Regulation of cell polarity during epithelial morphogenesis.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Current Opinion in Cell Biology

• Publication date

  2008-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.ceb.2008.01.001PMID 18282696
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway.

  2007cited by this paper
• Energy-dependent regulation of cell structure by AMP-activated protein kinase

  2007cited by this paper
• Par1b promotes hepatic-type lumen polarity in Madin Darby canine kidney cells via myosin II- and E-cadherin-dependent signaling.

  2007cited by this paper
• PtdIns(3,4,5)P3 regulates spindle orientation in adherent cells.

  2007cited by this paper
• PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.

  2007influential reference
• Wurst is essential for airway clearance and respiratory-tube size control

  2007cited by this paper
• The Rab8 GTPase regulates apical protein localization in intestinal cells

  2007cited by this paper
• Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6–aPKC

  2007cited by this paper
• Myosin V, Rab11, and dRip11 direct apical secretion and cellular morphogenesis in developing Drosophila photoreceptors

  2007cited by this paper
• LKB1 and AMPK maintain epithelial cell polarity under energetic stress

  2007cited by this paper
• Planar polarity and tissue morphogenesis.

  2007cited by this paper
• PDZ domains of Par-3 as potential phosphoinositide signaling integrators.

  2007cited by this paper
• The PAR proteins: fundamental players in animal cell polarization.

  2007cited by this paper
• Pseudomonas aeruginosa exploits a PIP3-dependent pathway to transform apical into basolateral membrane

  2007cited by this paper
• Phosphatidylinositol 4,5-bisphosphate mediates the targeting of the exocyst to the plasma membrane for exocytosis in mammalian cells.

  2007cited by this paper
• Evidence for a molecular link between the tuberous sclerosis complex and the Crumbs complex.

  2007cited by this paper
• Apical junctional complexes and cell polarity.

  2007cited by this paper
• Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase

  2007cited by this paper
• BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms.

  2007cited by this paper
• Sequential pulses of apical epithelial secretion and endocytosis drive airway maturation in Drosophila.

  2007cited by this paper
• Phosphoinositides Control Epithelial Development

  2007cited by this paper
• PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains

  2006cited by this paper
• PAR proteins and the cytoskeleton: a marriage of equals.

  2006cited by this paper
• Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells.

  2006cited by this paper
• Endothelial tubes assemble from intracellular vacuoles in vivo

  2006cited by this paper
• Phosphoinositides in cell regulation and membrane dynamics

  2006cited by this paper
• The agrin/perlecan-related protein eyes shut is essential for epithelial lumen formation in the Drosophila retina.

  2006cited by this paper
• The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size.

  2006cited by this paper
• Phosphoinositides in cell regulation and membrane dynamics

  2006cited by this paper
• Tubulogenesis: an inside job.

  2006cited by this paper
• Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells

  2006cited by this paper
• AMP-activated protein kinase regulates the assembly of epithelial tight junctions

  2006cited by this paper
• Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae.

  2005cited by this paper
• The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila

  2005cited by this paper
• Par-3 controls tight junction assembly through the Rac exchange factor Tiam1

  2005cited by this paper
• Modelling glandular epithelial cancers in three-dimensional cultures

  2005cited by this paper
• Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling

  2005cited by this paper
• Organization of vesicular trafficking in epithelia

  2005cited by this paper
• The phosphoinositol-3-kinase-protein kinase B/Akt pathway is critical for Pseudomonas aeruginosa strain PAK internalization.

  2005cited by this paper
• Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells

  2005cited by this paper
• Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro.

  2004cited by this paper
• Beta1-integrin orients epithelial polarity via Rac1 and laminin.

  2004cited by this paper
• Real-time three-dimensional imaging of lipid signal transduction: apical membrane insertion of epithelial Na(+) channels.

  2004cited by this paper
• Epithelial trafficking: new routes to familiar places.

  2004cited by this paper
• Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis.

  2004cited by this paper
• Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells.

  2004cited by this paper
• CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells.

  2003cited by this paper
• Direct interaction of two polarity complexes implicated in epithelial tight junction assembly

  2003cited by this paper
• Integrated activity of PDZ protein complexes regulates epithelial polarity

  2003cited by this paper
• An Integrin and Rho GTPase‐Dependent Pinocytic Vacuole Mechanism Controls Capillary Lumen Formation in Collagen and Fibrin Matrices

  2003cited by this paper
• Phosphoinositide regulation of the actin cytoskeleton.

  2003cited by this paper
• Tube Morphogenesis: Making and Shaping Biological Tubes

  2003cited by this paper
• Phosphorylation-dependent binding of 14-3-3 to the polarity protein Par3 regulates cell polarity in mammalian epithelia.

