Decreased expression of cell polarity protein Scribble correlated with altered subcellular localization of the Crumbs homologue 3 protein in human adenomyotic endometrial cells

Xiaoyi Wu,Weiwen Zuo,Haiou Liu,Zehua Wang,Congjian Xu

Published 2019 in The journal of obstetrics and gynaecology research

ABSTRACT

Previous studies have revealed that loss of cell apical‐basal polarity contributed to the early stages of tumorigenesis. Adenomyosis involves a down‐growth and aberrant implantation of the endometrial basalis into the myometrium. This study discovered aberrant expression of polarity protein Scribble (Scrib) and Crumbs homologue 3 protein (CRB3) in epithelial cells of diffuse adenomyosis.

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