role of Cell Cycle Regulators in Neuroblastoma Cell Differentiation

  2017influential citation
• Examining the cell cycle regulator, p21, in the regeneration competent newt species, Notophthalmus viridescens

  2016cites this paper
• The molecular mechanism of G2/M cell cycle arrest induced by AFB1 in the jejunum

  2016cites this paper
• Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression

  2015cites this paper
• Ionizing radiation induces neuronal differentiation of Neuro-2a cells via PI3-kinase and p53-dependent pathways

  2015cites this paper
• JAZ (Znf346), a SIRT1-interacting Protein, Protects Neurons by Stimulating p21 (WAF/CIP1) Protein Expression*

  2014cites this paper
• CORRELATION OF BCL-2 AND COX-2 EXPRESSION IN ORAL LICHEN PLANUS

  2014cites this paper
• Induction of Apoptosis in G1/S Blocked HeLa Cells by R-Roscovitine: A Preliminary Study

  2014cites this paper
• Characterization of the role of the Aurora B kinase in quiescent lymphocytes

  2013cites this paper
• Cellular Mechanisms of Drug Nephrotoxicity

  2013cites this paper
• concept co cept The non-apoptotic role of p 53 in neuronal biology : enlightening the dark side of the moon

  2013cites this paper
• p 53 facilitates pRb cleavage in IL-3-deprived cells : novel pro-apoptotic activity of p 53

  2013cites this paper
• Role of the cell cycle in regression of the corpus luteum.

  2013cites this paper
• Lengthened G1 Phase Indicates Differentiation Status in Human Embryonic Stem Cells

  2013cites this paper
• Copy number defects of G1‐Cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis

  2012cites this paper
• Synergistic Effects of Combined Wnt/KRAS Inhibition in Colorectal Cancer Cells

  2012cites this paper
• Antitumor activity of erythromycin on human neuroblastoma cell line (SH-SY5Y)

  2011cites this paper
• Evaluation of an 18F-labeled oligonucleotide probe targeting p21(WAF1) transcriptional changes in human tumor cells.

  2011cites this paper
• Antitumor activity of erythromycin on human neuroblastoma cell line (SH-SY5Y)

  2011cites this paper
• LENGTHENED G1 PHASE INDICATES DIFFERENTIATION STATUS IN HUMAN EMBRYONIC STEM CELLS

  2011cites this paper
• Dose-related effects of Quercetin in the human breast carcinoma MCF-7 cell line

  2010cites this paper
• Inhibition of p53 sensitizes MCF-7 cells to ceramide treatment.

  2010cites this paper
• Arginase 2 and nitric oxide synthase: Pathways associated with the pathogenesis of thyroid tumors.

  2010cites this paper
• P 21 WAF 1 / CIP 1 Protein and Tongue Cancer Prognosis

  2009cites this paper
• The non‐apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon

  2009cites this paper
• Involvement of cyclin D1/CDK4 and pRb mediated by PI3K/AKT pathway activation in Pb2+ -induced neuronal death in cultured hippocampal neurons.

  2008cites this paper
• BRAF Silencing by Short Hairpin RNA or Chemical Blockade by PLX4032 Leads to Different Responses in Melanoma and Thyroid Carcinoma Cells

  2008cites this paper
• Two distinctly altered cellular responses to DNA double-strand breaks in human neuroblastoma.

  2008cites this paper
• The guanine nucleotide exchange factor, C3G regulates differentiation and survival of human neuroblastoma cells

  2008cites this paper
• CHAPTER 87 – Cellular Mechanisms of Drug Nephrotoxicity

  2008cites this paper
• Automated radiosynthesis of N‐(4‐[18F]fluorobenzyl)‐2‐bromoacetamide: an F‐18‐labeled reagent for the prosthetic radiolabeling of oligonucleotides

  2008cites this paper
• Cell fate determination during G1 phase progression

  2007cites this paper
• Position-dependent expression of GADD45α in rat brain tumours

  2007cites this paper
• Position-dependent expression of GADD45alpha in rat brain tumours.

  2007cites this paper
• Chapter 6 – The Cell Cycle and Oxidative Neuronal Cell Death

  2007cites this paper
• Significance of liquefaction degeneration in oral lichen planus: a study of its relationship with apoptosis and cell cycle arrest markers

  2007cites this paper
• p21Cip1 is required for the development of monocytes and their response to serum transfer-induced arthritis.

  2006cites this paper
• Growth Factors, Cytokines, Cell Cycle Molecules p21 Is Required for the Development of Monocytes and Their Response to Serum Transfer-induced Arthritis

  2006cites this paper
• Overexpressed WAFl / Cipl Renders Glioblastoma Cells Resistant to Chemotherapy Agents l , 3-Bis ( 2-chloroethyl )-l-nitrosourea and Cisplatin 1

  2006cites this paper
• The susceptibility of granulosa cells to apoptosis is influenced by oestradiol and the cell cycle.

  2006cites this paper
• Elevated expression of p21 (WAF1/Cip1) in hormonally active pituitary adenomas.

  2005cites this paper
• The Role and Regulation of p21 in Myelopoiesis

  2005cites this paper
• Combined treatment of leukemia cells with vitamin K2 and 1alpha,25-dihydroxy vitamin D3 enhances monocytic differentiation along with becoming resistant to apoptosis by induction of cytoplasmic p21CIP1.

  2005cites this paper
• Apoptosis and oncosis in acute coronary syndromes: Assessment and implications

  2005cites this paper
• Induction of p21WAF1 Expression Protects HT29 Colon Cancer Cells From Apoptosis Induced by Cryoinjury

  2005cites this paper
• Effects of p21cip1/waf1 overexpression on growth, apoptosis and differentiation in human colon carcinoma cells.

