Full and Broad-Spectrum In Vivo Eradication of Catheter-Associated Biofilms Using Gentamicin-EDTA Antibiotic Lock Therapy

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Antimicrobial Agents and Chemotherapy

• Publication date

  2012-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/AAC.01606-12PMID 23027191PMCID PMC3497211
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Rat Model of Central Venous Catheter to Study Establishment of Long-Term Bacterial Biofilm and Related Acute and Chronic Infections

  2012influential reference
• Ethanol Locks to Prevent Catheter-Related Bloodstream Infections in Parenteral Nutrition: A Meta-Analysis

  2012cited by this paper
• New Challenges in the Diagnosis, Management, and Prevention of Central Venous Catheter–Related Infections

  2011cited by this paper
• Hospital Epidemiology and Infection Control in Acute-Care Settings

  2011cited by this paper
• New challenges in the diagnosis, management, and prevention of central venous catheter-related infections.

  2011cited by this paper
• Antimicrobial Activity of B-Lock against Bacterial and Candida spp. Causing Catheter-Related Bloodstream Infections

  2011cited by this paper
• Daptomycin Antibiotic Lock Therapy in a Rat Model of Staphylococcal Central Venous Catheter Biofilm Infections

  2011cited by this paper
• Effectiveness of antibiotic-lock therapy for long-term catheter-related bacteremia due to Gram-negative bacilli: a prospective observational study.

  2011cited by this paper
• Successful Treatment of Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus Aureus Bacteremia with the Addition of Rifampin to Daptomycin

  2010cited by this paper
• Determination of Therapeutic Equivalence of Generic Products of Gentamicin in the Neutropenic Mouse Thigh Infection Model

  2010cited by this paper
• Hospital-Acquired Staphylococcus aureus Infections at Texas Children's Hospital, 2001–2007

  2010cited by this paper
• Efficacy of ethanol locks in reducing central venous catheter infections in pediatric patients with intestinal failure.

  2010cited by this paper
• Activities of High-Dose Daptomycin, Vancomycin, and Moxifloxacin Alone or in Combination with Clarithromycin or Rifampin in a Novel In Vitro Model of Staphylococcus aureus Biofilm

  2010cited by this paper
• Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection:2009 update by the Infectious Diseases Society of America

  2010influential reference
• Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America.

  2009cited by this paper
• Vascular Access-Related Bloodstream Infections in First Nations, Community and Teaching Canadian Dialysis Units, and Other Centre-Level Predictors

  2009cited by this paper
• The Direct medical costs of healthcare-associated infections in U.S. hospitals and the benefits of prevention

  2009cited by this paper
• Effectiveness of teicoplanin versus vancomycin lock therapy in the treatment of port-related coagulase-negative staphylococci bacteraemia: a prospective case-series analysis.

  2009cited by this paper
• Novel synergistic antibiofilm combinations for salvage of infected catheters.

  2009cited by this paper
• In Vivo Bioluminescence Imaging for the Study of Intestinal Colonization by Escherichia coli in Mice

  2009cited by this paper
• Activity of Novel Antibiotic Lock Solutions in a Model Against Isolates of Catheter-Related Bloodstream Infections

  2009cited by this paper
• Development of real-time in vivo imaging of device-related Staphylococcus epidermidis infection in mice and influence of animal immune status on susceptibility to infection.

  2008cited by this paper
• Daily cost of antimicrobial therapy in patients with Intensive Care Unit-acquired, laboratory-confirmed bloodstream infection.

  2008cited by this paper
• Management of venous port systems in oncology: a review of current evidence.

  2008cited by this paper
• Control of Pseudomonas aeruginosa in the Lung Requires the Recognition of Either Lipopolysaccharide or Flagellin1

  2008cited by this paper
• The role of chelators in preventing biofilm formation and catheter-related bloodstream infections

  2008cited by this paper
• Role of ethylene diamine tetra-acetic acid (EDTA) in catheter lock solutions: EDTA enhances the antifungal activity of amphotericin B lipid complex against Candida embedded in biofilm.

  2008cited by this paper
• Current management of vascular access.

  2007cited by this paper
• Clinical and Economic Effects of Central Venous Catheters on Oncology Patient Care

  2007cited by this paper
• Persister cells, dormancy and infectious disease

  2007cited by this paper
• Catheter lock solutions influence staphylococcal biofilm formation on abiotic surfaces.

  2006cited by this paper
• Optimal Antimicrobial Catheter Lock Solution, Using Different Combinations of Minocycline, EDTA, and 25-Percent Ethanol, Rapidly Eradicates Organisms Embedded in Biofilm

  2006cited by this paper
• Antibiotic-lock therapy for long-term intravascular catheter-related bacteraemia: results of an open, non-comparative study.

  2006cited by this paper
• Treatment of long-term intravascular catheter-related bacteraemia with antibiotic-lock therapy.

  2006cited by this paper
• The risk of bloodstream infection in adults with different intravascular devices: a systematic review of 200 published prospective studies.

  2006cited by this paper
• Treatment of long-term intravascular catheter-related bacteraemia with antibiotic lock: randomized, placebo-controlled trial.

