Biological Validation of the CD45 Tyrosine Phosphatase as a Pharmaceutical Target

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Handbook of experimental pharmacology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/3-540-26670-4_10
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• The CD45 phosphotyrosine phosphatase

  2004cited by this paper
• Preclinical Studies Targeting Normal and Leukemic Hematopoietic Cells with Yttrium-90-Labeled anti-CD45 Antibody in Vitro and in Vivo in Nude Mice

  2003cited by this paper
• CD45: a critical regulator of signaling thresholds in immune cells.

  2003cited by this paper
• Either of the CD45RB and CD45RO Isoforms Are Effective in Restoring T Cell, But Not B Cell, Development and Function in CD45-Null Mice1

  2003cited by this paper
• CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

  2003cited by this paper
• Alefacept selectively promotes NK cell‐mediated deletion of CD45R0+ human T cells

  2003cited by this paper
• CD45 protein-tyrosine phosphatase inhibitor development.

  2003cited by this paper
• Regulation of Lck activity by CD4 and CD28 in the immunological synapse

  2002cited by this paper
• TCR Signals Mediated by Src Family Kinases Are Essential for the Survival of Naive T Cells1

  2002cited by this paper
• Bismuth 213-labeled anti-CD45 radioimmunoconjugate to condition dogs for nonmyeloablative allogeneic marrow grafts.

  2002cited by this paper
• In vivo depletion of hematopoietic stem cells in the rat by an anti-CD45 (RT7) antibody.

  2002cited by this paper
• Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation.

  2002influential reference
• Apoptosis Mediated Through CD45 Is Independent of Its Phosphatase Activity and Association with Leukocyte Phosphatase-Associated Phosphoprotein1

  2002cited by this paper
• Differential Association of CD45 Isoforms with CD4 and CD8 Regulates the Actions of Specific Pools of p56lck Tyrosine Kinase in T Cell Antigen Receptor Signal Transduction*

  2002cited by this paper
• A study on CD45 isoform expression during T-cell development and selection events in the human thymus.

  2002cited by this paper
• Antibody-based therapy of human leukemia

  2002cited by this paper
• Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms

  2002cited by this paper
• Staging and resetting T cell activation in SMACs

  2002influential reference
• SKAP55 Coupled with CD45 Positively Regulates T-Cell Receptor-Mediated Gene Transcription

  2002cited by this paper
• CD45 Controls Interleukin-4-mediated IgE Class Switch Recombination in Human B Cells through Its Function as a Janus Kinase Phosphatase*

  2002cited by this paper
• The tyrosine kinase Lyn is required for B cell development beyond the T1 stage in the spleen: rescue by over‐expression of Bcl‐2

  2002cited by this paper
• Potent reversible inhibitors of the protein tyrosine phosphatase CD45.

  2001cited by this paper
• A Deletion in the Gene Encoding the CD45 Antigen in a Patient with SCID

  2001cited by this paper
• B cells acquire antigen from target cells after synapse formation

  2001cited by this paper
• CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

  2001cited by this paper
• LONG-TERM ALLOGRAFT ACCEPTANCE INDUCED BY SINGLE DOSE ANTI-LEUKOCYTE COMMON ANTIGEN (RT7) ANTIBODY IN THE RAT1

  2001cited by this paper
• Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation

  2001cited by this paper
• The Role of the Protein Tyrosine Phosphatase CD45 in Regulation of B Lymphocyte Activation

  2001cited by this paper
• Immunosuppressive effects of (131)I-anti-CD45 antibody in unsensitized and donor antigen-presensitized H2-matched, minor antigen-mismatched murine transplant models.

  2001cited by this paper
• Careers in immunology: the new reality

  2001cited by this paper
• Development of Intestinal Intraepithelial Lymphocytes, NK Cells, and NK 1.1+ T Cells in CD45-Deficient Mice1

  2001cited by this paper
• TU-572, a Potent and Selective CD45 Inhibitor, Suppresses IgE-Mediated Anaphylaxis and Murine Contact Hypersensitivity Reactions

  2001cited by this paper
• Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes.

  2001cited by this paper
• The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function.

  2000cited by this paper
• Synthesis and characterization of a potent and selective protein tyrosine phosphatase inhibitor, 2.

  2000cited by this paper
• Stable interdomain interaction within the cytoplasmic domain of CD45 increases enzyme stability.

  2000cited by this paper
• Long-term survival but impaired homeostatic proliferation of Naïve T cells in the absence of p56lck.

  2000cited by this paper
• An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity.

  2000cited by this paper
• Development of T‐leukaemias in CD45 tyrosine phosphatase‐deficient mutant lck mice

  2000cited by this paper
• Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes.

  2000cited by this paper
• Thymic Selection Generates T Cells Expressing Self-Reactive TCRs in the Absence of CD451

  2000cited by this paper
• A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation.

  2000cited by this paper
• Regulation of mast cell signaling through high-affinity IgE receptor by CD45 protein tyrosine phosphatase.

  2000cited by this paper
• Intra‐ and intermolecular interactions of the catalytic domains of human CD45 protein tyrosine phosphatase

  2000cited by this paper
• The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease

  2000cited by this paper
• Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease

  2000cited by this paper
• Phase I study of 131I-anti-CD45 antibody plus cyclophosphamide and total body irradiation for advanced acute leukemia and myelodysplastic syndrome

  1999cited by this paper
• Biochemical association of CD45 with the T cell receptor complex: regulation by CD45 isoform and during T cell activation.

  1999cited by this paper
• Proline Residues in Cd28 and the Src Homology (Sh)3 Domain of Lck Are Required for T Cell Costimulation

  1999cited by this paper
• Adoptively transferable tolerance induced by CD45RB monoclonal antibody.

