The Major Yolk Protein Vitellogenin Interferes with the Anti-Plasmodium Response in the Malaria Mosquito Anopheles gambiae

Functional gene analysis in malaria mosquitoes reveals molecules underpinning the trade-off between efficient reproduction and the antiparasitic response.

• Publication year

  2010

• Venue

  PLoS Biology

• Publication date

  2010-07-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1371/journal.pbio.1000434PMID 20652016PMCID 2907290
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Human innate immunity against African trypanosomes.

  2009cited by this paper
• Caspar Controls Resistance to Plasmodium falciparum in Diverse Anopheline Species

  2009cited by this paper
• Mosquito immune responses and compatibility between Plasmodium parasites and anopheline mosquitoes

  2009cited by this paper
• Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium.

  2009cited by this paper
• The major insect lipoprotein is a lipid source to mosquito stages of malaria parasite.

  2009influential reference
• Leucine-Rich Repeat Protein Complex Activates Mosquito Complement in Defense Against Plasmodium Parasites

  2009cited by this paper
• Vitellogenin Functions as a Multivalent Pattern Recognition Receptor with an Opsonic Activity

  2008cited by this paper
• Molecular characteristics of insect vitellogenins.

  2008cited by this paper
• Antimalarial responses in Anopheles gambiae: from a complement-like protein to a complement-like pathway.

  2008cited by this paper
• Juvenile hormone connects larval nutrition with target of rapamycin signaling in the mosquito Aedes aegypti.

  2008cited by this paper
• Anopheles gambiae APL1 Is a Family of Variable LRR Proteins Required for Rel1-Mediated Protection from the Malaria Parasite, Plasmodium berghei

  2008cited by this paper
• Transmission Blocking Immunity in the Malaria Non-Vector Mosquito Anopheles quadriannulatus Species A

  2008cited by this paper
• Conserved Mosquito/Parasite Interactions Affect Development of Plasmodium falciparum in Africa

  2008cited by this paper
• Bacterial infection of fly ovaries reduces egg production and induces local hemocyte activation.

  2007cited by this paper
• Structural basis for conserved complement factor-like function in the antimalarial protein TEP1

  2007cited by this paper
• Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL.

  2007cited by this paper
• The Competence Factor βFtz-F1 Potentiates Ecdysone Receptor Activity via Recruiting a p160/SRC Coactivator

  2006cited by this paper
• Anopheles and Plasmodium: from laboratory models to natural systems in the field

  2006cited by this paper
• Regulation of Lipid Metabolism Genes, Lipid Carrier Protein Lipophorin, and Its Receptor during Immune Challenge in the Mosquito Aedes aegypti*

  2006cited by this paper
• Immune stimulation and malaria infection impose reproductive costs in Anopheles gambiae via follicular apoptosis.

  2006cited by this paper
• Anopheles gambiae Immune Responses to Human and Rodent Plasmodium Parasite Species

  2006cited by this paper
• Anopheles gambiae lipophorin: characterization and role in lipid transport to developing oocyte.

  2006cited by this paper
• Natural Malaria Infection in Anopheles gambiae Is Regulated by a Single Genomic Control Region

  2006cited by this paper
• Transgenic alteration of Toll immune pathway in the female mosquito Aedes aegypti.

  2005cited by this paper
• Aging of the innate immune response in Drosophila melanogaster

  2005cited by this paper
• Nutritional regulation of vitellogenesis in mosquitoes: implications for anautogeny.

  2005cited by this paper
• Lipoprotein particles are required for Hedgehog and Wingless signalling

  2005cited by this paper
• Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae.

  2005cited by this paper
• Mosquito immune responses against malaria parasites.

  2004cited by this paper
• Target of rapamycin-mediated amino acid signaling in mosquito anautogeny.

  2004cited by this paper
• DEQOR: a web-based tool for the design and quality control of siRNAs

  2004cited by this paper
• Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae.

  2004cited by this paper
• A Plasmodium berghei reference line that constitutively expresses GFP at a high level throughout the complete life cycle.

  2004cited by this paper
• Effects of Mosquito Genes on Plasmodium Development

  2004cited by this paper
• Fat metabolism in insects.

  2003cited by this paper
• Posttranscriptional control of the competence factor βFTZ-F1 by juvenile hormone in the mosquito Aedes aegypti

  2003cited by this paper
• Malaria-induced apoptosis in mosquito ovaries: a mechanism to control vector egg production.

