Early complement activation and decreased levels of glycosylphosphatidylinositol-anchored complement inhibitors in human and experimental diabetic retinopathy.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Diabetes

• Publication date

  2002-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2337/DIABETES.51.12.3499PMID 12453906
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Complement. Second of two parts.

  2001cited by this paper
• Report about a three months' stay in Milan supported by an EFSD MSD Travel Fellowship for Young Scientists 1999.

  2001cited by this paper
• Early cellular and molecular changes induced by diabetes in the retina

  2001cited by this paper
• IGF-I mRNA and signaling in the diabetic retina.

  2001cited by this paper
• Increased prevalence of microthromboses in retinal capillaries of diabetic individuals.

  2001cited by this paper
• COMPLEMENT AT THE INTERFACE BETWEEN INNATE AND ADAPTIVE IMMUNITY

  2001cited by this paper
• Bax is increased in the retina of diabetic subjects and is associated with pericyte apoptosis in vivo and in vitro.

  2000cited by this paper
• Local activation of the complement system in endoneurial microvessels of diabetic neuropathy

  2000cited by this paper
• Glucose-induced loss of glycosyl-phosphatidylinositol-anchored membrane regulators of complement activation (CD59, CD55) by in vitro cultured human umbilical vein endothelial cells

  2000cited by this paper
• Molecular basis for a link between complement and the vascular complications of diabetes.

  2000cited by this paper
• A critical role for murine complement regulator crry in fetomaternal tolerance.

  2000cited by this paper
• Complement-endothelial cell interactions: pathophysiological implications.

  1999cited by this paper
• The caveolae membrane system.

  1998cited by this paper
• Complement activation occurs on subendothelial extracellular matrix in vitro and is initiated by retraction or removal of overlying endothelial cells.

  1998cited by this paper
• Complement regulatory proteins in glomerular diseases.

  1998cited by this paper
• Expression of vascular endothelial growth factor in the human retina and in nonproliferative diabetic retinopathy.

  1998cited by this paper
• The Glycosylation of the Complement Regulatory Protein, Human Erythrocyte CD59*

  1997cited by this paper
• The glycosylation of the complement regulatory protein, human erythrocyte CD59.

  1997cited by this paper
• Glucose-induced sequential processing of a glycosyl-phosphatidylinositol-anchored ectoprotein in Saccharomyces cerevisiae

  1996cited by this paper
• Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy.

  1996cited by this paper
• Immunological detection of glycated proteins in normal and streptozotocin-induced diabetic rats using anti hexitol-lysine IgG.

  1995cited by this paper
• Activation of the alternative pathway of human complement by apoptotic human umbilical vein endothelial cells.

  1994cited by this paper
• Loss of expression of protectin (CD59) is associated with complement membrane attack complex deposition in myocardial infarction.

  1992cited by this paper
• Effects of the membrane attack complex of complement on nucleated cells.

  1992cited by this paper
• Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy.

  1991cited by this paper
• Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype

  1991cited by this paper
• Characteristics and Mechanisms of High-Glucose–Induced Overexpression of Basement Membrane Components in Cultured Human Endothelial Cells

  1991cited by this paper
• Inherited complete deficiency of 20-kilodalton homologous restriction factor (CD59) as a cause of paroxysmal nocturnal hemoglobinuria.

  1990cited by this paper
• Ultrastructural localization of the membrane attack complex of complement in human renal tissues.

  1987cited by this paper
• Assembly of the functional membrane attack complex of human complement: formation of disulfide-linked C9 dimers.

  1981cited by this paper
• Platelet Aggregation and Coagulation in the Pathogenesis of Diabetic Retinopathy in Rats

  1981cited by this paper
• Basal Lamina Layering in Diabetes Mellitus: Evidence for Accelerated Rate of Cell Death and Cell Regeneration

  1974cited by this paper

• Complement at the crossroads of inflammation and metabolism: implications for diabetes and metabolic functions.

  2025cites this paper
• Retinal Degenerative Diseases: Complement system-Microglia Crosstalk.

