Metabolism of cyclophosphamide by rat hepatic microsomes.

No abstract is available for this paper.

• Publication year

  1971

• Venue

  Cancer Research

• Publication date

  1971-06-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  PMID 4397323
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanism of cyclophosphamide activation.

  1970cited by this paper
• Enzymatic basis of cyclophosphamide activation by hepatic microsomes of the rat.

  1970cited by this paper
• Two-substrate kinetics of drug-metabolizing enzyme systems of hepatic microsomes.

  1970cited by this paper
• Microsomal activation of cyclophosphamide in vivo.

  1970cited by this paper
• Isolation and identification of 4-ketocyclophosphamide, a possible active form of the antitumor agent cyclophosphamide.

  1970cited by this paper
• Effect of microsomal enzyme modifiers on toxicity and therapeutic activity of cyclophosphamide in mice.

  1969cited by this paper
• Induction of Drug Metabolism: II. Qualitative Differences in the Microsomal N-Demethylating Systems Stimulated by Polycyclic Hydrocarbons and by Phenobarbital

  1969cited by this paper
• Effect of microsomal enzyme modifiers on toxicity and therapeutic activity of cyclophosphamide in mice.

  1969cited by this paper
• Kinetics of enzyme reactions with competing alternative substrates.

  1968cited by this paper
• Effect of phenobarbital and SKF 525-A on the teratogenicity of cyclophosphamide in mice.

  1968cited by this paper
• Effect of Chloramphenicol on the Metabolism and Lethality of Cyclophosphamide in Rats∗

  1968cited by this paper
• Kinetics of Enzyme Reactions with Competing Alternative Substrates

  1968cited by this paper
• On the use of nicotinamide in assays for microsomal mixed-function oxidase activity.

  1967cited by this paper
• Metabolism of radioactive cyclophosphamide. Animal tests and clinical studies

  1967cited by this paper
• Metabolism of cyclophosphamide

  1967cited by this paper
• Biochemistry of drug oxidation and reduction by enzymes in hepatic endoplasmic reticulum.

  1966cited by this paper
• [Alkylating substances in serum and urine after injection of cyclophosphamide].

  1965cited by this paper
• Metabolism of Drugs and Other Foreign Compounds by Enzymatic Mechanisms

  1963cited by this paper
• [ON THE ACTIVATION OF CYCLOPHOSPHAMIDE IN VIVO AND IN VITRO].

  1963cited by this paper
• Studies on the mechanism of action of cytoxan. Evidence of activation in vivo and in vitro.

  1961cited by this paper
• Statistical estimations in enzyme kinetics.

  1961cited by this paper
• Colorimetric Estimation of Nitrogen Mustards in Aqueous Media. Hydrolytic Behavior of Bis-(β-chloroethyl)amine, nor HN2

  1961cited by this paper
• Development of a Leukæmia resistant to Cyclophosphamide (‘Cytoxan’)

  1960cited by this paper
• Behavior of enzyme systems

  1959cited by this paper
• Chemotherapeutic Action of a Cyclic Nitrogen Mustard Phosphamide Ester (B 518-ASTA) in Experimental Tumours of the Rat

  1958cited by this paper
• [Pharmacological characterization of cyclic nitrogen mustard phosphamide esters as cancer therapeutic agents].

  1958cited by this paper
• A theoretical basis of molecular pharmacology. I. Interactions of one or two compounds with one receptor system.

  1956cited by this paper
• A theoretical basis of molecular pharmacology. I. Interactions of one or two compounds with one receptor system.

  1956cited by this paper
• Use of γ-(4-Nitrobenzyl)pyridine as Analytical Reagent for Ethylenimines and Alkylating Agents

  1955cited by this paper
• The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.

  1953cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper
• Histochemical Demonstration of Sites of Phosphamidase Activity.∗

  1948cited by this paper
• The Determination of Enzyme Dissociation Constants

  1934cited by this paper

• Protective effects of Sildenafil administration on chemotherapeutic-induced ovarian damage in rats.

  2022cites this paper
• Pretreatment with Gallic Acid Mitigates Cyclophosphamide Induced Inflammation and Oxidative Stress in Mice.

  2021cites this paper
• Curcumin nanocrystals attenuate cyclophosphamide-induced testicular toxicity in mice.

  2021cites this paper
• Geraniol protects against cyclophosphamide-induced hepatotoxicity in rats: Possible role of MAPK and PPAR-γ signaling pathways.