  2001cited by this paper
• Lipid storage and mobilization in insects: current status and future directions.

  2001cited by this paper
• Effects of malaria infection on vitellogenesis in Anopheles gambiae during two gonotrophic cycles

  2001cited by this paper
• Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae.

  2001cited by this paper
• Plasmodium differentiation in the mosquito.

  1999cited by this paper
• Molecular characteristics of insect vitellogenins and vitellogenin receptors.

  1998cited by this paper
• Accumulation of yolk proteins in insect oocytes.

  1992cited by this paper
• Biosynthesis of mosquito vitellogenin.

  1990cited by this paper
• Mosquito vitellogenin subunits originate from a common precursor.

  1988cited by this paper
• Production of monoclonal antibodies: strategy and tactics.

  1980cited by this paper

• Lipid Metabolism in Insect Vectors of Diseases.

  2026cites this paper
• Proteomic analysis unveils host-parasite interactions in Aedes togoi infected with Dirofilaria immitis and Brugia pahangi

  2025cites this paper
• Pickpocket315 affects male mating behavior in the yellow fever mosquito Aedes aegypti

  2025cites this paper
• Roles of Vitellogenin and Its Receptor Genes in Female Reproduction of the Cigarette Beetle, Lasioderma serricorne

  2025cites this paper
• How Insects Balance Reproductive Output and Immune Investment

  2025cites this paper
• Advances in the dissection of Anopheles–Plasmodium interactions

  2025cites this paper
• Reduced Genetic Diversity of Key Fertility and Vector Competency Related Genes in Anopheles gambiae s.l. Across Sub-Saharan Africa

  2025cites this paper
• Unstable laboratory Wolbachia strain w-Anga is negatively correlated with Plasmodium falciparum in wild malaria vectors

  2025cites this paper
• Effect of a Blood Meal on Plasmodium Oocyst Growth Using the Enema Injection Method

  2025cites this paper
• Lipid Metabolism in Insect Vectors of Diseases.

  2024cites this paper
• Challenges of Robust RNAi-Mediated Gene Silencing in Aedes Mosquitoes

  2024cites this paper
• Precise coordination between nutrient transporters ensures fertility in the malaria mosquito Anopheles gambiae

  2024influential citation
• Leafhopper salivary vitellogenin mediates virus transmission to plant phloem

  2024cites this paper
• Salivary-secreted vitellogenin suppresses H2O2 burst of plants facilitating Recilia dorsalis leafhopper feeding.

  2024cites this paper
• Signaling between mammalian adiponectin and a mosquito adiponectin receptor reduces Plasmodium transmission

  2023influential citation
• Comparative Analyses of Reproductive Caste Types Reveal Vitellogenin Genes Involved in Queen Fertility in Solenopsis invicta

  2023cites this paper
• Implications of mosquito metabolism on vector competence

  2023cites this paper
• Lipids as a key element of insect defense systems

  2023cites this paper
• Plasmodium berghei oocysts possess fatty acid synthesis and scavenging routes

  2023cites this paper
• Multiple hosts, multiple impacts: the role of vertebrate host diversity in shaping mosquito life history and pathogen transmission

  2023cites this paper
• Adipokinetic hormone signaling in the malaria vector Anopheles gambiae facilitates Plasmodium falciparum sporogony

  2023cites this paper
• Interplay between nutrient transporters ensures fertility in the malaria mosquito Anopheles gambiae

  2023cites this paper
• A population modification gene drive targeting both Saglin and Lipophorin impairs Plasmodium transmission in Anopheles mosquitoes

  2023influential citation
• Interaction of Liberibacter Solanacearum with Host Psyllid Vitellogenin and Its Association with Autophagy

  2022cites this paper
• The N-terminal subunit of vitellogenin in planthopper eggs and saliva acts as a reliable elicitor that induces defenses in rice

  2022cites this paper
• The ecdysone receptor regulates several key physiological factors in Anopheles funestus

  2022cites this paper
• Vitellogenin-2 Accumulation in the Fat Body and Hemolymph of Babesia-Infected Haemaphysalis longicornis Ticks

  2022cites this paper
• Aedes aegypti Malpighian tubules are immunologically activated following systemic Toll activation

  2022cites this paper
• Selection for insecticide resistance can promote Plasmodium falciparum infection in Anopheles

  2022cites this paper
• Knockout of Anopheles stephensi immune gene LRIM1 by CRISPR-Cas9 reveals its unexpected role in reproduction and vector competence

  2021cites this paper
• Mosquito transgenesis for malaria control.

