Biomarkers Utility for Sepsis Patients Management

Sepsis is a global problem in either developing or developed countries and it is expected that the number of patients with sepsis and septic shock will tremendously increase in next decades also because of the antibiotic resistance growing issue worldwide. Criteria for sepsis diagnosis and prognosis have been recently established, but still a further understanding of the role of biomarkers in this setting is needed. Better utilization of biomarkers such as white blood cell count, CRP, lactate, procalcitonin, presepsin and bioadrenomedullin in sepsis patients, a state of the art on how to use them is needed. This review will focus on the actual recognized role of sepsis biomarkers not only for diagnosis purpose but also to improve patients treatment results in order to reduce mortality, hospital length of stay and cost related.

• Publication year

  2018

• Venue

  Biomarker - Indicator of Abnormal Physiological Process

• Publication date

  2018-09-05

• Fields of study

  Medicine

• Identifiers
  DOI 10.5772/INTECHOPEN.76107
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit

  2017cited by this paper
• Systemic Inflammatory Response Syndrome, Quick Sequential Organ Function Assessment, and Organ Dysfunction: Insights From a Prospective Database of ED Patients With Infection

  2017cited by this paper
• Management of Sepsis and Septic Shock.

  2017influential reference
• Procalcitonin, C‐reactive protein, and presepsin for the diagnosis of sepsis in adults and children

  2017cited by this paper
• Comparison of diagnostic accuracy in sepsis between presepsin, procalcitonin, and C-reactive protein: a systematic review and meta-analysis

  2017cited by this paper
• Diagnostic accuracy of procalcitonin, neutrophil-lymphocyte count ratio, C-reactive protein, and lactate in patients with suspected bacterial sepsis

  2017cited by this paper
• Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

  2016influential reference
• Micro-organismen en infectieziekten bij de mens: algemene principes

  2016cited by this paper
• New clinical criteria for septic shock: serum lactate level as new emerging vital sign.

  2016cited by this paper
• Cost-effectiveness analysis of early point-of-care lactate testing in the emergency department.

  2016cited by this paper
• Comparison of diagnostic and prognostic utility of lactate and procalcitonin for sepsis in adult cancer patients presenting to emergency department with systemic inflammatory response syndrome

  2016cited by this paper
• Inflammation and Inflammatory Diseases, Markers, and Mediators: Role of CRP in Some Inflammatory Diseases

  2016cited by this paper
• Cost-Effectiveness of Point-of-Care C-Reactive Protein Tests for Respiratory Tract Infection in Primary Care in England

  2015cited by this paper
• Accuracy of Presepsin in Sepsis Diagnosis: A Systematic Review and Meta-Analysis

  2015cited by this paper
• Predicting mortality in patients with acute heart failure: Role of risk scores.

  2015cited by this paper
• Diagnostic and prognostic utility of soluble CD 14 subtype (presepsin) for severe sepsis and septic shock during the first week of intensive care treatment

  2014cited by this paper
• Biomarkers and Molecular Analysis to Improve Bloodstream Infection Diagnostics in an Emergency Care Unit

  2014cited by this paper
• Presepsin as a novel sepsis biomarker

  2014cited by this paper
• Prognostic scores for early stratification of septic patients admitted to an emergency department-high dependency unit

  2014cited by this paper
• Diagnostic characteristics of a clinical screening tool in combination with measuring bedside lactate level in emergency department patients with suspected sepsis.

  2014cited by this paper
• Usefulness of presepsin in the diagnosis of sepsis in patients with or without acute kidney injury

  2014cited by this paper
• Plasma adrenomedullin is associated with short-term mortality and vasopressor requirement in patients admitted with sepsis

  2014cited by this paper
• Sensitivity and Specificity of Procalcitonin in Predicting Bacterial Infections in Patients With Renal Impairment

  2014cited by this paper
• Cost-Effectiveness of Procalcitonin-Guided Antibiotic Use in Community Acquired Pneumonia

  2013cited by this paper
• Lactate metabolism in chronic liver disease

  2013cited by this paper
• Opinion paper on innovative approach of biomarkers for infectious diseases and sepsis management in the emergency department

  2013cited by this paper
• Diagnostic and prognostic value of presepsin in the management of sepsis in the emergency department: a multicenter prospective study

  2013cited by this paper
• Host innate immune responses to sepsis

  2013cited by this paper
• Severe sepsis and septic shock.