  2020cites this paper
• Hepato-preventive and anti-apoptotic role of boric acid against liver injury induced by cyclophosphamide.

  2019cites this paper
• Investigation of Antigenotoxic Potential of Wheatgrass (Triticumaestivum) Powder on Cyclophosphamide Induced Genotoxicity and Oxidative Stress in Mice

  2017cites this paper
• Amelioration of the cyclophosphamide induced genotoxic damage in mice by the ethanolic extract of Equisetum arvense

  2017cites this paper
• Protective Effect of d-Limonene Experimentally Induced Cardiotoxicity in Wistar Albino Rats

  2017cites this paper
• “STUDIES ON CLINICO-PATHOLOGICAL AND IMMUNOMODULATORY EFFECTS OF COW URINE AND ITS SYNERGISTIC ACTION WITH AQUEOUS POLY HERBAL EXTRACT IN COMMERCIAL BROILER CHICKS

  2016cites this paper
• Methanolic Extract of Curcuma caesia Roxb. Prevents the Toxicity Caused by Cyclophosphamide to Bone Marrow Cells, Liver and Kidney of Mice

  2016cites this paper
• Efficacy of Rosmarinus officinalis leaves extract against cyclophosphamide-induced hepatotoxicity

  2016cites this paper
• Cell-patterned glass spray for direct drug assay using mass spectrometry.

  2015cites this paper
• Cyklofosfamid. Dokumentacja proponowanych dopuszczalnych wielkości narażenia zawodowego

  2015cites this paper
• IMPACT OF GERANIOL ON CYCLOPHOSPHAMIDE PROVOKED CARDIOTOXIC PROPERTIES–AN IN VIVO STUDY

  2015cites this paper
• Vanadium as a chemoprotectant: effect of vanadium(III)-l-cysteine complex against cyclophosphamide-induced hepatotoxicity and genotoxicity in Swiss albino mice

  2014cites this paper
• An ethanol extract of Origanum vulgare attenuates cyclophosphamide-induced pulmonary injury and oxidative lung damage in mice

  2014cites this paper
• Amelioration of cyclophosphamide-induced hepatotoxicity by the root extract of Decalepis hamiltonii in mice.

  2013cites this paper
• Investigation of antimutagenic potential of Foeniculum vulgare essential oil on cyclophosphamide induced genotoxicity and oxidative stress in mice

  2013cites this paper
• Investigation of antigenotoxic potential of Syzygium cumini extract (SCE) on cyclophosphamide-induced genotoxicity and oxidative stress in mice

  2013cites this paper
• Cyclophosphamide-induced nephrotoxicity, genotoxicity, and damage in kidney genomic DNA of Swiss albino mice: the protective effect of Ellagic acid

  2012cites this paper
• Cytogenotoxicity and Lipid Peroxide Induction in Actinomycin D Post-treated Mice

  2011cites this paper
• Investigation of Antimutagenic Potential of Embelia Ribes Fruit Extract Against Genotoxicity and Oxidative Stress Induced by Cyclophosphamide

  2010cites this paper
• Pharmacokinetics of Cyclophosphamide after prolonged low dose treatment in ovarian cancer patients

  2010cites this paper
• Probucol Attenuates Cyclophosphamide-induced Oxidative Apoptosis, p53 and Bax Signal Expression in Rat Cardiac Tissues

  2010cites this paper
• The biotransformation of cyclophosphamide in man: analysis of the variation in normal subjects.

  2009cites this paper
• Cytosine arabinoside-induced cytogenotoxicity in bone marrow and spermatogonial cells of mice and its potential transmission through the male germline.

  2009cites this paper
• Alkylating Agents and Mouse Spermatogenesis: Effects of a Single Dose of Cyclophosphamide

  2009cites this paper
• Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in rats

  2008cites this paper
• Protective effects of ginsenoside Rg3 against cyclophosphamide-induced DNA damage and cell apoptosis in mice

  2008cites this paper
• Assessment of ifosfamide pharmacokinetics, toxicity, and relation to CYP3A4 activity as measured by the erythromycin breath test in patients with sarcoma

  2007cites this paper
• Attenuation of cyclophosphamide induced toxicity by squalene in experimental rats.

