Adipocytokines in Atherothrombosis: Focus on Platelets and Vascular Smooth Muscle Cells

Visceral obesity is a relevant pathological condition closely associated with high risk of atherosclerotic vascular disease including myocardial infarction and stroke. The increased vascular risk is related also to peculiar dysfunction in the endocrine activity of adipose tissue responsible of vascular impairment (including endothelial dysfunction), prothrombotic tendency, and low-grade chronic inflammation. In particular, increased synthesis and release of different cytokines, including interleukins and tumor necrosis factor-α (TNF-α), and adipokines—such as leptin—have been reported as associated with future cardiovascular events. Since vascular cell dysfunction plays a major role in the atherothrombotic complications in central obesity, this paper aims at focusing, in particular, on the relationship between platelets and vascular smooth muscle cells, and the impaired secretory pattern of adipose tissue.

• Publication year

  2010

• Venue

  Mediators of Inflammation

• Publication date

  2010-06-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2010/174341PMID 20652043PMCID 2905911
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Adipose tissue as an endocrine organ.

  2010influential reference
• The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases

  2010cited by this paper
• The CD40/CD40 ligand system: linking inflammation with atherothrombosis.

  2009cited by this paper
• Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide.

  2009cited by this paper
• Oxidative Stress and Insulin Resistance

  2009cited by this paper
• Platelet receptors and signaling in the dynamics of thrombus formation

  2009cited by this paper
• Lack of direct insulin-like action of visfatin/Nampt/PBEF1 in human adipocytes

  2009cited by this paper
• The status of iodine nutrition in newborn infants, schoolchildren, adolescents and adults in former East Germany.

  2009cited by this paper
• Mechanisms of coronary microvascular adaptation to obesity.

  2009cited by this paper
• The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases

  2009cited by this paper
• Metabolic syndrome: A predictor of adverse outcomes after carotid revascularization.

  2009cited by this paper
• Nampt: linking NAD biology, metabolism and cancer.

  2009cited by this paper
• Platelet alpha-granules: basic biology and clinical correlates.

  2009cited by this paper
• Interleukin-6 and insulin resistance.

  2009cited by this paper
• Ghrelin Restores the Endothelin 1/Nitric Oxide Balance in Patients With Obesity-Related Metabolic Syndrome

  2009cited by this paper
• Role of macrophage tissue infiltration in obesity and insulin resistance.

  2009cited by this paper
• Visfatin causes endothelium-dependent relaxation in isolated blood vessels.

  2009cited by this paper
• Ghrelin inhibits contraction and proliferation of human aortic smooth muscle cells by cAMP/PKA pathway activation.

  2009cited by this paper
• How much is too much? Interleukin-6 and its signalling in atherosclerosis

  2009influential reference
• 20-HETE and F2-isoprostanes in the metabolic syndrome: the effect of weight reduction.

  2009cited by this paper
• Adipokines as regulators of muscle metabolism and insulin sensitivity.

  2009cited by this paper
• Cardiovascular biology of interleukin-6.

  2009cited by this paper
• Mechanisms of obesity and related pathology: linking immune responses to metabolic stress

  2009cited by this paper
• Drug discovery possibilities from visfatin cardioprotection?

  2009cited by this paper
• Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics.

  2009influential reference
• The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes

  2009influential reference
• The role of resistin as a regulator of inflammation: Implications for various human pathologies.

  2009cited by this paper
• Visceral adipose tissue and atherosclerosis.

  2009cited by this paper
• Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation.

  2009cited by this paper
• Protective vascular and myocardial effects of adiponectin

  2009cited by this paper
• Contribution of insulin resistance to vascular dysfunction

  2009influential reference
• Atherosclerotic plaque development and instability: A dual role for VEGF

  2009cited by this paper
• Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International As

  2009cited by this paper
• Circulating endothelin-1 levels in obese patients with the metabolic syndrome.

  2009cited by this paper
• Platelet dysfunction in central obesity.

  2009influential reference
• Regulation of megakaryocyte maturation and platelet formation

  2009cited by this paper
• Soluble CD40 ligand induces human coronary artery smooth muscle cells proliferation and migration.

  2009cited by this paper
• Adipose inflammation, insulin resistance, and cardiovascular disease.