  2021cites this paper
• Plasmodium development in Anopheles: a tale of shared resources.

  2021cites this paper
• Non-immune Traits Triggered by Blood Intake Impact Vectorial Competence

  2021cites this paper
• Diapause Termination and Postdiapause in Lygus hesperus (Heteroptera: Miridae).

  2021cites this paper
• Increased insulin signaling in the Anopheles stephensi fat body regulates metabolism and enhances the host response to both bacterial challenge and Plasmodium falciparum infection.

  2021cites this paper
• Additional Feeding Reveals Differences in Immune Recognition and Growth of Plasmodium Parasites in the Mosquito Host

  2021cites this paper
• Trained Immunity in Anopheles gambiae: Antibacterial Immunity Is Enhanced by Priming via Sugar Meal Supplemented With a Single Gut Symbiotic Bacterial Strain

  2021cites this paper
• CRISPRing protozoan parasites to better understand the biology of diseases.

  2021cites this paper
• Plasmodium oocysts respond with dormancy to crowding and nutritional stress

  2021cites this paper
• Rapamycin inhibits pathogen transmission in mosquitoes by promoting immune activation

  2021cites this paper
• Intraspecific Transcriptome Variation and Sex-Biased Expression in Anopheles arabiensis

  2021influential citation
• Assessment of Plasmodium falciparum infection and fitness of genetically modified Anopheles gambiae aimed at mosquito population replacement

  2021cites this paper
• Anopheles metabolic proteins in malaria transmission, prevention and control: a review

  2020cites this paper
• A mating-induced reproductive gene promotes Anopheles tolerance to Plasmodium falciparum infection

  2020cites this paper
• Novel insights into a well-studied steroid hormone: The impacts of 20-hydroxyecdysone (20E) on mosquito immunity

  2020cites this paper
• Effect of geographic variation on the proteome of sea cucumber (Stichopus japonicus).

  2020cites this paper
• Aquatic Exposure to Abscisic Acid Transstadially Enhances Anopheles stephensi Resistance to Malaria Parasite Infection

  2020influential citation
• Multiple blood feeding in mosquitoes shortens the Plasmodium falciparum incubation period and increases malaria transmission potential

  2020cites this paper
• Plasmodium oocysts respond with dormancy to crowding and nutritional stress

  2020cites this paper
• Insect Defense Proteins and Peptides.

  2020cites this paper
• Vertebrate and Invertebrate Respiratory Proteins, Lipoproteins and other Body Fluid Proteins

  2020cites this paper
• Exposure of Anopheles mosquitoes to trypanosomes reduces reproductive fitness and enhances susceptibility to Plasmodium

  2020cites this paper
• 20-Hydroxyecdysone Primes Innate Immune Responses That Limit Bacterial and Malarial Parasite Survival in Anopheles gambiae

  2020cites this paper
• Comprehensive and Durable Modulation of Growth, Development, Lifespan and Fecundity in Anopheles stephensi Following Larval Treatment With the Stress Signaling Molecule and Novel Antimalarial Abscisic Acid

  2020cites this paper
• Distinct vitellogenin domains differentially regulate immunological outcomes in invertebrates

  2020cites this paper
• Steroid Hormone Function Controls Non-competitive Plasmodium Development in Anopheles.

  2019influential citation
• Time-of-day of blood-feeding: effects on mosquito life history and malaria transmission

  2019cites this paper
• Metabolic balancing by miR-276 shapes the mosquito reproductive cycle and Plasmodium falciparum development

  2019cites this paper
• Disruption of mosGILT in Anopheles gambiae impairs ovarian development and Plasmodium infection

  2019cites this paper
• Vitellogenin and Vitellogenin-Like Genes in the Brown Planthopper

  2019cites this paper
• Vector bionomics and malaria transmission in an area of sympatry of An. arabiensis, An. coluzzii and An. gambiae.

  2019cites this paper
• Combined infection with Tomato yellow leaf curl virus and Rickettsia influences fecundity, attraction to infected plants and expression of immunity-related genes in the whitefly Bemisia tabaci.

