Cholesterol transport through lysosome-peroxisome membrane contacts.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Cell

• Publication date

  2015-04-09

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.cell.2015.02.019PMID 25860611
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Localization of Phosphatidylinositol 4,5-Bisphosphate to Lipid Rafts and Uroids in the Human Protozoan Parasite Entamoeba histolytica

  2013cited by this paper
• Dietary treatment for X-linked adrenoleukodystrophy: is "Lorenzo's oil" useful?

  2013cited by this paper
• Dietary treatment for X-linked adrenoleukodystrophy: is "Lorenzo's oil" useful?

  2013cited by this paper
• Peroxisomes: offshoots of the ER.

  2013cited by this paper
• A role for oxysterol-binding protein–related protein 5 in endosomal cholesterol trafficking

  2011cited by this paper
• Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid

  2010cited by this paper
• Article Mixed Microtubules Steer Dynein-Driven Cargo Transport into Dendrites

  2010cited by this paper
• Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells

  2010cited by this paper
• Lipid rafts are essential for peroxisome biogenesis in HepG2 cells

  2010cited by this paper
• Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol.

  2009cited by this paper
• Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex

  2008cited by this paper
• Cholesterol sensing, trafficking, and esterification.

  2006cited by this paper
• Protein sensors for membrane sterols.

  2006cited by this paper
• Phosphoinositide synthesis and degradation in isolated rat liver peroxisomes

  2006cited by this paper
• There's more to life than neurotransmission: the regulation of exocytosis by synaptotagmin VII.

  2005cited by this paper
• Adrenoleukodystrophy: new approaches to a neurodegenerative disease.

  2005cited by this paper
• Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport.

  2004cited by this paper
• The pathogenic peroxin Pex26p recruits the Pex1p–Pex6p AAA ATPase complexes to peroxisomes

  2003cited by this paper
• Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis

  2002cited by this paper
• Mechanism of the Calcium-dependent Multimerization of Synaptotagmin VII Mediated by Its First and Second C2 Domains*

  2001cited by this paper
• SNARE-mediated membrane fusion

  2001cited by this paper
• The C2b Domain of Synaptotagmin Is a Ca2+–Sensing Module Essential for Exocytosis

  2000cited by this paper
• Intracellular cholesterol transport.

  1999cited by this paper
• Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol.

  1999cited by this paper
• Mirror expression of adrenoleukodystrophy and adrenoleukodystrophy related genes in mouse tissues and human cell lines.

  1998cited by this paper
• SNAREpins: minimal machinery for membrane fusion.

  1998cited by this paper
• Targeted inactivation of the X‐linked adrenoleukodystrophy gene in mice

  1997cited by this paper
• Acyl-coenzyme A:cholesterol acyltransferase.

  1997cited by this paper
• The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.

  1997cited by this paper
• Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.

  1997cited by this paper
• Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation.

  1996cited by this paper
• Intracellular cholesterol transport.

  1992cited by this paper
• Lipoprotein assembly and secretion by hepatocytes.

  1990cited by this paper
• Studies on peroxisomal membranes.

  1990cited by this paper
• The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one.

  1989cited by this paper
• A receptor-mediated pathway for cholesterol homeostasis.

  1986cited by this paper
• Receptor-mediated endocytosis of low-density lipoprotein in cultured cells.

  1983cited by this paper
• Lipoprotein-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesteryl ester metabolism in the adrenal gland of the rat.

  1977cited by this paper
• On the anatomy of amphotericin B-cholesterol pores in lipid bilayer membranes.

  1973cited by this paper

• The untapped potential of highly selective potentiometric cholesterol biosensors for the screening and monitoring of cholesterol concentrations in body fluids including serum

  2026cites this paper
• Loss of the CoA-degrading enzyme NUDT19 exacerbates albuminuria and disrupts renal lipid homeostasis in high fat diet-fed mice

  2026cites this paper
• Balancing cholesterol metabolism in the liver and gut: perspectives in health and disease.

  2026cites this paper
• A mutation in Tmem135 causes progressive sensorineural hearing loss.

  2025cites this paper
• Peroxisome Dysfunction and Steatotic Liver Disease

  2025cites this paper
• Lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension.

  2025cites this paper
• Spatial organization of phosphoinositide signaling.

  2025cites this paper
• Key challenges and recommendations for defining organelle membrane contact sites

  2025cites this paper
• Pexophagy Triggered by Enterovirus 71 Modulates the Production of Pro‐Inflammatory Cytokines Through Cholesterol Accumulation in Lysosomes

  2025cites this paper
• The Role of Oxidative Stress in Periodontitis.

  2025cites this paper
• Deletion of Nudt19 Increases Albuminuria in Mice Fed a High Fat Diet

  2025cites this paper
• ZBTB17/MIZ1 promotes peroxisome biogenesis by transcriptional regulation of PEX13

  2025cites this paper
• Comparison of 7-dehydrocholesterol and cholesterol in whole blood vs. plasma samples for diagnosis of SLOS.

