DNA Topoisomerases as Targets for the Chemotherapeutic Treatment of Cancer

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/978-1-59745-274-8_3
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1.

  2007cited by this paper
• Ataxie–télangiectasie : de la clinique à la physiopathologie

  2006cited by this paper
• Gene Expression Needs a Break to Unwind Before Carrying On

  2006cited by this paper
• HOX GENES: Seductive Science, Mysterious Mechanisms

  2006cited by this paper
• Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes.

  2006cited by this paper
• Beneficial effects of tea and its polyphenols against prostate cancer.

  2006cited by this paper
• The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy.

  2006cited by this paper
• Chromosomal translocations involving the MLL gene: molecular mechanisms.

  2006cited by this paper
• Cancer Chemotherapy and Biotherapy: Principles and Practice (4th Edition)

  2006cited by this paper
• Role of apoptotic nuclease caspase-activated DNase in etoposide-induced treatment-related acute myelogenous leukemia.

  2006cited by this paper
• The worldwide emergence of plasmid-mediated quinolone resistance.

  2006cited by this paper
• Genetic instability in cancer cells by impaired cell cycle checkpoints

  2006cited by this paper
• Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage.

  2006cited by this paper
• DNA Damage-Dependent Cell Cycle Checkpoints and Genomic Stability

  2006cited by this paper
• A Topoisomerase IIß-Mediated dsDNA Break Required for Regulated Transcription

  2006cited by this paper
• Surviving the breakup: the DNA damage checkpoint.

  2006cited by this paper
• Repair of topoisomerase I-mediated DNA damage.

  2006cited by this paper
• Tyrosyl-DNA phosphodiesterase (Tdp1) (3'-phosphotyrosyl DNA phosphodiesterase).

  2006cited by this paper
• Checkpoint and coordinated cellular responses to DNA damage.

  2006cited by this paper
• [Molecular genetics of inherited neuropathies].

  2006cited by this paper
• A Protease Pathway for the Repair of Topoisomerase II-DNA Covalent Complexes*

  2006cited by this paper
• Topoisomerase II and the etiology of chromosomal translocations.

  2006cited by this paper
• Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate.

  2006cited by this paper
• A concise review of DNA damage checkpoints and repair in mammalian cells.

  2006cited by this paper
• Topoisomerase I inhibitors: camptothecins and beyond

  2006cited by this paper
• Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells.

  2005cited by this paper
• DNA topoisomerase II in therapy-related acute promyelocytic leukemia.

  2005cited by this paper
• New insight into the molecular mechanisms of MLL-associated leukemia

  2005cited by this paper
• SCAN1 mutant Tdp1 accumulates the enzyme–DNA intermediate and causes camptothecin hypersensitivity

  2005cited by this paper
• The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint.

  2005cited by this paper
• Endonucleolytic processing of covalent protein-linked DNA double-strand breaks

  2005cited by this paper
• Surviving apoptosis: a possible mechanism of benzene-induced leukemia.

  2005cited by this paper
• Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity

  2005cited by this paper
• Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling.

  2005cited by this paper
• The Role of Checkpoint Kinase 1 in Sensitivity to Topoisomerase I Poisons*

  2005cited by this paper
• A COMPASS in the voyage of defining the role of trithorax/MLL‐containing complexes: Linking leukemogensis to covalent modifications of chromatin

  2005cited by this paper
• Etoposide, topoisomerase II and cancer.

  2005cited by this paper
• Human DNA topoisomerase I: relaxation, roles, and damage control

  2005cited by this paper
• Stimulation of topoisomerase II-mediated DNA cleavage by benzene metabolites.

  2005cited by this paper
• DNA loop organization and DNA fragmentation during radiation-induced apoptosis in human lymphocytes.

  2005cited by this paper
• Bacterial topoisomerase inhibitors: quinolone and pyridone antibacterial agents.

  2005cited by this paper
• Cisplatin Damage: Are DNA Repair Proteins Saviors or Traitors to the Cell?

  2005cited by this paper
• Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase II alpha: 1,4-hydroquinone is a topoisomerase II poison.

  2005cited by this paper
• Maternal Diet and Infant Leukemia: The DNA Topoisomerase II Inhibitor Hypothesis: A Report from the Children's Oncology Group

  2005cited by this paper
• Multiple Endonucleases Function to Repair Covalent Topoisomerase I Complexes in Saccharomyces cerevisiae

  2005cited by this paper
• Using yeast to study resistance to topoisomerase II-targeting drugs

  2004cited by this paper
• Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms.