  2006cites this paper
• Phà © nobarbitalEffects on Cyclophosphamide Pharmacokinetics in Man 1

  2006cites this paper
• Evidence for an Aldehyde Possessing Alkylating Activity as the Primary Metabolite of Cyclophosphamide1

  2006influential citation
• In vitro chromosome aberration tests using human dental pulp cells to detect the carcinogenic potential of chemical agents

  2006cites this paper
• Effects of Dosage, Phénobarbital,and 2-Diethylaminoethyl-2,2-diphen\ balenate on the Binding of Cyclophosphamide and/or Its Metabolites to the DNA, R N A, and Protein of the Embryo and Liver in Pregnant Mice1

  2006cites this paper
• Kinetics of Cyclophosphamide Biotransformation in

  2006cites this paper
• Effect of squalene on cyclophosphamide-induced toxicity.

  2006cites this paper
• /V-Demethylation of the Antineoplastic Agent Hexamethylmelamine by Rats and Man1

  2006influential citation
• Cyclophosphamide Metabolism in Children1

  2006cites this paper
• Brain and plasma pharmacokinetics and anticancer activities of cyclophosphamide and phosphoramide mustard in the rat

  2004cites this paper
• Rescue of rats from large dose cyclophosphamide toxicity using protein A

  2004cites this paper
• Pharmacokinetics of high-dose cyclophosphamide in patients with metastatic bronchogenic carcinoma

  2004cites this paper
• Application of a microsomal drug activation system in a human tumor cloning assay

  2004cites this paper
• Comparative in vitro cytotoxicity of cyclophosphamide, its major active metabolites and the new oxazaphosphorine ASTA Z 7557 (INN mafosfamide)

  2004cites this paper
• Protective effect of DL-alpha-lipoic acid on cyclophosphamide induced oxidative cardiac injury.

  2004cites this paper
• High-dose ifosfamide, carboplatin, and etoposide pharmacokinetics: correlation of plasma drug levels with renal toxicity

  2004cites this paper
• Cytogenetic Consequences of Vinblastine Treatment in Mouse Bone Marrow

  2004cites this paper
• Stability of solutions of antineoplastic agents during preparation and storage for in vitor assays

  2004cites this paper
• In vivo protection by protein A of hepatic microsomal mixed function oxygenase system of cyclophosphamide-treated rats

  2004cites this paper
• Wirkung von Cyclophosphamid bei Tumoren im Sensibilitäts-Test

  2004cites this paper
• Protective effect of DL-α-lipoic acid on cyclophosphamide induced oxidative cardiac injury

  2004cites this paper
• Cytogenetic risk assessment of etoposide from mouse bone marrow

  2004cites this paper
• Dose-dependent pharmacokinetics and cancer chemotherapy

  2004cites this paper
• Protection Against Cyclophosphamide-Induced Renal Oxidative Stress by Amifostine: The Role of Antioxidative Mechanisms

  2003cites this paper
• Enhancement of allyl alcohol hepatotoxicity by endotoxin requires extrahepatic factors.

  2002cites this paper
• EFFECT OF AMIFOSTINE ON LUNG OXIDATIVE STRESS AFTER CYCLOPHOSPHAMIDE THERAPY

  2002cites this paper
• Cytogenetic Toxicity of Cisplatin in Bone Marrow Cells of Swiss Mice

  2000cites this paper
• Cytogenetic toxicity of methotrexate in mouse bone marrow.

  2000cites this paper
• In vivo prevention of cyclophosphamide-induced Ca2+ dependent damage of rat heart and liver mitochondria by cyclosporin A.

  1998cites this paper
• Use of body surface area to calculate chemotherapeutic drug dose in dogs: II. Limitations imposed by pharmacokinetic factors.

  1998cites this paper
• Sex, time‐of‐day and estrous variations in behavioral and bladder histological consequences of cyclophosphamide‐induced cystitis in rats

  1997cites this paper
• Individualization of cancer therapy based on cytochrome P450 polymorphism: a pharmacogenetic approach.

  1997cites this paper
• Cyclophosphamide pharmacokinetics in children.

  1996cites this paper
• Cyclophosphamide metabolism in children.

  1995cites this paper
• CYCLOPHOSPHAMIDE: PULMONARY METABOLISM, TOXICITY AND PROTECTIVE EFFECT OF VITAMIN E

  1993cites this paper
• Differential Effects of Drugs upon Hematopoiesis Can Be Assessed in Long-Term Bone Marrow Cultures Established on Nylon Screens

  1992cites this paper
• Microcarrier-attached rat hepatocytes as a xenobiotic-metabolizing system in cocultures

  1991cites this paper
• Drug-Metabolizing Ability and Inducibility of Chromosomal Aberrations and Sister Chromatid Exchanges in LEC Rats Exposed to Cyclophosphamide

  1991cites this paper
• Potentiation of the cytotoxic action of mafosfamide by N-isopropyl-p-formylbenzamide, a metabolite of procarbazine.