  2025cites this paper
• Systematic interrogation of functional genes underlying cholesterol and lipid homeostasis

  2025cites this paper
• Neurons and astrocytes have distinct organelle signatures and responses to stress

  2025cites this paper
• Impact of Vitamin B12 Supplementation on Cardiovascular Health in the Silver Star Bamboo Rat, a Species That Feeds Primarily on Bamboo

  2025cites this paper
• Noncanonical PI(4,5)P2 coordinates lysosome positioning through cholesterol trafficking

  2025cites this paper
• Consuming your colors: carotenoid and retinol availability affects expression of color related genes in the mimic poison frog (Ranitomeya imitator)

  2025cites this paper
• Peroxisomes, PPARs, and Their Role in Macrophages

  2025influential citation
• From “lysosomal addiction” to targeted therapies: exploiting novel windows in colorectal cancer

  2025cites this paper
• Subcellular cartography of the phosphoinositide multiverse.

  2025cites this paper
• Peroxisomal integrity in demyelination-associated microglia enables cellular debris clearance and myelin renewal in mice

  2025cites this paper
• Tetrandrine regulates NAADP-mediated calcium signaling through a LIMP-2-dependent and sphingosine-mediated mechanism

  2025cites this paper
• The neurological pathology of peroxisomal ACBD5 deficiency – lessons from patients and mouse models

  2025cites this paper
• Peroxisome dynamics and inter-organelle interactions in neuronal health and disease

  2025influential citation
• Triclosan inhibits testosterone synthesis in male offspring by activating mitophagy.

  2025cites this paper
• Peroxisomes and their role in pediatric diseases

  2025cites this paper
• Lipid nanoparticles as the drug carrier for targeted therapy of hepatic disorders.

  2024cites this paper
• Regulation of mitochondria-lysosome interactions in skeletal muscle during exercise, disuse, and aging.

  2024cites this paper
• Unnatural Peptide Assemblies Rapidly Deplete Cholesterol and Potently Inhibit Cancer Cells.

  2024cites this paper
• NPC1 promotes the progression of hepatocellular carcinoma by mediating the accumulation of neutrophils into the tumor microenvironment

  2024cites this paper
• D NA methylation in cord blood partially mediates the effects of prepregnancy BMI on early childhood offspring BMI

  2024cites this paper
• Lysosomal membrane contact sites: Integrative hubs for cellular communication and homeostasis.

  2024cites this paper
• Molecular cloning, tissue distribution and nutritional regulation of four acyl-coenzyme A oxidase (acox) isoforms in Scylla paramamosain

  2024cites this paper
• Salmonella Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol

  2024influential citation
• Altered lipid homeostasis is associated with cerebellar neurodegeneration in SNX14 deficiency

  2024cites this paper
• Fatty acid–binding proteins 3, 7, and 8 bind cholesterol and facilitate its egress from lysosomes

  2024cites this paper
• SNX8 enables lysosome reformation and reverses lysosomal storage disorder

  2024influential citation
• Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

  2024cites this paper
• Opposing actions of JIP4 and RILPL1 provide antagonistic motor force to dynamically regulate membrane reformation during lysosomal tubulation/sorting driven by LRRK2

  2024cites this paper
• Cdc42-driven endosomal cholesterol transport promotes collateral resistance in HER2-positive gastric cancer.

  2024cites this paper
• Cholesterol: A friend to viruses

  2024cites this paper
• Roles of transmembrane protein 135 in mitochondrial and peroxisomal functions - implications for age-related retinal disease

  2024cites this paper
• Deciphering the influence of dietary synbiotics in white shrimp gut and its effects in regulating immune signaling pathways

  2024cites this paper
• Peroxisomal Localization of a Truncated HMG-CoA Reductase under Low Cholesterol Conditions

  2024cites this paper
• Pseudorabies virus inhibits progesterone-induced inactivation of TRPML1 to facilitate viral entry

  2024cites this paper
• Osteocytes/Osteoblasts Produce SAA3 to Regulate Hepatic Metabolism of Cholesterol

  2024cites this paper
• Proteomics and metabolomics analyses of urine for investigation of gallstone disease in a high-altitude area

  2024cites this paper
• Cholesterol crystals in the pathogenesis of atherosclerosis

  2024cites this paper
• A new role for phosphoinositides in regulating mitochondrial dynamics.

  2023cites this paper
• The combined characteristics of cholesterol metabolism and the immune microenvironment may serve as valuable biomarkers for both the prognosis and treatment of hepatocellular carcinoma

  2023cites this paper
• Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism

  2023cites this paper
• An adaptive stress response that confers cellular resilience to decreased ubiquitination

  2023cites this paper
• Glucose‐mediated mitochondrial reprogramming by cholesterol export at TM4SF5‐enriched mitochondria‐lysosome contact sites

  2023cites this paper
• Lysosomal Ion Channels and Lysosome-Organelle Interactions.