  2003cited by this paper
• Tube morphogenesis: making and shaping biological tubes.

  2003cited by this paper
• Tissue architecture: the ultimate regulator of breast epithelial function.

  2003cited by this paper
• Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization

  2003cited by this paper
• Polarized epithelial membrane traffic: conservation and plasticity

  2003cited by this paper
• Rho GTPases in cell biology

  2002cited by this paper
• Building epithelial architecture: insights from three-dimensional culture models

  2002cited by this paper
• The Cdc42 and Rac1 GTPases are required for capillary lumen formation in three-dimensional extracellular matrices.

  2002cited by this paper
• The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.

  2002cited by this paper
• Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly

  2001cited by this paper
• The glomerular epithelial cell anti-adhesin podocalyxin associates with the actin cytoskeleton through interactions with ezrin.

  2001cited by this paper
• Expression of podocalyxin inhibits cell-cell adhesion and modifies junctional properties in Madin-Darby canine kidney cells.

  2000cited by this paper
• Mechanism of N-Wasp Activation by Cdc42 and Phosphatidylinositol 4,5-Bisphosphate

  2000cited by this paper
• The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly.

  1999cited by this paper
• An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3

  1998cited by this paper
• Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors.

  1991cited by this paper
• Modulation of the expression of an apical plasma membrane protein of Madin-Darby canine kidney epithelial cells: cell-cell interactions control the appearance of a novel intracellular storage compartment

  1987cited by this paper

• From Darwin to teleonomy: A categorical final-cause calculus for evolution

  2026cites this paper
• Integrated profiling reveals polarity protein dysregulation during oral cancer progression

  2025cites this paper
• P-cadherin-dependent adhesions are required for single lumen formation and HGF-mediated cell protrusions during epithelial morphogenesis

  2025cites this paper
• Rosette formations as symmetry-breaking events: theory and experiment

  2025cites this paper
• Steady-state epithelial apical flatness is characterized by MLCK morphodynamics and asynchronous Ca 2+ oscillations, but not underlying ECM geometry

  2025cites this paper
• BET Inhibition Rescues Acinar-Ductal-Metaplasia and Ciliogenesis and Ameliorates Chronic Pancreatitis-Driven Changes in Mice with Loss of the Polarity Protein Par3

  2024cites this paper
• Myosin 1b regulates intestinal epithelial morphogenesis via interaction with UNC45A.

  2024cites this paper
• Inverted apicobasal polarity in health and disease

  2024cites this paper
• Using Microfluidics to Align Matrix Architecture and Generate Chemokine Gradients Promotes Directional Branching in a Model of Epithelial Morphogenesis

  2024cites this paper
• BET inhibition rescues ciliogenesis and ameliorates pancreatitis-driven phenotypic changes in mice with Par3 loss

  2023cites this paper
• Ccdc85c-Par3 condensates couple cell polarity with Notch to control neural progenitor proliferation.

  2023cites this paper
• TTLL12 is required for primary ciliary axoneme formation in polarized epithelial cells

  2023cites this paper
• Matriptase-dependent epidermal pre-neoplasm in zebrafish embryos caused by a combination of hypotonic stress and epithelial polarity defects

  2023cites this paper
• Helicobacter pylori and Epstein-Barr virus infection in cell polarity alterations

  2023cites this paper
• TTLL12 is required for primary ciliary axoneme formation in polarized epithelial cells

  2023cites this paper
• Epithelial-to-Mesenchymal Transition-Related Markers in Prostate Cancer: From Bench to Bedside

  2023cites this paper
• Morphogenesis and development of human telencephalic organoids in the absence and presence of exogenous extracellular matrix

  2023cites this paper
• Molecular Mechanisms Involved in Pseudomonas aeruginosa Bacteremia.

  2022cites this paper
• Dual Function of Par3 in Tumorigenesis

  2022cites this paper
• Morphogenesis and development of human telencephalic organoids in the absence and presence of exogenous ECM

  2022cites this paper
• The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces

  2022cites this paper
• Specialized protrusions coordinate migratory border cell cluster cohesion via Scribble, Cdep, and Rac

  2022cites this paper
• PARD3 gene variation as candidate cause of nonsyndromic cleft palate only

  2022cites this paper
• The Cdc42 GAP Rga6 promotes monopolar outgrowth of spores

  2022cites this paper
• FAM96A suppresses epithelial-mesenchymal transition and tumor metastasis by inhibiting TGFβ1 signals.

