Applications of Flavonoids, With an Emphasis on Hesperidin, as Anticancer Prodrugs: Phytotherapy as an Alternative to Chemotherapy

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/B978-0-444-64056-7.00006-4
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Anti-arthritogenic and cardioprotective action of hesperidin and daidzein in collagen-induced rheumatoid arthritis

  2016cited by this paper
• Mechanisms of Selective Autophagy in Normal Physiology and Cancer.

  2016cited by this paper
• Polymeric nanoparticles: Recent development in synthesis and application

  2016cited by this paper
• Hesperidin Attenuates Ultraviolet B-Induced Apoptosis by Mitigating Oxidative Stress in Human Keratinocytes

  2016cited by this paper
• Lipid Nanoparticles and their Application in Nanomedicine.

  2016cited by this paper
• Hesperetin induces apoptosis of esophageal cancer cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species

  2016cited by this paper
• Oxidative stress and cancer; the role of hesperidin, a citrus natural bioflavonoid, as a cancer chemoprotective agent

  2016cited by this paper
• Hesperetin Induces the Apoptosis of Gastric Cancer Cells via Activating Mitochondrial Pathway by Increasing Reactive Oxygen Species

  2015cited by this paper
• Industrial concentrates of dermal hesperidin smartCrystals®--production, characterization & long-term stability.

  2015cited by this paper
• Antioxidant and Anti‐Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

  2015cited by this paper
• Advances and new technologies applied in controlled drug delivery system

  2015cited by this paper
• The Biology of Cancer

  2015cited by this paper
• Development and evaluation of biodegradable polymeric nanoparticles for the effective delivery of quercetin using a quality by design approach

  2015cited by this paper
• Hesperidin: A promising anticancer agent from nature

  2015cited by this paper
• Hesperetin induces melanin production in adult human epidermal melanocytes.

  2015cited by this paper
• Exploitation of amaranth oil fractions enriched in squalene for dual delivery of hydrophilic and lipophilic actives

  2015cited by this paper
• Hesperidin from Citrus seed induces human hepatocellular carcinoma HepG2 cell apoptosis via both mitochondrial and death receptor pathways

  2015cited by this paper
• Anti-proliferative, apoptotic and signal transduction effects of hesperidin in non-small cell lung cancer cells

  2015cited by this paper
• Responsive Hydrogel Nanoparticles for Pulmonary Delivery.

  2015cited by this paper
• Toward understanding and exploiting tumor heterogeneity

  2015cited by this paper
• Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases.

  2015cited by this paper
• pH-sensitive nano-systems for drug delivery in cancer therapy.

  2014cited by this paper
• Metabolism of flavonoids in human: a comprehensive review.

  2014cited by this paper
• Antitumor activity of galactoxyloglucan-gold nanoparticles against murine ascites and solid carcinoma.

  2014cited by this paper
• Phospholipids in pulmonary drug delivery

  2014cited by this paper
• Chemopreventive effect of flavonoids from Ougan (Citrus reticulata cv. Suavissima) fruit against cancer cell proliferation and migration

  2014cited by this paper
• An overview of clinical and commercial impact of drug delivery systems.

  2014cited by this paper
• Solubility of Bioactive Compound Hesperidin in Six Pure Solvents at (298.15 to 333.15) K

  2014cited by this paper
• Autophagy and apoptosis: where do they meet?

  2014cited by this paper
• Nanocarriers for intravenous injection--the long hard road to the market.

  2013cited by this paper
• Surface modification of liposomes using polymer-wheat germ agglutinin conjugates to improve the absorption of peptide drugs by pulmonary administration.

  2013cited by this paper
• Skin cancer: an overview of epidemiology and risk factors.

  2013cited by this paper
• Effects of continuous ingestion of hesperidin and glucosyl hesperidin on vascular gene expression in spontaneously hypertensive rats.

  2013cited by this paper
• Oral delivery of anticancer drugs: challenges and opportunities.

  2013cited by this paper
• Flavonoids as prospective compounds for anti-cancer therapy.

  2013cited by this paper
• The citrus flavonoid hesperidin induces p53 and inhibits NF-κB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARγ-dependent mechanism

  2012cited by this paper
• Nanoparticle delivery for transdermal HRT.

  2012cited by this paper
• Autophagy and cancer cell metabolism.

  2012cited by this paper
• Evaluation of the Intravenous and Topical Routes for Ocular Delivery of Hesperidin and Hesperetin

  2012cited by this paper
• Melanogenesis of murine melanoma cells induced by hesperetin, a Citrus hydrolysate-derived flavonoid.

  2012cited by this paper
• The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice.

  2012cited by this paper
• Anti-inflammatory effect of flavonoids isolated from Korea Citrus aurantium L. on lipopolysaccharide-induced mouse macrophage RAW 264.7 cells by blocking of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathways

  2011cited by this paper
• Targeting apoptotic and autophagic pathways for cancer therapeutics.

  2011cited by this paper
• Hesperidin protects renal and hepatic tissues against free radical-mediated oxidative stress during DMBA-induced experimental breast cancer.

  2011cited by this paper
• The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kappaB in human hepatocellular carcinoma cells.

  2010cited by this paper
• Modulatory effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis with reference to COX-2, MMP-2 and MMP-9.

  2010cited by this paper
• Oxidative stress, inflammation, and cancer: how are they linked?

  2010cited by this paper
• Phase II Metabolism of Hesperetin by Individual UDP-Glucuronosyltransferases and Sulfotransferases and Rat and Human Tissue Samples

  2010cited by this paper
• Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles.

  2009cited by this paper
• Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

  2009cited by this paper
• Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

  2009cited by this paper
• Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes.