  2004cited by this paper
• 1,4-Benzoquinone is a topoisomerase II poison.

  2004cited by this paper
• TDP1 Overexpression in Human Cells Counteracts DNA Damage Mediated by Topoisomerases I and II*

  2004cited by this paper
• The Path of the DNA along the Dimer Interface of Topoisomerase II*

  2004cited by this paper
• DNA Topoisomerases: Type II

  2004cited by this paper
• Functional compatibility between isoform α and β of type II DNA topoisomerase

  2004cited by this paper
• Recombination and chromosome segregation.

  2004cited by this paper
• The DNA damage response: sensing and signaling.

  2004cited by this paper
• Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties.

  2004cited by this paper
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  2004cited by this paper
• MLL: a histone methyltransferase disrupted in leukemia.

  2004cited by this paper
• A topological view of the replicon

  2004cited by this paper
• Repair of DNA covalently linked to protein.

  2004cited by this paper
• Mechanisms of transformation by MLL.

  2004cited by this paper
• Apoptotic Topoisomerase I-DNA Complexes Induced by Oxygen Radicals and Mitochondrial Dysfunction

  2004cited by this paper
• RecQ helicases and topoisomerase III in cancer and aging

  2003cited by this paper
• Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: Implications for interactions with intercalating anticancer agents

  2003cited by this paper
• Regulation and mechanisms of mammalian double-strand break repair

  2003cited by this paper
• DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

  2003cited by this paper
• Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I.

  2003cited by this paper
• Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes.

  2003cited by this paper
• Homocamptothecins: potent topoisomerase I inhibitors and promising anticancer drugs.

  2003cited by this paper
• Repair of and checkpoint response to topoisomerase I-mediated DNA damage.

  2003cited by this paper
• Apoptosis induced by topoisomerase inhibitors.

  2003cited by this paper
• Activation of the DNA-Dependent Protein Kinase by Drug-Induced and Radiation-Induced DNA Strand Breaks

  2003cited by this paper
• Holliday junctions in the eukaryotic nucleus: resolution in sight?

  2003cited by this paper
• Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks.

  2003cited by this paper
• Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.

  2003cited by this paper
• Checkpoint signaling: epigenetic events sound the DNA strand-breaks alarm to the ATM protein kinase.

  2003cited by this paper
• Non-camptothecin DNA topoisomerase I inhibitors in cancer therapy.

  2003cited by this paper
• Molecular structure of nucleic acids

  2003cited by this paper
• The quinolone family: from antibacterial to anticancer agents.

  2003cited by this paper
• An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication.

  2003cited by this paper
• Transcription-Dependent Degradation of Topoisomerase I-DNA Covalent Complexes

  2003cited by this paper
• Apoptotic stimuli initiate MLL-AF9 translocations that are transcribed in cells capable of division.

  2003cited by this paper
• Albumin adducts of benzene oxide and 1,4-benzoquinone as measures of human benzene metabolism.

  2002cited by this paper
• Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage

  2002cited by this paper
• Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects

  2002cited by this paper
• Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins.

  2002cited by this paper
• Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin.

  2002cited by this paper
• The Role of Topoisomerase II in the Excision of DNA Loop Domains during Apoptosis*

  2002cited by this paper
• Defending genome integrity during S-phase: putative roles for RecQ helicases and topoisomerase III.

  2002cited by this paper
• Dynamics of human DNA topoisomerases IIα and IIβ in living cells

  2002cited by this paper
• DNA structure dependent checkpoints as regulators of DNA repair.

  2002cited by this paper
• Cellular roles of DNA topoisomerases: a molecular perspective

  2002cited by this paper
• The mechanism of topoisomerase I poisoning by a camptothecin analog

  2002cited by this paper
• Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children.

  2002cited by this paper
• S Phase and G2 Arrests Induced by Topoisomerase I Poisons Are Dependent on ATR Kinase Function*

  2002cited by this paper
• Wiley encyclopedia of molecular medicine

  2002cited by this paper
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  2001cited by this paper
• Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation.

  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Chromosome damage from biological reactive intermediates of benzene and 1,3-butadiene in leukemia.

  2001cited by this paper

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  2020cites this paper
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  2018cites this paper
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  2017cites this paper
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• Phytochemicals as anticancer and chemopreventive topoisomerase II poisons

  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2013cites this paper
• Topoisomerase II Inhibitors: Chemical Biology

  2012cites this paper
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  2012cites this paper
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  2010cites this paper
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  2009cites this paper
• The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

  2008influential citation
• DNA topology and topoisomerases

  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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