  2022cites this paper
• Journal of Reproduction and Development

  2022cites this paper
• Basement Membrane of Tissue Engineered Extracellular Matrix Scaffolds Modulates Rapid Human Endothelial Cell Recellularization and Promote Quiescent Behavior After Monolayer Formation

  2022cites this paper
• Cell fate decisions, transcription factors and signaling during early retinal development

  2022cites this paper
• The PI3K/Akt/mTORC signaling axis in head and neck squamous cell carcinoma: Possibilities for therapeutic interventions either as single agents or in combination with conventional therapies

  2021cites this paper
• Congenital biliary atresia is correlated with disrupted cell junctions and polarity caused by Cdc42 insufficiency in the liver

  2021cites this paper
• Cleavage of E-cadherin by porcine respiratory bacterial pathogens facilitates airway epithelial barrier disruption and bacterial paracellular transmigration

  2021cites this paper
• Recent Updates on the Involvement of PI3K/AKT/mTOR Molecular Cascade in the Pathogenesis of Hyperproliferative Skin Disorders

  2021cites this paper
• Specification of the patterning of a ductal tree during branching morphogenesis of the submandibular gland

  2021cites this paper
• Induction of apically mistrafficked epiregulin disrupts epithelial polarity via aberrant EGFR signaling.

  2021cites this paper
• Kinase Signaling in Dendritic Development and Disease

  2021cites this paper
• Myosin-1b interacts with UNC45A and controls intestinal epithelial morphogenesis

  2021cites this paper
• CagA–ASPP2 complex mediates loss of cell polarity and favors H. pylori colonization of human gastric organoids

  2020cites this paper
• Coordinated assembly and release of adhesions builds apical junctional belts during de novo polarisation of an epithelial tube

  2020cites this paper
• Coordinated assembly and release of adhesions builds apical junctional belts during <italic>de novo</italic> polarisation of an epithelial tube

  2020cites this paper
• Elucidation of the Genetic and Developmental Mechanisms Underlying Choroid Fissure Closure

  2020influential citation
• Cell‐extracellular matrix interactions in the fluidic phase direct the topology and polarity of self‐organized epithelial structures

  2020cites this paper
• Coordinated assembly and release of adhesions builds apical junctional belts during de novo polarisation of an epithelial tube

  2020cites this paper
• The role of tetraspanin 6 in colorectal cancer

  2019cites this paper
• Bisphenol S increases EZRIN expression and the detrimental effects induced by dehydroepiandrosterone in rat endometrium.

  2019cites this paper
• ROLE OF IRSP53 IN EPITHELIAL POLARITY ESTABLISHMENT AND LUMEN MORPHOGENESIS

  2019cites this paper
• Predictive value of EGFR-PI3K-pAKT-mTOR-pS6 pathway in sinonasal squamous cell carcinomas.

  2019cites this paper
• Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte Recruitment

  2019cites this paper
• LongAxis: a MATLAB-based program for 3D quantitative analysis of epithelial cell shape and orientation

  2019cites this paper
• Contact lens-related corneal infection: Intrinsic resistance and its compromise.

  2019cites this paper
• Predictive Value of EGFR-PI3K-pAKT-mTOR-pS6 Pathway in Sinonasal Squamous Cell Carcinomas

  2019cites this paper
• Micropattern-based platform as a physiologically relevant model to study epithelial morphogenesis and nephrotoxicity.

  2019cites this paper
• Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins

  2019cites this paper
• Decreased expression of cell polarity protein Scribble correlated with altered subcellular localization of the Crumbs homologue 3 protein in human adenomyotic endometrial cells

  2019cites this paper
• Hippo‐Yap/Taz signaling: Complex network interactions and impact in epithelial cell behavior

  2019cites this paper
• Arabidopsis Protein Kinase D6PKL3 Is Involved in the Formation of Distinct Plasma Membrane Aperture Domains on the Pollen Surface[OPEN]

  2018cites this paper
• Polarity protein Canoe mediates overproliferation via modulation of JNK, Ras‐MAPK and Hippo signalling

  2018cites this paper
• L'interaction entre les voies de signalisation TGF-B et Hippo : implication de la polarité apico-basale et de le protéine ZO-1

  2018cites this paper
• An integrated computational & mammalian synthetic biology framework for engineering Turing patterns

  2018cites this paper
• Targeting phosphoinositide 3-kinase (PI3K) in head and neck squamous cell carcinoma (HNSCC)

  2018cites this paper
• Subventricular zone lipidomic architecture loss in Huntington's disease

  2018cites this paper
• The transmembrane protein Crb2a regulates cardiomyocyte apicobasal polarity and adhesion in zebrafish

  2018cites this paper
• Role of Electrical Forces in Angiogenesis

  2018cites this paper
• The Role of Polarity Protein Angiomotin (AMOT) in the Human Placenta

  2018influential citation
• Degradation for better survival? Role of ubiquitination in epithelial morphogenesis

  2018cites this paper
• exc-2, an intermediate filament gene, maintains tubular excretory canals in Caenorhabditis elegans along with ifa-4 and other novel genes.