  2005influential reference
• Risk factors for hematogenous complications of intravascular catheter-associated Staphylococcus aureus bacteremia.

  2005cited by this paper
• Clinical and economic outcomes in critically ill patients with nosocomial catheter-related bloodstream infections.

  2005cited by this paper
• Randomized, clinical trial comparison of trisodium citrate 30% and heparin as catheter-locking solution in hemodialysis patients.

  2005cited by this paper
• A Randomized, Controlled Trial of a New Vascular Catheter Flush Solution (Minocycline-EDTA) in Temporary Hemodialysis Access

  2005cited by this paper
• Treatment of infections associated with surgical implants.

  2004cited by this paper
• Prevention of dialysis catheter-related sepsis with a citrate-taurolidine-containing lock solution.

  2004cited by this paper
• Locking of tunneled hemodialysis catheters with gentamicin and heparin.

  2004cited by this paper
• Stability and in vitro efficacy of antibiotic-heparin lock solutions potentially useful for treatment of central venous catheter-related sepsis.

  2003cited by this paper
• Ethanol‐Lock Technique in the Treatment of Bloodstream Infections in Pediatric Oncology Patients With Broviac Catheter

  2003cited by this paper
• Evaluation of infectious complications of the implantable venous access system in a general oncologic population.

  2003cited by this paper
• Differential Expression of Methicillin Resistance by Different Biofilm-Negative Staphylococcus epidermidis Transposon Mutant Classes

  2002cited by this paper
• Applying the science to the prevention of catheter-related infections.

  2002cited by this paper
• Biofilms: Microbial Life on Surfaces

  2002cited by this paper
• Riddle of Biofilm Resistance

  2001cited by this paper
• Antibiotic resistance of bacteria in biofilms.

  2001cited by this paper
• Randomized, Double-Blind Trial of an Antibiotic-Lock Technique for Prevention of Gram-Positive Central Venous Catheter-Related Infection in Neutropenic Patients with Cancer

  1999cited by this paper
• Intravascular-catheter-related infections.

  1998cited by this paper
• Intravascular-catheter-related infections.

  1998cited by this paper
• The relationship between the thrombotic and infectious complications of central venous catheters.

  1994cited by this paper
• Effect of gentamicin on heparin activity.

  1981cited by this paper
• The randomized clinical trial.

  1972cited by this paper

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• A Prospective Pilot Clinical Study reveals a promising non-toxic anti-biofilm activity of Gentamicin-EDTA-Na2 Central Venous Catheter Lock Solution

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• WGS of a lytic phage targeting biofilm-forming carbapenem-resistant Klebsiella pneumoniae prevalent in a tertiary healthcare setup.

  2025cites this paper
• Pseudomonas aeruginosa Biofilms: Pathogenicity, Clinical Challenges and Emerging Therapeutic Strategies

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• Effective biofilm eradication in MRSA isolates with aminoglycoside-modifying enzyme genes using high-concentration and prolonged gentamicin treatment

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• A New Casjensviridae Bacteriophage Isolated from Hospital Sewage for Inactivation of Biofilms of Carbapenem Resistant Klebsiella pneumoniae Clinical Isolates

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• Engineering of new anti-biofilm phosphonium thin coatings onto polymeric films

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• A Novel Brevinin2 HYba5 Peptide against Polymicrobial Biofilm of Staphylococcus aureus and Enterococcus faecalis.

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• Characterization of Pseudomonas aeruginosa l,d-Transpeptidases and Evaluation of Their Role in Peptidoglycan Adaptation to Biofilm Growth

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• A Narrative Review of Experimental Assessment to Study Vascular Biomaterials Infections and Infectability

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• In silico and in vitro studies of GENT-EDTA encapsulated niosomes: A novel approach to enhance the antibacterial activity and biofilm inhibition in drug-resistant Klebsiella pneumoniae.

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• In vitro activities of N‐acetyl cysteine and levofloxacin as a catheter lock therapy against catheter‐associated infections

  2022cites this paper
• Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

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• Successfully treating biofilms of extensively drug resistant Klebsiella pneumoniae isolates from hospital patients with N-Acetyl Cysteine

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• Detection of blatem, blactx-m, and blashv genes in clinical isolates of multidrug-resistant pseudomonas aeruginosa

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• Treatment of Pseudomonas aeruginosa infectious biofilms: Challenges and strategies

  2022cites this paper
• Evaluation of antibacterial activity of five biocides and the synergistic effect of biocide/EDTA combinations on biofilm-producing and non-producing Stenotrophomonas maltophilia strains isolated from clinical specimens in Iran

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• High prevalence of mgrB-mediated colistin resistance among carbapenem-resistant Klebsiella pneumoniae is associated with biofilm formation, and can be overcome by colistin-EDTA combination therapy

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• Analysis of related complications of totally implantable venous access ports in children’s chemotherapy: Single center experience

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• In Vitro and In Vivo Antimicrobial Activity of Hypochlorous Acid against Drug-Resistant and Biofilm-Producing Strains