  2023cites this paper
• The murine retinal pigment epithelium requires peroxisomal β-oxidation to maintain lysosomal function and prevent dedifferentiation

  2023cites this paper
• TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport

  2023cites this paper
• Copper‐independent lysosomal localisation of the Wilson disease protein ATP7B

  2023cites this paper
• Enhancement of lysosome biogenesis as a potential therapeutic approach for neurodegenerative diseases

  2023influential citation
• Reducing Cholesterol Level in Live Macrophages Improves Delivery Performance by Enhancing Blood Shear Stress Adaptation.

  2023cites this paper
• Convergent and divergent mechanisms of peroxisomal and mitochondrial division

  2023cites this paper
• Cholesterol Trafficking, Lysosomal Function and Atherosclerosis.

  2023cites this paper
• SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells

  2023cites this paper
• Circular RNA circARPC1B functions as a stabilisation enhancer of Vimentin to prevent high cholesterol‐induced articular cartilage degeneration

  2023cites this paper
• Peroxisomal defects in microglial cells induce a disease-associated microglial signature

  2023cites this paper
• PI(4,5)P2 and Cholesterol: Synthesis, Regulation, and Functions.

  2023cites this paper
• Construction and Mechanism of IL‐15‐Based Coactivated Polymeric Micelles for NK Cell Immunotherapy

  2023cites this paper
• The ultrastructural function of MLN64 in the late endosome-mitochondria membrane contact sites in placental cells.

  2023cites this paper
• CRISPR screening in cardiovascular research

  2023cites this paper
• Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging.

  2023cites this paper
• Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis

  2023cites this paper
• Lysosomal cholesterol accumulation is commonly found in most peroxisomal disorders and reversed by 2-hydroxypropyl-β-cyclodextrin

  2023influential citation
• The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping

  2023cites this paper
• Intracellular Cholesterol Trafficking.

  2023cites this paper
• Resveratrol Modulates the Redox Response and Bile Acid Metabolism to Maintain the Cholesterol Homeostasis in Fish Megalobrama amblycephala Offered a High-Carbohydrate Diet

  2023cites this paper
• TTBK2 mutations associated with spinocerebellar ataxia type 11 disrupt peroxisome dynamics and ciliary localization of SHH signaling proteins

  2023cites this paper
• Alterations in Cholesterol and Phosphoinositides Levels in the Intracellular Cholesterol Trafficking Disorder NPC.

  2023cites this paper
• Salmonella Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol for better intracellular growth

  2023cites this paper
• Biogenesis of specialized lysosomes in differentiated keratinocytes relies on close apposition with the Golgi apparatus

  2023cites this paper
• Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism

  2023cites this paper
• Reversible translocation of acyl-CoA:cholesterol acyltransferase (ACAT) between the endoplasmic reticulum and vesicular structures

  2023cites this paper
• The role of lysosomes in lipid homeostasis

  2023cites this paper
• Organelle stress and alterations in interorganelle crosstalk during liver fibrosis

  2023cites this paper
• Paternal cadmium exposure affects testosterone synthesis by reducing the testicular cholesterol pool in offspring mice.

  2022cites this paper
• The physiological functions of human peroxisomes.

  2022cites this paper
• Peroxisomal regulation of energy homeostasis: Effect on obesity and related metabolic disorders

  2022cites this paper
• Molecular insights into peroxisome homeostasis and peroxisome biogenesis disorders.

  2022cites this paper
• Cholesterol Transport to the Endoplasmic Reticulum.

  2022cites this paper
• The peroxisome: an up-and-coming organelle in immunometabolism.

  2022cites this paper
• Ciliary membrane, localised lipid modification and cilia function

  2022cites this paper
• Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma

  2022cites this paper
• Intracerebral lentiviral ABCD1 gene therapy in an early disease onset ALD mouse model

  2022cites this paper
• Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells

  2022cites this paper
• Dysregulation of organelle membrane contact sites in neurological diseases.

  2022cites this paper
• Lactose-Appended Hydroxypropyl-β-Cyclodextrin Lowers Cholesterol Accumulation and Alleviates Motor Dysfunction in Niemann-Pick Type C Disease Model Mice.

  2022cites this paper
• Septin 9 and phosphoinositides regulate lysosome localization and their association with lipid droplets

  2022cites this paper
• Lysosome-Targeted Biosensor for the Super-Resolution Imaging of Lysosome–Mitochondrion Interaction

  2022cites this paper
• Intracellular Cholesterol Synthesis and Transport

  2022influential citation
• Stable Integration of Inducible SPLICS Reporters Enables Spatio-Temporal Analysis of Multiple Organelle Contact Sites upon Modulation of Cholesterol Traffic

  2022cites this paper
• Coordination of inter-organelle communication and lipid fluxes by OSBP-related proteins.

  2022cites this paper