  2025cites this paper
• Exploration Progress on Inflammatory Responses and Immune Regulatory Mechanisms in Diabetic Retinopathy

  2025cites this paper
• THE ROLE OF MANNOSE-BINDING LECTIN (MBL) IN DIABETIC RETINOPATHY: A SCOPING REVIEW.

  2024cites this paper
• Complement regulation in the eye: implications for age-related macular degeneration

  2024cites this paper
• The complement system and diabetic retinopathy.

  2024cites this paper
• The rs2564978(T) Allele Associated with Severe Influenza A Disrupts the Binding Site for Myeloid Differentiation Factor PU.1 and Reduces CD55/DAF Gene Promoter Activity in Macrophages

  2024cites this paper
• rs2564978(T) allele associated with severe influenza a disrupts binding site for myeloid differentiation factor PU.1 and reduces CD55/DAF gene promoter activity in macrophages

  2024cites this paper
• Aqueous humor proteomics analyzed by bioinformatics and machine learning in PDR cases versus controls

  2024cites this paper
• Therapeutic targeting of the complement system in ocular disease.

  2023cites this paper
• Immune Fingerprint in Diabetes: Ocular Surface and Retinal Inflammation

  2023cites this paper
• (Patho)Physiology of Glycosylphosphatidylinositol-Anchored Proteins I: Localization at Plasma Membranes and Extracellular Compartments

  2023cites this paper
• Inflammation: The Link between Neural and Vascular Impairment in the Diabetic Retina and Therapeutic Implications

  2023cites this paper
• Correlation of Complement Activation in Aqueous and Vitreous in Patients With Proliferative Diabetic Retinopathy

  2022cites this paper
• The Role of Adaptive Immunity in Diabetic Retinopathy

  2022cites this paper
• OPTH_A_346065 135..143

  2022cites this paper
• As in Real Estate, Location Matters: Cellular Expression of Complement Varies Between Macular and Peripheral Regions of the Retina and Supporting Tissues

  2022cites this paper
• Emerging opportunities for C3 inhibition in the eye.

  2022cites this paper
• Lipids, hyperreflective crystalline deposits and diabetic retinopathy: potential systemic and retinal-specific effect of lipid-lowering therapies

  2022cites this paper
• Intravitreal Injection for Diabetic Macular Edema as Adjunctive Therapy for Proliferative Diabetic Retinopathy: A Retrospective Study

  2022cites this paper
• Inflammatory mediators in diabetic retinopathy: Deriving clinicopathological correlations for potential targeted therapy

  2021cites this paper
• Research Progress of circRNAs in Inflammatory Mechanisms of Diabetic Retinopathy: An Emerging Star with Potential Therapeutic Targets

  2021cites this paper
• The NLRP3 inflammasome in age-related eye disease: Evidence-based connexin hemichannel therapeutics.

  2021cites this paper
• Possible roles of anti-type II collagen antibody and innate immunity in the development and progression of diabetic retinopathy

  2021cites this paper
• Extensive Sub-RPE Complement Deposition in a Nonhuman Primate Model of Early-Stage Diabetic Retinopathy

  2021cites this paper
• Exposure to Porphyromonas gingivalis and Modifiable Risk Factors Modulate Risk for Early Diabetic Retinopathy

  2021cites this paper
• The innate immune system in diabetic retinopathy.

  2021cites this paper
• Complement activation in obesity, insulin resistance, and type 2 diabetes mellitus

  2020cites this paper
• Complement Activation in the Vitreous of Patients With Proliferative Diabetic Retinopathy

  2020cites this paper
• Patrolling Monocytes Are Recruited and Activated by Diabetes to Protect Retinal Microvessels

  2020cites this paper
• Fufang Xueshuantong alleviates diabetic retinopathy by activating the PPAR signalling pathway and complement and coagulation cascades.

  2020cites this paper
• Effects of Complement Regulators and Chemokine Receptors in Type 2 Diabetes

  2020cites this paper
• Association between severe diabetic retinopathy and lectin pathway proteins - an 18-year follow-up study with newly diagnosed type 1 diabetes patients.

