Fifty-seven-kDa protein in royal jelly enhances proliferation of primary cultured rat hepatocytes and increases albumin production in the absence of serum.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2001-04-13

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1006/BBRC.2001.4656PMID 11352630
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Enhancement of albumin production by hepatocyte growth factor in rat hepatocytes: distinction in mode of action from stimulation of DNA synthesis.

  2008cited by this paper
• Apoptosis of serum-free C2.8 mouse embryo hepatocytic cells caused by hepatocyte growth factor deprivation

  2004cited by this paper
• The Effect of Lecithin Supplementation on the Biochemical Profile and Morphological Changes in the Liver of Rats Fed Different Animal Fats

  2004cited by this paper
• Stimulation of cell growth in the U-937 human myeloid cell line by honey royal jelly protein

  2004cited by this paper
• Storage-dependent Degradation of 57-kDa Protein in Royal Jelly: a Possible Marker for Freshness

  2001cited by this paper
• Serum deprivation-induced apoptosis in cultured porcine granulosa cells is characterized by increased expression of p53 protein, Fas antigen and Fas ligand and by decreased expression of PCNA.

  1998cited by this paper
• Abrogation of Fas-induced fulminant hepatic failure in mice by hepatocyte growth factor.

  1998cited by this paper
• Density-dependent proliferation of adult rat hepatocytes in primary culture induced by epidermal growth factor is potentiated by cAMP-elevating agents.

  1997cited by this paper
• Emerging multipotent aspects of hepatocyte growth factor.

  1996cited by this paper
• Removal of serum from primary cultures of cerebellar granule neurons induces oxidative stress and DNA fragmentation: Protection with antioxidants and glutamate receptor antagonists

  1996cited by this paper
• Effect of 350 kDa Glycoprotein in Royal Jelly on Primary Culture of Rat Hepatocytes

  1996cited by this paper
• Epidermal growth factor, but not hepatocyte growth factor, suppresses the apoptosis induced by transforming growth factor‐beta in fetal hepatocytes in primary culture

  1996cited by this paper
• Long-term maintenance of functional rat hepatocytes in primary culture by additions of pyruvate and various hormones.

  1995cited by this paper
• Effect of Royal Jelly on serum lipids in experimental animals and humans with atherosclerosis

  1995cited by this paper
• Hepatocyte growth factor stimulates liver regeneration and elevates blood protein level in normal and partially hepatectomized rats.

  1995cited by this paper
• Cell density-dependent DNA fragmentation and its suppression by heparin in primary culture of adult rat hepatocytes.

  1993cited by this paper
• Cell density-dependent regulation of albumin synthesis and DNA synthesis in rat hepatocytes by hepatocyte growth factor.

  1992cited by this paper
• The Effect of Human Milk on DNA Synthesis of Neonatal Rat Hepatocytes in Primary Culture

  1991cited by this paper
• Multiple cell cycles occur in rat hepatocytes cultured in the presence of nicotinamide and epidermal growth factor

  1991cited by this paper
• Augmentation of wound healing by royal jelly (RJ) in streptozotocin-diabetic rats.

  1990cited by this paper
• A potent antibacterial protein in royal jelly. Purification and determination of the primary structure of royalisin.

  1990cited by this paper
• Heparin-binding growth factor type 1 (acidic fibroblast growth factor): a potential biphasic autocrine and paracrine regulator of hepatocyte regeneration.

  1989cited by this paper
• Nicotinamide prolongs survival of primary cultured hepatocytes without involving loss of hepatocyte-specific functions.

  1989cited by this paper
• Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism.

  1989cited by this paper
• Book Review: Humans and Other Animals

  1989cited by this paper
• 5 – Control of Hepatocyte Proliferation in Vitro

  1987cited by this paper
• [Antitumor effects of royal jelly (RJ)].

  1987cited by this paper
• ローヤルゼリー(Royal Jelly)の抗腫瘍効果に関する研究

  1987cited by this paper
• Comparative studies on chemical composition of honey, royal jelly and pollen loads

  1986cited by this paper
• Composition of freshly harvested and commercial royal jelly

  1985cited by this paper
• Hepatocyte proliferation in vitro: its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix.