  2005cites this paper
• Chloramphenicol-induced Mitochondrial Stress Increases p21 Expression and Prevents Cell Apoptosis through a p21-dependent Pathway*

  2005cites this paper
• Apoptosis and cell cycle arrest in oral lichen planus Hypothesis on their possible influence on its malignant transformation.

  2005cites this paper
• Hepatitis C virus core, NS3, NS5A, NS5B proteins induce apoptosis in mature dendritic cells

  2005cites this paper
• p53 deficiency exacerbates pleiotropic mitotic defects, changes in nuclearity and polyploidy in transdifferentiating pancreatic acinar cells

  2005cites this paper
• Ovarian follicular growth and atresia: the relationship between cell proliferation and survival.

  2004cites this paper
• Deficiency of the Cyclin Kinase Inhibitor p21(WAF-1/CIP-1) Promotes Apoptosis of Activated/Memory T Cells and Inhibits Spontaneous Systemic Autoimmunity

  2004cites this paper
• Detection of p21WAF1/Cip1 in brain metastases

  2004cites this paper
• The tumor suppressor p16INK4a gene is a regulator of apoptosis induced by ultraviolet light and cisplatin

  2004cites this paper
• Activation of Cell Cycle Regulatory Proteins in the Apoptosis of Terminally Differentiated Oligodendrocytes

  2004cites this paper
• P21WAF1/CIP1 protein and tongue cancer prognosis.

  2004cites this paper
• p21(WAF1/Cip1) is not involved in kainic acid-induced apoptosis in murine cerebellar granule cells.

  2004cites this paper
• Smad and p 38-MAPK signaling mediates apoptotic effects of transforming growth factor-1 in human airway epithelial cells

  2004cites this paper
• Methodes et compositions d'inhibition de la replication du vih-1

  2004cites this paper
• Oxidative stress–associated mitochondrial dysfunction in corticosteroid‐treated muscle cells

  2004cites this paper
• Smad and p38-MAPK signaling mediates apoptotic effects of transforming growth factor-beta1 in human airway epithelial cells.

  2004cites this paper
• Overcoming of Radioresistance in Human Gliomas by p21WAF1/CIP1 Antisense Oligonucleotide

  2004cites this paper
• Progesterone receptor and the cell cycle modulate apoptosis in granulosa cells.

  2004cites this paper
• Oxidative stress‐induced death in the nervous system: Cell cycle dependent or independent?

  2004cites this paper
• NGF activation of TrkA decreases N-myc expression via MAPK path leading to a decrease in neuroblastoma cell number

  2004cites this paper
• Cell cycle regulation: repair and regeneration in acute renal failure.

  2004cites this paper
• Regulation of neuronal proliferation and differentiation by nitric oxide

  2003cites this paper
• Apoptosis and tumor remission in liver tumor xenografts by 4-phenylbutyrate.

  2003cites this paper
• Cell cycle regulation: repair and regeneration in acute renal failure.

  2003cites this paper
• Downregulation of p21waf/cip-1 mediates apoptosis of human hepatocellular carcinoma cells in response to interferon-γ

  2003cites this paper
• Bcr‐Abl upregulates cytosolic p21WAF‐1/CIP‐1 by a phosphoinositide‐3‐kinase (PI3K)‐independent pathway

  2003cites this paper
• Neural Stem Cell Models of Development and Disease

  2003cites this paper
• p21WAF1/CIP1 Acts as a Brake in Osteoblast Differentiation

  2003cites this paper
• Nerve growth factor induces proliferation of PC12 cells through Cdc42

  2003cites this paper
• Increased radiation-induced apoptosis and altered cell cycle progression of human lung cancer cell lines by antisense oligodeoxynucleotides targeting p53 and p21WAF1/CIP1

  2003cites this paper
• Essential embryonic roles of the CKI-1 cyclin-dependent kinase inhibitor in cell-cycle exit and morphogenesis in C elegans.

  2003cites this paper
• Differential expressions of cyclin-dependent kinase inhibitors (p27 and p21) and their relation to p53 and Ki-67 in oral squamous tumorigenesis.

  2003cites this paper
• High expression of p21Waf1 in sarcoid granulomas: a putative role for long‐lasting inflammation

  2003cites this paper
• Downregulation of p21(waf/cip-1) mediates apoptosis of human hepatocellular carcinoma cells in response to interferon-gamma.

  2003cites this paper
• Cip1/WAF1 regulates neurite remodeling by inhibiting Rho-kinase activity

  2002cites this paper
• Cyclin-dependent kinases as potential targets to improve stroke outcome.

  2002cites this paper
• The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.

  2002cites this paper
• Prostate Gland Development and Estrogenic Imprinting

  2002cites this paper
• Induction of p21 mRNA Synthesis After Short-wavelength UV Light Visualized in Individual Cells by RNA FISH

  2002cites this paper
• Differential post‐transcriptional regulation of p21WAF1/Cip1 levels in the developing nervous system following γ‐irradiation

  2002cites this paper
• MyoD induces apoptosis in the absence of RB function through a p21WAF1-dependent re-localization of cyclin/cdk complexes to the nucleus

  2002cites this paper
• Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects

  2002influential citation
• p21 modulates threshold of apoptosis induced by DNA-damage and growth factor withdrawal in prostate cancer cells.

  2002cites this paper
• Inactivation of p21 WAF1 Sensitizes Cells to Apoptosis via an Increase of Both p14ARF and p53 Levels and an Alteration of the Bax/Bcl-2 Ratio*

  2002cites this paper