Blood–Brain Barrier

Abstract The central nervous system (CNS) requires precise maintenance of its ionic environment for appropriate neuronal synaptic activity. The regulatory elements comprising the blood–brain barrier (BBB) protect the stability of the CNS and ensure an adequate supply of nutrients and oxygen to neurons and glial cells. BBB permeability, transport function, and metabolism are influenced by inflammatory mediators that play important roles in the inflammatory transduction signals to the brain parenchyma. BBB dysfunction and inflammatory stress represent underlying mechanisms for the manifestation of many neurological diseases. Both mechanisms closely interact to further exacerbate pathological brain lesions. As such, both BBB dysfunction and inflammatory stressors can be targeted for the development of therapeutic strategies for many neurological disorders.

• Publication year

  2019

• Venue

  Stress

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/b978-0-12-813146-6.00024-2
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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