Structural control of chemoselectivity, stereoselectivity, and substrate specificity in membrane-bound fatty acid acetylenases and desaturases.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Biochemistry

• Publication date

  2009-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/bi901605dPMID 19950909
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Desaturases: Emerging Models for Understanding Functional Diversification of Diiron-containing Enzymes*

  2009cited by this paper
• Primary Structure, Regioselectivity, and Evolution of the Membrane-bound Fatty Acid Desaturases of Claviceps purpurea*

  2007cited by this paper
• Fatty Acid Desaturases: Selecting the Dehydrogenation Channel

  2004cited by this paper
• Properties of two multifunctional plant fatty acid acetylenase/desaturase enzymes.

  2004cited by this paper
• Fatty acid desaturases: selecting the dehydrogenation channel.

  2004cited by this paper
• Dimorphecolic Acid Is Synthesized by the Coordinate Activities of Two Divergent Δ12-Oleic Acid Desaturases*

  2004cited by this paper
• Mechanistic study of an improbable reaction: alkene dehydrogenation by the delta12 acetylenase of Crepis alpina.

  2003cited by this paper
• Mutagenesis of the borage Delta(6) fatty acid desaturase.

  2000cited by this paper
• Identification of non-heme diiron proteins that catalyze triple bond and epoxy group formation.

  1998influential reference
• Catalytic plasticity of fatty acid modification enzymes underlying chemical diversity of plant lipids.

  1998influential reference
• DESATURATION AND RELATED MODIFICATIONS OF FATTY ACIDS1.

  1998cited by this paper
• Redesign of soluble fatty acid desaturases from plants for altered substrate specificity and double bond position.

  1997cited by this paper
• Functional Expression of the Extraplastidial Arabidopsis thaliana Oleate Desaturase Gene (FAD2) in Saccharomyces cerevisiae

  1996cited by this paper
• Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-CoA desaturase, and are conserved in alkane hydroxylase and xylene monooxygenase.

  1994cited by this paper
• CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

  1994cited by this paper
• Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis.

  1994cited by this paper
• In vivo desaturation of cis-delta 9-monounsaturated to cis-delta 9,12-diunsaturated alkenylether glycerolipids.

  1993cited by this paper
• A family of yeast expression vectors containing the phage f1 intergenic region.

  1987cited by this paper
• Selective constraint in protein polymorphism: study of the effectively neutral mutation model by using an improved pseudosampling method.

  1983cited by this paper

• Terminal alkyne formation by a pyridoxal phosphate-dependent enzyme

  2025cites this paper
• Desaturase specificity is controlled by the physicochemical properties of a single amino acid residue in the substrate binding tunnel

  2020cites this paper
• Global gene expression analyses of the alkamide-producing plant Heliopsis longipes supports a polyketide synthase-mediated biosynthesis pathway

  2020cites this paper
• The FATTY ACID DESATURASE2 Family in Tomato Contributes to Primary Metabolism and Stress Responses1[OPEN]

  2019cites this paper
• Characterization and molecular docking of new Δ17 fatty acid desaturase genes from Rhizophagus irregularis and Octopus bimaculoides

  2019cites this paper
• Identification of a mutant from Arachis veigae with enhanced seed oleic and very long-chain fatty acid content

  2019cites this paper
• Structural determinant of functionality in acyl lipid desaturases[S]

  2018cites this paper
• Molecular mechanism of substrate preference for ω-3 fatty acid desaturase from Mortierella alpina by mutational analysis and molecular docking

  2018cites this paper
• Biotechnological potential of insect fatty acid-modifying enzymes

  2017cites this paper
• Importance of phosphatidylcholine on the chloroplast surface.

  2017cites this paper
• Directed evolution increases desaturation of a cyanobacterial fatty acid desaturase in eukaryotic expression systems

  2016cites this paper
• Sequence variation determining stereochemistry of a Δ11 desaturase active in moth sex pheromone biosynthesis.

  2016cites this paper
• Studies on the structure and function of fatty acid desaturase

  2016cites this paper
• Identification of amino acid residues that determine the substrate specificity of mammalian membrane-bound front-end fatty acid desaturases[S]

  2016cites this paper
• Lipid trafficking at endoplasmic reticulum-chloroplast membrane contact sites.

  2015cites this paper
• ALA10, a Phospholipid Flippase, Controls FAD2/FAD3 Desaturation of Phosphatidylcholine in the ER and Affects Chloroplast Lipid Composition in Arabidopsis thaliana1

  2015cites this paper
• desaturation of phosphatidylcholine in the ER, and affects chloroplast lipid composition in Arabidopsis

  2015cites this paper
• De novo biosynthesis of terminal alkyne-labeled natural products.

  2015cites this paper
• The molecular basis of conjugated polyyne biosynthesis in phytopathogenic bacteria.

  2014cites this paper
• Metabolic engineering of plant oils and waxes for use as industrial feedstocks.

  2013cites this paper
• ω3 fatty acid desaturases from microorganisms: structure, function, evolution, and biotechnological use

  2013cites this paper
• Conjugated Fatty Acid Synthesis

  2012cites this paper
• Elucidation of the Pathway to Astaxanthin in the Flowers of Adonis aestivalis[C][W]

  2011cites this paper
• Highly specific methyl-end fatty-acid desaturases of trypanosomatids.

  2011cites this paper
• Mechanistic and Structural Insights into the Regioselectivity of an Acyl-CoA Fatty Acid Desaturase via Directed Molecular Evolution*

  2011cites this paper
• Dissection of the phytohormonal regulation of trichome formation and biosynthesis of the antimalarial compound artemisinin in Artemisia annua plants.

  2011cites this paper