Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Nature Immunology

• Publication date

  2008-06-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ni.1626PMID 18568028PMCID PMC2699484
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5

  2008cited by this paper
• Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling.

  2008cited by this paper
• Pax5: the guardian of B cell identity and function

  2007cited by this paper
• Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits.

  2007cited by this paper
• The transcriptional regulation of B cell lineage commitment.

  2007cited by this paper
• Yin Yang 1 is a critical regulator of B-cell development.

  2007cited by this paper
• Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function.

  2007cited by this paper
• Distinct Promoters Mediate the Regulation of Ebf1 Gene Expression by Interleukin-7 and Pax5

  2006cited by this paper
• Foxp1 is an essential transcriptional regulator of B cell development

  2006cited by this paper
• Early hematopoietic lineage restrictions directed by Ikaros

  2006cited by this paper
• Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells.

  2006cited by this paper
• The mechanism of repression of the myeloid‐specific c‐fms gene by Pax5 during B lineage restriction

  2006cited by this paper
• A recombination silencer that specifies heterochromatin positioning and ikaros association in the immunoglobulin kappa locus.

  2006cited by this paper
• Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus.

  2006cited by this paper
• Complete Sequence Assembly and Characterization of the C57BL/6 Mouse Ig Heavy Chain V Region1

  2006cited by this paper
• Characterization of the proximal enhancer element and transcriptional regulatory factors for murine recombination activating gene‐2

  2005cited by this paper
• Ikaros Induces Quiescence and T-Cell Differentiation in a Leukemia Cell Line

  2005cited by this paper
• PU.1 is not strictly required for B cell development and its absence induces a B-2 to B-1 cell switch

  2005cited by this paper
• Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells.

  2005cited by this paper
• Ikaros-family proteins: in search of molecular functions during lymphocyte development.

  2005cited by this paper
• Contingent gene regulatory networks and B cell fate specification.

  2005cited by this paper
• Genetic networks that regulate B lymphopoiesis

  2005cited by this paper
• Epigenetic ontogeny of the Igk locus during B cell development

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• Regulation of interleukin 7–dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5

  2005cited by this paper
• Antisense intergenic transcription in V(D)J recombination

  2004cited by this paper
• Early B Cell Factor Promotes B Lymphopoiesis with Reduced Interleukin 7 Responsiveness in the Absence of E2A

  2004cited by this paper
• How to keep V(D)J recombination under control

  2004cited by this paper
• Assembling a gene regulatory network for specification of the B cell fate.

  2004cited by this paper
• Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription

  2004cited by this paper
• Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene.

  2004cited by this paper
• Complementary Signaling through flt3 and Interleukin-7 Receptor α Is Indispensable for Fetal and Adult B Cell Genesis

  2003cited by this paper
• A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.

  2003cited by this paper
• IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development.

  2003cited by this paper
• Thymopoiesis independent of common lymphoid progenitors

  2003cited by this paper
• Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement

  2003cited by this paper
• The CD8α Gene Locus Is Regulated by the Ikaros Family of Proteins

  2002cited by this paper
• Ikaros is critical for B cell differentiation and function

  2002cited by this paper
• Haematopoietic cell-fate decisions, chromatin regulation and ikaros

  2002cited by this paper
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  2002cited by this paper
• Subnuclear Compartmentalization of Immunoglobulin Loci During Lymphocyte Development

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  2002cited by this paper
• Stepwise activation of the immunoglobulin μ heavy chain gene locus

  2001cited by this paper
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  2001cited by this paper
• Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding.

  2000cited by this paper
• Defects in Hemopoietic Stem Cell Activity in Ikaros Mutant Mice

  1999cited by this paper
• Distinct Factors Regulate the MurineRAG-2 Promoter in B- and T-Cell Lines

  1999cited by this paper
• Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

  1999cited by this paper
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  1999cited by this paper
• Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A.

  1999cited by this paper
• A right royal rumpus.

  1998cited by this paper
• Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors.

  1998cited by this paper
• Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes.

  1998cited by this paper
• Identification and characterization of the murine Rag1 promoter.

  1997cited by this paper
• Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation

  1997cited by this paper
• Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin.

  1997cited by this paper
• Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation.

  1996cited by this paper
• V(D)J recombination and the cell cycle.

  1995cited by this paper
• The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene.

  1994cited by this paper
• The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins

  1994cited by this paper
• The Ikaros gene is required for the development of all lymphoid lineages.

  1994cited by this paper
• RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.

  1992cited by this paper

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• EBF1, PAX5, and MYC: regulation on B cell development and association with hematologic neoplasms

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• IKAROS Family Transcription Factors in Lymphocyte Differentiation and Function.

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• From Genotype to Phenotype: How Enhancers Control Gene Expression and Cell Identity in Hematopoiesis

  2023cites this paper
• PTEN regulates hematopoietic lineage plasticity via PU.1-dependent chromatin accessibility.

  2023cites this paper
• Ikaros is a principal regulator of Aire+ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance

  2023cites this paper
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  2023cites this paper
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