  2009cited by this paper
• Production and characterization of Hesperetin nanosuspensions for dermal delivery.

  2009cited by this paper
• Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells.

  2009cited by this paper
• Classics in Spectroscopy: Isolation and Structure Elucidation of Natural Products

  2009cited by this paper
• Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products.

  2009cited by this paper
• Molecular mechanisms of anti-inflammatory activity mediated by flavonoids.

  2008cited by this paper
• Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways.

  2008cited by this paper
• Dendrimers as drug carriers: applications in different routes of drug administration.

  2008cited by this paper
• Transdermal drug delivery

  2008cited by this paper
• Hesperidin a flavanoglycone protects against gamma-irradiation induced hepatocellular damage and oxidative stress in Sprague-Dawley rats.

  2008cited by this paper
• Apoptotic effect of hesperidin through caspase3 activation in human colon cancer cells, SNU-C4.

  2008cited by this paper
• Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo.

  2008cited by this paper
• Multifunctional nanoparticles--properties and prospects for their use in human medicine.

  2008cited by this paper
• Pharmacology: Principles and Practice

  2008cited by this paper
• Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies

  2007cited by this paper
• Molecular Carcinogenesis and the Molecular Biology of Human Cancer

  2007cited by this paper
• Melanocyte biology and skin pigmentation

  2007cited by this paper
• Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial.

  2006cited by this paper
• Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses

  2006cited by this paper
• Nanoparticulates as Drug Carriers

  2006cited by this paper
• Liposomes in analyses.

  2006cited by this paper
• Development of functionalized superparamagnetic iron oxide nanoparticles for interaction with human cancer cells.

  2005cited by this paper
• Absorption, Bioavailability, and Metabolism of Flavonoids

  2004cited by this paper
• Identification and quantification of the conjugated metabolites derived from orally administered hesperidin in rat plasma.

  2004cited by this paper
• Cytotoxicity and Antiproliferative Activities of Several Phenolic Compounds Against Three Melanocytes Cell Lines: Relationship Between Structure and Activity

  2004cited by this paper
• Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy.

  2004cited by this paper
• Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins.

  2004cited by this paper
• Drug complexation, in vitro release and cellular entry of dendrimers and hyperbranched polymers.

  2003cited by this paper
• Inhibition of inducible isoforms of cyclooxygenase and nitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line.

  2003cited by this paper
• Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoids.

  2003cited by this paper
• Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice

  2003cited by this paper
• Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships.

  2002cited by this paper
• Proliferation, cell cycle and apoptosis in cancer

  2001cited by this paper
• Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice.

  2001cited by this paper
• Chemistry and pharmacology of the citrus bioflavonoid hesperidin

  2001cited by this paper
• Stem cells, cancer, and cancer stem cells

  2001cited by this paper
• The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man.

  1999cited by this paper
• Textbook of Natural Medicine

  1999cited by this paper
• Antiproliferative activity of flavonoids on several cancer cell lines.

  1999cited by this paper
• Inhibitory effect of Hesperidin on tumour initiation and promotion in mouse skin

  1998cited by this paper
• Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats by flavonoids diosmin and hesperidin, each alone and in combination.

  1997cited by this paper
• Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin.

  1997cited by this paper
• Medicinal Natural Products: A Biosynthetic Approach

  1997cited by this paper
• Flavonoids as potential protective agents against photo-oxidative skin damage

  1996cited by this paper
• Flavonoids as antioxidant agents: importance of their interaction with biomembranes.

  1995cited by this paper
• Flavonoids as Antioxidants

  1994cited by this paper
• Role of superoxide dismutase in cancer: a review.

  1979cited by this paper
• Superoxide radicals and hydrogen peroxide formation in mitochondria from normal and neoplastic tissues.

  1975cited by this paper
• Natural Products: A Laboratory Guide

  1969cited by this paper

• Recent developments in sustained-release and targeted drug delivery applications of solid lipid nanoparticles

  2025cites this paper
• Development and Validation of an HPLC-DAD Method for the Determination of Seven Antioxidants in a Nano-Emulsion: Formulation and Stability Study

  2024cites this paper
• Simultaneous estimation of neratinib and naringenin from pharmaceuticals using a stability-indicating liquid chromatographic method: application to analytical quality by design concept and multi-tool method greenness assessment

  2023cites this paper
• Elucidating molecular and cellular targets and the antiprostate cancer potentials of promising phytochemicals: a review

  2023cites this paper
• Exploring the Natural Compounds in Flavonoids for Their Potential Inhibition of Cancer Therapeutic Target MEK1 Using Computational Methods

  2022cites this paper
• Recent developments in citrus bioflavonoid encapsulation to reinforce controlled antioxidant delivery and generate therapeutic uses: Review

  2021cites this paper
• The clinical path to deliver encapsulated phages and lysins.

  2021cites this paper
• Repurposed drug against COVID-19: nanomedicine as an approach for finding new hope in old medicines

  2021cites this paper
• Ternary Alloys Enable Efficient Production of Methoxylated Chemicals via Selective Electrocatalytic Hydrogenation of Lignin Monomers.

  2021cites this paper
• Phytoestrogens for Cancer Prevention and Treatment

  2020cites this paper
• New Sustainable Process for Hesperidin Isolation and Anti-Ageing Effects of Hesperidin Nanocrystals

  2020cites this paper
• Magnetic casein-CaFe2O4 nanohybrid carrier conjugated with progesterone for enhanced cytotoxicity of citrus peel derived hesperidin drug towards breast and ovarian cancer.

  2020cites this paper
• Recent advances in topical delivery of flavonoids: A review

  2019cites this paper
• Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions.

  2019cites this paper