A novel “Integrated Biomarker Response” calculation based on reference deviation concept

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Environmental science and pollution research international

• Publication date

  2013-05-01

• Fields of study

  Medicine, Engineering, Environmental Science

• Identifiers
  DOI 10.1007/s11356-012-1359-1PMID 23208755
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Perspectives from the French workshop on the development and validation of biomarkers and bioassays for the monitoring of aquatic environments

  2012cited by this paper
• Application of an integrated biomarker response index (IBR) to assess temporal variation of environmental quality in two Portuguese aquatic systems

  2012cited by this paper
• Age-altered susceptibility in hexavalent chromium-exposed Daphnia schodleri (Anomopoda: Daphniidae): integrated biomarker response implementation.

  2011cited by this paper
• Comparison of two reference systems for biomarker data analysis in a freshwater biomonitoring context.

  2010cited by this paper
• Using biological effects tools to define Good Environmental Status under the European Union Marine Strategy Framework Directive.

  2010cited by this paper
• Fish biomarkers for environmental monitoring within the Water Framework Directive of the European Union

  2009cited by this paper
• Application of biomarkers for improving risk assessments of chemicals under the Water Framework Directive: a case study.

  2008cited by this paper
• Biomarker responses in wild three-spined stickleback (Gasterosteus aculeatus L.) as a useful tool for freshwater biomonitoring: a multiparametric approach.

  2008influential reference
• Assessment of seasonal variability of biomarkers in three-spined stickleback (Gasterosteus aculeatus L.) from a low contaminated stream: implication for environmental biomonitoring.

  2008influential reference
• Ethoxyresorufin-O-deethylase (EROD) and vitellogenin (VTG) in flounder (Platichthys flesus): system interaction, crosstalk and implications for monitoring.

  2007cited by this paper
• Integrated biomarker response index as a useful tool for environmental assessment evaluated using transplanted mussels.

  2007cited by this paper
• The use of biomarkers in biomonitoring: a 2-tier approach assessing the level of pollutant-induced stress syndrome in sentinel organisms.

  2007cited by this paper
• Bioaccumulation, oxidative stress, and neurotoxicity in Danio rerio exposed to different isotopic compositions of uranium

  2007cited by this paper
• The "bioeffect assessment index" (BAI). A concept for the quantification of effects of marine pollution by an integrated biomarker approach.

  2005cited by this paper
• Development of a biomarker-based index for assessing the ecotoxic potential of aquatic sites

  2003cited by this paper
• Integrated biomarker response: A useful tool for ecological risk assessment

  2002influential reference
• Scale of classification based on biochemical markers in mussels: application to pollution monitoring in European coasts.

  1999cited by this paper
• Acetylcholinesterase an old biomarker with a new future ? Field trials in association with two urban rivers and a paper mill in Newfoundland

  1996cited by this paper

• Cadmium toxicity in the black clam Villorita cyprinoides (Gray 1825): insights for developing seawater quality criteria

  2026cites this paper
• Toxic Effects of Polystyrene Microplastics and Sulfamethoxazole on Early Neurodevelopment in Embryo–Larval Zebrafish (Danio rerio)

  2026cites this paper
• Graphene Oxide-Induced Toxicity in Social Insects: Study on Ants Through Integrated Analysis of Physiology, Gut Microbiota, and Transcriptome

  2026cites this paper
• Comparative developmental toxicity of the herbicide imazapyr in Takifugu obscurus and Danio rerio: antioxidant imbalance, apoptosis, and immune-related transcriptional responses

  2026cites this paper
• Immunotoxic Effects of Oman Crude Oil Water-Accommodated Fractions on Cellular and Humoral Immune Functions in Sea Cucumber (Apostichopus japonicus)

  2026cites this paper
• Differential responses of soil microbial community structure and function to conventional and biodegradable microplastics

  2026cites this paper
• Chronic sublethal effects of pulsed versus constant pesticide exposures on the freshwater amphipod Gammarus fossarum: Behavioural and biochemical impairments under field-realistic conditions.

  2026cites this paper
• Effects of quinolone antibiotics on spearmint (Mentha spicata L.) cuttings: Insights into growth, biological activity, and computational modeling perspectives

  2026cites this paper
• Enhanced toxicity of hexavalent chromium combined with microplastics on earthworms

  2026cites this paper
• From Antioxidant Defenses to Transcriptomic Signatures: Concentration-Dependent Responses to Polystyrene Nanoplastics in Reef Fish

  2026cites this paper
• Toxic effects of microplastic (polyethylene) exposure: Stress, immune responses and neurotoxicity in crucian carp, Carassius carassius.

