Is Science the Only Driver in Species Selection? An Internal Study to Evaluate Compound Requirements in the Minipig Compared to the Dog in Preclinical Studies

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Toxicologic pathology (Print)

• Publication date

  2016-02-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1177/0192623315624572PMID 26839331
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Efficacy of the porcine species in biomedical research

  2015cited by this paper
• Comparison of minipig, dog, monkey and human drug metabolism and disposition.

  2015cited by this paper
• The immunology of the porcine skin and its value as a model for human skin.

  2015cited by this paper
• Xenobiotic-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models

  2014cited by this paper
• Estrous Cycle-dependent Morphology in the Reproductive Organs of the Female Göttingen Minipig

  2014cited by this paper
• Onset of Puberty and Normal Histological Appearances of the Reproductive Organs in Peripubertal Female Göttingen Minipigs

  2013cited by this paper
• Swine as Models in Biomedical Research and Toxicology Testing

  2012cited by this paper
• The Minipig as Nonrodent Species in Toxicology—Where Are We Now?

  2012cited by this paper
• Critical evaluation of the use of dogs in biomedical research and testing in Europe.

  2011cited by this paper
• Cardiovascular and respiratory safety pharmacology in Göttingen minipigs: Pharmacological characterization.

  2011cited by this paper
• The utility of the minipig as an animal model in regulatory toxicology.

  2010influential reference
• Spontaneous and Age-Related Testicular Findings in Beagle Dogs

  2008cited by this paper
• Review of Nonprimate, Large Animal Models for Osteoporosis Research

  2008cited by this paper
• Frequency of Different Estrous Stages in Purpose-bred Beagles: A Retrospective Study

  2008cited by this paper
• Growth curve and body weight in Göttingen minipigs - a phenotypic and genetic study

  2007cited by this paper
• The minipig in toxicology.

  2006cited by this paper
• Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs

  2001cited by this paper
• Importance of species selection in drug toxicity testing.

  1998cited by this paper
• Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human liver samples.

  1998cited by this paper
• Fertility and Obstetrics in the Dog

  1995cited by this paper
• Swine in cardiovascular research.

  1986cited by this paper
• Swine in cardiovascular research.

  1986cited by this paper
• THE SKIN OF THE DOMESTIC PIG.

  1964cited by this paper
• Ossification

  1920cited by this paper

• Establishment and transcriptomic characterization of canine organoids from multiple tissues

  2025cites this paper
• Opportunities and Challenges for Use of Minipigs in Nonclinical Pharmaceutical Development: Results of a Follow-Up IQ DruSafe Survey.

  2024cites this paper
• Artificial-enzymes-armed Bifidobacterium longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis

  2023cites this paper
• Advances in organoid technology for veterinary disease modeling

  2023cites this paper
• Establishment and Characterization of Novel Canine Organoids with Organ-Specific Physiological Similarity

  2022cites this paper
• Species selection for nonclinical safety assessment of drug candidates: Examples of current industry practice.

  2021cites this paper
• Dynamic Monitoring of Cross-Bred Dogs for Translational Research in Ulcerative Colitis

  2020cites this paper
• Justification for species selection for pharmaceutical toxicity studies

  2020cites this paper
• Derivation of adult canine intestinal organoids for translational research in gastroenterology

  2019cites this paper
• Adult Canine Intestinal Derived Organoids: A Novel In Vitro System for Translational Research in Comparative Gastroenterology

  2018cites this paper
• Trauma as a Cause for Hepatopathy in Newborn Göttingen Minipigs

  2016cites this paper