  2020cites this paper
• Extracellular Vesicle-Induced Classical Complement Activation Leads to Retinal Endothelial Cell Damage via MAC Deposition

  2020influential citation
• A Systematic Investigation on Complement Pathway Activation in Diabetic Retinopathy

  2020cites this paper
• Role of vitamin D in diabetic retinopathy: Pathophysiological and clinical aspects

  2020cites this paper
• Role of complement in diabetes.

  2019cites this paper
• Diabetic Retinopathy, lncRNAs, and Inflammation: A Dynamic, Interconnected Network

  2019cites this paper
• A systematic investigation on the involvement of complement pathway in diabetic retinopathy

  2019cites this paper
• The role of inflammation in diabetic eye disease

  2019cites this paper
• INCREASED COMPLEMENT LEVELS IN HUMAN VITREOUS ASPIRATES OF PROLIFERATIVE DIABETIC RETINOPATHY AND RETINAL DETACHMENT EYES.

  2019cites this paper
• Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina

  2019cites this paper
• Decreased Ficolin-3-mediated Complement Lectin Pathway Activation and Alternative Pathway Amplification During Bacterial Infections in Patients With Type 2 Diabetes Mellitus

  2019cites this paper
• Inflammation In The Pathogenesis Of Diabetic Retinopathy

  2018cites this paper
• Complement activation in the arteries of patients with severe atherosclerosis.

  2018cites this paper
• Complement 7 Is Up-Regulated in Human Early Diabetic Kidney Disease.

  2018cites this paper
• Modulation of three key innate immune pathways for the most common retinal degenerative diseases

  2018cites this paper
• The Role of Microglia in Diabetic Retinopathy: Inflammation, Microvasculature Defects and Neurodegeneration

  2018cites this paper
• The meaning of the cellular release of glycosylphosphatidylinositol–anchored proteins–Potential use as biomarkers

  2018cites this paper
• Cell type-specific complement expression from healthy and diseased retinae

  2018cites this paper
• An investigation into changes to trace metals and metabolic profiling in the diabetic retina

  2018cites this paper
• Role of Inflammation in Diabetic Retinopathy

  2018cites this paper
• A model to study complement involvement in experimental retinal degeneration

  2018cites this paper
• Complement C3 and Risk of Diabetic Microvascular Disease: A Cohort Study of 95202 Individuals from the General Population.

  2018cites this paper
• Identification of urinary biomarkers for the prediction of gestational diabetes mellitus in early second trimester of young gravidae based on iTRAQ quantitative proteomics.

  2018cites this paper
• Plasma Exosomes Contribute to Microvascular Damage in Diabetic Retinopathy by Activating the Classical Complement Pathway

  2018cites this paper
• Molecular pathobiology of Diabetic Retinopathy

  2018cites this paper
• Deficiency of the complement regulatory protein CD59 accelerates the development of diabetes-induced atherosclerosis in mice.

  2017cites this paper
• The eye as a complement dysregulation hotspot

  2017cites this paper
• Diabetic retinopathy and dysregulated innate immunity

  2017cites this paper
• Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration

  2017cites this paper
• Interaction between Multimeric von Willebrand Factor and Complement: A Fresh Look to the Pathophysiology of Microvascular Thrombosis

  2017cites this paper
• The Diabetic Retina: Anatomy and Pathophysiology

  2017cites this paper
• Antiglycemic and anticomplementary potential of an edible plant Gnaphalium hypoleucum DC

  2017cites this paper
• Interaction between the metalloprotease ADAMTS-13 and the proteins of the alternative pathway of the complement system

  2017cites this paper
• Version : Peer reviewed version Queen ' s University Belfast-Research Portal : Link to publication record in Queen ' s University Belfast Research Portal

  2016cites this paper
• Genetic Investigation of Complement Pathway Genes in Type 2 Diabetic Retinopathy: An Inflammatory Perspective

  2016cites this paper
• Presence of retinal pericyte-reactive autoantibodies in diabetic retinopathy patients

  2016cites this paper
• The role of pharmacogenetics and advances in gene therapy in the treatment of diabetic retinopathy.