  1984cited by this paper
• Cell Culture Studies Using Extracts of Extracellular Matrix to Study Growth and Differentiation in Mammalian Cells

  1984cited by this paper
• Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats.

  1984cited by this paper
• Mammalian cell culture : the use of serum-free hormone-supplemented media

  1984cited by this paper
• Pyruvate promotion of DNA synthesis in serum-free primary cultures of adult rat hepatocytes

  1983cited by this paper
• Density-dependent growth control of adult rat hepatocytes in primary culture.

  1983cited by this paper
• Reciprocal modulation of growth and differentiated functions of mature rat hepatocytes in primary culture by cell--cell contact and cell membranes.

  1983cited by this paper
• Liver regeneration studies with rat hepatocytes in primary culture.

  1982cited by this paper
• A high concentration of pyruvate is essential for survival and DNA synthesis in primary cultures of adult rat hepatocytes in a serum-free medium

  1981cited by this paper
• DNA synthesis in primary cultures of adult rat hepatocytes in a defined medium: Effects of epidermal growth factor, insulin, glucagon, and cyclic‐AMP

  1981cited by this paper
• Hormonal regulation of DNA synthesis in primary cultures of adult rat hepatocytes: action of glucagon.

  1981cited by this paper
• Chemical composition of royal jelly.

  1980cited by this paper
• BIOCHEMICAL FUNCTIONS OF ADULT RAT HEPATOCYTES IN PRIMARY CULTURE *

  1980cited by this paper
• [Biochemical studies on vasodilative factor in royal jelly (author's transl)].

  1978cited by this paper
• Hormonal stimulation of DNA synthesis in primary cultures of adult rat hepatocytes.

  1976cited by this paper
• Preparation of isolated rat liver cells.

  1976cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• Honey Bee Nutrition

  1970cited by this paper
• DISC ELECTROPHORESIS – II METHOD AND APPLICATION TO HUMAN SERUM PROTEINS *

  1964cited by this paper
• Studies on the in vitro antitumor activity of fatty acids. IV. The esters of acids closely related to 10-hydroxy-2-decenoic acids from royal jelly against transplantable mouse leukemia.

  1961cited by this paper
• Studies on the in vitro antitumor activity of fatty acids. I. 10-Hydroxy-2-decenoic acid from royal jelly.

  1960cited by this paper
• Electrophoretic Components of the Proteins in Honeybee Larval Food

  1960cited by this paper
• Activity of 10-Hydroxydecenoic Acid from Royal Jelly against Experimental Leukæmia and Ascitic Tumours

  1959cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper
• Experimental pathology of the liver

  1931cited by this paper
• The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2000 by The Endocrine Society Serum Withdrawal-Induced Apoptosis in Thyroid Cells Is Caused by Loss of Fibronectin-Integrin Interaction*

  year unknowncited by this paper

• Quantification of major royal jelly protein variants and concurrent fraud identification to confirm royal jelly quality employing the native LC-SEC-UV methodology

  2026cites this paper
• Potential Role of Intravenous Royal Jelly in Reducing Post-hepatectomy Liver Dysfunction: A Randomized Controlled Animal StudY

  2025cites this paper
• MRJP3-C113, a major royal jelly protein 3-derived fragment, accelerated cutaneous wound healing through RHBDF2-mediated activation of EGFR/AKT/mTOR signaling pathway

  2025cites this paper
• Studies on the interactional characterization of major royal jelly proteins with cyanidin-3-O-glucoside and their effect on Blueberry anthocyanin extracts stability

  2025cites this paper
• Research progress on rat model of drug-induced liver injury established by nonsteroidal anti-inflammatory drug (celecoxib) and royal jelly ameliorative effect

  2024cites this paper
• Royal Jelly: Biological Action and Health Benefits

  2024cites this paper
• Nutrient Composition and Quality Assessment of Royal Jelly Samples Relative to Feed Supplements

