Regulation of the Development and Function of B Cells by ZBTB Transcription Factors

The large ZBTB family comprises a diverse group of transcriptional factors. Several ZBTB proteins have emerged as critical factors that regulate the lineage commitment, differentiation, and function of lymphoid cells as well as many other developmental events. For instance, dysfunctions of ZBTB20 or ZBTB24 have been linked to multisystem failures in humans. Within the B-cell lineage, BCL6, ZBTB7A, ZBTB17, and ZBTB1 regulate the development/differentiation of B cells in both bone marrow and peripheral lymphoid organs, while ZBTB20 and ZBTB32 seem to mainly impact the maintenance of terminal plasma cells. Given the importance of B cells in the prevention and treatment of infectious or autoimmune disorders, we herein summarize the roles of seven ZBTB family members (BCL6, ZBTB7A, ZBTB17, ZBTB20, ZBTB32, ZBTB1, and ZBTB24) in the development, differentiation, and function of B cells as well as the underlying molecular mechanisms.

• Publication year

  2018

• Venue

  Frontiers in Immunology

• Publication date

  2018-03-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3389/fimmu.2018.00580PMID 29616049PMCID 5869932
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Plasma cell and memory B cell differentiation from the germinal center.

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• Regulation of hematopoietic development by ZBTB transcription factors

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  2016influential reference
• Genetic, Cellular and Clinical Features of ICF Syndrome: a French National Survey

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• Breaking bad in the germinal center: how deregulation of BCL6 contributes to lymphomagenesis.

  2014cited by this paper
• Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation.

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  2013cited by this paper
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  2013cited by this paper
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• A Microarray Platform-Independent Classification Tool for Cell of Origin Class Allows Comparative Analysis of Gene Expression in Diffuse Large B-cell Lymphoma

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• The many roles of IL-7 in B cell development; mediator of survival, proliferation and differentiation.

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• The BTB-ZF Family of Transcription Factors: Key Regulators of Lineage Commitment and Effector Function Development in the Immune System

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• Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation.

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  2010cited by this paper
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  2009cited by this paper
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• BCL6 is critical for the development of a diverse primary B cell repertoire

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• Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis.

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• The BTB–zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions

  2008cited by this paper
• Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros

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• Distinct roles for Foxo1 at multiple stages of B cell differentiation

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• Regulation of B Versus T Lymphoid Lineage Fate Decision by the Proto-Oncogene LRF

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• Early hematopoietic lineage restrictions directed by Ikaros

  2006cited by this paper
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  2005cited by this paper
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  2020cites this paper
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