  1991cites this paper
• Cooxidation of cyclophosphamide as an alternative pathway for its bioactivation and lung toxicity.

  1991cites this paper
• Pathology of transplant rejection and immunosuppressive therapy: Part II--Pathologic effects of immunosuppressive therapy.

  1990cites this paper
• The in vitro activation of cyclophosphamide in the Hydra Developmental Toxicology Assay.

  1990cites this paper
• Cytochrome P-450 and chromosome damage by cyclophosphamide in LEC strain rats predisposed to hereditary hepatitis and liver cancer.

  1990cites this paper
• Efficacy, toxicity, pharmacokinetics, and in vitro metabolism of the enantiomers of ifosfamide in mice.

  1990cites this paper
• Metabolism and pulmonary toxicity of cyclophosphamide.

  1990cites this paper
• A rapid in vitro method for the evaluation of potential antitumor drugs requiring metabolic activation by hepatic S9 enzymes.

  1989cites this paper
• Metabolism of oxazaphosphorines.

  1988cites this paper
• Involvement of monoamine oxidase and diamine oxidase in the metabolism of the cell differentiating agent hexamethylene bisacetamide (HMBA).

  1988cites this paper
• Phenotypically deficient urinary elimination of carboxyphosphamide after cyclophosphamide administration to cancer patients.

  1988cites this paper
• Metabolism of oxazaphosphorines

  1988cites this paper
• A rapid, simple in vitro screening test, using [(3)H]glutathione and l-[(35)S]cysteine as trapping agents, to detect reactive intermediates of xenobiotics.

  1988cites this paper
• Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays

  1986cites this paper
• Effect of cigarette-smoke condensate and norharman on the induction of SCEs by direct and indirect mutagens in CHO cells.

  1986cites this paper
• Induction of sister chromatid exchanges in human and rat hepatoma cell lines by cyclophosphamide and phosphoramide mustard and the effects of cytochrome P-450 inhibitors.

  1986cites this paper
• Hepatic drug-metabolizing enzymes in lung tumor-bearing rats.

  1985cites this paper
• Formation, toxicity and inactivation of acrolein during biotransformation of cyclophosphamide as studied in freshly isolated cells from rat liver and kidney

  1985cites this paper
• Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. General considerations, the nitrosoureas and alkylating agents.

  1985cites this paper
• Search for and establishment of the structure of certain products of the metbolism of 1,4-di(β-bromopropionyl)-hexahydrodiazepine

  1985cites this paper
• Diallyl sulfide. A naturally occurring thioether that inhibits carcinogen-induced nuclear damage to colon epithelial cells in vivo.

  1985cites this paper
• Morphological and biochemical aspects of monofunctional phosphoramide mustard teratogenicity in rat embryos cultured in vitro.

  1985cites this paper
• Effects of hypoxia, pH, and growth stage on cell killing in Chinese hamster V79 cells in vitro by activated cyclophosphamide.

  1985cites this paper
• Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays

  1985cites this paper
• A bioassay for cyclophosphamide in blood, lung and tumour.

  1984cites this paper
• Alterations in hepatic heme and cytochrome P-450 metabolism in Murphy-Sturm lymphosarcoma-bearing rats. Implications for drug metabolism.

  1984cites this paper
• Alterations of Drug Transport

  1984cites this paper
• Effect of lipopolysaccharide (from Escherichia coli) on the hepatic drug-metabolizing activities in successively LPS-treated mice.

  1984cites this paper
• An assay to detect chemically induced DNA repair in rat spermatocytes.

  1984cites this paper
• Effects of propylthiouracil on urinary metabolites of cyclophosphamide in rats.

  1983influential citation
• Metabolism of the carcinogen 1,2‐dimethylhydrazine by isolated human colon microsomes and human colon tumor cells in culture

  1983cites this paper
• Antitumor effect and metabolic activation of cyclophosphamide and 4-hydroperoxycyclophosphamide in the human breast carcinoma (MX-1)-nude mouse system.

  1983cites this paper