  2013cited by this paper
• Presepsin (sCD14-ST) in preoperative diagnosis of abdominal sepsis

  2013cited by this paper
• Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

  2013cited by this paper
• Procalcitonin and mid-regional pro-adrenomedullin test combination in sepsis diagnosis

  2013cited by this paper
• Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy

  2013cited by this paper
• Usefulness of severity scores in patients with suspected infection in the emergency department: a systematic review.

  2012cited by this paper
• Usefulness of presepsin (Soluble CD14 subtype) as a diagnostic marker of sepsis

  2012influential reference
• A New Marker For The Diagnosıs Of Sepsis: Presepsin

  2012cited by this paper
• Adrenomedullin and cardiovascular diseases

  2012cited by this paper
• Combined Values of Serum Albumin, C-Reactive Protein and Body Mass Index at Dialysis Initiation Accurately Predicts Long-Term Mortality

  2012cited by this paper
• Comparison of C-reactive protein and high-sensitivity C-reactive protein levels in patients on hemodialysis.

  2012cited by this paper
• suPAR as a prognostic biomarker in sepsis

  2012cited by this paper
• Utility of Procalcitonin (PCT) and Mid regional pro-Adrenomedullin (MR-proADM) in risk stratification of critically ill febrile patients in Emergency Department (ED). A comparison with APACHE II score

  2012influential reference
• Procalcitonin as a marker for the detection of bacteremia and sepsis in the emergency department.

  2011cited by this paper
• Diagnostic and prognostic biomarkers of sepsis in critical care.

  2011cited by this paper
• New technology for rapid molecular diagnosis of bloodstream infections

  2010cited by this paper
• Additional value of procalcitonin for diagnosis of infection in patients with fever at the emergency department

  2010cited by this paper
• Mechanisms of leukocyte distribution during sepsis: an experimental study on the interdependence of cell activation, shear stress and endothelial injury

  2010cited by this paper
• Biomarkers in lower respiratory tract infections.

  2010cited by this paper
• Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trial.

  2010cited by this paper
• Blood cultures: key elements for best practices and future directions

  2010cited by this paper
• The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis

  2010cited by this paper
• Prognostic value of procalcitonin in community-acquired pneumonia

  2010cited by this paper
• Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and a therapeutic target

  2010cited by this paper
• The stress hormone copeptin: a new prognostic biomarker in acute illness.

  2010cited by this paper
• Sepsis biomarkers: a review

  2010cited by this paper
• Prediction about severity and outcome of sepsis by pro-atrial natriuretic peptide and pro-adrenomedullin.

  2010cited by this paper
• Serum procalcitonin levels in patients with multiple injuries including visceral trauma.

  2009cited by this paper
• Diagnostic Efficacy and Prognostic Value of Serum Procalcitonin Concentration in Patients With Suspected Sepsis

  2009cited by this paper
• The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation*

  2009cited by this paper
• Assessment of pro-vasopressin and pro-adrenomedullin as predictors of 28-day mortality in septic shock patients

  2009cited by this paper
• Procalcitonin as a prognostic and diagnostic tool for septic complications after major trauma*

  2009cited by this paper
• Empirical Antimicrobial Therapy for Bloodstream Infection Due to Methicillin-Resistant Staphylococcus aureus: No Better than a Coin Toss

  2009cited by this paper
• Multiplex PCR To Diagnose Bloodstream Infections in Patients Admitted from the Emergency Department with Sepsis

  2009cited by this paper
• Procalcitonin levels and bacterial aetiology among COPD patients admitted to the ICU with severe pneumonia: a prospective cohort study

  2009cited by this paper
• Procalcitonin in patients with acute coronary syndromes and cardiogenic shock submitted to percutaneous coronary intervention

  2009cited by this paper
• Procalcitonin and acute coronary syndromes: a new biomarker for an old disease

  2009cited by this paper
• Biomarkers of sepsis

  2009cited by this paper
• Accuracy of white blood cell count, C-reactive protein, interleukin-6 and tumor necrosis factor alpha for diagnosing late neonatal sepsis.