  2026cites this paper
• Integrated biomarker assessment of sublethal effects of a tebuconazole-based fungicide in Rhinella arenarum larvae.

  2026cites this paper
• Copper-Induced Thyroid Disruption and Oxidative Stress in Schizopygopsis younghusbandi Larvae

  2026cites this paper
• Contrasting responses of Ruditapes philippinarum and Mytilus galloprovincialis to gadolinium and salinity stress

  2026cites this paper
• Joint exposure to sulfoxaflor and prochloraz alters enzymatic and genetic profiles in honey bees (Apis mellifera L.).

  2026cites this paper
• Ecotoxicological effects of soil microplastic types and concentrations on earthworms.

  2026cites this paper
• The effect of urea and glyphosate co-application on glyphosate degradation and soil nutrient cycling functions.

  2026cites this paper
• Microplastics and bisphenol A co-exposure causes oxidative damage and induces ion regulation disorders in the gills of Portunus trituberculatus.

  2026cites this paper
• Molecular and histopathological mechanisms underlying pesticide-induced disruption of the hypothalamic-pituitary-gonadal axis in Japanese medaka.

  2026cites this paper
• HFPO-DA and PFOA exert differential combined toxicity with Cd in Paramecium: growth, behavior and molecular insights

  2026cites this paper
• Effects of Acute and Chronic Exposure to Grassland fire Ash on Life-History Traits and Locomotion of Daphnia magna

  2026cites this paper
• Lead acetate (PbAc) impairs blood-brain barrier in zebrafish via MMP-9/13-induced pericyte developmental defects.

  2025cites this paper
• Toxic effects of enrofloxacin on grass carp (Ctenopharyngodon idellus): an ecological risk assessment based on cross-system regulatory mechanisms and network toxicology.

  2025cites this paper
• Twenty exposure concentrations, zero dose-response for subcellular biomarkers: unravelling this paradox in cadmium and copper exposed Dreissena polymorpha

  2025cites this paper
• Phosphogypsum leachate exacerbates histological damage, oxidative stress, apoptosis in the liver, and genotoxicity of heat-stressed zebrafish (Danio rerio).

  2025cites this paper
• Small indigenous cyprinids as bioindicators of freshwater ecosystem health: a comprehensive monitoring assessment from the Gumti River, Northeast India

  2025cites this paper
• Toxic effects of microplastic (Polyethylene) on accumulation, hematological parameters and antioxidant responses in mirror carp, Cyprinus carpio nudus according to different particle sizes.

  2025cites this paper
• GC-MS metabolomics coupled with multi-biomarker analysis reveal toxic effects of functionalized nanoplastics in Paphia undulata.

  2025cites this paper
• Comparative hepatotoxicity of HFPO-TA and PFOA in Opsariichthys bidens: Greater liver injury induced by the PFOA alternative.

  2025cites this paper
• Synergistic and antagonistic effects of chemical pollutants and parasitic fungi on cyanobacterial metabolism

  2025cites this paper
• Comparison of toxic effects of phenanthrene and perfluorooctane sulfonate on Chinese tongue sole Cynoglossus semilaevis larva in a muti-biomarker approach.

  2025cites this paper
• Semicarbazide conferred developmental toxicity in Oryzias melastigma embryos by oxidative stress and energy metabolism disorder.

  2025cites this paper
• Toxic interactions between cadmium and salt: Insights into alleviation strategies for the defense system of medicinal hyperaccumulator Solanum nigrum

  2025cites this paper
• Emergent pollutants, escalating pressures: GenX effects on mussels in a changing environment.

  2025cites this paper
• Effect of dimethyl phthalate and salinity on barium bioavailability and bioaccessibility in the soil-plant-human systems near a shale gas development area.

  2025cites this paper
• Oxidative Stress and Apoptosis of Adult Zebrafish ( Danio rerio ) Liver Exposed to Tire Wear Particle (TWP) Leachates

  2025cites this paper
• Influence of prolonged exposure to acetamiprid on the toxicology of the decapod crustacean Pacific white shrimp Penaeus vannamei.

  2025cites this paper
• Toxicity and risk assessment of landfill leachate on the earthworm, Eisenia fetida.

  2025cites this paper
• Coexposure to microplastic and arsenic induces prooxidative situation in Laeonereis culveri (Annelida, Polychaeta).

  2025cites this paper
• Assessing nanoencapsulated geraniol as a safer pesticide alternative: insights from biomarker responses in a neotropical fish species

  2025cites this paper
• The threshold effect of Ce-Zn compound pollution on maize roots: Implications for plant tolerance to combined metal pollution.

  2025cites this paper
• Combined effects of λ-cyhalothrin and imidacloprid formulated insecticides on the embryo-larval development of Danio rerio

  2025cites this paper
• Investigating the physiological mechanisms of juvenile flounder in response to waterborne exposure of methylmercury.