  2019cites this paper
• 20-hydroxyecdysone (20E) primes innate immune responses that limit bacteria and malaria parasite survival in Anopheles gambiae

  2019cites this paper
• 3D imaging of undissected optically cleared Anopheles stephensi mosquitoes infected with Plasmodium parasites

  2019cites this paper
• The male mosquito contribution towards malaria transmission: Mating influences the Anopheles female midgut transcriptome and increases female susceptibility to human malaria parasites

  2019cites this paper
• Recherche des molécules antiparasitaires à l’interface de l’ethnopharmacologie, des sciences analytiques et de la biologie

  2018cites this paper
• Effects of “Candidatus Liberibacter solanacearum” (haplotype B) on Bactericera cockerelli fitness and vitellogenesis

  2018cites this paper
• Insect tissue-specific vitellogenin facilitates transmission of plant virus

  2018cites this paper
• Bactericera cockerelli vitellogenin‐6 like, a vitellogenin without a direct reproductive function?

  2018cites this paper
• Diverse Host and Restriction Factors Regulate Mosquito-Pathogen Interactions.

  2018cites this paper
• Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence

  2018cites this paper
• Lipid metabolism in insect disease vectors.

  2018cites this paper
• Mosquitoes and the Lymphatic Filarial Parasites: Research Trends and Budding Roadmaps to Future Disease Eradication

  2018cites this paper
• CTL14, a recognition receptor induced in late stage larvae, modulates anti‐fungal immunity in cotton bollworm Helicoverpa armigera

  2018cites this paper
• Molecular and ecological factors modulating the fitness of Anopheles gambiae mosquitoes infected with Plasmodium falciparum

  2018cites this paper
• Anopheles gambiae larvae mount stronger immune responses against bacterial infection than adults: evidence of adaptive decoupling in mosquitoes

  2017cites this paper
• Transgenic Expression of the Anti-parasitic Factor TEP1 in the Malaria Mosquito Anopheles gambiae

  2017cites this paper
• Response to Blood Meal in the Fat Body of Anopheles stephensi Using Quantitative Proteomics: Toward New Vector Control Strategies Against Malaria

  2017influential citation
• MicroRNA Tissue Atlas of the Malaria Mosquito Anopheles gambiae

  2017cites this paper
• Anopheline Reproductive Biology: Impacts on Vectorial Capacity and Potential Avenues for Malaria Control.

  2017influential citation
• Protein content of the Hylesia metabus egg nest setae (Cramer [1775]) (Lepidoptera: Saturniidae) and its association with the parental investment for the reproductive success and lepidopterism.

  2017cites this paper
• Hormone and receptor interplay in the regulation of mosquito lipid metabolism

  2017cites this paper
• Transgenic Expression of the Antiparasitic Factor TEP 1 in the Malaria Mosquito Anopheles gambiae

  2017cites this paper
• Non-competitive resource exploitation within-mosquito shapes evolution of malaria virulence

  2017cites this paper
• Functional Interaction between Apolipophorins and Complement Regulate the Mosquito Immune Response to Systemic Infections

  2016cites this paper
• Plasmodium Oocysts: Overlooked Targets of Mosquito Immunity.

  2016cites this paper
• Wolbachia infections in natural Anopheles populations affect egg laying and negatively correlate with Plasmodium development

  2016cites this paper
• Molecular Profiling of Phagocytic Immune Cells in Anopheles gambiae Reveals Integral Roles for Hemocytes in Mosquito Innate Immunity*

  2016cites this paper
• Mosquito gut antiparasitic and antiviral immunity.

  2016cites this paper
• Novel factors of Anopheles gambiae haemocyte immune response to Plasmodium berghei infection

  2016cites this paper
• Fitness consequences of altered feeding behavior in immune-challenged mosquitoes

  2016cites this paper
• The Complement System of Malaria Vector Mosquitoes

  2016cites this paper
• Exome and Transcriptome Sequencing of Aedes aegypti Identifies a Locus That Confers Resistance to Brugia malayi and Alters the Immune Response

  2015cites this paper
• Tools for Anopheles gambiae Transgenesis

  2015influential citation
• Interactions between a fungal entomopathogen and malaria parasites within a mosquito vector

  2015cites this paper
• Immune-Relevant and Antioxidant Activities of Vitellogenin and Yolk Proteins in Fish

  2015cites this paper
• Don't pull the plug! the Drosophila mating plug preserves fertility

  2015cites this paper
• An unexpected cost of sex

  2015cites this paper
• The effect of environmental and metabolic stress on the expression of insecticide resistance phenotype and longevity in the Southern African malaria vectors anopheles arabiensis and anopheles funestus

  2015cites this paper
• Population structure and genome-wide association in the malaria vectors Anopheles gambiae and Anopheles coluzzii

  2015cites this paper