Preliminary Assessment of the Efficacy of a T-Cell–Based Influenza Vaccine, MVA-NP+M1, in Humans

P. Lillie,T. Berthoud,T. Powell,T. Lambe,Caitlin E. Mullarkey,Alexandra J. Spencer,M. Hamill,Yanchun Peng,M. Blais,C. Duncan,Susanne H. Sheehy,T. Havelock,S. Faust,Rob Lambkin Williams,A. Gilbert,J. Oxford,T. Dong,A. Hill,S. Gilbert

Published 2012 in Clinical Infectious Diseases

ABSTRACT

A single vaccination with MVA-NP+M1 boosts T-cell responses to conserved influenza antigens in humans. Protection against influenza disease and virus shedding was demonstrated in an influenza virus challenge study.

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