  2024cites this paper
• Current Status of the Bioactive Properties of Royal Jelly: A Comprehensive Review with a Focus on Its Anticancer, Anti-Inflammatory, and Antioxidant Effects

  2023cites this paper
• Major Royal-Jelly Proteins Intake Modulates Immune Functions and Gut Microbiota in Mice

  2023cites this paper
• In vitro and in vivo models to study the biological and pharmacological properties of queen bee acid (QBA, 10-hydroxy-2-decenoic acid): A systematic review

  2022cites this paper
• Biological properties and activities of major royal jelly proteins and their derived peptides

  2022cites this paper
• Royal Jelly: Beneficial Properties and Synergistic Effects with Chemotherapeutic Drugs with Particular Emphasis in Anticancer Strategies

  2022cites this paper
• Royal Jelly Proteins and Their Derived Peptides: Preparation, Properties, and Biological Activities.

  2021cites this paper
• In vitro analysis of the biological activity of royal jelly on different cell lines

  2021cites this paper
• Multifunctionality and intrinsic disorder of royal jelly proteome

  2021cites this paper
• Health Promoting Properties of Bee Royal Jelly: Food of the Queens

  2021cites this paper
• The Carboxyl-Terminal Penta-Peptide Repeats of Major Royal Jelly Protein 3 Enhance Cell Proliferation.

  2020cites this paper
• Major royal jelly proteins accelerate onset of puberty and promote ovarian follicular development in immature female mice

  2020cites this paper
• ROYAL JELLY: PROTEINS AND PEPTIDES

  2020cites this paper
• The effect of short-term royal jelly supplement on testoster- one levels in sedentary and healthy individuals

  2020cites this paper
• Purification and characteristics of individual major royal jelly protein 1–3

  2020cites this paper
• Does in Ovo Injection of Two Chicken Strains with Royal Jelly Impact Hatchability, Post-Hatch Growth Performance and Haematological and Immunological Parameters in Hatched Chicks?

  2019cites this paper
• Royal jelly: a natural therapeutic?

  2019cites this paper
• Royal jelly-derived proteins enhance proliferation and migration of human epidermal keratinocytes in an in vitro scratch wound model

  2019cites this paper
• Honeybee (Apis cerana) major royal jelly protein 4 exhibits antimicrobial activity

  2019cites this paper
• Inhibition of Specific Degradation of 57-kDa during Storage by EthylenediaminetetraaceticProtein in Royal Jelly Acid JSem

  2018cites this paper
• Anti-senescence effect and molecular mechanism of the major royal jelly proteins on human embryonic lung fibroblast (HFL-I) cell line

  2018cites this paper
• Architecture of the native major royal jelly protein 1 oligomer

  2018cites this paper
• Genoprotective Effects of Thai Royal Jelly against Doxorubicin in Human Lymphocytes in Vitro

  2018cites this paper
• A review on Royal Jelly proteins and peptides

  2018cites this paper
• Sugaring-Out Assisted Liquid-Liquid Extraction Combined with High-Performance Liquid Chromatography-Fluorescence Detection for the Determination of Bisphenol A and Bisphenol B in Royal Jelly

  2018cites this paper
• Chemical Composition of Royal Jelly

  2017cites this paper
• Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

  2017cites this paper
• Transgenic silkworms secrete the recombinant glycosylated MRJP1 protein of Chinese honeybee, Apis cerana cerana

  2017cites this paper
• Effect of Major Royal Jelly Proteins on Spatial Memory in Aged Rats: Metabolomics Analysis in Urine.

  2017cites this paper
• Estrutura oligomérica e dinâmica de Major Royal Jelly Protein 1 (MRJP1)/apisimina analisadas por espectrometria de massas e técnicas complementares

  2017cites this paper
• Epigenetics-A New Way to Rejuvenate Skin

  2017cites this paper
• Supplementation with Major Royal-Jelly Proteins Increases Lifespan, Feeding, and Fecundity in Drosophila.

