The in vivo function of mammalian cell and tissue polarity regulators – how to shape and maintain the epidermal barrier

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Cell Science

• Publication date

  2012-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.092890PMID 22935653
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011influential reference
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• Neurogenesis and asymmetric cell division.

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  2008influential reference
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  2008influential reference
• Quantitative proliferation dynamics and random chromosome segregation of hair follicle stem cells

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• Mammalian aPKC/Par polarity complex mediated regulation of epithelial division orientation and cell fate.

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