  2008cited by this paper
• Procalcitonin predicts patients at low risk of death from community-acquired pneumonia across all CRB-65 classes

  2008cited by this paper
• PROCALCITONIN AS A PREDICTOR OF SEVERE APPENDICITIS IN CHILDREN

  2008cited by this paper
• Validation of the Mortality in Emergency Department Sepsis (MEDS) score in patients with the systemic inflammatory response syndrome (SIRS)*

  2008cited by this paper
• Severity scoring systems in the critically ill

  2008cited by this paper
• Biomarkers: diagnosis and risk assessment in sepsis.

  2008cited by this paper
• Acurácia diagnóstica do leucograma, proteína C-reativa, interleucina-6 e fator de necrose tumoral-alfa na sepse neonatal tardia

  2008cited by this paper
• Serum Soluble ICAM-1, VCAM-1, L-Selectin, and P-Selectin Levels as Markers of Infection and their Relation to Clinical Severity in Neonatal Sepsis

  2007cited by this paper
• Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators

  2007cited by this paper
• Molecular diagnosis of bloodstream infections caused by non-cultivable bacteria.

  2007cited by this paper
• Serum procalcitonin measurement as diagnostic and prognostic marker in febrile adult patients presenting to the emergency department

  2007cited by this paper
• LACTATE – A MARKER FOR SEPSIS AND TRAUMA

  2007cited by this paper
• Diagnostic value of signs, symptoms and laboratory values in lower respiratory tract infection.

  2006cited by this paper
• Management of sepsis.

  2006cited by this paper
• Procalcitonin kinetics in the prognosis of severe community-acquired pneumonia

  2006cited by this paper
• Procalcitonin—A marker or modulator of the acute immune response?

  2005cited by this paper
• Prolonged incubation and extensive subculturing do not increase recovery of clinically significant microorganisms from standard automated blood cultures.

  2005cited by this paper
• Correlation of procalcitonin and C-reactive protein to inflammation, complications, and outcome during the intensive care unit course of multiple-trauma patients

  2005cited by this paper
• Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study

  2005cited by this paper
• What cardiologists do need to know about procalcitonin.

  2005cited by this paper
• Adrenomedullin is both proinflammatory and antiinflammatory: its effects on gene expression and secretion of cytokines and macrophage migration inhibitory factor in NR8383 macrophage cell line.

  2005cited by this paper
• Beyond sepsis pathophysiology with cytokines: what is their value as biomarkers for disease severity?

  2005cited by this paper
• Serum lactate as a predictor of mortality in emergency department patients with infection.

  2005cited by this paper
• Routine Incubation of BacT/ALERT FA and FN Blood Culture Bottles for More than 3 Days May Not Be Necessary

  2005cited by this paper
• Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study

  2004cited by this paper
• New developments in the diagnosis of bloodstream infections.

  2004cited by this paper
• Optimal testing parameters for blood cultures.

  2004cited by this paper
• Bacteremic elder emergency department patients: procalcitonin and white count.

  2004cited by this paper
• Toward resolving the challenges of sepsis diagnosis.

  2004cited by this paper
• Adrenomedullin--what do we know 10 years since its discovery?

  2004cited by this paper
• Clinical review 167: Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors.

  2004cited by this paper
• C-reactive protein levels correlate with mortality and organ failure in critically ill patients.

  2003influential reference
• 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

  2003cited by this paper
• C-Reactive Protein, the Metabolic Syndrome, and Risk of Incident Cardiovascular Events: An 8-Year Follow-Up of 14 719 Initially Healthy American Women

  2003cited by this paper

• Role of procalcitonin, C-reactive protein and ferritin in cytokine release syndrome after CAR T-cell therapy in children and young adults

  2025influential citation
• Monocyte Distribution Width as a predictor of community acquired sepsis in patients prospectively enrolled at the Emergency Department

  2022cites this paper