  2025cites this paper
• A multi-biomarker approach to study the toxic effects of thallium on earthworms (Eisenia fetida) fed with different food sources

  2025cites this paper
• The Effect of the Antidepressant Citalopram on the Bioconcentration and Biomarker Response of Daphnia magna at Environmentally Relevant Concentrations

  2025cites this paper
• Soil and earthworm-derived enzymatic activities in soil microcosms following addition of a N- and P-enriched polysaccharide-based vs a conventional starch-based mulching film.

  2025cites this paper
• Imidacloprid impacts oxidative stress and neurotoxic biomarkers in different marine organisms (fish, mysid and clamworm).

  2025cites this paper
• Risks of microplastics on germination and growth of pepper (Capsicum annuum L.) depending on the type, concentration and particle size

  2025cites this paper
• Network-based investigation of norfloxacin-induced nasal immune-related inflammatory responses in carp (Cyprinus carpio) and its cross-species implications for olfactory immune disturbance.

  2025cites this paper
• Insights into the disinfection byproduct bromochloroacetamide-induced cardiotoxicity of zebrafish embryo-larvae: A multiomics approach and comparison of biomarker responsiveness.

  2025cites this paper
• Evaluation of cadmium toxicity in Penaeus monodon using ecotoxicological tools: A foundational step for deriving seawater quality criteria.

  2025cites this paper
• Impact of the Fungicide picoxystrobin on earthworm health: insights from antioxidant responses and DNA integrity in Eisenia fetida

  2025cites this paper
• The regulatory network of antioxidant enzyme synergy in ROS homeostasis and Photosynthesis: Multilevel response mechanisms of rye seedlings under nicosulfuron-atrazine-freeze-thaw combined stress.

  2025cites this paper
• A Multibiomarker Approach to Delineate the Toxicity of Methoxyfenozide on Oncorhynchus mykiss

  2025cites this paper
• Combined effects of guanitoxin and insecticides on the health of Oreochromis niloticus (Teleostei: Cichlidae): A comprehensive toxicological study.

  2025cites this paper
• Reclaiming Saline Soils with Rice Husk Biochar as a Soil Amendment: Enhancing Soil Health and Promoting Okra Growth

  2025cites this paper
• Heteroaggregation between polystyrene micro(nano)plastics and dibutyl phthalate mediates toxicity reduction in macroalgae: Physiological and transcriptomic evidence from Gracilariopsis lemaneiformis.

  2025cites this paper
• Aged and nano-sized polylactic acid enhanced arsenic accumulation and phytotoxicity in rice seedlings: Compared with micro-sized polylactic acid.

  2025cites this paper
• Property evolution and driving factors of electrolytic manganese residue (EMR) during long-term natural weathering

  2025cites this paper
• Rapid fate of benzophenone in artificial soil and comprehensive toxicity assessment in Eisenia fetida

  2025cites this paper
• Environmental assessment of three Southern Brazilian rivers using an integrated biomarker response index in Hypostomus ancistroides applied to GIS.

  2025cites this paper
• Sublethal effects of diclofenac and ibuprofen, individually and in mixture, in a Neotropical fish: A multi-biomarker assessment under environmentally realistic concentrations.

  2025cites this paper
• Chemical stress assessment in large rivers using the average biomarker response approach with caged fish in situ: a case study on the Danube River in Novi Sad (Serbia)

  2025cites this paper
• Metabolomic insights into the synergistic effects of nanoplastics and freeze-thaw cycles on Secale cereale L. seedling physiology.

  2025cites this paper
• Dealkylation metabolites of Atrazine: A previously Neglected Contributor to soybean phytotoxicity within atrazine residue.

  2025cites this paper
• Assessing the impacts of nanoencapsulated geraniol on amphibians: A step toward sustainable pesticide alternatives?

  2025cites this paper
• Hidden costs of beauty: An in vitro study on the ecotoxicological impacts of ultraviolet filters and parabens on the bioindicator species Mytilus galloprovincialis.

  2025cites this paper
• Novel insights into copper-induced Chinese mitten crab hepatopancreas mitochondrial toxicity: Oxidative stress, apoptosis and BNIP3L-mediated mitophagy.

  2025cites this paper
• The Ecotoxicological effects of Diclofenac and Gentamicin on Mytilus galloprovincialis: What Does In Vivo Reveal That In Vitro Fails to Show?

  2025cites this paper
• Species-Specific Bioaccumulation and Sensitivity to Microplastics in Freshwater Snails: Insights from Cipangopaludina chinensis and Semisulcospira libertina

  2025cites this paper
• Hepatotoxic Effect of DEP in Zebrafish is via Oxidative Stress, Genotoxicity, and Modulation of Molecular Pathways.