  2008cited by this paper
• Adipokines, insulin resistance, and coronary artery calcification.

  2008influential reference
• Endothelin-1 signalling in vascular smooth muscle: pathways controlling cellular functions associated with atherosclerosis.

  2008cited by this paper
• Modulating an oxidative-inflammatory cascade: potential new treatment strategy for improving glucose metabolism, insulin resistance, and vascular function

  2008cited by this paper
• Cell Adhesion Mechanisms in Platelets

  2008influential reference
• Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease.

  2008cited by this paper
• Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology.

  2008cited by this paper
• Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis.

  2008cited by this paper
• Adipocytokines and the metabolic complications of obesity.

  2008cited by this paper
• Human Biochemistry of the Isoprostane Pathway*

  2008cited by this paper
• Intra-abdominal adiposity, inflammation, and cardiovascular risk: New insight into global cardiometabolic risk

  2008cited by this paper
• Platelet Counts and Platelet Activation Markers in Obese Subjects

  2008cited by this paper
• The PPAR&agr;/p16INK4a Pathway Inhibits Vascular Smooth Muscle Cell Proliferation by Repressing Cell Cycle–Dependent Telomerase Activation

  2008cited by this paper
• Cardiomyocyte apoptosis in animal models of obesity

  2008cited by this paper
• Absence of leptin resistance in platelets from morbidly obese individuals may contribute to the increased thrombosis risk in obesity

  2008cited by this paper
• Resistance to the nitric oxide/cyclic guanosine 5'-monophosphate/protein kinase G pathway in vascular smooth muscle cells from the obese Zucker rat, a classical animal model of insulin resistance: role of oxidative stress.

  2008cited by this paper
• The role of apelin in cardiovascular function and heart failure

  2008cited by this paper
• Apelin-induced vascular smooth muscle cell proliferation: the regulation of cyclin D1.

  2008cited by this paper
• VEGF-enhanced proliferation under hypoxia by an autocrine mechanism in human vascular smooth muscle cells.

  2008cited by this paper
• The proinflammatory mediator CD40 ligand is increased in the metabolic syndrome and modulated by adiponectin.

  2008cited by this paper
• Metabolic syndrome, haemostasis and thrombosis

  2008influential reference
• Leptin, obesity and platelet responsiveness: Another piece in the puzzle

  2008cited by this paper
• P2 receptors, platelet function and pharmacological implications

  2008cited by this paper
• Interleukin-6 Stimulates Circulating Blood-Derived Endothelial Progenitor Cell Angiogenesis in vitro

  2008cited by this paper
• Determinants of mean platelet volume (MPV) in an elderly population: Relevance of body fat, blood glucose and ischaemic electrocardiographic changes

  2008cited by this paper
• Circulating ghrelin, leptin, and soluble leptin receptor concentrations and cardiometabolic risk factors in a community-based sample.

  2008cited by this paper
• Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease.

  2008cited by this paper
• Characterization of isoprostane signaling: evidence for a unique coordination profile of 8-iso-PGF(2alpha) with the thromboxane A(2) receptor, and activation of a separate cAMP-dependent inhibitory pathway in human platelets.

  2008cited by this paper
• Platelet Chemokines in Vascular Disease

  2008cited by this paper
• Plasma Leptin Levels and Incidence of Heart Failure, Cardiovascular Disease, and Total Mortality in Elderly Individuals

  2008cited by this paper
• Insulin resistance associated to obesity: the link TNF-alpha

  2008cited by this paper
• Platelet-vessel wall interactions in atherosclerotic disease

  2008cited by this paper
• Platelet activation and atherothrombosis.

  2007cited by this paper
• An Essential Role for gp130 in Neointima Formation Following Arterial Injury

  2007cited by this paper
• Links between adipose tissue and thrombosis in the mouse.

  2007cited by this paper
• CD40/CD40L system and vascular disease

  2007cited by this paper
• Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis.

  2007cited by this paper
• Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance.

  2007cited by this paper
• Insulin-like growth factor type-1 receptor transactivation in vasoactive peptide and oxidant-induced signaling pathways in vascular smooth muscle cells.

  2007cited by this paper
• Cardiovascular actions of insulin.

