CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability

Inoue et al. report that CNOT3, a subunit of the CCR4–NOT deadenylase complex regulating mRNA decay and translational repression, controls Igh gene rearrangement and destabilizes the mRNA of the tumor suppressor p53. Loss of CNOT3 results in a block of pro- to pre–B cell transition.

• Publication year

  2015

• Venue

  Journal of Experimental Medicine

• Publication date

  2015-08-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20150384PMID 26238124PMCID 4548056
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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