Obesity resistance and increased hepatic expression of catabolism‐related mRNAs in Cnot3+/− mice

No abstract is available for this paper.

• Publication year

  2011

• Venue

  EMBO Journal

• Publication date

  2011-11-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/emboj.2011.320PMID 21897366PMCID PMC3243589
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2003cited by this paper
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  2003cited by this paper
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  2002influential reference
• Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae

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• The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae.

  2001cited by this paper
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  2000cited by this paper
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  1999cited by this paper
• Hypoglycemia and impaired hepatic glucose production in mice with a deletion of the C/EBPbeta gene.

  1999cited by this paper
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  1997cited by this paper
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  1995influential reference
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  1995cited by this paper
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