  2018cites this paper
• Liver Regeneration and New Technical Possibilities by Two-photon Based Intravital Imaging

  2018cites this paper
• Emergent patterns of collective cell migration under tubular confinement

  2017cites this paper
• Crosstalk of cell polarity signaling pathways

  2017cites this paper
• Many roads to symmetry breaking: molecular mechanisms and theoretical models of yeast cell polarity

  2017cites this paper
• Rare Deleterious PARD3 Variants in the aPKC‐Binding Region are Implicated in the Pathogenesis of Human Cranial Neural Tube Defects Via Disrupting Apical Tight Junction Formation

  2017influential citation
• Downregulation of PKCζ/Pard3/Pard6b is responsible for lung adenocarcinoma cell EMT and invasion.

  2017cites this paper
• Roles of Grainyhead-like transcription factors in cancer

  2017cites this paper
• The PAR proteins: from molecular circuits to dynamic self-stabilizing cell polarity

  2017cites this paper
• Targeting the Mucosal Barrier: How Pathogens Modulate the Cellular Polarity Network.

  2017cites this paper
• A targeted RNAi screen identifies factors affecting diverse stages of receptor-mediated transcytosis

  2017cites this paper
• Synthetic hydrogels mimicking basement membrane matrices to promote cell-matrix interactions.

  2017cites this paper
• Role of apoptosis in the development of autosomal dominant polycystic kidney disease (ADPKD)

  2017cites this paper
• A targeted RNAi screen identifies factors affecting diverse stages of receptor-mediated transcytosis

  2017cites this paper
• Embryoids, organoids and gastruloids: new approaches to understanding embryogenesis

  2017cites this paper
• Cellular Potts modeling of complex multicellular behaviors in tissue morphogenesis

  2017cites this paper
• Type VII collagen regulates tumour expression of organic anion transporting polypeptide OATP 1 B 3 , promotes front to rear polarity and increases structural organisation in 3 D spheroid cultures of recessive dystrophic epidermolysis bullosa tumour keratinocytes

  2017influential citation
• PI3K regulates intraepithelial cell positioning through Rho GTP-ases in the developing neural tube

  2017cites this paper
• Correction: Shot and Patronin polarise microtubules to direct membrane traffic and biogenesis of microvilli in epithelia

  2017cites this paper
• The embryonic development of hindbrain respiratory networks is unaffected by mutation of the planar polarity protein Scribble.

  2017cites this paper
• Signaling Networks in Epithelial Tube Formation.

  2017cites this paper
• A targeted RNAi screen identifies factors affecting diverse stages of receptor-mediated transcytosis

  2017cites this paper
• Ultrastructural features of the differentiating thyroid primordium in the sand lizard (Lacerta agilis L.) from the differentiation of the cellular cords to the formation of the follicular lumen.

  2016cites this paper
• Shot and Patronin polarise microtubules to direct membrane traffic and biogenesis of microvilli in epithelia

  2016cites this paper
• Prkci is required for a non-autonomous signal that coordinates cell polarity during cavitation.

  2016cites this paper
• Looking Beyond the Genes: The Interplay Between Signaling Pathways and Mechanics in the Shaping and Diversification of Epithelial Tissues.

  2016cites this paper
• Disruption of the Cdc42/Par6/aPKC or Dlg/Scrib/Lgl Polarity Complex Promotes Epithelial Proliferation via Overlapping Mechanisms

  2016cites this paper
• Regulation of podocalyxin trafficking by Rab small GTPases in 2D and 3D epithelial cell cultures

  2016cites this paper
• Screen to identify the novel pancreatic gene Synaptotagmin 13 (Syt13)

  2016influential citation
• Loss of laminin alpha 1 results in multiple structural defects and divergent effects on adhesion during vertebrate optic cup morphogenesis.

  2016cites this paper
• aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis

  2016cites this paper
• Retromer in Polarized Protein Transport.

  2016cites this paper
• Formins at the Junction.

  2016cites this paper
• Lumen Formation Is an Intrinsic Property of Isolated Human Pluripotent Stem Cells

  2015influential citation
• LumenFormationIs anIntrinsicPropertyofIsolatedHumanPluripotentStem Cells

  2015cites this paper
• Mechanisms of apical-basal axis orientation and epithelial lumen positioning.

  2015cites this paper