  1999cited by this paper
• Expression of the p56lckY505F Mutation in CD45-Deficient Mice Rescues Thymocyte Development

  1999cited by this paper
• Regulation of integrin-mediated T cell adhesion by the transmembrane protein tyrosine phosphatase CD45.

  1999cited by this paper
• The CD45 tyrosine phosphatase regulates CD3‐induced signal transduction and T cell development in recombinase‐deficient mice: restoration of pre‐TCR function by active p56lck

  1999cited by this paper
• Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase‐deficient mice

  1999cited by this paper
• Activation of the Lck Tyrosine-protein Kinase by the Binding of the Tip Protein of Herpesvirus Saimiri in the Absence of Regulatory Tyrosine Phosphorylation*

  1999cited by this paper
• Rapid and irreversible inactivation of protein tyrosine phosphatases PTP1B, CD45, and LAR by peroxynitrite.

  1999cited by this paper
• Domain organization of the extracellular region of CD45.

  1999cited by this paper
• Tyrosine 319 in the Interdomain B of ZAP-70 Is a Binding Site for the Src Homology 2 Domain of Lck*

  1999cited by this paper
• CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells.

  1999cited by this paper
• CD45 Is Essential for FcεRI Signaling by ZAP70, But Not Syk, in Syk-Negative Mast Cells

  1999cited by this paper
• Positive and negative regulation of Src-family membrane kinases by CD45.

  1999cited by this paper
• ThymocytesPhosphatase Is an Inhibitor of Lck Activity in Cutting Edge: The CD45 Tyrosine

  1999cited by this paper
• Contribution of kinases and the CD45 phosphatase to the generation of tyrosine phosphorylation patterns in the T-cell receptor complex zeta chain.

  1999cited by this paper
• CD45 and Src-family kinases: and now for something completely different.

  1999cited by this paper
• Characterization of Recombinant CD45 Cytoplasmic Domain Proteins

  1998cited by this paper
• Antibody-mediated targeting of CD45 isoforms: a novel immunotherapeutic strategy.

  1998cited by this paper
• Monoclonal antibody against CD45RB for the therapy of rejection and autoimmune diseases

  1998cited by this paper
• Three-dimensional segregation of supramolecular activation clusters in T cells

  1998cited by this paper
• Inhibition of protein tyrosine phosphatases PTP1B and CD45 by sulfotyrosyl peptides.

  1998cited by this paper
• Pulchellalactam: a CD45 protein tyrosine phosphatase inhibitor from the marine fungus Corollospora pulchella.

  1998cited by this paper
• Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge.

  1998cited by this paper
• The Second Domain of the CD45 Protein Tyrosine Phosphatase Is Critical for Interleukin-2 Secretion and Substrate Recruitment of TCR-ζ in Vivo*

  1998cited by this paper
• Physical association of CD4 and CD45 in primary, resting CD4+ T cells.

  1997cited by this paper
• Nitroarylhydroxymethylphosphonic acids as inhibitors of CD45.

  1997cited by this paper
• T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45.

  1997cited by this paper
• Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells.

  1997cited by this paper
• Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70.

  1997cited by this paper
• CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway.

  1997cited by this paper
• CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion.

  1997cited by this paper
• Indefinite islet allograft survival in mice after a short course of treatment with anti-CD45 monoclonal antibodies.

  1997cited by this paper
• Lymphocyte signalling : mechanisms, subversion, and manipulation

  1997cited by this paper
• Alterations in the level of CD45 surface expression affect the outcome of thymic selection.

  1997cited by this paper
• The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation

  1996cited by this paper
• Enhanced generation of NK cells with intact cytotoxic function in CD45 exon 6-deficient mice.

  1996cited by this paper
• CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

  1996cited by this paper
• Immunoglobulin-mediated signal transduction in B cells from CD45- deficient mice

  1996cited by this paper
• Short course single agent therapy with an LFA-3-IgG1 fusion protein prolongs primate cardiac allograft survival.

  1996cited by this paper
• CD45 ligation induces programmed cell death in T and B lymphocytes.

  1996cited by this paper
• CD45 Modulates Phosphorylation of Both Autophosphorylation and Negative Regulatory Tyrosines of Lyn in B Cells*

  1996cited by this paper
• Prevention and reversal of renal allograft rejection by antibody against CD45RB

  1996cited by this paper
• Anti-CD45 and anti-CD52 (Campath) monoclonal antibodies effectively eliminate systematically disseminated human non-Hodgkin's lymphoma B cells in Scid mice.

  1996cited by this paper
• Defective depletion of CD45-null thymocytes by the Staphylococcus aureus enterotoxin B superantigen.

  1996cited by this paper
• Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity

  1996cited by this paper
• The structure and ligand interactions of CD2: implications for T-cell function.

  1996cited by this paper
• Development of Intestinal Intraepithelial Lymphocytes

  1996cited by this paper
• Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45

  1996influential reference
• Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase

  1995cited by this paper
• Synthesis and protein tyrosine phosphatase inhibitory activity of dephostatin analogs.

  1995cited by this paper
• Differential requirements of CD45 for lymphocyte development and function

  1995influential reference
• Point mutation in the second phosphatase domain of CD45 abrogates tyrosine phosphatase activity.

  1995cited by this paper

• Explorer The differential regulation of Lck kinase phosphorylation sites by CD 45 is critical for T cell receptor signaling responses

  2017cites this paper
• Natural products with protein tyrosine phosphatase inhibitory activity.

  2014cites this paper
• The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses.

  2007cites this paper
• Inhibitors of Protein Kinases and Protein Phosphates Contributors

  2005cites this paper