  2007influential reference
• Matrix metalloproteinases: influence on smooth muscle cells and atherosclerotic plaque stability

  2007cited by this paper
• Transcriptional Control of Vascular Smooth Muscle Cell Proliferation by Peroxisome Proliferator-Activated Receptor-γ: Therapeutic Implications for Cardiovascular Diseases

  2007cited by this paper
• Metalloproteinases and vulnerable atherosclerotic plaques.

  2007cited by this paper
• Adiponectin and cardiovascular disease: response to therapeutic interventions.

  2007cited by this paper
• Platelets, inflammation and atherosclerosis

  2007cited by this paper
• The endothelium and vascular inflammation in diabetes

  2007cited by this paper
• Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity

  2007cited by this paper
• Insulin action and insulin resistance in vascular endothelium

  2007cited by this paper
• Obesity–hypertension: an ongoing pandemic

  2007cited by this paper
• Expanding role for the apelin/APJ system in physiopathology

  2007cited by this paper
• Endocrine functions of adipose tissue.

  2007cited by this paper
• Adiponectin as an anti-inflammatory factor.

  2007cited by this paper
• Adiponectin, ghrelin, and leptin differentially influence human platelet and human vascular endothelial cell functions: implication in obesity-associated cardiovascular diseases.

  2007cited by this paper
• The effect of weight loss on the mean platelet volume in obese patients

  2007cited by this paper
• Inflammatory markers, angiographic severity of coronary artery disease, and patient outcome.

  2007cited by this paper
• HIF-1 alpha expression is associated with an atheromatous inflammatory plaque phenotype and upregulated in activated macrophages.

  2007cited by this paper
• Platelet resistance to the antiaggregatory cyclic nucleotides in central obesity involves reduced phosphorylation of vasodilator-stimulated phosphoprotein.

  2007cited by this paper
• Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity.

  2007cited by this paper
• Relationship between metabolic syndrome and platelet responsiveness to leptin in overweight and obese patients

  2007cited by this paper
• The central role of thrombin in hemostasis

  2007cited by this paper
• Dynamic Visualization of Thrombopoiesis Within Bone Marrow

  2007cited by this paper
• Waist Circumference and Cardiometabolic Risk

  2007cited by this paper
• Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes

  2007cited by this paper

• The Effect of Visfatin Levels on Blood Pressure and Cardiac Risk Factors in Patients with Acromegaly

  2025cites this paper
• PCSK9 Expression in Vascular Smooth Muscle Cells: Role of Insulin Resistance and High Glucose

  2025cites this paper
• Biomolecules of Adipose Tissue in Atherosclerotic Plaques of Men With Coronary Atherosclerosis.

  2024cites this paper
• Effect of Green Tea Supplementation on Inflammatory Markers among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis

  2024cites this paper
• Serum leptin levels in patients with chronic kidney disease and hypertensive heart disease: An observational cross‐sectional study

  2023cites this paper
• Understanding the Potential Function of Perivascular Adipose Tissue in Abdominal Aortic Aneurysms: Current Research Status and Future Expectation.

  2022cites this paper
• The Functional Effects of Visfatin on Human Left Internal Mammary Artery

  2022cites this paper
• Resistin plays an essential role in the incidence of obesity and insulin resistance in mice [5]. Beside its roles on insulin sensitivity and glucose metabolism and through its action on many cell targets in rodents and human, it

  2021cites this paper
• Dimethylamine enhances platelet hyperactivity in chronic kidney disease model

  2021cites this paper
• Adipokines: New Potential Therapeutic Target for Obesity and Metabolic, Rheumatic, and Cardiovascular Diseases

  2020cites this paper
• Effect of Sleeve Gastrectomy on the Neutrophil-to-Lymphocyte Ratio, the Platelet-to-Lymphocyte Ratio, Platelet Counts, and Mean Platelet Volumes

  2020cites this paper
• Influence of Cardiometabolic Risk Factors on Platelet Function

  2020cites this paper
• Association of adipocytokines serum levels with left atrial thrombus formation in atrial fibrillation patients on oral anticoagulation (Alert) - A cross-sectional study.

  2020cites this paper
• Custodiol-N™ cardioplegia lowers cerebral inflammation and activation of hypoxia-inducible factor-1α.