  2016cites this paper
• Association of Low Ficolin–Lectin Pathway Parameters with Cardiac Syndrome X

  2016cites this paper
• Soluble CD59 is a Novel Biomarker for the Prediction of Obstructive Chronic Lung Allograft Dysfunction After Lung Transplantation

  2016cites this paper
• Targeting the complement system for the management of retinal inflammatory and degenerative diseases

  2016cites this paper
• Angiogenesis and Inflammation Crosstalk in Diabetic Retinopathy

  2016cites this paper
• Novel approaches for treating diabetic retinopathy based on recent pathogenic evidence.

  2015cites this paper
• Role of complement and complement regulatory proteins in the complications of diabetes.

  2015cites this paper
• A preliminary study on the role of the complement regulatory protein, cluster of differentiation 55, in mice with diabetic neuropathic pain.

  2015cites this paper
• Estudio de la variación a largo plazo de los parámetros bioquímicos metabólicos en pacientes con obesidad mórbida e intervenidos mediante bypass gástrico laparoscópico

  2015cites this paper
• Complement and Complement Regulatory Proteins in Diabetes

  2015cites this paper
• Glycation of the complement regulatory protein CD59 is a novel biomarker for glucose handling in humans.

  2014cites this paper
• Complement regulatory protein CD46 protects against choroidal neovascularization in mice.

  2014cites this paper
• Protective Effects of Astragaloside IV on db/db Mice with Diabetic Retinopathy

  2014cites this paper
• Correlation between metabolic controls and changes in retina in patients having diabetes.

  2014cites this paper
• Proteomic analysis of human vitreous humor

  2014cites this paper
• Retinal and nonocular abnormalities in Cyp27a1(-/-)Cyp46a1(-/-) mice with dysfunctional metabolism of cholesterol.

  2014cites this paper
• Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions.

  2013cites this paper
• Association of CFH and CFB Gene Polymorphisms with Retinopathy in Type 2 Diabetic Patients

  2013cites this paper
• Complement expression in retinal pigment epithelial cells is modulated by activated macrophages.

  2013cites this paper
• Single injection of triamcinolone versus three repeated injections of bevacizumab for treatment of diabetic macular edema

  2013cites this paper
• A specific and sensitive assay for blood levels of glycated CD59: A novel biomarker for diabetes

  2013cites this paper
• Influência da hiperglicemia sobre os perfis de expressão transcricional de mRNAs e microRNAs em linfócitos de pacientes com Diabetes Mellitus tipo 2

  2013cites this paper
• Adeno-Associated Virus Mediated Delivery of a Non-Membrane Targeted Human Soluble CD59 Attenuates Some Aspects of Diabetic Retinopathy in Mice

  2013cites this paper
• Modulation of retinal Müller cells by complement receptor C5aR.

  2013cites this paper
• Complement C3: an emerging risk factor in cardiometabolic disease

  2012cites this paper
• Gene expression profiles displayed by peripheral blood mononuclear cells from patients with type 2 diabetes mellitus focusing on biological processes implicated on the pathogenesis of the disease.

  2012cites this paper
• Correlation of complement fragment C5a with inflammatory cytokines in the vitreous of patients with proliferative diabetic retinopathy

  2012cites this paper
• [Role of CFH and ARMS2 polymorphisms in retinopathy and coronary artery disease in type 1 diabetes].

  2012cites this paper
• Corticosteroid Use for Diabetic Macular Edema: Old Fad or New Trend?

  2012cites this paper
• Drosophila GPI-mannosyltransferase 2 is required for GPI anchor attachment and surface expression of chaoptin

  2012cites this paper
• Elevated Properdin and Enhanced Complement Activation in First-Degree Relatives of South Asian Subjects With Type 2 Diabetes

  2012cites this paper
• Complement involvement in neovascular ocular diseases.

  2012cites this paper