  2016cites this paper
• Evaluation of the major royal jelly proteins as an alternative to fetal bovine serum in culturing human cell lines

  2016cites this paper
• The MRJP1 honey glycoprotein does not contribute to the overall antibacterial activity of natural honey

  2016cites this paper
• pp45-48 PCEuroJun16.qxp_Layout 1

  2016cites this paper
• Polyphenol-Protein Complexes and Their Consequences for the Redox Activity, Structure and Function of Honey. A Current View and New Hypothesis – a Review

  2015cites this paper
• Royal jelly promotes the viability and proliferation of periodontal ligament fibroblasts in an In Vitro tooth avulsion simulation

  2015cites this paper
• Purification and identification of angiotensin I-converting enzyme-inhibitory peptides from apalbumin 2 during simulated gastrointestinal digestion.

  2015cites this paper
• In-Depth N-Glycosylation Reveals Species-Specific Modifications and Functions of the Royal Jelly Protein from Western (Apis mellifera) and Eastern Honeybees (Apis cerana).

  2015cites this paper
• Determination of royal jelly freshness by ELISA with a highly specific anti-apalbumin 1, major royal jelly protein 1 antibody

  2015cites this paper
• Heat Resistant Characteristics of Major Royal Jelly Protein 1 (MRJP1) Oligomer

  2015cites this paper
• Major royal jelly proteins as markers of authenticity and quality of honey / Glavni proteini matične mliječi kao markeri izvornosti i kakvoće meda

  2015cites this paper
• Origin and function of the major royal jelly proteins of the honeybee (Apis mellifera) as members of the yellow gene family

  2014cites this paper
• Osteoporosis Myths , Perceptions , and Truths , and Natural Solutions with Nutrition and Botanicals

  2014cites this paper
• Recovery of major royal jelly protein 1 expressed in Pichia pastoris in aqueous two‐phase systems

  2014cites this paper
• The Effects of Royal Jelly on In-Vitro Cytotoxicity of K562 Cells and Peripheral Blood Mononuclear Cells

  2014cites this paper
• Functions of serotonin receptors in integration of physiology and behavior in insects

  2014cites this paper
• Apitherapy: Holistic Healing Through the Honeybee and Bee Products in Countries with Poor Healthcare System

  2014cites this paper
• Chemistry and Bioactivities of Royal Jelly

  2014cites this paper
• What's the buzz: bee products and their potential value in diabetic wound healing.

  2014cites this paper
• UČINKOVITOST BIOLOŠKI AKTIVNIH SASTAVNICA MATIČNE MLIJEČI: ANALIZA I STANDARDIZACIJA

  2013cites this paper
• Isolation and characterization of proteins and lipids from honeybee (Apis mellifera L.) queen larvae and royal jelly

  2013cites this paper
• Quantification of Major Royal Jelly Protein 1 in Fresh Royal Jelly by Indirect Enzyme-Linked Immunosorbent Assay

  2013cites this paper
• Methylglyoxal-induced modifications of significant honeybee proteinous components in manuka honey: Possible therapeutic implications.

  2012cites this paper
• A rapid method to isolate soluble royal jelly proteins.

  2012cites this paper
• Construction of a Recombinant Major Royal Jelly Protein 1 (MRJP1) Expression Vector for Mammary Gland-Specific Expression

  2012cites this paper
• Bioactive compounds and health-promoting properties of royal jelly: A review

  2012cites this paper
• Zum Einfluss von Gelée royale auf den Lipidstoffwechsel bei Patienten mit bekannter Hypercholesterinämie

  2012cites this paper
• Royal Jelly, Bee Brood: Composition, Health, Medicine: A Review

  2011cites this paper
• Calcium effect and pH-dependence on self-association and structural stability of the Apis mellifera major royal jelly protein 1

  2011cites this paper
• Biological Activities of Royal Jelly-Review Crengu ţ

  2011cites this paper
• The In Vitro Effect of Royal Jelly, Apis mellifera, on Proliferation of Human Gingival,Periodontal Ligament Fibroblasts and Human Bone Cells

  2011cites this paper
• Biological Activities of Royal Jelly - Review

  2011cites this paper
• Royalactin induces queen differentiation in honeybees

  2011cites this paper
• Novel royal jelly proteins identified by gel-based and gel-free proteomics.