  2019cites this paper
• ORIGINAL RESEARCH PAPER SIGNIFICANT DIFFERENT SERUM LEVELS OF INTERLEUKIN-6 AND ADIPOKINES IN PATIENTS WITH METABOLIC SYNDROME

  2019cites this paper
• Interpretation of maximum absorbance data obtained from turbidimetry in plasma samples with varying fibrinogen concentration

  2019cites this paper
• Relation between platelet coagulant and vascular function, sex-specific analysis in adult survivors of childhood cancer compared to a population-based sample

  2019cites this paper
• Platelet Aggregation and Interleukins Indicators Impacting the Outcomes of Ischemic Stroke.

  2019cites this paper
• Adipokines in neurovascular diseases.

  2018cites this paper
• Cardioprotection by Bioactive Polyphenols: A Strategic View

  2018cites this paper
• The value of serum visfatin in predicting in-stent restenosis of drug-eluting stents.

  2018cites this paper
• Cardioprotection by Bioactive Polyphenols: A Strategic View

  2018cites this paper
• Associations of Platelet Indices with Body Fat Mass and Fat Distribution

  2018cites this paper
• Autologous Platelet Concentrate Preparations in Dentistry

  2018cites this paper
• Pulmonary intravascular macrophages regulate the pathogenetic mechanisms of pulmonary lesions during acute courses of classical swine fever

  2018cites this paper
• Effects of significant weight loss following bariatric surgery on red cell distribution width and mean platelet volume

  2018cites this paper
• Racial differences in intracerebral haemorrhage outcomes in patients with obesity

  2018cites this paper
• Adipokines as atherothrombotic risk factors in obese subjects: Associations with haemostatic markers and common carotid wall thickness.

  2017cites this paper
• Postural Stability Induced by Supervised Physical Training may improve also Oxygen Cost of Exercise and Walking Capacity in Post-Menopause, Obese Women

  2017cites this paper
• Effects of Weight Loss with Bariatric Surgery on Platelet Count and Volume

  2017cites this paper
• Effect of Bariatric Surgery-Induced Weight Loss on Platelet Count and Mean Platelet Volume: a 12-Month Follow-Up Study

  2017cites this paper
• AdipoRon, an adiponectin receptor agonist, attenuates PDGF‐induced VSMC proliferation through inhibition of mTOR signaling independent of AMPK: Implications toward suppression of neointimal hyperplasia

  2017cites this paper
• Clinical Significance of Serum IL-6 and TNF-α Levels in Patients with Metabolic Syndrome.

  2017cites this paper
• Training impulses: A method to quantify exercise intensity in postmenopausal obese women

  2016cites this paper
• Regulación de la viabilidad y el metabolismo cardiomiocitario por fármacos (aliskiren) y hormonas (chemerina) con capacidad de modular procesos inflamatorios

  2016cites this paper
• Adipo/cytokines in atherosclerotic secretomes: increased visfatin levels in unstable carotid plaque

  2016cites this paper
• Impacto de la infección con Trypanosoma cruzi y la nutrición sobre la expresión de receptores innatos y parámetros inmuno-metabólicos en un modelo de obesidad.

  2016cites this paper
• Plasma markers of inflammation and hemostatic and endothelial activity in naturally overweight and obese dogs

  2016cites this paper
• The cardiovascular impact of visfatin - an inflammation predictor biomarker in metabolic syndrome

  2016influential citation
• Atorvastatin antagonizes the visfatin-induced expression of inflammatory mediators via the upregulation of NF-κB activation in HCAECs

  2016cites this paper
• The Intricate Network of Adipokines and Stroke

  2015cites this paper
• Efeito farmacogenético do polimorfismo Ala16Val do gene da MnSOD na resposta de pacientes hipercolesterolêmicos a rosuvastatina

  2015cites this paper
• Melatonin reduces obesity and restores adipokine patterns and metabolism in obese (ob/ob) mice.

  2015cites this paper
• Interleukin-1 and acute brain injury

  2015cites this paper
• Platelet hemostasis in patients with metabolic syndrome and type 2 diabetes mellitus: cGMP- and NO-dependent mechanisms in the insulin-mediated platelet aggregation

  2015influential citation
• Cardiovascular Complications of Obesity

  2014cites this paper
• Reduced vasodilator function following acute resistance exercise in obese women

  2014cites this paper
• Network Analysis of Inflammatory Genes and Their Transcriptional Regulators in Coronary Artery Disease

  2014cites this paper
• Leptin and vascular smooth muscle cells.