  2025cites this paper
• Combined toxicity of microplastic fibers and dibutyl phthalate on algae: Synergistic or antagonistic?

  2025cites this paper
• Physiological effects of sulfadiazine and sulfamethoxazole on Skeletonema costatum and toxicological evaluation using IBRv2 index.

  2025cites this paper
• Transgenerational toxicity assessment of [C8mim]Br: Focus on early development, antioxidant defense, and transcriptome profiles in zebrafish.

  2025cites this paper
• Biochemical dynamics of the invasive clams Ruditapes philippinarum and Corbicula fluminea in response to caffeine concentrations under present and future climate scenarios

  2025cites this paper
• Effects of Chemical Speciation on Chronic Thyroid Toxicity of Representative Perfluoroalkyl Acids.

  2025cites this paper
• Growth and physiological responses of spearmint (Mentha spicata) cuttings to norfloxacin.

  2025cites this paper
• Molecular and physiological responses of black rockfish (Sebastes schlegelii) to short- and medium-term ocean acidification.

  2025cites this paper
• Effects of Exposure to Bauxite Residue Leachates from Short-Term Revegetation on Oxidative Stress and DNA Damage in Zebrafish (Danio rerio)

  2025cites this paper
• Detrimental impact of photo-Fenton treated COVID-19 drugs on liver function: A thorough investigation in Danio rerio.

  2025cites this paper
• Exogenous γ-aminobutyric acid (GABA) effectively alleviates the synergistic inhibitory effect of freeze-thaw and copper combined stress on rye seedling growth.

  2025cites this paper
• Buprofezin causes early developmental toxicity of zebrafish (Danio rerio) embryos: morphological, physiological and biochemical responses.

  2025cites this paper
• Synergistic toxicity of DBDPE and Cd in a microcosm agrosystem: Insights into physiological, biochemical, nutrient elements and amino acid metabolic responses.

  2025cites this paper
• Biomarker responses in wild brown trout from a headwater stream and their causal link to water pollution assessed through chemical analysis and in vitro reporter gene bioassays.

  2025cites this paper
• Breaking new ground: Gadolinium and Microplastics co-exposure and biochemical alterations in marine clam Donax trunculus.

  2025cites this paper
• Toxic effects of co-exposure to polystyrene nanoplastics and arsenic in zebrafish (Danio rerio): Oxidative stress, physiological and biochemical responses.

  2025cites this paper
• Locomotor activity alterations in zebrafish following cisplatin exposure: An assessment of neurobehavioral toxicity.

  2025cites this paper
• Molecular and Physiological Adaptations of Scartelaos histophorus to Air Exposure: Implications for Amphibious Fish Survival.

  2025cites this paper
• Combined toxicity of polyethylene microplastics and soil salinization to earthworms is generally antagonistic or additive.

  2025cites this paper
• Ecotoxicological effects of individual and combined treatments of chlortetracycline and oxytetracycline on seed germination and seedling growth of wheat (Triticum aestivum L.).

  2025cites this paper
• Physiological and molecular responses to different sizes of polystyrene micro/nanoplastics in the model unicellular eukaryote Paramecium tetraurelia.

  2025cites this paper
• Sustained exposure to triclocarban and triclosan at environmental relevant concentration disrupts gut-liver axis in the black-spotted frog.

  2025cites this paper
• Bioaccumulation, Ecotoxicity, and Microbial Responses in Hoplobatrachus rugulosus Tadpoles Following Co-Exposure to Imidacloprid and Microplastics

  2025cites this paper
• Enrofloxacin exposure enhances GABA synthesis via PI3K/Akt signaling pathway in crucian carp brain

  2025cites this paper
• Carbonsulfan-induced physiological, histopathological, and ultrastructural alterations in Tubifex tubifex (Müller, 1774)

  2025cites this paper
• Interactive effects of Titanium-based compounds with Gadolinium and Mercury in Mytilus galloprovincialis.

  2025cites this paper
• Trade-off strategy under stress: Growth, reproduction, and antioxidant defense in Daphnia magna exposed to 6PPD-Q.

  2025cites this paper
• Differential biochemical responses of Cyprinus carpio after dietary and waterborne exposure to microplastics from polyethylene-based biodegradable and conventional bags

  2025cites this paper
• What do emerging PFAS tell us that the classic ones did not? Insights from in vitro assays.

  2025cites this paper
• Impact of 4-tert-Butylphenol on Inflammation and Glycogen Metabolism in Cyprinus carpio L via the miR-363/PKCδ Axis

  2025cites this paper