  2011cites this paper
• New criterion for evaluation of honey: quantification of royal jelly protein apalbumin 1 in honey by ELISA.

  2010cites this paper
• Bugs as drugs, Part 1: Insects: the "new" alternative medicine for the 21st century?

  2010cites this paper
• Expression of recombinant AccMRJP1 protein from royal jelly of Chinese honeybee in Pichia pastoris and its proliferation activity in an insect cell line.

  2010cites this paper
• Towards functional proteomics of minority component of honeybee royal jelly: The effect of post‐translational modifications on the antimicrobial activity of apalbumin2

  2009cites this paper
• Royal Jelly Protein and Lipid Composition in Apis cerana indica F.

  2009cites this paper
• Molecular characteristics and physiological functions of major royal jelly protein 1 oligomer

  2009cites this paper
• Effect of honey and its major royal jelly protein 1 on cytokine and MMP‐9 mRNA transcripts in human keratinocytes

  2009cites this paper
• Estimation and characterisation of major royal jelly proteins obtained from the honeybee Apis merifera

  2009cites this paper
• High concentrations of stavudine impair fatty acid oxidation without depleting mitochondrial DNA in cultured rat hepatocytes.

  2008cites this paper
• Expression of apalbumin1 of Apis cerana cerana in the larvae of silkworm, Bombyx mori.

  2008cites this paper
• A New Marker for Evaluation of Royal Jelly

  2008cites this paper
• Alleviation of Fatigue after Exercise by Fresh Royal Jelly 395 added to the chest

  2008cites this paper
• Sequence analysis of functional Apisimin-2 cDNA from royal jelly of Chinese honeybee and its expression in Escherichia coli.

  2007cites this paper
• The immunostimulatory effect of the recombinant apalbumin 1-major honeybee royal jelly protein-on TNFalpha release.

  2006cites this paper
• The effects of royal jelly on autoimmunity in Graves' disease

  2006cites this paper
• A hypopharyngeal gland protein of the worker honeybee Apis mellifera L. enhances proliferation of primary-cultured rat hepatocytes and suppresses apoptosis in the absence of serum.

  2006cites this paper
• Changes in hepatic gene expression associated with the hypocholesterolaemic activity of royal jelly

  2006cites this paper
• Molecular cloning and analysis of four cDNAs from the heads of Apis cerana cerana nurse honeybees coding for major royal jelly proteins

  2005influential citation
• Molecular cloning and analysis of four cDNAs from the heads of Apis cerana cerana nurse honeybees coding for major royal jelly proteins 1

  2005cites this paper
• Inhibition of specific degradation of 57-kDa protein in royal jelly during storage by citrate buffer.

  2005cites this paper
• Screening of biological activities present in honeybee (Apis mellifera) royal jelly.

  2005cites this paper
• The MRJP/YELLOW protein family of Apis mellifera: identification of new members in the EST library.

  2004cites this paper
• Engineering the Hepatocyte Differentiation–Proliferation Balance by Acellular Cadherin Micropresentation

  2004cites this paper
• Immunochemical approach to detection of adulteration in honey: physiologically active royal jelly protein stimulating TNF-alpha release is a regular component of honey.

  2004cites this paper
• Major royal jelly protein 3 modulates immune responses in vitro and in vivo.

  2003influential citation
• Isolation and characterisation of substances from Royal Jelly

  2003cites this paper
• Honeybee (Apis mellifera L.) mrjp gene family: computational analysis of putative promoters and genomic structure of mrjp1, the gene coding for the most abundant protein of larval food.

  2003cites this paper
• Apisimin, a new serine–valine‐rich peptide from honeybee (Apis mellifera L.) royal jelly: purification and molecular characterization 1

  2002cites this paper
• Signal transduction mechanism leading to enhanced proliferation of primary cultured adult rat hepatocytes treated with royal jelly 57-kDa protein.

  2002cites this paper