  2014cites this paper
• Adipocytokine concentrations in children with different types of beta-thalassemia

  2014cites this paper
• The relationship between inflammatory and oxidative stress biomarkers, atherosclerosis and rheumatic diseases.

  2014cites this paper
• Caring for the critically ill obese patient: challenges and opportunities.

  2014cites this paper
• Retinol‐binding protein 4 levels and susceptibility to ischaemic events in men

  2014cites this paper
• Weight Reduction Is Associated With Increased Plasma Fibrin Clot Lysis

  2014cites this paper
• VISFATIN AND CARDIOVASCULAR PROTECTION

  2014cites this paper
• Plasma levels of resistin predict cardiovascular events

  2014influential citation
• The Conundrum of Cardiovascular Dysfunction in the Critically Ill Obese Patient

  2014cites this paper
• Tkanka tłuszczowa nasierdziowa. Znaczenie fizjologiczne oraz rola w patofizjologii chorób serca* Epicardial adipose tissue and its role in cardiac physiology and disease

  2013cites this paper
• Honey for Cardiovascular Diseases

  2013cites this paper
• Antecedents, characterisation and validity of cardiovascular disease biomarkers amongst South Asians in the UK

  2013cites this paper
• Profile of intraocular tumour necrosis factor‐α and interleukin‐6 in diabetic subjects with different degrees of diabetic retinopathy

  2013cites this paper
• The critically injured obese patient: a review and a look ahead.

  2013cites this paper
• [Epicardial adipose tissue and its role in cardiac physiology and disease].

  2013cites this paper
• [Tumor necrosis factor alfa in cardiovascular diseases: molecular biology and genetics].

  2013cites this paper
• Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3–TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study

  2013cites this paper
• Oleic Acid Increases Synthesis and Secretion of VEGF in Rat Vascular Smooth Muscle Cells: Role of Oxidative Stress and Impairment in Obesity

  2013cites this paper
• Adiposity, Adipokines, and Risk of Incident Stroke in Older Men

  2013cites this paper
• Maternal serum visfatin at 11–13 weeks’ gestation in preeclampsia

  2013cites this paper
• Vascular Dysfunction in Women with Recurrent Pregnancy Loss

  2012cites this paper
• Platelet activation in obesity and metabolic syndrome

  2012cites this paper
• Interleukin-6, Tumor Necrosis Factor alpha and Metabolic Disorders in Youth

  2012cites this paper
• Presence of anti‐ADAMTS13 antibodies in obesity

  2012cites this paper
• The effects of (-)-epigallocatechin-3-O-gallate (EGCG), a green tea catechin, on blood cholesterol

  2012cites this paper
• Neutrophil extracellular traps contain mitochondrial as well as nuclear DNA and exhibit inflammatory potential

  2012cites this paper
• Evaluation of Serum Adipokines in Peripheral Arterial Occlusive Disease

  2012influential citation
• Characterization of the Human Smooth Muscle Cell Secretome for Regenerative Medicine

  2012cites this paper
• Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications.

  2012cites this paper
• Cardiovascular metabolic syndrome: mediators involved in the pathophysiology from obesity to coronary heart disease.

  2012cites this paper
• ADIPOCITOQUINAS Y SÍNDROME METABÓLICO: ROL DE LA VISFATINA EN LA PATOGENIA DE ENFERMEDAD CARDIOVASCULAR

  2011cites this paper
• Vaspin prevents TNF-α-induced intracellular adhesion molecule-1 via inhibiting reactive oxygen species-dependent NF-κB and PKCθ activation in cultured rat vascular smooth muscle cells.

  2011cites this paper
• Synergistic effects of apelin and leptin on isolated rat pulmonary arteries

  2011cites this paper
• Adipokines as regulators of muscle metabolism and insulin sensitivity.

  2009cites this paper
• Adiposity , Adipokines , and Risk of Incident Stroke in Older Men

  year unknowncites this paper
• Adiposity , Adipokines , and Risk of Incident Stroke in Older Men

  year unknowncites this paper