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• Phenotype and genetic determination of resistance to common disinfectants among biofilm-producing and non-producing Pseudomonas aeruginosa strains from clinical specimens in Iran

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• Biofilm Formation and Pathogenesis

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• Modulation of Quorum Sensing and Biofilms in Less Investigated Gram-Negative ESKAPE Pathogens

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• Synergistic Antifungal Activity of Chito-Oligosaccharides and Commercial Antifungals on Biofilms of Clinical Candida Isolates

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• Novel colistin-EDTA combination for successful eradication of colistin-resistant Klebsiella pneumoniae catheter-related biofilm infections

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• Destruction of Biofilms on Silicone Tubes under the Action of a Mixture of Nocardia vaccinii IMV B-7405 Surfactants with other Biocides

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• Phenotypic and Genotypic Determination of Resistance to Common Disinfectants Among Strains of Pseudomonas Aeruginosa Producing and Non-Producing Bio�lm Isolated From Iran

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• Pharmacokinetics, Tissue Distribution, and Efficacy of VIO-001 (Meropenem/Piperacillin/Tazobactam) for Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia in Immunocompetent Rabbits with Chronic Indwelling Vascular Catheters

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• Synergistic activity of tetrasodium-EDTA, ethanol and chlorhexidine hydrochloride against planktonic and biofilm cells of clinically relevant pathogens.

  2020cites this paper
• Nanoparticulate drug-delivery systems for fighting microbial biofilms - from bench to bedside.

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• Ursodeoxycholic acid abrogates gentamicin-induced hepatotoxicity in rats: Role of NF-κB-p65/TNF-α, Bax/Bcl-xl/Caspase-3, and eNOS/iNOS pathways.

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• Ethylenediaminetetraacetic Acid Disodium Salt Acts as an Antifungal Candidate Molecule against Fusarium graminearum by Inhibiting DON Biosynthesis and Chitin Synthase Activity

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• Antibacterial synergy between linezolid and baicalein against methicillin-resistant Staphylococcus aureus biofilm in vivo.

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• General Assembly, Prevention, Local Antimicrobials: Proceedings of International Consensus on Orthopedic Infections.

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• An update on recent developments in the prevention and treatment of Staphylococcus aureus biofilms.

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• EDTA-Na3 functionalized Fe3O4 nanoparticles: grafting density control for MRSA eradication.

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• 1 " Understanding biofilm formation in intravascular device-related infections " 1 2

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• Ephemeral biogels to control anti-biofilm agent delivery: From conception to the construction of an active dressing.

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• 1 pH-mediated potentiation of aminoglycosides kills bacterial 2 persisters and eradicates in vivo biofilms 3

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• In-vitro and in-vivo therapeutic study the effect of Ca-EDTA against Salmonella typhimurium infection in experimental local rabbits

  2018cites this paper
• 48 – Infections Associated with Intravascular Lines and Grafts

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• Battling bacterial infection with hexamethylene diisocyanate cross-linked and Cefaclor-loaded collagen scaffolds

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• Hydrogels Containing Antibiofilm and Antimicrobial Agents Beneficial for Biofilm-Associated Wound Infection: Formulation Characterizations and In vitro Study

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• Risk factors for central line–associated bloodstream infection in pediatric oncology patients with a totally implantable venous access port: A cohort study

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• Central venous catheters and biofilms: where do we stand in 2017?

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  2017cites this paper
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• Streptokinase Treatment Reverses Biofilm-Associated Antibiotic Resistance in Staphylococcus aureus

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  2016cites this paper
• Study of in vivo catheter biofilm infections using pediatric central venous catheter implanted in rat

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
• In vivo infection studies

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• Investigation of existing and novel therapeutics to treat intravascular catheter-related infections caused by staphylococci using a combination of in vitro and animal models

  2015influential citation
• Antimicrobial lock therapy in central-line associated bloodstream infections: a systematic review

  2015cites this paper
• Real-Time Monitoring of Catheter-Related Biofilm Infection in Mice.

  2015cites this paper
• Evaluation of antibiotic efficacy against infections caused by planktonic or biofilm cultures of Pseudomonas aeruginosa and Klebsiella pneumoniae in Galleria mellonella.

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• Tolérance des biofilms aux antibiotiques : comprendre pour mieux traiter

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  2014cites this paper
• Nanostructuring carbon fibre probes for use in central venous catheters.

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• Novel approaches to combat bacterial biofilms.

  2014cites this paper
• Antibiotic-lock therapy: a clinical viewpoint

  2014cites this paper
• Pseudomonas aeruginosa Biofilms in Disease

  2014cites this paper
• Identification of small molecules inhibiting diguanylate cyclases to control bacterial biofilm development

  2014cites this paper
• Current and future approaches to the prevention and treatment of staphylococcal medical device-related infections.

  2014cites this paper
• Biofilms Formed by Gram-Negative Bacteria Undergo Increased Lipid A Palmitoylation, Enhancing <italic toggle='yes'>In Vivo</italic> Survival

  2014cites this paper
• Stability and compatibility of antimicrobial lock solutions.

  2013cites this paper
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  2013cites this paper
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  2013cites this paper